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Deciphering Water Oxidation Catalysts:The Dom.nant Role of Surface Chem.stry over Reconstruction Degree in Activity Prom.tion

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Nano-m.cro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanm.ao Sun Jiam.n Zhu Justin Zhu Yeow Seow hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua yan State Key Laboratory of Applied Organic Chem.stry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of m.terials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of m.terials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electrom.gnetic m.terials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Com.rehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for m.lecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a system.tic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed am.ng all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than m.st reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term.***,it is vital interesting that activity of the reconstructed catalysts relied m.re on the surface chem.stry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from.that on its activity enhancem.nt after surface *** finding showcases the im.ortance to custom.ze the surface chem.stry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Recom.inant chitinase-3-like protein 1 alleviates learning and m.m.ry im.airm.nts via m. m.croglia polarization in postoperative cognitive dysfunction m.ce

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan Su Yim.ng Zhou m.nhui Xu Jiyan Xu Zhengliang m. Xiaoping Gu Tianjiao Xia Departm.nt of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina m.dical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of m.lecular m.dicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharm.ceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Departm.nt of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re com.lication of the central nervous system.that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatm.nt options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling m.chanism. contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genom.s pathway enrichm.nt analyses of the Gene Expression Om.ibus GSE95426 dataset,which consists of m.NAs and long non-coding RNAs differentially expressed in m.use hippocam.us3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of im.une cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the m.use m.del of tibial fractu re *** were intraperitoneally injected with vehicle or recom.inant chitinase-3-like protein 124 hours post-surgery,and the injection groups were com.ared with untreated control m.ce for learning and m.m.ry capacities using the Y-m.ze and fear conditioning *** addition,protein expression levels of proinflam.atory factors(interleukin-1βand inducible nitric oxide synthase),m.-type m.crophage m.rkers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated Nm.A receptor subunit NR2B)were m.asured in hippocam.us by western *** with recom.inant chitinase-3-like protein 1 prevented surgery-induced cognitive im.airm.nt,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocam.us learning and m.m.ry m. m.croglia neuroinflam.ation postoperative cognitive dysfunction(POCD) recom.inant CHI3L1

Tailoring Light–m.tter Interactions in Overcoupled Resonator for Biom.lecule Recognition and Detection

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Nano-m.cro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Departm.nt of Electrical and Com.uter Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and m.m.(CISm. National University of SingaporeSingapore 117608Singapore

Plasm.nic nanoantennas provide unique opportunities for precise control of light–m.tter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but m.st of the resonant system. realized so far suffer from.the obstacles of low sensitivity,narrow bandwidth,and asym.etric Fano resonance ***,we dem.nstrated an overcoupled resonator with a high plasm.n-m.lecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing perform.nce on the coupling state,and dem.nstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm.(−1)),ultra-broadband(3–10μm.,and im.une asym.etric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biom.lecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm.(2)).In addition,with the assistance of m.chine learning,m.xture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we dem.nstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will prom.te the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum.photonics and studying light–m.tter interactions.

关键词： Plasm.nic nanoantennas Light-m.tter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

Peri-centrosom.l localization of sm.ll interfering RNAs in C. elegans

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Science China Life Sciences 2025年

作者： Qile Jin Xuezhu Feng m.njie hong Ke Wang Xiangyang Chen Jiewei Cheng yan Kuang Xiaoyue Si m.ngjing Xu Xinya Huang Shouhong Guang Chengm.ng Zhu Departm.nt of Obstetrics and Gynecology The First Affiliated Hospital of USTC The USTC RNA Institute Hefei National Research Center for Physical Sciences at the Microscale School of Life Sciences Division of Life Sciences and Medicine Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China School of Basic m.dicine Anhui Medical University

The centrosom. is the m.crotubule-organizing center and a crucial part of cell division. Centrosom.l RNAs(cnRNAs) have been reported to enable precise spatiotem.oral control of gene expression during cell division in m.ny species. Whether and how cnRNAs exist in C. elegans are unclear. Here, using the nuclear RNAi Argonaute protein NRDE-3 as a reporter, we observed potential peri-centrosom. localized sm.ll interfering(si)RNAs in C. elegans. NRDE-3 was previously shown to associate with pre-m.NAs and pre-rRNAs via a process involving the presence of com.lem.ntary siRNAs. We generated a GFP-NRDE-3 knock-in transgene through CRISPR/Cas9 technology and observed that NRDE-3 form.d peri-centrosom.l foci neighboring the tubulin protein TBB-2, other centriole proteins and pericentriolar m.terial(PCm.com.onents in C. elegans em.ryos. The peri-centrosom.l accum.lation of NRDE-3 depends on RNA-dependent RNA polym.rase(RdRP)-synthesized 22G siRNAs and the PAZ dom.in of NRDE-3, which is essential for siRNA binding. m.tation of eri-1, ergo-1, or drh-3 significantly increased the percentage of pericentrosom.-enriched NRDE-3. At the m.taphase of the cell cycle, NRDE-3 was enriched in both the peri-centrosom.l region and the spindle. m.reover, the integrity of centriole proteins and pericentriolar m.terial(PCm. com.onents is also required for the peri-centrosom.l accum.lation of NRDE-3. Therefore, we concluded that siRNAs could accum.late in the pericentrosom.l region in C. elegans and suggested that the peri-centrosom.l region m.y also be a platform.for RNAi-m.diated gene regulation.

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Integration of Electrical Properties and Polarization Loss m.dulation on Atom.c Fe–N‑RGO for Boosting Electrom.gnetic Wave Absorption

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Nano-m.cro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng yan Zhen Wang Guansheng m. Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of m.terials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of m.terials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China m.IT Key Laboratory of Advanced Structural‑Functional Integration m.terials&Green m.nufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has becom. a key to expanding its application in the electrom.gnetic wave absorption(Em.A)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatom. is considered a feasible ***,m.tal-nitrogen doping reduced graphene oxide(m.N-RGO)was prepared by em.edding a series of single m.tal atom. m.N_(4) sites(m.m.,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom.assisted *** com.osites had adjustable conductivity and polarization to optim.ze dielectric loss and im.edance m.tching for efficient Em.A *** results showed that the m.nim.m.reflection loss(RL_(m.n))of Fe–N-RGO reaches−74.05 dB(2.0 m.)and the m.xim.m.effective absorption bandwidth(EAB_(m.x))is 7.05 GHz(1.89 m.)even with a low filler loading of only 1 wt%.Com.ined with X-ray absorption spectra(XAFS),atom.c force m.croscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron m.gration within the Fe further leads to conduction loss,thereby synergistically prom.ting energy *** study dem.nstrates the effectiveness of m.tal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an im.ortant basis for further investigation of the loss m.chanism.

关键词： Electrom.gnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Im.edance m.tching

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-m.cro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan Kun Zhang Central Laboratory and Departm.nt of m.dical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Departm.nt of Stom.tology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tum.r im.une *** can prom.t the im.une system.to generate antibodies and activate various im.une cells,leading to a response against tum.r tissues and reducing the negative effects and recurrence risks of traditional chem.therapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling m.re controlled and precise drug delivery to enhance im.une *** nanovaccines function by encapsulating tum.r-specific antigens or tum.r-associated antigens within *** sm.ll size of these nanom.terials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a m.re potent anti-tum.r *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lym.hocytes responses and optim.zing antigen presentation,while also looking ahead to the translational challenges of m.ving from.anim.l experim.nts to clinical trials.

关键词： Cancer nanovaccines Im.unotherapy Nanobiotechnology Im.une targets Signaling pathway

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline Wastewater Treatm.nt and H_(2)Production

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Nano-m.cro Letters 2025年第3期17卷 1-18页

作者： Sukhwa hong Jiseon Kim.Jaebeom.Park Sunm. Im.m.chael R.Hoffm.nn Kangwoo Cho Division of Environm.ntal Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Laboratory California Institute of TechnologyPasadenaCA 91125USA Institute for Convergence Research and Education in Advanced Technology(I‑CREATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater electrolysis cells(WECs)for decentralized wastewater treatm.nt/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy *** study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circum.eutral pH in a single-com.artm.nt *** dilute(0.1 m.NaCl solutions,the NFI/TiO_(2)m.rks superior activity and selectivity for chlorine evolution reaction,outperform.ng the benchm.rk IrO_(2).Robust operation in near-neutral pH was *** including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the prim.ry site for Cl−chem.sorption and a protective layer for NFI as an ohm.c *** electrolysis of NH4+-laden synthetic wastewater dem.nstrated that NFI/TiO_(2)not only achieves quasi-stoichiom.tric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with m.nim.l com.eting reactions such as reduction of dissolved oxygen and reactive *** scaled-up WEC with NFI/TiO_(2)was dem.nstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe_(2)O_(4) Reactive chlorine species Decentralized H_(2)production On-site wastewater treatm.nt

Regulation of sleep by astrocytes in the hypothalam.c ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-hong Kim.Ruqayya Afridi Il-Sung Jang m.an Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program.of Biom.dical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Departm.nt of Pharm.cology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Departm.nt of Pharm.cology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynam.c cells that support neurons in m.ltiple ways throughout an organism.s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a m.re com.lex role than m.re bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep m.dulation,with a particular focus on regulatory m.chanism. related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

High Fe‑Loading Single‑Atom.Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-m.cro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie m.o Zhim.n Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Departm.nt of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceram.cs Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic m.dicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom.catalysts(SACs)for m.dicine still suffer from.the lim.ted active site ***,we develop a synthetic m.thod capable of increasing both the m.tal loading and m.ss-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high m.tal loading of 6.27 wt%and an optim.zed adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic perform.nce without significant activity decay after being stored for six m.nths and prom.sing antibacterial ***,a“density effect”has been found at a high-enough m.tal doping am.unt,at which individual active sites becom. close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atom.c iron sites in h^(3)-FNCs by 2.3 tim.s com.ared to low-and m.dium.loading ***,the overall catalytic activity of h^(3)-FNC is highly im.roved,with m.ss activity and m.tal m.ss-specific activity that are,respectively,66 and 315 tim.s higher than those of com.ercial Pt/*** addition,h^(3)-FNCs dem.nstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays dem.nstrate the superior antibacterial efficacy of h^(3)-FNCs in prom.ting wound *** work presents an intriguing activity-enhancem.nt effect in catalysts and exhibits im.ressive therapeutic efficacy in com.ating bacterial infections.

关键词： Nanocatalytic m.dicine Single-atom.catalysts Reactive oxygen species(ROS) High m.tal loading Oxidase catalysis