检索结果-南通市图书馆

ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 341-353页

作者： zhibin yan Ying SHI Runling yanG Jijun XUE Caiyun FU Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou University Lanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000China

Kidney fibrosis is an inevitable result of various chronic kidney diseases(CKDs)and significantly contributes to end-stage renal ***,there is no specific treatment available for renal ***13(amino acid sequence:RRCMPLHSRVPFP)is a conserved region of ELABELA in all vertebrates;however,its biological activity has been very little *** the present study,we evaluated the therapeutic effect of ELA13 on transforming growth factor-β1(TGF-β1)-treated NRK-52E cells and unilateral ureteral occlusion(UUO)*** results demonstrated that ELA13 could improve renal function by reducing creatinine and urea nitrogen content in serum,and reduce the expression of fibrosis biomarkers confirmed by Masson staining,immunohistochemistry,real-time polymerase chain reaction(RT-PCR),and western *** biomarkers were increased after UUO and decreased by administration of ***,we found that the levels of essential molecules in the mothers against decapentaplegic(Smad)and extracellular signal-regulated kinase(ERK)pathways were reduced by ELA13 treatment in vivo and in *** conclusion,ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.

关键词： ELA13 Kidney fibrosis Inflammation Smad Extracllular signal-regulated kinase(ERK)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation

引用

Genes & Diseases 2024年第5期11卷 33-35页

作者： zhibin yan Xiangyu Hong Qihao Lin Leijie Wang Gang Shao Chentao Ge Ruilong Xia Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China College of Life Sciences China Jiliang UniversityHangzhouZhejiang 310018China

Increasing evidence highlight tachykinin receptors as a prominent player in hematological *** previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 whereas the role of neurokinin-2 receptor(NK-2R)has not been ***,we found NK-2R was significantly up-regulated in AML patients in The Cancer Genome Atlas *** result was further confirmed in blood from AML patients and a range of human leukemia ***,we verified that blocking NK-2R by SR48968 markedly promoted cell death in human myeloid leukemia without cytotoxicity to normal ***,we uncovered that SR48968 induced cytotoxicity through necroptosis mediated by calcium overload-driven reactive oxygen species(ROS)*** summary,our results propose that NK-2R antagonist SR48968 may be used as a new therapeutic approach for myeloid leukemia.

关键词： myeloid antagonist markedly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

闽南山地贝壳杉与杉木混交造林生长效应初报

引用

林业勘察设计 2024年第2期44卷 62-63,66页

作者：颜志彬福建省永春碧卿国有林场福建泉州362606

为探究不同混交比例下贝壳杉与杉木的生长状况,探索适宜的贝壳杉混交造林模式,研究设置了贝壳杉与杉木混交株数比例分别4∶6、3∶7、2∶8的对比试验。研究结果表明,造林后6年7个月,不同混交比例的贝壳杉的胸径、树高生长存在极显著差异... 详细信息

为探究不同混交比例下贝壳杉与杉木的生长状况,探索适宜的贝壳杉混交造林模式,研究设置了贝壳杉与杉木混交株数比例分别4∶6、3∶7、2∶8的对比试验。研究结果表明,造林后6年7个月,不同混交比例的贝壳杉的胸径、树高生长存在极显著差异,贝壳杉占比越高的林分其胸径、树高生长越好;杉木与贝壳杉已产生明显的生长空间竞争,并且贝壳杉在林分中处于明显劣势,应对杉木实施间伐,及时调整混交林的密度结构和树种组成比例,以促进后期贝壳杉的生长以及快速成林。

关键词：贝壳杉杉木混交比例生长效应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Convergence Analysis of Parameter Estimation in System Identification 25th

Convergence Analysis of Parameter Estimation in System Ident...

引用

第25届中国控制与决策会议

作者： yan zhibin Chen Caiyun Natural Science Research Center Harbin Institute of Technology

ISBN: (纸本)9781467355322

For linear time-invariant system model, this paper analyzes the convergence of parameter estimations as the length of the input-output data tends to infinity through prediction error method. It is known that the sequence of the prediction errors, called criterion functions, converges uniformly in the parameter with probability one as the data length tends to infinity. Given an input-output data of fixed length, the parameter estimation is represented by a set in general, instead of by a single point, on which the criterion function takes its minimum. Thus a mathematical feature of the convergence problem of parameter estimation is in that we are needed, from the convergence of a sequence of functions, to infer the convergence of the sequence of their sets of minimizing arguments. The Hausdorff metric, as a rational due tool, is suggested to measure the distance between sets and then is used to discuss the convergence problem here. We show that, according to Hausdorff metric, the convergence of parameter estimation can not be guaranteed in general, and give some conditions to guarantee.

关键词： system identification parameter estimate prediction error method Hausdorff metric

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

玉米机械化收获技术现状分析及发展趋势

引用

农机化研究 2024年第10期46卷 9-14页

作者：辛尚龙赵武云曲浩杨天史瑞杰闫治斌马海军甘肃农业大学机电工程学院兰州730070 甘肃省敦煌种业集团股份有限公司甘肃酒泉735000 甘肃洮河拖拉机制造有限公司甘肃定西730500

玉米机械化收获对我国玉米生产综合经济效益和国际竞争力的提高具有重要意义,是目前我国玉米全程机械化的重点研究内容。当前,我国玉米机械化摘穗过程还存在割台果穗啃伤及籽粒损失等问题,影响玉米收获由机械化摘穗向籽粒直收的转变。为... 详细信息

玉米机械化收获对我国玉米生产综合经济效益和国际竞争力的提高具有重要意义,是目前我国玉米全程机械化的重点研究内容。当前,我国玉米机械化摘穗过程还存在割台果穗啃伤及籽粒损失等问题,影响玉米收获由机械化摘穗向籽粒直收的转变。为此,从玉米收获的机械化摘穗技术入手,分析了国内外相关玉米收获技术的研究进展与应用现状,提出了基于不同种植模式下因地制宜开展机具适应性研究和减损摘穗技术攻关与应用的发展思路。

关键词：玉米果穗收获机械化

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

制种玉米连作对土壤氮组分含量及根腐病发病的影响

引用

中国农业大学学报 2024年第2期29卷 23-35页

作者：甫文疆赵芸晨王文丽闫治斌王治江陈叶陈广泉河西学院农业与生态工程学院甘肃张掖734000 西北农林科技大学资源与环境学院陕西杨凌712100 甘肃省敦煌种业集团股份有限公司研究院甘肃酒泉735000

为探究制种玉米连作根内微生物、土壤氮素与根腐病发病率间的相关关系,采用大田试验及高通量测序技术,以不同连作年限(5、10、15、20、25年)制种玉米田为研究对象,未种植玉米的地块为对照(CK),调查玉米根腐病发病率,测定玉米根部内生菌... 详细信息

为探究制种玉米连作根内微生物、土壤氮素与根腐病发病率间的相关关系,采用大田试验及高通量测序技术,以不同连作年限(5、10、15、20、25年)制种玉米田为研究对象,未种植玉米的地块为对照(CK),调查玉米根腐病发病率,测定玉米根部内生菌与土壤不同形态氮素含量。结果表明,与对照(CK)比较,连作25年的地块土壤全氮含量显著降低,至0.72 g/kg;铵态氮含量显著升高,至72.97 mg/kg;而硝态氮与水解氮含量呈现先增加后下降趋势。5个连作地块的酸解氮、水解氮和铵态氮含量均显著增加,氨态氮含量显著下降;除连作5年外,其余4个连作地块的氨基酸态氮含量显著增加,全氮、非酸解氮和氨基糖态氮含量显著下降(P<0.05)。连作显著降低根内微生物多样性与丰富度(P<0.05)。在属水平,制种玉米根内优势细菌13个属,其中假单胞菌属(Pseudomonas)、根瘤菌属(Rhizobium)、鞘氨醇单胞菌属(Sphingomonas)、地杆菌属(Pedobacter)与泛菌属(Pantoea)丰度最高;优势真菌10个属,其中隔孢伏革属(Peniophora)、曲霉属(Aspergillus)、裂褶菌属(Schizophyllum)与单孢平霉属(Phialemoniopsis)丰度最高。连作对制种玉米根内细菌与真菌属的类型变化无显著影响,但连作改变了根内细菌与真菌属的相对丰度。此外,制种玉米根腐病发病率均显著上升,根腐病发病率与土壤酸解氮、氨基酸态氮、水解氮、铵态氮及硝态氮含量均呈极显著正相关(P<0.01),与土壤全氮、非酸解氮含量却呈极显著负相关(P<0.01);根腐病发病率与镰刀菌属、曲霉属的相对丰度均呈显著正相关(P<0.05)。综上,制种玉米连作生产中土壤有效态氮,特别是酸解氮和非酸解氮的含量与优势病原菌的相对丰度、根腐病发病率均呈显著正相关(P<0.05),可用来准确地预测玉米根腐病的发生。

关键词：制种玉米连作土壤氮根腐病酸解氮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic potential for targeting Annexin A1 in fibrotic diseases

引用

Genes & Diseases 2022年第6期9卷 1493-1505页

作者： zhibin yan Xurui Cheng Tao Wang Xiangyu Hong Gang Shao Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018PR China Department of Oncology No.903 Hospital of PLA Joint Logistic Support ForceXi Hu Affiliated Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310013PR China

Annexin A1,a well-known endogenous anti-inflammatory mediator,plays a critical role in a variety of pathological *** is described by a failure of tissue regeneration and contributes to the development of many *** evidence supports that Annexin A1 participates in the progression of tissue ***,the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive,and even the functions of Annexin A1 in fibrotic diseases are still *** review focuses on the roles of Annexin A1 in the development of fibrosis of lung,liver,heart,and other tissues,with emphasis on the therapy potential of Annexin A1 in fibrosis,and presents future research interests and directions in fibrotic diseases.

关键词： Annexin A1 Anti-inflammatory Fibrosis Fibrotic diseases Sequence alignment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于矩阵补全的电网边缘终端隐私数据防篡改

引用

电子设计工程 2024年第12期32卷 109-112,117页

作者：闫志彬康健郑伟宁永龙袁昊国网宁夏电力有限公司宁夏银川750000 国网银川供电公司宁夏银川750000

电网边缘终端隐私数据容易被篡改,导致数据防篡改成功率与加密安全性下降,防篡改工作时间增加,设计基于矩阵补全的电网边缘终端隐私数据防篡改方法。采用低秩函数采集电网边缘终端隐私数据,通过随机噪声干扰识别和奇异值阈值恢复,结合... 详细信息

电网边缘终端隐私数据容易被篡改,导致数据防篡改成功率与加密安全性下降,防篡改工作时间增加,设计基于矩阵补全的电网边缘终端隐私数据防篡改方法。采用低秩函数采集电网边缘终端隐私数据,通过随机噪声干扰识别和奇异值阈值恢复,结合拉格朗日乘子算法实现电网边缘终端隐私数据矩阵补全。根据矩阵补全结果,对数据进行全局模糊化处理,通过矩阵补全识别数据特性,根据数据特性设置加密维度,阻止外部的篡改攻击行为,实现数据防篡改。实验结果表明,所提方法的防篡改成功率在90%以上,数据安全系数在9.9以上,防篡改工作时间最大值仅为1.73 s,实际应用效果好。

关键词：矩阵补全电网边缘终端数据隐私数据防篡改

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Therapeutic peptides: current applications and future directions

引用

Signal Transduction and Targeted Therapy 2022年第3期7卷 686-712页

作者： Lei Wang Nanxi Wang Wenping Zhang Xurui Cheng zhibin yan Gang Shao Xi Wang Rui Wang Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech University310018 HangzhouChina State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210046China Department of Oncology No.903 Hospital of PLA Joint Logistic Support ForceXi Hu Affiliated Hospital of Hangzhou Medical CollegeHangzhou 310013China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou University730000 LanzhouChina Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College100050 BeijingChina

Peptide drug development has made great progress in the last decade thanks to new production,modification,and analytic *** have been produced and modified using both chemical and biological methods,together with novel design and delivery strategies,which have helped to overcome the inherent drawbacks of peptides and have allowed the continued advancement of this field.

关键词： directions overcome continued

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Uncertainty-Aware Deep Learning: A Promising Tool for Trustworthy Fault Diagnosis

引用

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1317-1330页

作者： Jiaxin Ren Jingcheng Wen zhibin Zhao Ruqiang yan Xuefeng Chen Asoke K.Nandi School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Electronic and Electrical Engineering Brunel University LondonKingston LaneUxbridgeUB83PHUK IEEE

Recently,intelligent fault diagnosis based on deep learning has been extensively investigated,exhibiting state-of-the-art ***,the deep learning model is often not truly trusted by users due to the lack of interpretability of“black box”,which limits its deployment in safety-critical applications.A trusted fault diagnosis system requires that the faults can be accurately diagnosed in most cases,and the human in the deci-sion-making loop can be found to deal with the abnormal situa-tion when the models *** this paper,we explore a simplified method for quantifying both aleatoric and epistemic uncertainty in deterministic networks,called *** SAEU,Multivariate Gaussian distribution is employed in the deep architecture to compensate for the shortcomings of complexity and applicability of Bayesian neural *** on the SAEU,we propose a unified uncertainty-aware deep learning framework(UU-DLF)to realize the grand vision of trustworthy fault ***,our UU-DLF effectively embodies the idea of“humans in the loop”,which not only allows for manual intervention in abnor-mal situations of diagnostic models,but also makes correspond-ing improvements on existing models based on traceability ***,two experiments conducted on the gearbox and aero-engine bevel gears are used to demonstrate the effectiveness of UU-DLF and explore the effective reasons behind.

关键词： Out-of-distribution detection traceability analysis trustworthy fault diagnosis uncertainty quantification.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：