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High levels of glucose induce epithelial-mesenchymal transition in renal proximal tubular cells through PERK-eIF2αpathway

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Chinese Medical Journal 2019年第7期132卷 868-872页

作者： yan bao Ying Ao Bo Yi Jo Batubayier Department of Endocrinology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Pharmacology School of Basic Medical ScienceWuhan UniversityWuhanHubei 430071China Department of Internal medicine Hoboksar Mongol Autonomous County HospitalTachengXinjiang 834499China

To the Editor:Diabetic kidney disease (DKD) is one of the major causes of end-stage renal failure.Progressive mesangial expansion in the glomerulus is widely recognized.More and more evidence shows that tubulointerstitial fibrosis is also regarded as a prominent feature of DKD,in which tubular epithelial-mesenchymal transition (EMT) may play an important role.[1] During EMT,tubular epithelial cells lose their characteristic and produce high levels of myofibroblast makers such as α-smooth actin (α-SMA) which is the signature protein of EMT.[2]However,renal fibrogenesis is a complicated process in which the contribution of DKD is unknown.

关键词： cells ep protein is tra EMT

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as depression.However,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely unexplored.Here we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression resilience.We determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA circuit.Furthermore,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic manner.Regulation of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic pain.Our study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

Clinical study on the treatment of acute pancreatitis with external application of Yi-Dan Therapy based on the method of“stagnation requiring dispersion”:study protocol for a randomized controlled trial

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Gastroenterology & Hepatology Research 2024年第2期6卷 1-7页

作者： Pei-Xin Ge Bo-Yi Jia Nai-Wei Zhang Li-bao An Qiao-yan Zhang yan-Mei Cai Xiao-Na Zhang Shao-Dong Hao Hong-Jie Cheng Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing100029China Department of Gastrointestinal Disease Fangshan HospitalBeijing University of Chinese MedicineBeijing 102488China.

Background:Acute pancreatitis is an unpredictable and potentially lethal disease,causing tremendous pain in patients.The initial treatment of acute pancreatitis in modern medicine is supportive,but it is generally ineffective in relieving abdominal pain and distension.Traditional Chinese medicine has been shown to be more effective in regulating the body’s homeostasis and reducing the clinical symptoms of pancreatitis.Yi-Dan ointment,derived from Dahuang-Mudan Decoction,is an effective external ointment for treating acute pancreatitis.The aim of this trial is to investigate the clinical efficacy of Yi-Dan ointment,providing a valuable complement to existing treatment options for pancreatitis.Methods:This is a randomized controlled clinical trial with two parallel groups.Patients in the control group were given basic treatment and nursing for 7 days;in the treatment group,Yi-Dan ointment was applied externally in addition to basic treatment and nursing.The main indicator is the overall efficacy,serum amylase,acute physiology and chronic health evaluationⅡscore,symptom score,inflammatory markers,and classification of computed tomography.Conclusion:The trial results will provide high-quality evidence for Yi-Dan ointment,and provide a complement to existing treatment options for pancreatitis.

关键词： acute pancreatitis traditional Chinese medicine external treatment Yi-Dan ointment randomized controlled trial

Anlotinib in combination with Envolizumab plus Etoposide for the treatment of EX-SCLC:a case report

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Clinical Research Communications 2024年第1期7卷 29-33页

作者： Hong-Lei Guo Hong Wang yan-Qi Song Xin-Long Song Ai-Di Wang bao-Shan Liu Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China

Background:Small cell lung cancer(SCLC)is an aggressive malignant tumor with strong immunosuppressive effects,characterized by rapid doubling time and poor prognosis.Currently,effective therapeutic options are urgently needed for Extensive-stage small-cell lung Cancer.Case description:In the present case,a combination therapy of anlotinib,envolizumab,and etoposide was administered to treat an 80-year-old female patient with extensive-stage SCLC accompanied by mediastinal lymph node and bone metastasis.After two cycles of treatment,the tumor lesions in the right lungs decreased from 5.04*3.44 cm to 1.65*1.42 cm.As of now,no significant mass is seen there and no serious adverse reactions in this patient.Until September 2023,she has survived for 18 months with no disease progression.Conclusions:Research shows that Alectinib,in combination with evolocumab plus etoposide,could be an original,viable therapeutic option for the treatment option of patients with extensive-stage SCLC.

关键词： Extensive-stage Small Cell Lung Cancer anti-angiogenesis PD-1 inhibitors Combined treatment case report

Graphene-Based Photo-Fenton Catalysts for Pollutant Control

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Transactions of Tianjin University 2021年第2期27卷 110-126页

作者： yan bao Qingyun yan Jiahui Ji Bocheng Qiu Jinlong Zhang Mingyang Xing Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Jiangsu Key Laboratory of Pesticide Sciences Department of ChemistryCollege of SciencesNanjing Agricultural UniversityNanjing 210095China

Water pollution is a global environmental issue with multi-dimensional infl uences on human life.Some strategies,such as photo-Fenton reaction,have been employed to remove recalcitrant pollutants.Two-dimensional(2D)graphene and its threedimensional(3D)confi gurations have attracted considerable attention as emerging carbon-based catalysts in photo-Fenton fi elds owing to their alluring properties in electron transfer,reactant adsorption,and light response.This review summarizes the recent developments in 2D and 3D graphene-based catalysts for photo-Fenton reactions.Their structures,characteristics,activity,and mechanisms are discussed.The conclusions and outlooks are proposed for the profound understanding of challenges and future directions.

关键词： Photo-Fenton Graphene Pollutant control Aerogel Hydrogel

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji yan Xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang yan-Qiao Zhang Guo-Xin Li Jun Liang bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision medicine.These updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer patients.Key revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric cancer.For advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)patients.Additionally,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric cancer.The 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

不同官能团微塑料对斑马鱼胚胎菌群和代谢功能的胁迫效应

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环境科学 2024年第3期45卷 1859-1868页

作者：闫振华张燕包旭辉朱培元陈玉芳河海大学浅水湖泊综合治理与资源开发教育部重点实验室南京210098 河海大学环境学院南京210098 上海勘测设计研究院有限公司上海200335

为探究官能团修饰对微塑料生物效应的影响规律和机制,分析了3种聚苯乙烯微塑料(PS、PS—NH_(2)和PS—COOH)在斑马鱼(Danio rerio)胚胎内的累积特征,并利用微生物组学和代谢组学相结合的分析技术,解析了斑马鱼幼鱼体内代谢功能及微生物... 详细信息

为探究官能团修饰对微塑料生物效应的影响规律和机制,分析了3种聚苯乙烯微塑料(PS、PS—NH_(2)和PS—COOH)在斑马鱼(Danio rerio)胚胎内的累积特征,并利用微生物组学和代谢组学相结合的分析技术,解析了斑马鱼幼鱼体内代谢功能及微生物群落的响应规律.结果显示,3种微塑料都可以在斑马鱼体内产生累积,其含量范围为143~175μg·g^(-1),且不存在明显差异性.斑马鱼胚胎绒毛膜是微塑料早期暴露的主要累积场所,但不能有效阻止小粒径微塑料的穿透.未修饰的PS明显影响了斑马鱼幼鱼体内氨基糖苷类的代谢能力,PS—NH_(2)主要对氨基酸的代谢过程产生了影响,而PS—COOH则主要作用于三羧酸循环、氨基酸及糖酵解等代谢通路.3种微塑料均导致了斑马鱼幼鱼体内代谢功能的变化,从而对斑马鱼产生了毒性效应,而微塑料的官能团修饰则加强了这一影响程度.与对照组相比,PS—NH_(2)明显降低了斑马鱼幼鱼体内的微生物群落的多样性,显著增加了变形菌门(Proteobacteria)的占比,导致斑马鱼幼鱼体内的菌群失衡,从而引起鱼体代谢功能的紊乱.微塑料的官能团修饰可能会明显改变其对生物体的胁迫效应,导致难以预测的生态风险.

关键词：微塑料官能团代谢物菌群累积

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对STRICTA清单几个关键问题的梳理

针刺研究 2024年第6期49卷 661-666页

作者：谢依璇刘晓玉马培宏刘保延刘存志闫世艳北京中医药大学针灸推拿学院北京100029 北京中医药大学国际针灸创新研究院北京100029 天津中医药大学针灸推拿学院天津301617 中国中医科学院北京100700

STRICTA清单是针对针刺临床试验中干预措施报告的指南。作为CONSORT清单的扩展版,STRICTA清单促进了针刺临床研究干预措施报告质量的提升。随着时代的发展,临床研究范式不断更新,现有的STRICTA清单能否继续指导当下及未来的临床研究的报... 详细信息

STRICTA清单是针对针刺临床试验中干预措施报告的指南。作为CONSORT清单的扩展版,STRICTA清单促进了针刺临床研究干预措施报告质量的提升。随着时代的发展,临床研究范式不断更新,现有的STRICTA清单能否继续指导当下及未来的临床研究的报告,是亟需考虑的问题。本文系统梳理了STRICTA清单的发展与更新过程,对STRICTA清单的效用特点及有待改进之处进行了分析,并就当前遇到的困境与挑战提出了几点改进建议,以促进STRICTA清单的进一步更新与完善。

关键词： STRICTA清单针灸临床研究报告规范指南

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复合材料T型节点强度直接计算模型研究

舰船科学技术 2024年第7期46卷 52-56页

作者：石宝松严仁军武汉理工大学船海与能源动力工程学院湖北武汉430063 武汉理工大学高性能船舶技术教育部重点实验室湖北武汉430063

针对T型节点强度预测大多是通过试验进行,但试验测试存在周期长、成本高等问题,特别是对节点进行尺寸优化后再次进行试验效率较低,有必要针对复合材料T型节点直接计算模型进行研究,实现对T型节点强度的快速校核。因此以复合材料T型节点... 详细信息

针对T型节点强度预测大多是通过试验进行,但试验测试存在周期长、成本高等问题,特别是对节点进行尺寸优化后再次进行试验效率较低,有必要针对复合材料T型节点直接计算模型进行研究,实现对T型节点强度的快速校核。因此以复合材料T型节点作为研究对象,参考相关规范确定节点直接计算模型的边界条件、尺寸以及强度校核标准,得到一个用于T型节点强度校核的直接计算模型。

关键词：夹芯复合材料结构 T型节点直接计算