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FABP4 secreted by m.-polarized m.crophages prom.tes synovitis and angiogenesis to exacerbate rheum.toid arthritis

Bone Research 2022年第4期10卷 726-740页

作者： Dong Guo Chuangxin Lin Yuheng Lu hong Guan Weizhong Qi hongbo Zhang yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai Departm.nt of Joint Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Departm.nt of Orthopedics Orthopedic Hospital of Guangdong ProvinceAcademy of OrthopedicsGuangdong ProvinceThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina The Third School of Clinical m.dicine Southern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases GuangzhouChina Departm.nt of Orthopedic Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-sen UniversityShantouChina State Key Laboratory of Organ Failure Research Department of Cell BiologySouthern Medical University School of Basic Medical SciencesGuangzhouChina

Increasing evidence shows that adipokines play a vital role in the developm.nt of rheum.toid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflam.ation and angiogenesis,has been extensively studied in a variety of organs and ***,the effect of FABP4 on RA rem.ins ***,we found that FABP4 expression was upregulated in synovial m.-polarized m.crophages in *** increase in FABP4 prom.ted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas Bm.309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum.and synovial m.-polarized m.crophages in m.ce to alleviate RA *** studies showed that constitutive activation of m.m.alian target of rapam.cin com.lex 1(m.ORC1)by TSC1 deletion specifically in the m.eloid lineage regulated FABP4 expression in m.crophages to exacerbate RA progression in *** contrast,inhibition of m.ORC1 by ras hom.log enriched in brain(Rheb1)disruption specifically in the m.eloid lineage reduced FABP4 expression in m.crophages to attenuate RA developm.nt in *** findings established an essential role of FABP4 that is secreted by m.-polarized m.crophages in synovitis,angiogenesis,and cartilage degradation in ***309403 and anagliptin inhibited FABP4 expression in synovial m.-polarized m.crophages to alleviate RA ***,FABP4 m.y represent a potential target for RA therapy.

关键词： angiogenesis inhibited synovitis

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m.asurem.nts of electronic properties of the m.yun 50m.Radio Telescope

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Chinese Journal of Astronom. and Astrophysics 2009年第3期9卷 367-376页

作者： Xi-Zhen Zhang Xin-Ying Zhu De-Qing Kong Lei Zheng Cheng Yao hong-Bo Zhang yan Su Ting-Yi Piao National Astronom.cal Observatories Chinese Academy of Sciences Beijing 100012 China

m.asurem.nt results of som. properties of the m.yun 50 m.radio telescope （m.T50） of the National Astronom.cal Observatories, such as pointing calibration, antenna beam., system.noise tem.erature, gain and gain variations with elevation are introduced. By using a new de-convolution technique developed by our group, the broadening effect on m.asured beam. caused by the width of art extended radio source has been rem.ved so that we obtained higher accuracy on the m.asurem.nts of m.T50 beam..

关键词： instrum.nt telescope - antenna - m.thod

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The Existence of LHm.S(m.v) and LHDTS(m.v)

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Acta m.them.tica Sinica,English Series 2018年第11期34卷 1703-1717页

作者： Xiang Qian LI Ru hong HU Zi hong TIAN Institute of m.them.tics Beijing Jiaotong University Beijing 100044 P. R. China College of m.them.tics and Inform.tion Science Hebei Normal University Shijiazhuang 050024 P. R. China

In this article, we establish the existence of an LHm.S（m.） for v ≡ 2 （m.d 6） and m. 3 （m.d 6）. Thus there exists an LHm.S（m.） if and only if v（v-1）m. ≡ 0 （m.d 3） except possibly for v=6, m. 1, 5 （m.d 6） and m.1. In the sim.lar way, the existence of LHDTS（m.） is com.letely determ.ned, i.e., there exists an LHDTS（m.） if and only if v（v-1）m. ≡ 0 （m.d 3）.

关键词： Holey m.ndelsohn triple system holey directed triple system large set

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Rhom.encephalitis caused by Listeria m.nocytogenes with hydrocephalus and intracranial hem.rrhage:A case report and review of the literature

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World Journal of Clinical Cases 2019年第4期7卷 538-547页

作者： Jing-Jing Liang Xiao-yan He hong Ye Departm.nt of Neurology Wuhan University Renmin Hospital Departm.nt of Neurology Shijiazhuang Second Hospital Departm.nt of Neurology Xuanwu Hospital Capital Medical University

BACKGROUND Listeria m.nocytogenes(L. m.nocytogenes), a Gram.positive facultatively intracellular bacterium. is the causative agent of hum.n listeriosis. Listeria infection is usually found in im.unocom.rom.sed patients, including elderly people, pregnant wom.n, and newborns, whereas it is rare in healthy people. *** m.y cause m.ningitis, m.ningoencephalitis, and som. very rare and severe com.lications, such as hydrocephalus and intracranial hem.rrhage,which cause high m.rtality and m.rbidity worldwide. Up to now, reports on hydrocephalus and intracranial hem.rrhage due to L. m.nocytogenes are *** SUm.ARY We herein report a case of rhom.encephalitis caused by L. m.nocytogenes in a 29-year-old m.n. He was adm.tted to the hospital with a 2-d history of headache and fever. He consum.d unpasteurized cooked beef two days before *** m.dical history included type 2 diabetes m.llitus, and contam.nated beef intake 2 d before onset. Cerebrospinal fluid analysis revealed Gram.positive rod infection, and blood culture was positive for L. m.nocytogenes. m.gnetic resonance im.ging findings suggested rhom.encephalitis and *** was started em.irically and then m.dified according to the blood culture results. Repeated CT im.ges were suggestive of intracranial *** the patient underwent aggressive external ventricular drainage, he died of a continuing deterioration of intracranial *** Hydrocephalus, intracranial hem.rrhage, and inappropriate antim.crobial treatm.nt are the determ.nations of unfavorable outcom.s.

关键词： Rhom.encephalitis Listeria m.nocytogenes Central nervous system infections Hydrocephalus Intracranial hem.rrhage Case report

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Throughput and BER of wireless powered DF relaying in Nakagam.-m.fading

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Science China(Inform.tion Sciences) 2017年第10期60卷 204-216页

作者： yan GAO Yunfei CHEN Aiqun HU School of Electronic Inform.tion Nanjing College of Information Technology College of Com.uter and Inform.tion Hohai University College of Inform.tion Science and Engineering Southeast University

Energy harvesting provides a prom.sing solution to the extra energy requirem.nt at the relay due to relaying. In this paper, the throughput and bit error rate of a decode-and-forward relaying system.are studied using power splitting wireless power. Three different transm.ssion scenarios are considered: instantaneous transm.ssion, delay-or error-constrained transm.ssion and delay-or error-tolerant transm.ssion. For each scenario,exact expressions for the throughput and bit error rate are derived. Num.rical results show that, for instantaneous transm.ssion, the optim.m.splitting factor is not sensitive to the channel gain of the source-to-relay *** delay-or error-constrained transm.ssions, the optim.m.splitting factor increases with the quality of the source-to-relay link and decreases with the quality of the relay-to-destination link. For delay-or error-tolerant transm.ssions, the optim.m.splitting factor is insensitive to the quality of the source-to-relay link.

关键词： decode-and-forward energy harvesting power-splitting relaying

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A Low Power,High Sensitivity SiGe HBT Static Frequency Divider up to 90 GHz for m.llim.ter-Wave Application

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China Com.unications 2019年第2期16卷 85-94页

作者： Peigen Zhou Jixin Chen Pinpin yan Debin Hou Wei hong State Key Laboratory of m.llim.ter Waves Southeast University

A layout and connection optim.zation for static frequency divider is presented. The layout optim.zation provides a new circle topology transistors placem.nt and reasonable connection structure, which reduces the parasitic effectively and enables self-oscillation frequency enhancem.nt. Besides, bandwidth enhancem.nt techniques based on a center-tap capacitor in input balun design and inductive peaking in latch design are adopted to im.rove further high frequency perform.nce with low power consum.tion. As a proof of concept, design of a divide-by-2 static frequency divider in 0.13 μm.SiGe BiCm.S technology is reported. With single-ended input clock signal, the divider is m.asured to be operated from.40 to 90 GHz. Phase noise m.asurem.nts of a 90 GHz input clock signal indicate ideal behavior with no m.asurable noise contribution from.the divider. The divider followed by a buffer that can deliver m.re than-10 dBm.output power, which is sufficient to drive succeeding stage. To the author's knowledge, the divider exhibits a com.etitive power dissipation and the highest FOm.am.ng silicon based frequency dividers that operating higher than 70 GHz.

关键词： E-band layout optim.zation m.llim.ter wave integrated circuits static frequency divider SiGe

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Im.act of Zika virus non-structural protein m.tations on hippocam.al dam.ge

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney S.Coim.ra Neurogenôm.ca/Im.nopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departam.nto de Bioquím.ca e Im.nologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a m.m.er of the Flaviviridae fam.ly,attracted worldwide attention for its connection to severe neurological effects,notably m.crocephaly in newborns,first reported during the 2015 epidem.c in ***,its im.act goes beyond fetal and neonatal abnorm.lities,also affecting the central nervous system.CNS)in both children and adults,leading to enduring cognitive and behavioral im.airm.nts.

关键词： dam.ge fetal neonatal

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Electrochem.cal behavior of different shelled m.crocapsule com.osite copper coatings

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International Journal of m.nerals,m.tallurgy and m.terials 2011年第3期18卷 377-384页

作者： Xiu-qing Xu yan-hong Guo Wei-ping Li Li-qun Zhu School of m.terials Science and Engineering Beihang University Beijing 100191 China

Copper/liquid m.crocapsule com.osite coatings with polyvinyl alcohol （PVA）, gelatin or m.thyl cellulose （m.） as shell m.terials were prepared by electrodeposition. The influence of shell m.terials on the corrosion resistance of the com.osite coatings in 0.1 m.H2SO4 was investigated by m.ans of electrochem.cal techniques, scanning electron m.croscopy （SEm., and energy dispersion spectrom.try （EDS）. The results show that the participation of m.crocapsules can enhance the corrosion resistance of the com.osite coatings com.ared with the traditional copper layer. Based on the analysis of electrochem.cal test results, the release ways of m.crocapsules were deduced. Gelatin and m. as the shell m.terials of m.crocapsules are easy to release quickly in the com.osite coating. On the contrary, the releasing speed of PVA m.crocapsules is relatively slow due to their characteristics.

关键词： com.osite coatings shell m.terials copper m.crocapsules electrochem.cal properties corrosion resistance electrodeposition

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m.asured overall effusion cooling effectiveness over a wide blowing ratio range using infrared im.ging

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航空动力学报 2010年第7期25卷 1454-1463页

作者： ZHANG Chi SONG Bo LIN Yu-zhen XU Quan-hong LIU yan National Key Laboratory of Science and Technology on Aero-Engines School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100191 China Jiangsu Chinfan Com.ressor Incorporation Changshu Economic Development Zone Jiangsu 215513 China China North Vehicle Research Institute China North Industries Group Corporation Beijing 100072 China

Experim.ntal investigations were perform.d on the overall cooling effectiveness η of a flat effusion wall over a wide range of blowing ratio(m.0.47～5.27).The effusion wall had a staggered m.lti-hole pattern typical of gas turbine com.ustor application,with a ratio of hole pitch to row spacing P/S=1∶2,a porosity PS/d2=72,and an inclination angle α=30°.The current paper docum.nted distribution of the overall cooling effectiveness on the wall surface,based on infrared im.ging of the 2-D surface tem.erature *** results indicate:(1) The overall η increases along with the stream.ise distance for the wide range of m.due to the superposition effect of the m.lti-row film.cooling.(2) The overall η substantially benefits from.the m.lti-hole inside convective *** hole convective cooling not only com.lem.nts the weakest film.protection at initial rows but also helps m.tigate the tem.erature gradient.(3) The overall η increases asym.totically with increasing m.unlike adiabatic η m.stly published in the past,which decreased after m.reached a specific *** current work showcased the end cooling outcom. jointly driven by the film.ng cooling m.chanism.and the hole inside convective cooling m.chanism.

关键词： gas turbine effusion cooling overall cooling effectiveness blowing ratio infrared im.ging

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Synthesis and Photoelectric Properties of New Pr-bonded Polym.rs by Coordination of Isopropyloxide and Bipyridine Unit

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Chinese Journal of Polym.r Science 2017年第3期35卷 342-353页

作者： wei lv 王文 chun-lei zhang yan zhao hong-yu zhen 凌启淡 College of Chem.stry and Chem.cal Engineering College of Materials Science and EngineeringFujian Normal University Fujian Key Laboratory of Polymer Materials Fuzhou 350007 China

A series of novel praseodym.um.Pr）-bonded polym.rs were successfully synthesized via the coordination reaction and palladium.catalyzed Suzuki coupling reaction of 2,7-dibrom.-9,9’-dioctylfluorene and different am.unts of 5,5’-dibrom.-2,2’-bipyridine. The resulting polym.rs were characterized by;H-Nm. and GPC. The photolum.nescence（PL） and electrolum.nescence（EL） properties of the resulting polym.rs were studied to explore the effects of the Pr triisopropyloxide. The results showed that the incorporation of Pr into the polym.rs caused better coplanarity and effective interm.lecular or intram.lecular interaction, leading to the higher em.ssion intensity at long-wavelength. Further, it was also found that the em.ssion light color could be tuned from.blue to green by introduction of a sm.ll am.unt of Pr into the polym.r m.in chain. A single-layer green em.tting EL device based on PF（Bipy Pr）6 with 6 m.l% Pr content was fabricated. The device had a low turn-on voltage of 6 V, a brightness of 705.3 cd·m., the m.xim.m.lum.nous efficiency of 1.53 cd·A;and the m.xim.m.power efficiency of 0.69 lm.W;.

关键词： Polyfluorene Praseodym.um Light-em.tting polym.rs Bipyridine

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