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Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern

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Life Metabolism 2024年第1期3卷 21-36页

作者： shuo Wang Lingling Zhang Jingyu Zhao Meijuan Bai Yijun Lin Qianqian Chu Jue Gong Ju Qiu yan Chen CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

The monocarboxylate transporter 1(MCT1),encoded by gene Slc16a1,is a proton-coupled transporter for lactate and other monocar***1-mediated lactate transport was recently found to regulate various biological ***,how MCT1 and lactate in the intestine modulate the physiology and pathophysiology of the body is *** this study,we generated a mouse model with specific deletion of Slc16a1 in the intestinal epithelium(Slc16a1IKO mice)and investigated the functions of MCT1 in the *** fed a high-fat diet,Slc16a1IKO male mice had improvement in glucose tolerance and insulin sensitivity,while Slc16a1IKO female mice only had increased *** of intestinal MCT1 in male mice was associated with downregulation of pro-inflammatory pathways,together with decreased circulating levels of inflammatory cytokines including tumor necrosis factor alpha(TNFα)and C-C motif chemokine ligand 2(CCL2).Lactate had a stimulatory effect on pro-inflammatory macrophages in *** number of intestinal macrophages was reduced in Slc16a1IKO male mice in *** deletion of Slc16a1 in male mice reduced interstitial lactate level in the *** addition,treatment of male mice with estrogen lowered interstitial lactate level in the intestine and abolished the difference in glucose homeostasis between Slc16a1IKO and wild-type *** of intestinal MCT1 also blocked the transport of lactate and short-chain fatty acids from the intestine to the portal *** effect of Slc16a1 deletion on glucose homeostasis in male mice was partly mediated by alterations in gut *** conclusion,our work reveals that intestinal MCT1 regulates glucose homeostasis in a sex-dependent manner.

关键词： MCT1 intestine lactate short-chain fatty acids insulin resistance obesity

多中心城市模式与中国式现代化——以东莞为例

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城市发展研究 2023年第7期30卷 28-34页

作者：阎硕郭荔程哲西安建筑科技大学公共管理学院

中国式现代化在城市发展中如何体现?围绕这个问题，系统梳理多中心城市区域理论和中国式现代化特征，发现二者间存在呼应，即“形态多中心性—人口规模”“功能多中心性—共同富裕”“治理多中心性—双文明、人与自然和谐、和平发展”... 详细信息

中国式现代化在城市发展中如何体现?围绕这个问题，系统梳理多中心城市区域理论和中国式现代化特征，发现二者间存在呼应，即“形态多中心性—人口规模”“功能多中心性—共同富裕”“治理多中心性—双文明、人与自然和谐、和平发展”。基于此，构建理论框架，以东莞为例展开分析，阐释潜在的机理，剖析多中心城市区域发展的中国式现代化特征。研究发现：(1)东莞空间形态层面的多中心性发展具有与人口规模巨大的中国式现代化发展相一致的动态性和复杂性；(2)东莞功能层面的多中心性发展是实现共同富裕的中国式现代化发展的关键手段；(3)东莞治理层面的多中心性发展满足了中国式现代化发展更深层次的双文明、人与自然和谐、和平发展需要。

关键词：中国式现代化多中心城市区域区域协调发展空间治理

金融发展、环境规制与工业绿色技术创新——基于偏向性内生增长视角的研究

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中国工业经济 2023年第12期 99-116页

作者：熊灵闫烁杨冕武汉大学中国边界与海洋研究院、国际问题研究院武汉大学中国边界与海洋研究院武汉大学经济与管理学院

工业绿色技术创新是推动经济绿色转型、实现“双碳”目标的重要引擎。为探讨工业绿色技术创新所面临的“动力”与“方向”问题,本文基于熊彼特内生增长模型以及偏向性技术进步模型,将金融发展与环境规制纳入统一理论框架,论证金融发展... 详细信息

工业绿色技术创新是推动经济绿色转型、实现“双碳”目标的重要引擎。为探讨工业绿色技术创新所面临的“动力”与“方向”问题,本文基于熊彼特内生增长模型以及偏向性技术进步模型,将金融发展与环境规制纳入统一理论框架,论证金融发展的融资动力、环境规制的偏向性绿色调节以及两者协同的作用机制,并使用省份—细分工业行业的面板数据进行实证验证。研究发现:金融发展可以为工业部门的研发投入提供融资动力,但无法引导其进行偏向性绿色技术创新;环境规制具有偏向性绿色调节作用,能够引导工业部门进行偏向性绿色技术创新,其中,“污染税收+绿色技术补贴”的环境政策组合调节效果最好。金融发展与环境规制存在协同作用机制,能够形成“准绿色金融”路径,引导更多资源投入绿色技术研发,从而促进工业部门绿色技术创新。异质性分析表明,在绿色金融试验区和金融发展高水平地区,金融发展与环境规制的协同效应能有效发挥作用,并与绿色金融形成互促或替代效应,而在金融发展中低水平地区则不起作用;对于清洁型产业,“环保法规+绿色技术补贴”与金融发展的协同效应最显著,而对于污染型产业,“环保法规+污染税收”与金融发展的协同效应更能有效引导其进行绿色技术创新。

关键词：金融发展环境规制工业绿色技术创新偏向性内生增长

Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao Wang Tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-Long Yuan A-Long Cui Wei-Wei Guo yan-Fang Wang Shi-Ming yang Jian-Guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for *** investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are *** have been extensively used as valuable large animal models in biomedical *** this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing ***,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL ***,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

Endoleak management and postoperative surveillance following endovascular repair of internal carotid artery vascular diseases using Willis covered stent

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Journal of Interventional Medicine 2021年第4期4卷 212-218页

作者： Lin Ma shuo yan Hao Feng Jichong Xu Huaqiao Tan Chun Fang Department of Interventional Radiology Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina

Background:To report the clinical results and experiences of endoleak management and postoperative surveillance following endovascular repair of internal carotid artery vascular diseases(ICAVDs)using Willis covered ***:Seventy-three patients with ICAVD who received Willis covered stent implantation between November 2013 and September 2018 were retrospectively *** clinical data of endoleak management and postoperative surveillance were ***:Seventy-three cases with ICAVD,including 57 aneurysms,11 carotid-cavernous sinus fistulas(CCF),and 5 surgical injuries,were all successfully installed with covered *** isolation of ICAVDs was achieved in 59 patients(80.8%),and endoleaks were observed in 14 patients(19.2%).Of the 14 patients with endoleaks,12 had type I endoleaks and 2 had type II;13 had aneurysms and one had CCF.10 patients with type I endoleaks received balloon dilatation,and 7 of them underwent a second stent-graft implantation after *** patient with type II endoleak received embolization of the branch artery,and another one received follow-up *** resolved in 6 patients and were minimal in 5 patients after balloon dilatation or the second stent *** the follow-up period,minor endoleaks spontaneously resolved in 4 patients and minimal endoleaks were still demonstrated in 4 patients without enlargement of residual lumen and ***:Endoleaks are the major complication after endovascular repair of ICAVDs and represent one of the limitations of this *** the understanding and management of endoleaks can be beneficial in the clinical setting,including the popularization and application of this technique.

关键词： Covered stent Endovascular repair Internal carotid artery Endoleak

Daily expression of two circadian clock genes in compound eyes of Helicoverpa armigera: evidence for peripheral tissue circadian timing

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Insect Science 2019年第2期26卷 217-228页

作者： shuo yan yan-Jun Liu Jia-Lin Zhu Wei-Na Cui Xin-Fang Zhang Yu-Hui yang Xiao-Ming Liu Qing-Wen Zhang Xiao-Xia Liu Department of Entomology China Agricultural University Beijing China National Agricultural Technology Extension and Service Center Beijing China Beijing Entry-Exit Inspection and Quarantine Bureau Beijing China Zoucheng Plant Protection Station Zoucheng Shandong Province China Changli Institute of Pomology Hebei Academy of Agriculture and Forestry Sciences Changli Hebei Province China

Circadian clock genes in peripheral tissues usually play an important role in regulating the circadian rhythms. Light is the most important environmental signal for synchronizing endogenous rhythms with the daily light-dark cycle, and compound eyes are known as the principal circadian photoreceptor for photic entrainment in most moths. However, there is little evidence for circadian timing in compound eyes. In the current study, we isolated the timeless gene, designated Ha-tim (GenBank accession number: KM233162), from the cotton bo 11 worm Helicoverpa armigera. Ha-tim and period (Haper) showed low messenger RNA levels in the compound eyes compared to the other tested adult organs. Ha-tim and Ha-per transcript levels were dependent on an endogenous rhythm that fluctuated over a daily cycle in the compound eyes and heads. The cycles of Hatim and Ha-per transcript levels followed similar time courses, and identical expression patterns of the two genes were observed in the compound eyes and heads. Ha-tim and Ha-per were dowregulated in the compound eyes after light exposure, copulation and starvation. These results indicated that Ha-tim and Ha-per transcript levels were regulated by endogenous and exogenous factors. Our study helped to improve our understanding of the circadian clock machinery in compound eyes and other peripheral tissues.

关键词： circadian clock compound eye photoreceptor period timeless rhythm

Prolonged Consumption of Dietary Advanced Lipoxidation End Products contributes to renal impairment in mice through Dysregulated Intestinal homeostasis

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Food Science and Human Wellness 2024年

作者： Yaya Wang Lu Dong Yaozhong Hu Tianchang Zhang Ruican Wang Linqing Nie Junping Wang yan Zhang shuo Wang Tianjin Key Laboratory of Food Science and Health School of Medicine Nankai University State Key Laboratory of Food Nutrition and Safety Key Laboratory of Food Nutrition and Safety College of Food Engineering and Biotechnology Tianjin University of Science and Technology

Heat processing of food has been well validated as the trigger to generate heat-processing side product of advanced lipoxidation end products (ALEs)， which potentially engenders the threat on systemic health or progression of diseases， especially the accumulated effect after long-term intake. Thus， the study was proposed to evaluate the effect of dietary ALEs on health after long-term ingestion， specifically through simulating the intake of dietary ALE in mice within 9 months to investigate the intervention effect and underlying mechanism. The unexpected observation of renal insufficiency or impairment after long-term intake of dietary ALEs indicated the negative impact on renal health， which has been verified by the pathological analysis. Further studies revealed that a high-ALEs diet disrupted the intestinal barrier， with enhanced impact after disturbing the gut microbiota to potentially lower the abundance of beneficial microbiome through producing nephrotoxic metabolites. Correlation analysis showed that the proliferation of harmful bacteria and the reduction of beneficial bacteria were strongly correlated with intestinal barrier damage and the development of renal insufficiency. Furthermore， the underlying mechanism was unveiled as that ALEs could inhibit AMPK/SIRT1 signaling to fundamentally induce renal inflammation and oxidative stress. Thus， it was revealed that long-term intake of dietary ALE could result in renal impairment， and the results emphasized the control or intervention on dietary ALE to decrease to accumulated impairment on systemic health.

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Petrogenesis of early Paleozoic granitoids in the North Qinling Orogen,Central China:Implications for crustal evolution in an accretionary orogen

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Geoscience Frontiers 2024年第2期15卷 183-201页

作者： Leran Hao Debin yang Anqi Wang Yikang Quan Xiangyu yan shuo Wang College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia(Jilin University) Ministry of Natural ResourcesChangchun 130061China

Accretionary orogens are sites of extensive continental crustal growth and *** mechanism by which mafic crust is transformed into silicic melts(i.e.,maturation of continental crust)is important for understanding the formation of the continental *** North Qinling Orogen(NQO)is a composite orogenic belt and contains an early Paleozoic accretion-dominated orogenic system,which is ideal for investigating continental crustal *** obtained zircon and monazite U–Pb age and O isotope data,zircon Lu–Hf isotope data,and whole-rock major-and trace-element and Sr–Nd isotope data for early Paleozoic granitoids of the *** granitoids are divided into three *** 1 includes the Taiping tonalite(445±3 Ma),the Manziying syenogranite(445±2 Ma),and the Huoshenmiao granodiorite(436±2 Ma).The Taiping and Huoshenmiao plutons have relatively high SiO_(2)contents(68.64–71.67 wt.%)and Na_(2)O/K_(2)O ratios(1.15–4.19),with enrichments in Rb,Ba,Th,and U and depletions in Nb,Ta,P,and Ti,and they are geochemically similar to sodic arc *** Manziying syenogranite is a peraluminous potassic granite with high K_(2)O contents(4.59–5.27 wt.%).Grantioids from Group 1 have similarly depleted Sr–Nd–Hf–O isotopic features(eHf[t]=+5.9 to+8.8;δ^(18)O=3.98‰–5.41‰),indicative of derivation via partial melting of oceanic arc crust,which suggests that partial melting of oceanic arc crust in a subduction system contributes to the generation of continental crust and causes its *** 2 consists of the Wuduoshan monzogranite(418±2 Ma)and the Sikeshu granodiorite(423±3 Ma).These plutons have relatively high SiO_(2)(65.59–72.06 wt.%),K_(2)O(3.26–4.79 wt.%),and Al2O3(14.65–16.12 wt.%)contents and Sr/Y(33–87)and(La/Yb)N(23–48)*** Wuduoshan monzogranite has positive zircon eHf(t)(+0.4 to+3.1)and uniformδ^(18)O(6.38‰–8.07‰)values,but the Sikeshu granodiorite has more variable isotopic compositions(eHf[t]=-1.9 to+5.0;δ^(18)O=6.37‰–10.60‰).The Wuduoshan monzog

关键词： Zircon Hf-O isotopes Granite Continental crust Accretionary orogen

基于云模型的城市占道施工区交通安全风险评价方法

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交通工程 2022年第4期22卷 65-70,76页

作者：闫硕中国人民公安大学交通管理学院北京100038

为保障城市道路交通安全运行,针对城市道路施工区交通安全隐患突出以及当前交通安全风险评价方法存在不足等问题,本文将云模型理论应用于城市道路施工区交通安全风险评价中.通过建立施工区交通安全风险评价指标体系,采用AHP法与灰色关... 详细信息

为保障城市道路交通安全运行,针对城市道路施工区交通安全隐患突出以及当前交通安全风险评价方法存在不足等问题,本文将云模型理论应用于城市道路施工区交通安全风险评价中.通过建立施工区交通安全风险评价指标体系,采用AHP法与灰色关联度分析法组合计算指标权重,运用云模型算法计算施工区交通安全风险评价指标体系中各级指标的云模型数字特征,进而构建出了施工区交通安全风险评价云模型,并将模型应用于郑州市地铁7号线占道施工区的交通安全风险评价,结果表明该处施工区域的施工现场管理、施工位置、施工类型、施工人员安全意识、安全防护设施等6个指标的安全隐患较大,需要采取风险应对措施.该模型为城市道路占道施工区的交通安全风险评定、预防及应对提供了有用信息.

关键词：占道施工区交通安全风险评价云模型

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