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二甲双胍联合运动疗法干预妊娠期糖尿病患者的临床研究

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现代生物医学进展 2024年第1期24卷 87-90,45页

作者：郭宝英王瑞青高秀莹郭彩红鲁辛安妍董雪洁于萍朱巍北京航天总医院内分泌科北京100076

目的:探讨二甲双胍联合运动疗法对妊娠期糖尿病(GDM)患者临床效果的影响。方法:将2020年3月到2022年3月北京航天总医院收治的89例GDM患者,按照抛掷硬币法随机分为组分为观察组(n=45)和对照组(n=44)。对照组口服盐酸二甲双胍片,观察组在... 详细信息

目的:探讨二甲双胍联合运动疗法对妊娠期糖尿病(GDM)患者临床效果的影响。方法:将2020年3月到2022年3月北京航天总医院收治的89例GDM患者,按照抛掷硬币法随机分为组分为观察组(n=45)和对照组(n=44)。对照组口服盐酸二甲双胍片,观察组在对照组基础上加用运动疗法。对比两组患者的临床疗效、血糖指标、氧化应激指标、炎症因子水平、妊娠结局及不良反应。结果:治疗后观察组临床疗效总有效率93.33(42/45)高于对照组75.00%(33/44)(P0.05)。结论:二甲双胍联合运动疗法能有效控制GDM患者血糖水平,优化氧化应激指标,降低炎症因子水平,改善妊娠结局,且具有一定的安全性。

关键词：妊娠期糖尿病二甲双胍运动疗法炎症因子氧化应激妊娠结局

Hot Deformation Behavior of a New 9%Cr Heat Resistant Steel G115

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Journal of Iron and Steel Research International 2013年第9期20卷 73-79页

作者： yan Peng LIU Zheng-dong LIU Wei bao Han-sheng WENG Yu-qing Key Laboratory of Advanced Material of Ministry of Eclucation of China School of Materials Science and EngineeringTsinghua University Institute for Special Steels China Iron and Steel Research Institute

The hot deformation behavior of a new heat resistant steel Gl15 designed for 650 ℃ ultra-supercritical （USC） power plants was experimentally studied. Hot compression test was carried out in the temperature range of 900-1 200 ℃ and the strain rate range of 0.1-20 s i by using Gleeble 3800 thermal-mechanical simulator, and the corresponding flow curves were obtained. Experimental results show that the flow stress increases with the decrease of deformation temperature and the increase of strain rate. The hot deformation activation energy of G115 steel was determined to be 494 kJ/mol and the constitutive equation was also obtained. For convenience of the practical applica-tion, a good approximate equation was obtained for calculating the peak stress values of Gl15 steel under different deformation conditions. At the strain value of 0.9, natural logarithm of the critical Zener Hollomon parameter Zc of Gl15 steel was determined to be in the scope of 49.67 and 50.65, above which there will be no dynamic recrystalliza-tion （DRX）. And natural logarithm of the critical Zener-Hollomon parameter Zc of Gl15 steel was determined to be in the scopes of 45.58 and 46.27, below which full DRX may occur. Then, the status diagram of dynamic micro structures of G115 steel was established. In addition, the strain rate sensitivity of Gl15 steel is not constant during the test temperature range and it increases linearly from 900 to 1 200 ℃. Therefore, hot deformation at higher tem- peratures would obtain better workability.

关键词： heat resistant steel G115 hot deformation dynamic recrystallization constitutive equation Zener Hol-lomon parameter

GSK3β inhibitor promotes myelination and mitigates muscle atrophy after peripheral nerve injury

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Neural Regeneration Research 2018年第2期13卷 324-330页

作者： Jian Weng yan-hua Wang Ming Li Dian-ying Zhang bao-guo Jiang Department of Orthopedics and Trauma Peking University People's Hospital

Delay of axon regeneration after peripheral nerve injury usually leads to progressive muscle atrophy and poor functional recovery. The Wnt/β-catenin signaling pathway is considered to be one of the main molecular mechanisms that lead to skeletal muscle atrophy in the elderly. We hold the hypothesis that the innervation of target muscle can be promoted by accelerating axon regeneration and decelerating muscle cell degeneration so as to improve functional recovery of skeletal muscle following peripheral nerve injury. This process may be associated with the Wnt/β-catenin signaling pathway. Our study designed in vitro cell models to simulate myelin regeneration and muscle atrophy. We investigated the effects of SB216763, a glycogen synthase kinase 3 beta inhibitor, on the two major murine cell lines RSC96 and C2C12 derived from Schwann cells and muscle satellite cells. The results showed that SB216763 stimulated the Schwann cell migra- tion and myotube contraction. Quantitative polymerase chain reaction results demonstrated that myelin related genes, myelin associated glycoprotein and cyclin-D1, muscle related gene myogenin and endplate-associated gene nicotinic acetylcholine receptors levels were stimulated by SB216763. Immunocytochemical staining revealed that the expressions of ^-catenin in the RSC96 and C2C12 cytosolic and nuclear compartments were increased in the SB216763-treated cells. These findings confirm that the glycogen synthase kinase 3 beta in- hibitor, SB216763, promoted the myelination and myotube differentiation through the Wnt/β-catenin signaling pathway and contributed to nerve remyelination and reduced denervated muscle atrophy after peripheral nerve injury.

关键词： nerve regeneration glycogen synthase kinase 3 beta inhibitor SB216763 myelination myotube differentiation denervated muscle atrophy Wnt/^-catenin Schwann cell muscle cells peripheral nerve injury neural regeneration

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单侧双通道内镜技术治疗腰椎管狭窄症

临床骨科杂志 2024年第3期27卷 318-322页

作者：薛双桃赵广超吴天亮夏太宝严政桂召柳王玉梅华东师范大学附属芜湖医院骨科安徽芜湖241000

目的探讨单侧双通道内镜(UBE)技术治疗腰椎管狭窄症(LSS)的疗效。方法采用UBE技术治疗30例LSS患者。观察指标:术后住院时间,并发症发生情况,腰、腿痛VAS评分,ODI评分。采用MacNab评分评价疗效。结果患者均获得随访,时间6~24个月。术后... 详细信息

目的探讨单侧双通道内镜(UBE)技术治疗腰椎管狭窄症(LSS)的疗效。方法采用UBE技术治疗30例LSS患者。观察指标:术后住院时间,并发症发生情况,腰、腿痛VAS评分,ODI评分。采用MacNab评分评价疗效。结果患者均获得随访,时间6~24个月。术后住院时间3~13(6.17±2.44)d。除1例出现马尾神经损伤症状外,29例术后均无神经损伤、硬膜囊撕裂及脑脊液漏、椎管内血肿、切口感染等并发症发生。腰、腿痛VAS评分及ODI评分:术后各时间段均低于术前(P<0.05);随时间推移,各指标均越来越优(P<0.05)。末次随访时采用MacNab评分评价疗效:优20例,良8例,可1例,差1例,优良率28/30。结论UBE技术治疗LSS,既可单、双侧减压,也可镜下融合,而且对脊柱稳定性破坏小,患者术后恢复较好,疗效满意。

关键词：单侧双通道内镜技术腰椎管狭窄症单侧入路双侧减压

File format for storage of scalable video

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 706-712页

作者： BAI Gang SUN Xiao-yan WU Feng YIN bao-cai LI Shi-peng Beijing Municipal Multimedia and Intelligent Software Key Laboratory Beijing University of Technology Beijing 100022 China Microsoft Research Asia Beijing 100086 China Microsoft Research Asia Beijing 100086 China Beijing Municipal Multimedia and Intelligent Software Key Laboratory Beijing University of Technology Beijing 100022 China Microsoft Research Asia Beijing 100086 China

A file format for storage of scalable video is proposed. A generic model is presented to enable a codec independent description of scalable video stream. The relationships, especially the dependencies, among sub-streams in a scalable video stream are specified sufficiently and effectively in the proposed model. Complying with the presented scalable video stream model, the file format for scalable video is proposed based on ISO Base Media File Format, which is simple and flexible enough to address the demands of scalable video application as well as the non-scalable ones.

关键词： Codes (standards) Data structures Digital storage Internet Mathematical models Multimedia systems

Interfacial precipitation in{1012}twin boundaries of a Mg-Gd-Zn-Zr alloy

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Journal of Materials Science & Technology 2021年第34期93卷 103-109页

作者： Zixiang yan Qiang yang Fanzhi Meng Rui Ma Rirong bao Xiaojuan Liu Jian Meng Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China University of Science&Technology of China Hefei 230026PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001 PR China

Twinning and precipitation play important roles in deformation and strengthening of magnesium *** this work,interfacial precipitation in{1012}twin boundaries(TBs)of a cold-stamped Mg-12Gd-1.2Zn-0.4Zr alloy was investigated using atomic-resolution high-angle annular dark-field scanning transmission electron *** periodic segregation of Gd+Zn atoms in the~86.2°{1012}TBs with basal-prismatic facets and in the symmetric tilting TBs(obviously>86.2°)frequently occurred,resulted in the formation of new interfacial phases,namelyβ_(TB)’having a monoclinic structure in the TBs with two segregation layers andβ_(TB) having a tetragonal structure in the TBs with three or more segregation *** formation ofβ_(TB) clearly accelerates peak-aging and improves the alloy’s strength.

关键词： Magnesium alloys Twinning Scanning/transmission electron microscopy(STEM) Segregation Interfacial precipitate

Primary spinal melanoma： a case report and literature review

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Chinese Medical Journal 2012年第22期125卷 4138-4141页

作者： yan Liang CHANG Zhen LIU yang HE bao-rong HAO Ding-jun Xi An Jiao Tong Univ Coll Med Hong Hui Hosp Xian 710054 Shaanxi Peoples R China

This case report describes a 44-year-old woman with primary spinal cord malignant melanoma localized in the lumbar region. This is a very rare lesion. The patient presented with back pain and slight weakness in her lower extremities. Magnetic resonance imaging showed hyperintense signals on Tl-weighted images and hypointense signals on T2-weighted images. The entire tumor was removed surgically. The patient＇s postoperative clinical examination revealed mild neurological improvements. Histopathological investigations confirmed the tumor was a malignant melanoma. When treating common lesions of the lumbar spinal cord with a benign appearance, surgeons should be aware of the potential for malignant tumors.

关键词： spinal melanoma primary

聚乙二醇接枝炭黑纳米导电复合材料气敏性研究

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江苏化工 2004年第1期32卷 27-30,49页

作者：王晓玲罗延龄张宝旺桑德文陕西师范大学化学与材料科学学院陕西西安710062

以聚乙二醇接枝炭黑(PEG-g-CB)为导电粒子,不同相对分子质量的聚乙二醇(PEG)为基体,制备了PEG/PEG-g-CB纳米导电高分子复合材料,并研究了其气敏性能。结果发现,该复合材料在PEG极性溶剂蒸汽中电阻响应快,而在非极性溶剂蒸气中电阻几乎... 详细信息

以聚乙二醇接枝炭黑(PEG-g-CB)为导电粒子,不同相对分子质量的聚乙二醇(PEG)为基体,制备了PEG/PEG-g-CB纳米导电高分子复合材料,并研究了其气敏性能。结果发现,该复合材料在PEG极性溶剂蒸汽中电阻响应快,而在非极性溶剂蒸气中电阻几乎不改变;PEG的晶相结构以及CB的接枝与否对响应重复性有很大影响。

关键词：聚乙二醇接枝炭黑纳米导电复合材料气敏性电阻响应性蒸汽响应性蒸汽响应重复性

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冷热流体湍性射流增压过程中的温度特性研究

液压气动与密封 2015年第2期35卷 4-7页

作者：罗天洪陈才鲍延年范玉德马翔宇重庆交通大学机电与汽车工程学院重庆400074 中国工程物理研究院化工材料研究所四川绵阳621900

基于计算流体动力学(CFD)软件STAR-CCM+对冷热流体湍性射流增压过程进行了数值模拟,运用大涡模拟湍性射流模型及Smqgorinsky-Lilly亚格子模型,对冷热流体湍性射流增压过程中容器内部速度场、压力场和温度场进行模拟,获得了速度、压力变... 详细信息

基于计算流体动力学(CFD)软件STAR-CCM+对冷热流体湍性射流增压过程进行了数值模拟,运用大涡模拟湍性射流模型及Smqgorinsky-Lilly亚格子模型,对冷热流体湍性射流增压过程中容器内部速度场、压力场和温度场进行模拟,获得了速度、压力变化及温度分布规律,揭示高压容器增压过程中冷热流体混合的温度特性。从CAE的角度分析了高压容器增压过程中冷然流体混合的压强变化和温度分布不均的原因,为高压容器增压和内部温度均匀化提供理论依据。

关键词：高压容器湍性射流大涡模拟卷吸温度均匀化