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BIOCELL 2022年第8期46卷 1917-1924页

作者： ZHIYONG ZHANG yan PAN yan ZHAO MUDAN REN YARUI LI YUN FENG GUIFANG LU SHUIXIANG HE Gastroenterology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710032China Cancer Biology National Clinical Research Center for Digestive Diseasesand Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an710032China

:Colorectal cancer(CRC)is a heterogeneous cancer,and many risk factors for colorectal cancer have been *** CRC metastasis,tumor cell migration,adhesion as well as invasion are important ***-Aldrich syndrome protein family member 3(WASF3)is necessary for metastasis of various types of ***,its role in CRC progression has not been fully *** study examined the in vitro functional roles of WASF3 in the CRC and explored the underlying molecular *** used siRNA-WASF3 to gene silence WASF3 in colon cancer cell(HCT116)in *** effects of WASF3 silencing on HCT116 cell apoptosis,proliferation,migration,as well as invasion were assessed by flow cytometry,CCK-8,and transwell ***471 protein expressions were detected by immunofluorescence staining and ***,the effects of ZNF471 were studied on a series of in vitro antitumor-promoting assays using ***3 knockdown expression using small interfering RNA(siRNA)ameliorated CRC cell proliferation,anchorage-independent growth,invasion,and ***,we observed that WASF3 contributed to upregulating the metastasis signaling pathway through inhibiting the expression of *** study suggests that targeting WASF3 signaling might be a novel therapeutic strategy for treating CRC.

关键词： WASF3 Colorectal cancer ZNF471 Proliferation Metastasis

饱和烷烃处理下紫花苜蓿(Medicago sativa)的转录学特征

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西北大学学报（自然科学版） 2024年第5期54卷 889-898页

作者：李岩李云昊李雅茹赵敏秦天宇王洪粤黄萱低渗透油气田勘探开发国家工程实验室陕西西安710018 长庆油田油气工艺研究院陕西西安710018 陕西省生物技术重点实验室陕西西安710069 西北大学生命科学学院陕西西安710069

为探究紫花苜蓿在石油污染下的耐受机理,采用超声碎促溶的方法,将3种有机物(十二烷、十六烷和二十四烷)配置成质量分数均为1%的混合溶液,模拟饱和烷烃污染对紫花苜蓿幼苗进行处理,分别对污染0,6,24 h的植株取样进行转录组学分析,共获得1... 详细信息

为探究紫花苜蓿在石油污染下的耐受机理,采用超声碎促溶的方法,将3种有机物(十二烷、十六烷和二十四烷)配置成质量分数均为1%的混合溶液,模拟饱和烷烃污染对紫花苜蓿幼苗进行处理,分别对污染0,6,24 h的植株取样进行转录组学分析,共获得1431个差异表达基因(DEGs)。GO富集分析表明,这些DEGs主要涉及蛋白结合、代谢途径和催化活性等;KEGG富集分析表明,DEGs主要富集到植物病原体相互作用、MAPK信号通路和光合生物碳固定途径等。qRT-PCR验证转录组结果可靠。研究结果为研究植物降解和耐受原油中饱和石油烃污染机制原理及后续筛选和培育耐石油污染植物提供理论依据。

关键词：石油烃污染紫花苜蓿转录组差异表达基因

关于Pell方程组x^(2)-39y^(2)=1与y^(2)-Dz^(2)=16的公解

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曲阜师范大学学报（自然科学版） 2024年第4期50卷 39-44页

作者：闫档档杨海沈秦豫西安工程大学理学院陕西省西安市710048

利用同余、递归序列的方法以及Pell方程解的性质,证明了Pell方程组x^(2)-39y^(2)=1与y^(2)-Dz^(2)=16的公解,情况如下:(1)当D=2^(n)(n∈Z^(+))时,方程组只有平凡解(x,y,z)=(±25,±4,0);(2)当D=2p_(1)…p_(s)(1≤s≤4,p_(1),…,p_(s)是... 详细信息

关键词： Pell方程递归序列同余奇素数

基于粗糙径向基神经网络的刮板输送机负载预测方法研究

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煤炭工程 2024年第2期56卷 138-145页

作者：郭刚汪海涛高晓成闫尚彬黄晓俊中煤陕西榆林能源化工有限公司陕西榆林719000 中煤能源研究院有限责任公司陕西西安710001 西安科技大学通信与信息工程学院陕西西安710054

刮板输送机负载的准确预测对实现采煤机和刮板输送机的协同控制至关重要。刮板输送机短期负载受工作面环境、冲击载荷等不确定性因素的影响,具有很强的非线性和非平稳性,难以准确预测。针对此问题,本研究提出一种基于粗糙径向基神经网... 详细信息

刮板输送机负载的准确预测对实现采煤机和刮板输送机的协同控制至关重要。刮板输送机短期负载受工作面环境、冲击载荷等不确定性因素的影响,具有很强的非线性和非平稳性,难以准确预测。针对此问题,本研究提出一种基于粗糙径向基神经网络的刮板输送机负载预测方法。该方法首先建立刮板输送机电流去噪模型,得到反映综采工作面刮板输送机真实负载的电流分量;然后针对刮板输送机负载电流波动大导致的神经网络预测模型训练误差增大、预测精度低的问题,引入表征负载变化波动的上下输入粗糙神经元,提出一种粗糙径向基神经网络(RRBFNN)模型;最后基于粗糙径向基神经网络建立刮板输送机短期负载预测模型,并进行仿真实验验证。结果表明:本研究提出的RRBFNN刮板输送机短期负载预测模型,比传统RBF模型的平均绝对误差(MAE)、平均绝对百分误差(MAPE)和均方根误差(RMSE)分别降低26.22%,25.39%和14.72%,该方法能有效提高刮板输送机负载的预测精度。

关键词：刮板输送机负载预测粗糙神经元径向基神经网络

Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice

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Neural Regeneration Research 2018年第8期13卷 1368-1374页

作者： Ru-Lin Li Wei-Wei Zhao Bing-yan Gao Laboratory for Development College of Life Sciences Northwest University

Our previous study showed an association between advanced glycation end products （AGEs） and neural tube defects （NTDs）. To understand the molecular mechanisms underlying the effect of AGEs on neural tube development, C57BL/6 female mice were fed for 4 weeks with com- mercial food containing 3% advanced glycation end product bovine serum albumin （AGE-BSA） or 3% bovine serum albumin （BSA） as a control. After mating mice, oxidative stress markers including malondialdehyde and H202 were measured at embryonic day 7.5 （E7.5） of ges- tation, and the level of intracellular reactive oxygen species （ROS） in embryonic cells was determined at E8.5. In addition to evaluating NTDs, an enzyme-linked immunosorbent assay was used to determine the effect of embryonic protein administration on the N-（carboxymethyl） lysine reactivity of acid and carboxyethyl lysine antibodies at E10.5. The results showed a remarkable increase in the incidence of NTDs at El0.5 in embryos of mice fed with AGE-BSA （no hyperglycemia） compared with control mice. Moreover, embryonic protein administration resulted in a noticeable increase in the reactivity of N-（carboxymethyl） lysine and N（ε）-（carboxyethyl） lysine antibodies. Malondialdehyde and H2O2 levels in embryonic cells were increased at E7.5, followed by increased intracellular ROS levels at E8.5. Vitamin E supplementation could partially recover these phenomena. Collectively, these results suggest that AGE-BSA could induce NTDs in the absence of hyperglycemia by an underlying mechanism that is at least partially associated with its capacity to increase embryonic oxidative stress levels.

关键词： nerve regeneration neural tube defects advanced glycation end products diabetic embryopathy oxidative stress N-(carboxymethyl)lysine malondiadehyde N(ε)-(carboxyethyl) lysine embryo H2O2 bovine serum albumin neural regeneration

Radial Distribution Characteristics of Microstructure and Mechanical Properties of Ti–6Al–4V Butt Joint by Rotary Friction Welding

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Acta Metallurgica Sinica(English Letters) 2015年第10期28卷 1291-1298页

作者： Hai-yan Chen Li Fu Wen-Yuan Zhang Fen-Jun Liu State Key Laboratory of Solidification Processing Northwestern Polytechnical University Shaanxi Key Laboratory of Friction Welding Technologies

Ti-6Al-4V rods were butt-welded by rotary friction welding in this study. Additionally, the radial differences in microstructure and mechanical property of joints were investigated by hierarchy slicing method. The results displayed that the width of weld zone and heat-affected zone of joints became wider along radial direction. Meanwhile, the tensile strength of joints decreased gradually along the radial direction. According to the theoretical analysis, the temperature gradient and inhomogeneous forging pressure leaded to the radial differences. Through K-type thermocouples, the actual temperatures at different locations were measured, and the results were consistent with the theoretical analysis. Theoretically, the radial differences of rotary friction welding joint are an inherent phenomenon; thus, the size of weldment should be limited strictly below the corresponding critical size. In order to prevent radial differences from enlarging, the welding surface profile of weldment can be processed into oval shape, and a larger forging pressure can be used within the scope of the joint deformation allowed according to causes for radial differences.

关键词： Titanium alloys Friction welding Microstructure Mechanical property

Quantum multicast schemes of different quantum states via non-maximally entangled channels with multiparty involvement

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Chinese Physics B 2021年第9期30卷 101-106页

作者： yan Yu Nan Zhao Chang-Xing Pei Wei Li State Key Laboratory of Integrated Services Networks Xidian UniversityXi'an 710071China Cloud Computing Center of Xi'an Branch of Shaanxi Telecom China TelecomXi'an 710002China

Due to the unavoidable interaction between the quantum channel and its ambient environment,it is difficult to generate and maintain the maximally ***,the research on multiparty information transmission via non-maximally entangled channels is of academic value and general ***,we utilize the non-maximally entangled channels to implement two multiparty remote state preparation schemes for transmitting different quantum information from one sender to two receivers *** first scheme is adopted to transmit two different four-qubit cluster-type entangled states to two receivers with a certain *** order to improve success probabilities of such multicast remote state preparation using non-maximally entangled channels,we put forward the second scheme,which deals with the situation that is a synchronous transfer of an arbitrary single-qubit state and an arbitrary two-qubit state from one sender to two *** particular,its success probability can reach 100%in principle,and independent of the entanglement degree of the shared non-maximally entangled ***,in the second scheme,the auxiliary particle is not required.

关键词： quantum multicast communications non-maximally entangled states remote state preparation

SCIM: Incorporating secure communication and interference management in one operation

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Digital Communications and Networks 2023年第2期9卷 512-522页

作者： Zhao Li Pintian Lyu Jun Li Zhixian Chang Jia Liu Zheng yan School of Cyber Engineering Xidian UniversityXi'an710126China Technol.on Commun.Net.Lab The 54th Research Inst.of China Elec.Technol.Group CorpShijiazhuang050081China School of Telecommun.and Inf.Engineering Xi'an University of Posts&TelecommunXi'an710071China School of Computer Science and Technology Xidian UniversityXi'an710126China The Department of Comnet Aalto UniversityEspoo02150Finland

Due to the broadcast nature of wireless communications,users’data transmitted wirelessly is susceptible to security/privacy ***,as a result of the limitation of spectrum resources,massive wireless connections will incur serious interference,which may damage the efficiency of data ***,improving both efficiency and secrecy of data transmission is of research *** this paper,we propose a wireless transmission scheme by taking both Secure Communication(SC)and Interference Management(IM)into account,namely *** this scheme,an SCIM signal is generated by the legitimate transmitter(Tx)and sent along with the desired signal,so that the SCIM signal can interact with and suppress the environmental interference at the legitimate receiver(Rx).Meanwhile,the SCIM signal may interfere with the eavesdropper in the coverage of legitimate transmission so as to deteriorate the eavesdropping ***,the secrecy of desired transmission is *** this way,both the transmission efficiency and privacy are ***,by taking various transmission preferences into account,we develop different implementations of SCIM,including Interference Suppression First SCIM(ISF-SCIM),Data Transmission First SCIM(DTF-SCIM),Anti-Eavesdropping First SCIM(AEF-SCIM),and Secrecy Rate Maximization SCIM(SRM-SCIM).Our in-depth simulation results have shown the proposed methods to effectively improve the efficiency and secrecy of the legitimate transmission.

关键词： Physical-layer security Secure communication Anti-eavesdropping Interference management Secrecy rate

胸腺瘤组织Slug、TdT、SOX9蛋白表达与临床病理特征及预后的关系分析

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现代生物医学进展 2024年第11期24卷 2062-2067页

作者：王晓敏陈亚龙雷光焰李林晏俊王祥丁彩霞西安交通大学医学院附属陕西省肿瘤医院病理科陕西西安710061 联勤保障部队临潼康复疗养中心检验科陕西西安710600 西安交通大学医学院附属陕西省肿瘤医院胸外科陕西西安710061

目的:分析锌指转录因子(Slug)、末端脱氧核糖核苷酸转移酶(TdT)、Y染色体性别决定区相关高速泳动族框因子9(SOX9)蛋白表达与胸腺瘤患者临床病理特征及预后的关系。方法:选择2016年5月至2018年11月在本院接受手术切除的113例胸腺瘤组织... 详细信息

目的:分析锌指转录因子(Slug)、末端脱氧核糖核苷酸转移酶(TdT)、Y染色体性别决定区相关高速泳动族框因子9(SOX9)蛋白表达与胸腺瘤患者临床病理特征及预后的关系。方法:选择2016年5月至2018年11月在本院接受手术切除的113例胸腺瘤组织及癌旁组织,利用免疫组织化学法测定Slug、TdT、SOX9蛋白阳性表达,分析Slug、TdT、SOX9蛋白表达与胸腺瘤患者临床病理特征、预后的关系。结果:胸腺瘤组织Slug、TdT、SOX9蛋白阳性表达率均高于癌旁组织(P0.05);胸腺瘤组织Slug、TdT、SOX9蛋白阳性表达在Masaoka-Koga分期、WHO分型方面比较,差异有统计学意义(P<0.05);胸腺瘤组织Slug、TdT、SOX9蛋白阳性表达与Masaoka-Koga分期、WHO分型呈正相关(P<0.05);113例胸腺瘤患者随访5年总生存率为81.42%(92/113),Slug阳性组5年生存率低于Slug阴性组(70.18%VS 92.86%),TdT阳性组5年生存率低于TdT阴性组(79.790%VS 89.57%),SOX9阳性组5年生存率低于SOX9阴性组(79.35%VS 90.48%)(χ^(2)=9.669、9.515、17.008,P<0.05);Cox比例风险回归模型分析发现,Masaoka-Koga分期(Ⅲ期/Ⅳ期)、WHO分型(B2/B3)、Slug蛋白阳性表达、TdT蛋白阳性表达、SOX9蛋白阳性表达是影响胸腺瘤患者预后的独立危险因素(HR:3.518、2.921、4.536、1.402、2.921,P<0.05)。结论:胸腺瘤组织Slug、TdT、SOX9呈高表达,三者蛋白表达与患者Masaoka-Koga分期、WHO分型有关,且是影响胸腺瘤患者5年生存率的独立危险因素。

关键词：胸腺瘤 Slug TdT SOX9 临床病理特征预后

Carrier-driven magnetic and topological phase transitions in twodimensional III-V semiconductors

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Nano Research 2023年第2期16卷 3443-3450页

作者： yan Li Xinru Ma Hongwei Bao Jian Zhou Fei Ma Jingbo Li State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Center for Alloy Innovation and Design Xi’an Jiaotong UniversityXi’an 710049China Institute of Semiconductors South China Normal UniversityGuangzhou 510631China

III-V semiconductors such as GaAs are widely studied as promising candidates for high-speed integrated *** these applications for conventional bulk structures,their fundamental physical properties in the nanoscale limit are still in scarcity,which is of great importance for the development of *** this work,we demonstrate that the III-V semiconductor MX(M=Al,Ga,In;X=P,As,Sb)in its two-dimensional(2D)limit could exhibit double layer honeycomb(DLHC)configuration and distorted tetrahedral coordination,according to our first-principles calculations with HSE06 hybrid *** is found that surface reconstruction endows 2D III-V DLHCs with pronouncedly different electronic and magnetic properties from their bulk counterparts due to strong interlayer ***-hat-shape bands emerge at the top valence bands of pristine AlP,GaP,InP,AlAs,and InAs DLHCs,inducing the density of states showing a sharp van Hove singularity near the Fermi *** a result,these DLHCs exhibit itinerant magnetism upon moderate hole doping,while the rest GaAs,AlSb,GaSb,and InSb DLHCs become magnetic under tensile strain with hole *** an exchange splitting of the localized pz states at the top valence bands,the hole-doped III-V DLHCs become half-metals with 100%***,the InSb DLHC shows inverted band structure near the Fermi level,bringing about nontrivial topological band structures in stacked InSb DLHC due to the strong spin-orbital *** III-V DLHCs expand the members of 2D material family and their exotic magnetic and topological properties may offer great potential for applications in the novel electronic and spintronic devices.

关键词： III-V semiconductors HSE06 hybrid functional Mexican-hat-shape bands magnetism topological bands