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Light(Science & Applications) 2024年第9期13卷 1878-1887页

作者： yang Lu Xu Zhao dongmei yan Yingqian Mi Peng Sun Xu yan Xiaomin Liu Geyu Lu State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University130012 ChangchunChina Department of Immunology College of Basic Medical SciencesJilin University130021 ChangchunChina

Chiral assemblies have become one of the most active research areas due to their versatility,playing an increasingly important role in bio-detection,imaging and *** this work,chiral UCNPs/CuxOS@ZIF nanoprobes are prepared by encapsulating upconversion nanoparticles(UCNPs)and CuxOS nanoparticles(NPs)into zeolitic imidazolate framework-8(ZIF-8).The novel excited-state energy distribution-modulated upconversion nanostructure(NaYbF4@-NaYF4:Yb,Er)is selected as the fluorescence source and energy donor for highly efficient fluorescence resonance energy transfer(FRET).CuxOS NP is employed as chiral source and energy acceptor to quench upconversion luminescence(UCL)and provide circular dichroism(CD)*** the natural adsorption and sorting advantages of ZIF-8,the designed nanoprobe can isolate the influence of other common disruptors,thus achieve ultra-sensitive and highly selective UCL/CD dual-mode quantification of H2S in aqueous solution and in living ***,the nanoprobe is also capable of in vivo intra-tumoral H2S *** work highlights the multifunctional properties of chiral nanocomposites in sensing and opens a new vision and idea for the preparation and application of chiral nanomaterials in biomedical and biological analysis.

关键词： chiral sulfide donor

Study on the four Qi of Pfaffia glomerata based on the metabolomics technology and comparison of Dangshen(Radix Codonopsis) in the equivalent substitution prescription

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Journal of Traditional Chinese Medicine 2024年第4期44卷 713-721页

作者： SONG Zhenguang yanG Bin WANG Fei yan dongmei ZHOU Xiaoqing HUANG Liping GAO Xuemei LI Bin HUANG Luqi Academician Workstation Jiangxi University of Chinese MedicineNanchang 330004China State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 610075China National Resource Center for Chinese Materia Medica Chinese Academy of Chinese Medical Sciences(CACMS)Beijing 100700China

OBJECTIVE:To explore the four Qi of Pfaffia glomerata(PG)and endow this foreign folk herb with the properties of Chinese medicine,make it Chinese medicinal and localized,and could be used as a Chinese ***:The normal group,six cold herb groups,six hot herb groups,six cool herb groups,PG prescription group(PGPG),and Dangshen(Radix Codonopsis)prescription group(CPPG)were prepared with corresponding concentrations of water extracts,these herb extracts were administered by gavage to SpragueDawley rats,and the 12 h urine at night on the 29th day of the SD rats in each group were collected,Liquid Chromatograph Mass Spectrometer system was used to analyze them,the best discriminant models for the medicinal properties of cold-hot and cold-cool were set up,so as to the medicinal properties of PGPG,CPPG and PG were *** on the Progenesis QI,Human Metabolome Database,Kyoto Encyclopedia of Genes and Genomes,MetaboAnalyst 5.0 database,we enriched metabolic pathway and classification mechanism of medicinal properties of cold-cool Chinese herbs and the molecular mechanism of PG ***:We established a best model of cold-hot herbal discrimination in the positive ion mode,then the probability that PGPG was predicted cold property was 88.9%.Furthermore,a model of cold-cool herbal discrimination was established,then the probability of PGPG containing the cool property was 77.8%.In addition,typical cold and cool herbs mainly affected nine biomarkers such as tyrosine-proline,(R)-3',7-Dihydroxy-2',4'-dimethoxyisoflavane in *** regulation trend of PGPG on markers was basically as same as the cool herbs and mainly involved in regulating the two pathways of cytochrome P450 and purine ***:The results showed PGPG had a cool medicinal property as same as CPPG,and the regulation trend of PGPG on markers was consistent with cool ***,the medicine properties PG and CP should be consistent,and the Traditional Chinese Medicine p

关键词： Pfaffia glomerata medicinal properties of Chinese medicine metabolomics molecular mechanism equivalent substitution

Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

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China CDC weekly 2024年第16期6卷 344-349页

作者： Hong yang Ning Wen Chunxiang Fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao dongmei yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

Evolutionary Diversity of Coxsackievirus A6 Causing Severe Hand,Foot,and Mouth Disease—China,2012-2023

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China CDC weekly 2024年第20期6卷 442-449页

作者： Huanhuan Lu Jinbo Xiao Wenhui Wang dongmei yan Tianjiao Ji Qian yang Haiyan Wei yanhua Du Yunting Zeng Jun Guo Jianhua Chen Hanri Zeng Yingying Liu Shuaifeng Zhou Hong Ji Jianxing Wang Xiaofang Zhou Yong Zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases World Health Organization Polio Reference Laboratory for the Western Pacific RegionKey Laboratory of Laboratory BiosafetyNational Health and Key Laboratory of Laboratory Biosafety of the National Health CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Linyi Center for Disease Control and Prevention Linyi CityShandong ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina Shaanxi Provincial Center for Disease Control and Prevention Xi’an CityShaanxi ProvinceChina Hainan Provincial Center for Disease Control and Prevention Haikou CityHainan ProvinceChina Guizhou Provincial Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Hunan Provincial Center for Disease Control and Prevention Changsha CityHunan ProvinceChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Yunnan Provincial Center for Disease Control and Prevention Kunming CityYunnan ProvinceChina

Introduction:Coxsackievirus A6(CVA6)has emerged as a significant pathogen responsible for severe cases of hand,foot,and mouth disease(HFMD).This study aims to delineate the demographic characteristics and analyze the viral evolution of severe HFMD associated with CVA6,thereby assisting in its surveillance and ***:In this investigation,74 strains of CVA6 were isolated from samples collected from severe HFMD cases between 2012 and *** VP1 gene sequences of CVA6 were amplified and analyzed to assess population historical dynamics and evolutionary characteristics using BEAST,DnaSP6,and ***:A significant portion(94.4%)of severe CVA6-associated HFMD cases(51 out of 54,with 20 lacking age information)were children under 5 years *** the 74 CVA6 strains analyzed,72 belonged to the D3a sub-genotype,while only two strains were D2 *** average genetic distance between VP1 sequences prior to 2015 was 0.027,which increased to 0.051 when compared to sequences *** population dynamics analysis indicated three significant population expansions of severe CVA6-associated HFMD during 2012-2013,2013-2014,and 2019-2020,resulting in the formation of 65 distinct *** with the MCC tree findings,transitioning between regional haplotypes required multiple base substitutions,showcasing an increase in population diversity during the evolutionary process(from 14 haplotypes in 2013 to 55 haplotypes over the subsequent decade).Conclusions:CVA6,associated with severe HFMD,is evolving and presents a risk of outbreak ***,enhanced surveillance of severe HFMD is imperative.

关键词： thereby subsequent finding

0~3岁早产/低出生体重儿养育问题调查:一项多中心横断面研究

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临床儿科杂志 2024年第7期42卷 606-612页

作者：赵风华张悦孙瑾严双琴吕兰秋穆立娟杨静骆艳闫冬梅赵冬梅中国疾病预防控制中心妇幼保健中心北京100081 大连妇幼保健院辽宁大连116033 马鞍山市妇幼保健院安徽马鞍山243011 宁波市妇女儿童医院浙江宁波315000 北京市房山区妇幼保健院北京102488 秦皇岛市妇幼保健院河北秦皇岛066001 贵阳市妇幼保健院贵州贵阳550003 连云港市妇幼保健院江苏连云港222000 山东大学齐鲁儿童医院儿童保健所山东济南250022

目的了解我国城市地区0~3岁早产/低出生体重儿的家庭主要养育问题与需求,为我国儿童健康临床工作者针对性地开展高危儿家庭养育指导提供依据。方法采用我国14省15个城市的1989名0~3岁儿童及家长的家庭养育调查资料进行研究,比较分析早产... 详细信息

目的了解我国城市地区0~3岁早产/低出生体重儿的家庭主要养育问题与需求,为我国儿童健康临床工作者针对性地开展高危儿家庭养育指导提供依据。方法采用我国14省15个城市的1989名0~3岁儿童及家长的家庭养育调查资料进行研究,比较分析早产/低出生体重儿家庭与正常儿童家庭面临的养育问题及其影响因素。结果接受调查的城市地区早产/低出生体重儿151名(7.6%),其中76.8%的早产/低出生体重儿的家长在过去3个月内遇到了≥3个家庭养育问题,高于正常组的66.8%,差异有统计学意义(χ^(2)=6.44,P=0.011)。早产/低出生体重儿的家庭养育问题主要集中在喂养或进餐(67.6%)、睡眠(66.2%)和行为(61.6%)三方面。多因素logistic回归发现,早产/低出生体重儿是婴幼儿家庭养育问题的风险因素(P<0.05);早产/低出生体重儿家庭养育问题的发生与儿童性别、儿童年龄、主要照养人、家庭结构等因素有关。结论早产/低出生体重儿的家长面临养育问题风险普遍较高,且不同年龄阶段存在具体问题差异,有必要及时发现养育风险因素,为该群体提供有针对性的养育照护咨询指导。

关键词：家庭养育问题影响因素早产儿低出生体重儿

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Venlo型温室柱脚螺栓节点力学性能

农业工程学报 2024年第3期40卷 240-250页

作者：李雄彦徐航徐开亮闫冬梅张秋生曹楠北京工业大学城市建设学部北京100124 军事科学院国防工程研究院北京100850 农业农村部规划设计研究院北京100125 农业农村部农业设施结构设计与智能建造重点实验室北京100125

为研究连栋温室柱脚节点尺寸对节点承载力的影响,依托珠海某Venlo型温室项目,基于《混凝土结构设计规范》《化工设备基础设计规定》以及《混凝土结构构造手册》对中柱基础短柱和边柱柱脚节点的构造进行设计,通过数值模拟和节点试验研究... 详细信息

为研究连栋温室柱脚节点尺寸对节点承载力的影响,依托珠海某Venlo型温室项目,基于《混凝土结构设计规范》《化工设备基础设计规定》以及《混凝土结构构造手册》对中柱基础短柱和边柱柱脚节点的构造进行设计,通过数值模拟和节点试验研究了中柱基础短柱柱脚节点的抗弯性能、边柱柱脚节点的抗剪性能以及破坏机理。结果表明:2种节点的屈服荷载和极限荷载随着节点构造尺寸的减小而降低,其破坏过程可划分为3个阶段:弹性阶段、屈服阶段、极限承载力阶段。中柱基础短柱柱脚节点破坏模式为受拉侧混凝土锥形破坏,边柱柱脚节点的破坏模式为混凝土楔形体破坏,研究结果可为连栋温室柱底地脚螺栓节点设计提供参考。

关键词：温室荷载力学性能连栋温室柱脚节点优化分析

考虑源荷双重不确定性的多源系统鲁棒模糊动态综合环境经济调度

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高电压技术 2024年第4期50卷 1446-1456,I0014-I0020页

作者：张宏陈燕楠王洪坤常喜强赵咪严冬梅石河子大学机械电气工程学院石河子832000 新疆大学电气工程学院乌鲁木齐830011 国网新疆电力有限公司乌鲁木齐830011

“双碳”目标下,以风电、光伏、光热发电为主的源端新能源规模化并网以及荷端供给需求和种类的多样性使得系统源荷平衡受到极大影响,给新型电力系统运行带来严峻挑战。基于此,以风电-光伏-光热-火电联合发电系统为研究对象,提出一种考... 详细信息

“双碳”目标下,以风电、光伏、光热发电为主的源端新能源规模化并网以及荷端供给需求和种类的多样性使得系统源荷平衡受到极大影响,给新型电力系统运行带来严峻挑战。基于此,以风电-光伏-光热-火电联合发电系统为研究对象,提出一种考虑源荷双重不确定性的鲁棒模糊动态综合环境经济调度模型。首先,分别基于鲁棒理论和模糊理论对多源系统源荷不确定因素建模,同时构建鲁棒模糊数学模型并推导其等价确定模型;其次,综合考虑各种环境经济因素,构建多源系统鲁棒模糊动态综合环境经济调度模型;然后,根据其等价确定转化思想对模型进行转化并采用基于差分进化的粒子群算法求解;最后,基于新疆哈密电网实际数据和改进IEEE-39节点系统,验证所建模型的寻优效果在环境经济上的可行性、有效性及优越性。

关键词：多源系统环境经济调度双重不确定性鲁棒理论模糊理论

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Weak node protection to maximize the lifetime of wirelesssensor networks

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Journal of Systems Engineering and Electronics 2018年第4期29卷 693-706页

作者： MAO Yuxing ZHAO Huiyuan yan dongmei State Key Lab of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China Science and Technology Enterprise Group of Chongqing University Chongqing 400044China

Wireless sensor networks （WSN） provide an approachto collecting distributed monitoring data and transmiting them tothe sink node. This paper proposes a WSN-based multi-hop networkinfrastructure, to increase network lifetime by optimizing therouting strategy. First, a network model is established, an operatingcontrol strategy is devised, and energy consumption characteristicsare analyzed. Second, a fast route-planning algorithm isproposed to obtain the original path that takes into account the remainingenergy of communicating nodes and the amount of energyconsumed in data transmission. Next, considering the amount ofenergy consumed by an individual node and the entire network,a criterion function is established to describe node performanceand to evaluate data transmission ability. Finally, a route optimizingalgorithm is proposed to increase network lifetime by adjusting thetransmission route in protection of the weak node （the node withlow transmission ability）. Simulation and comparison experimentalresults demonstrate the good performance of the proposed algorithmsto increase network lifetime.

关键词： wireless sensor network (WSN) multi-hop transmission routing network lifetime energy efficient

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全钒液流电池在储能领域的应用与展望

电池 2024年第3期54卷 422-426页

作者：李振鹏颜东梅李军黄福川广西大学机械工程学院广西南宁530004 广西供销生态循环农业有限公司广西南宁530007

随着可再生能源发电量的迅速提高,快速增长的储能需求使全钒氧化还原液流电池逐渐成为行业的热点之一。虽然全钒液流电池存在能量效率低、成本高等问题,但是在储能领域应用前景广阔。从全钒液流电池的主要运行特点出发,分析和综述全钒... 详细信息

随着可再生能源发电量的迅速提高,快速增长的储能需求使全钒氧化还原液流电池逐渐成为行业的热点之一。虽然全钒液流电池存在能量效率低、成本高等问题,但是在储能领域应用前景广阔。从全钒液流电池的主要运行特点出发,分析和综述全钒液流电池运行中主要性能损失、经济性和环保性的研究现状,介绍全钒液流电池的应用现状及未来展望,为后续的工程应用研究决策提供参考。

关键词：全钒氧化还原液流电池(全钒液流电池) 储能能量效率经济性分析

基于网络药理学和分子对接研究竹沥-生姜配伍治疗中风病的作用机制

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中医临床研究 2024年第22期16卷 8-15页

作者：颜冬梅卢文滢石强王飞江西中医药大学院士工作站江西南昌330025 江西中医药大学岐黄国医书院江西南昌330025

目的:采用网络药理学和分子对接技术预测竹沥-生姜配伍治疗中风病的作用靶点,探讨其治疗中风病的潜在分子作用机制和有效物质。方法:利用PubChem、SwissTargetPrediction和UniProt数据库挖掘竹沥-生姜药对的潜在活性成分及药物靶点,通过... 详细信息

目的:采用网络药理学和分子对接技术预测竹沥-生姜配伍治疗中风病的作用靶点,探讨其治疗中风病的潜在分子作用机制和有效物质。方法:利用PubChem、SwissTargetPrediction和UniProt数据库挖掘竹沥-生姜药对的潜在活性成分及药物靶点,通过GeneCards数据库筛选疾病靶点。将药物靶点与疾病靶点匹配所得交集靶点导入STRING构建蛋白质-蛋白质相互作用网络。借助Cytoscape软件筛选关键靶点,将关键靶点与对应成分联系起来绘制网络图,筛选关键成分;对关键靶点进行基因本体论(GO)和京都基因与基因组百科全书(KEGG)富集分析。通过AutoDock软件对关键活性成分与潜在作用靶点进行分子对接验证。结果:筛选得到药组活性成分41个,相关靶点291个,中风病相关靶基因729个,以及竹沥-生姜药对治疗中风病的交集靶点67个。这些交集靶点主要参与细胞炎症反应、细胞活化、细胞免疫反应等过程,并与癌症的途径、脂质与动脉粥样硬化及糖尿病并发症中的晚期糖基化终末产物(Advanced Glycation EndProduct,AGE)-晚期糖基化终末产物受体(Receptor for Advanced Glycation End Products,RAGE)信号通路等相关。分子对接结果显示,竹沥、生姜的主要活性成分与中风病的潜在作用靶点间具有一定的结合活性。结论:竹沥-生姜可通过多成分、多靶点、多通路发挥对中风病的治疗作用。本研究为后续药理机制探索提供方向,为该药对临床应用提供了理论依据。

关键词：网络药理学分子对接竹沥-生姜药对中风病机制