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Chinese Journal of Chemistry 2024年第10期42卷 1128-1132页

作者： Chao Li Lei Chen Hongye Wang zixi yan Bin Lyu Weiping Lyu Changwei Jiang Dehua Lu Jiaxing Li Ning Jiao Song Song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China

A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into indoles using CHBr_(2)*** simple conditions,readily availability of CHBr_(2)F,as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and *** mechanistic studies reveal that bromofluorocarbene generated in-situ under basic condition was the key intermediate.

关键词： Skeleton edit Fluorocarbene Ring expansion Quinoline Quinolone

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演播室声音环境改造对混响时间的影响

电视技术 2023年第11期47卷 19-21页

作者：闫子熙河北省广播电视科学技术研究所河北石家庄050011

演播室的声学环境直接影响节目拍摄的声音质量。混响时间是影响声学环境的一个重要因素。介绍河北广播电视台一个演播室建设的案例,介绍该演播室使用的各种声学处理措施,分析演播室施工前后的混响时间变化,对变化结果进行比较,为演播室... 详细信息

演播室的声学环境直接影响节目拍摄的声音质量。混响时间是影响声学环境的一个重要因素。介绍河北广播电视台一个演播室建设的案例,介绍该演播室使用的各种声学处理措施,分析演播室施工前后的混响时间变化,对变化结果进行比较,为演播室声音环境改造提供参考。

关键词：演播室混响时间声学处理

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冰屋与蒙古包——中外传统民居比较

艺术科技 2022年第15期35卷 208-210页

作者：刘聪严子茜南通大学艺术学院江苏南通226000

冰屋和蒙古包,虽然隔着半个地球,却在形态和构造上有很多相似之处。基于此,文章从历史和气候上归纳二者的形成原因,并从空间格局和构造体系分析其特点。通过中外这两种传统民居的比较,阐释其对低碳时代建筑设计的启示,对社会的可持续发... 详细信息

冰屋和蒙古包,虽然隔着半个地球,却在形态和构造上有很多相似之处。基于此,文章从历史和气候上归纳二者的形成原因,并从空间格局和构造体系分析其特点。通过中外这两种传统民居的比较,阐释其对低碳时代建筑设计的启示,对社会的可持续发展有深远的影响。

关键词：冰屋蒙古包中外传统民居

A new breakthrough in fracture transformation of aromatic derivatives of research group of Professor Ning Jiao was published in Nature

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Journal of Chinese Pharmaceutical Sciences 2021年第7期30卷 619-620页

作者： Qiu, Xu Sang, Yueqian Wu, Hao Xue, Xiao-Song yan, zixi Wang, Yachong Cheng, Zengrui Wang, Xiaoyang Tan, Hui Song, Song Zhang, Guisheng Zhang, Xiaohui HoukB, K.N. JiaoS, Ning 北京大学药学院天然药物及仿生药物国家重点实验室

7月19日,北京大学药学院天然药物及仿生药物国家重点实验室焦宁研究团队在《自然(Nature)》在线发表了题为《芳环断裂制备烯基腈》的最新研究论文,报道了关于芳环选择性催化断裂转化的突破性研究成果。通过仿生设计,该团队提出级联活化... 详细信息

7月19日,北京大学药学院天然药物及仿生药物国家重点实验室焦宁研究团队在《自然(Nature)》在线发表了题为《芳环断裂制备烯基腈》的最新研究论文,报道了关于芳环选择性催化断裂转化的突破性研究成果。通过仿生设计,该团队提出级联活化的策略,首次解决了惰性芳香化合物选择性催化开环转化的重大科学难题,开发出了一种新型催化惰性碳碳键活化模式,实现了苯胺等多种简单易得的芳烃衍生物到烯基腈的转化,取得了该领域的突破性进展,或为推动煤炭液化、生物质转化、石油裂解等提供新思路。

关键词：选择性催化石油裂解煤炭液化芳烃衍生物研究团队北京大学药学院烯基芳香化合物

苦水玫瑰中49项营养及活性成分指标分析与评价

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北京林业大学学报 2023年第2期45卷 120-128页

作者：颜子曦李永慧孟德豪张跃斌吕兆林北京林业大学生物科学与技术学院北京100083 瑞康医疗健康产业股份有限公司甘肃兰州730000 林业食品加工与安全北京市重点实验室北京100083

【目的】通过对苦水玫瑰营养及活性成分进行全方面分析,确定其营养利用价值,为苦水玫瑰的精加工深加工、高附加值产品研究以及资源开发利用提供借鉴。【方法】本研究以原产地甘肃省兰州市永登县苦水镇苦水玫瑰和引种产地甘肃省庆阳市的... 详细信息

【目的】通过对苦水玫瑰营养及活性成分进行全方面分析,确定其营养利用价值,为苦水玫瑰的精加工深加工、高附加值产品研究以及资源开发利用提供借鉴。【方法】本研究以原产地甘肃省兰州市永登县苦水镇苦水玫瑰和引种产地甘肃省庆阳市的玫瑰为实验材料,采用电感耦合等离子体质谱、气相色谱串联四极杆飞行时间质谱联用等技术手段,对苦水玫瑰中的总多糖、总黄酮、维生素C、矿质元素、脂肪酸和氨基酸等营养及活性成分进行了表征,并运用偏最小二乘法对49项营养及活性指标进行分析判定。【结果】苦水玫瑰花瓣中总黄酮、总多糖、粗蛋白含量相对丰富,含有人体所需的常量元素和微量元素。苦水玫瑰花瓣中不饱和脂肪酸所占比重高于饱和脂肪酸;所含氨基酸种类丰富,鉴定出了7种人体必须氨基酸。原产地苦水玫瑰的总黄酮、总多糖、天冬氨酸、亚油酸、维生素C、谷氨酸、α-亚麻酸等37项指标的含量均高于引种产地玫瑰。总黄酮、粗蛋白是组成苦水玫瑰营养及活性成分的主要物质。【结论】苦水玫瑰营养和活性成分含量高、种类齐全,满足现代人对低脂肪、必需氨基酸摄入以及增加功能活性因子及微量元素的需求,利用价值高。甘肃省兰州市永登县苦水镇的苦水玫瑰在各项指标中的含量要高于甘肃省庆阳市,品质较好。研究结果为苦水玫瑰产品的资源开发利用提供理论基础和科学依据。

关键词：苦水玫瑰营养及活性成分全方面分析差异性分析营养利用价值

Bio-inspired surface manipulation of halloysite nanotubes for highperformance flame retardant polylactic acid nanocomposites

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Nano Research 2024年第3期17卷 1595-1606页

作者： Yaru Sun Bin Yu yan Liu Junbo yan zixi Xu Bo Cheng Fenglei Huang Jun Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China National Engineering Research Center of Flame Retardant Materials Beijing Institute of TechnologyBeijing 100081China

High-performance flame-retardant polylactic acid(PLA)bio-composites based on biobased fillers to meet usage requirements represents a promising direction for creating a sustainable *** flame retardant PLA composites have been reported extensively,it still remains a huge challenge to develop mechanically *** flame retardant PLA composites due to plastication effect of organic flame retardants and poor compatibility of organic fillers with the matrix lead to the severe deterioration in mechanical *** this work,a bio-inspired surface manipulation strategy for halloysite nanotubes(HNTs)was proposed via a facile and green self-assembly *** structure and morphology of bio-inspired HNTs(b-HNTs)proved that biomass nanofillers(PA-NA-Fe)grew well both within the lumen and on the surface of *** growth of biomass on the inner and outer surfaces of HNTs was inspired from wooden towards enhancing the interface compatibility and imparting multi-properties to PLA *** mechanical properties(tensile,thermomechanical and anti-impact mechanical),great fire safety(heat release and smoke emission),thermostability and improved electromagnetic interference shielding effectiveness of this well-designed PLA nanocomposite were *** mechanisms of the enhanced performances of the PLA bio-composites by loading b-HNTs were *** work presents a facile and environmentally-friendly bio-inspired modification strategy for HNTs to fabricate high-performance,multi-functional polymer composites,which is also suitable for surface modification of many other nanomaterials,including nanofibers,nanotubes,nanowires,and nanosheets.

关键词： mechanical properties thermostability fire safety electromagnetic interference shielding biomass

An improved transfer learning strategy for short-term cross-building energy prediction usingdata incremental

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Building Simulation 2024年第1期17卷 165-183页

作者： Guannan Li Yubei Wu Chengchu yan Xi Fang Tao Li Jiajia Gao Chengliang Xu zixi Wang School of Urban Construction Wuhan University of Science and TechnologyWuhan 430065China Anhui Province Key Laboratory of Intelligent Building and Building Energy-saving Anhui Jianzhu UniversityHefei 230601China State Key Laboratory of Green Building in Western China Xi'an University of Architecture and TechnologyXi'an 710055China College of Urban Construction Nanjing Tech UniversityNo.200North Zhongshan RoadNanjing 210009China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Chongqing University) Ministry of Education of ChinaChongqing UniversityChongqing 400044China College of Civil Engineering Hunan UniversityChangsha 410082China Hubei Provincial Engineering Research Center of Urban Regeneration Wuhan University of Science and TechnologyWuhan 430065China

The available modelling data shortage issue makes it difficult to guarantee the performance of data-driven building energy prediction(BEP)models for both the newly built buildings and existing information-poor *** knowledge transfer learning(KTL)and data incremental learning(DIL)can address the data shortage issue of such *** new building scenarios with continuous data accumulation,the performance of BEP models has not been fully investigated considering the data accumulation ***,which can learn dynamic features from accumulated data adapting to the developing trend of new building time-series data and extend BEP model's knowledge,has been rarely *** studies have shown that the performance of KTL models trained with fixed data can be further improved in scenarios with dynamically changing ***,this study proposes an improved transfer learning cross-BEP strategy continuously updated using the coarse data incremental(CDI)*** hybrid KTL-DIL strategy(LSTM-DANN-CDI)uses domain adversarial neural network(DANN)for KLT and long short-term memory(LSTM)as the Baseline BEP *** evaluation is conducted to systematically qualify the effectiveness and applicability of KTL and improved ***-world data from six-type 36 buildings of six types are adopted to evaluate the performance of KTL and KTL-DIL in data-driven BEP tasks considering factors like the model increment time interval,the available target and source building data *** with LSTM,results indicate that KTL(LSTM-DANN)and the proposed KTL-DIL(LSTM-DANN-CDI)can significantly improve the BEP performance for new buildings with limited *** with the pure KTL strategy LSTM-DANN,the improved KTL-DIL strategy LSTM-DANN-CDI has better prediction performance with an average performance improvement ratio of 60%.

关键词： building energy prediction(BEP) cross-building data incremental learning(DIL) domain adversarial neural network(DANN) knowledge transfer learning(KTL)

Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer

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Chinese Journal of Cancer Research 2014年第1期26卷 72-80页

作者： Kai Huang Rongfa Yuan Kai Wang Junwen Hu zixi Huang Chen yan Wei Shen Jianghua Shao Department of General Surgery Second Affiliated Hospital of Nanchang University Department of Gastrointestinal Surgery Jiangxi Provincial Cancer Hospital Jiangxi Province Key Laboratory of Molecular Medicine

Objective：Homeobox B9 （HOXB9） is proposed to be involved in tumor angiogenesis and *** investigated the role of HOXB9 in the progression of colon ***：HOXB9 expression was investigated by immunohistochemically and Western blotting in 128 colon cancer patients and the results were analyzed statistically associated with clinicopathological data and survival of the *** effect of HOXB9 on cell invasion and metastases abilities were analyzed in vitro and in ***：HOXB9 is overexpressed in colon cancer tissues and significandy correlated with metastasis and poor survival of patients （P＜0.05,respectively）.Additionally,high levels of expression of HOXB9 were observed in metastatic lymph *** down-regulation of HOXB9 expression can inhibit the migration and invasive ability of colon cancer cells,while exogenous expression of HOXB9 in colon cancer cells enhanced cell migration and ***,stable knockdown of HOXB9 reduced the liver and lung metastasis of colon cancer in ***：HOXB9 may play an important role in the invasion and metastasis of colon cancer cells and may be a useful biomarker for metastasis and prognostic of colon cancer.

关键词： Homeobox B9 (HOXB9) colon cancer prognostic invasion metastasis

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不同破片对典型飞机目标的毁伤效应

兵工学报 2020年第S2期41卷 63-68页

作者：徐梓熙刘彦闫俊伯司鹏黄风雷北京理工大学爆炸科学与技术国家重点实验室北京100081 北京理工大学重庆创新中心重庆401120

为研究惰性破片及活性破片对飞机目标的毁伤情况,以某飞机为研究对象,采用起爆杀爆战斗部方式产生破片,实现对目标的动态加载;通过调整战斗部内预制破片类型,分别获得钢破片及活性破片作用下飞机的毁伤情况。实验后统计飞机关键部件毁... 详细信息

为研究惰性破片及活性破片对飞机目标的毁伤情况,以某飞机为研究对象,采用起爆杀爆战斗部方式产生破片,实现对目标的动态加载;通过调整战斗部内预制破片类型,分别获得钢破片及活性破片作用下飞机的毁伤情况。实验后统计飞机关键部件毁伤元的特征量,对比两类破片作用下飞机目标的毁伤效应。实验结果表明:钢破片对飞机发动机类高强度部件的毁伤能力高于活性破片,而活性破片对机翼类部件具有更强的毁伤能力。

关键词：飞机目标钢破片活性破片关键部件毁伤效应

箍筋间距和轴压比对爆炸载荷作用下钢筋混凝土柱动态响应的影响

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兵工学报 2020年第S2期41卷 35-43页

作者：闫俊伯刘彦李臻徐梓熙黄风雷北京理工大学爆炸科学与技术国家重点实验室北京100081 北京理工大学重庆创新中心重庆401120

以钢筋混凝土柱毁伤特性和抗爆机理为背景,通过实验研究钢筋混凝土柱在近距离爆炸载荷作用下的动态响应,得到不同比例距离下钢筋混凝土柱的破坏特征。为准确快速地评估钢筋混凝土柱的爆炸响应,利用有限元显示动力分析软件LS-DYNA,建立... 详细信息

以钢筋混凝土柱毁伤特性和抗爆机理为背景,通过实验研究钢筋混凝土柱在近距离爆炸载荷作用下的动态响应,得到不同比例距离下钢筋混凝土柱的破坏特征。为准确快速地评估钢筋混凝土柱的爆炸响应,利用有限元显示动力分析软件LS-DYNA,建立钢筋混凝土柱的三维有限元模型,同时考虑震塌效应与材料应变率效应。数值模拟结果与实验结果对比发现,该数值模拟模型可以准确模拟钢筋混凝土柱在爆炸载荷作用下动态响应。采用参数化分析方法,进一步研究箍筋配筋率和轴向载荷对钢筋混凝土柱在近距离以及远距离爆炸载荷作用下动态响应和破坏模式的影响。参数分析结果表明:箍筋配筋率对钢筋混凝土柱弯曲响应影响不大,但是可以通过提高剪切承载力提高其抗爆性能;当轴压比为0.1时,钢筋混凝土柱的抗爆能力最高。

关键词：爆炸载荷钢筋混凝土柱轴压比箍筋间距动态响应破坏模式