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Journal of Systems Engineering and Electronics 2017年第5期28卷 971-978页

作者： Jiufu Liu Wenliang Liu Jianyong Zhou yan sun Zhisheng Wang College of Automation Nanjing University of Aeronautics and Astronautics

This paper investigates the fault detection problem for discrete event systems (DESs) which can be modeled by partially observed Petri nets (POPNs). To overcome the problem of low diagnosability in the POPN online fault diagnoser in current use, an improved online fault diagnosis algorithm that integrates generalized mutual exclusion constraints (GMECs) and integer linear programming (ILP) is proposed. Assume that the POPN structure and its initial markings are known, and the faults are modeled as unobservable transitions. First, the event sequence is observed and recorded. GMEC is used for elementary diagnosis of the system behavior, then the ILP problem of POPN is solved for further diagnosis. Finally, an example of a real DES to test the new fault diagnoser is analyzed. The proposed algorithm increases the diagnosability of the DES remarkably, and the effectiveness of the new algorithm integrating GMEC and ILP is verified.

关键词： fault diagnosis partially observed Petri nets (POPNs) integer linear programming (ILP) generalized mutual exclusion constraints (GMECs)

Hiding neutrinoless double beta decay in the minimal seesaw model with the TM1 orμ-τreflection symmetry

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Communications in Theoretical Physics 2022年第11期74卷 98-105页

作者： Zhen-Hua Zhao yan-Bin sun Ying-Ke Lei Department of Physics Liaoning Normal UniversityDalian 116029China Institute of Physics Chinese Academy of SciencesBeijing 100190China

In Asaka et al(2021 ***.D 103,015014),Asaka,Ishida and Tanaka put forward an interesting possibility that the neutrinoless double beta decay can be hidden in the minimal seesaw model with the two right-handed neutrinos having a hierarchical mass structure:the lighter one is lighter enough than the typical Fermi-momentum scale of nuclei while the heavier one is sufficiently heavy to decouple from the neutrinoless double beta ***,in the basis where the mass matrices of the charged leptons and right-handed neutrinos are diagonal,for some particular texture of the Dirac neutrino mass matrix M_(D),the neutrinoless double beta decay can be *** this paper,on top of this specified model,we study the interesting scenario that M_(D)further obeys the TM1 symmetry orμ-τreflection symmetry which are well motivated by the experimental results for the neutrino mixing parameters.

关键词： neutrino mass neutrinoless double beta decay minimal seesaw model

Zinccopperite-A New Variety of Zinc-CopperIntermetallic Compounds Discovered in aPorphyry-Copper Deposit

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Acta Geologica Sinica(English Edition) 1998年第3期72卷 308-313页

作者： XIAO Yuanfu sun yan LU yan WEN Chunqi WANG Jiangzhen Department of Geology Chengdu Institute of Technology Shilidian Chengdu Sichuan 610059

: Zinccopperite (tentatively named) is a rare native alloy mineral discovered in quartz monzonite—porphyry in the Xifanping area, yanyuan County, Sichuan Province. It is a new variety of zinc—copper alloy mineral found for the first time in the porphyry-copper deposit in China. Its intergrown minerals are K—feldspar (mainly perthite), albite—oligoclase, quartz and biotite; and the associated minerals include pyrite and chalcopyrite. It is characterized by a golden reflection colour, being isotropic (isometric), with the grain size ranging from 10 to 50 μm, microhardness VHN10 = 190 kg/mm2, and reflectance RVM = 67.97%. Electron microprobe (Model JXA—733) analysis shows Cu = 59.15%–62.55% and Zn = 36.32%–39.85%. The crystallochemical formula is Cu6.27-7.0Zn4.0, simplified as Cu7Zn4.

关键词： zinccopperite native alloy mineral porphyry-copper deposit quartz monzonitic porphyry Xifanping yanyuan County

Integrated guidance and control of guided projectile with multiple constraints based on fuzzy adaptive and dynamic surface

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Defence Technology（防务技术） 2020年第6期16卷 1130-1141页

作者： Shang Jiang Fu-qing Tian Shi-yan sun Wei-ge Liang Naval Engineering University Ordnance Engineering CollegeWuhanHubeiChina

Based on fuzzy adaptive and dynamic surface(FADS),an integrated guidance and control(IGC)approach was proposed for large caliber naval gun guided projectile,which was robust to target maneuver,canard dynamic characteristics,and multiple constraints,such as impact angle,limited measurement of line of sight(LOS)angle rate and nonlinear saturation of canard ***,a strict feedback cascade model of IGC in longitudinal plane was established,and extended state observer(ESO)was designed to estimate LOS angle rate and uncertain disturbances with unknown boundary inside and outside of system,including aerodynamic parameters perturbation,target maneuver and model ***,aiming at zeroing LOS angle tracking error and LOS angle rate in finite time,a nonsingular terminal sliding mode(NTSM)was designed with adaptive exponential reaching ***,combining with dynamic surface,which prevented the complex differential of virtual control laws,the fuzzy adaptive systems were designed to approximate observation errors of uncertain disturbances and to reduce chatter of control ***,the adaptive Nussbaum gain function was introduced to compensate nonlinear saturation of canard *** LOS angle tracking error and LOS angle rate were convergent in finite time and whole system states were uniform ultimately bounded,rigorously proven by Lyapunov stability ***-in-the-loop simulation(HILS)and digital simulation experiments both showed FADS provided guided projectile with good guidance performance while striking targets with different maneuvering forms.

关键词： Integrated guidance and control Multiple constraints Fuzzy adaptive Dynamic surface Nonsingular terminal sliding mode Extended state observer

Lysozyme adsorption to cation exchanger derivatized by sequential modification of poly(ethylenimine)-Sepharose with succinic anhydride and ethanolamine: Effect of p H and ionic strength

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Chinese Journal of Chemical Engineering 2020年第2期28卷 440-444页

作者： yangyang Zhao Xianxiu Li Linling Yu Xiaoyan Dong yan sun Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300354China

In our previous work, a series of polyethylenimine(PEI)-derived cation exchangers were synthesized using PEIgrafted resin FF-PEI-L740(ionic capacity, 740 mmol·L^-1) as the basic resin to study lysozyme adsorption and chromatographic behavior. It was found that the resin with an ionic capacity of 630 mmol·L^-1(FF-PEI-CR630)possessed high adsorption performance towards lysozyme at 0–100 mmol·L^-1 Na Cl. Therefore, in this work,FF-PEI-CR630 was selected to study the influences of pH and ionic strength(IS) on protein adsorption and chromatographic behavior towards lysozyme. The increase of lysozyme adsorption capacity in the pH range of 6 to 10 was observed. However, the uptake rate decreased in the pH range of 6 to 8 and then remained essentially unchanged from pH 8 to pH 10. Increasing IS led to decreased protein adsorption capacity and increased uptake rate in different pH ranges. Besides, FF-PEI-CR630 maintained dynamic binding capacity as high as over150 mg·ml^-1 at pH 8–10 without NaCl. The research has thus provided insight into the selection of proper pH and IS conditions for protein purification by using FF-PEI-CR630.

关键词： Ion exchange pH value Adsorption Kinetics Chain delivery Dynamic binding capacity

Real-time model correction using Kalman filter for Raman-controlled cell culture processes

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Chinese Journal of Chemical Engineering 2024年第6期70卷 251-260页

作者： Xiaoxiao Dong Zhuohong He Xu yan Dong Gao Jingyu Jiao yan sun Haibin Wang Haibin Qu Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Hisun Biopharmaceutical Co.Ltd. Hangzhou 311404China

Raman spectroscopy has found extensive use in monitoring and controlling cell culture *** this context,the prediction accuracy of Raman-based models is of paramount ***,models established with data from manually fed-batch cultures often exhibit poor performance in Raman-controlled ***,there is a need for effective methods to rectify these *** objective of this paper is to investigate the efficacy of Kalman filter(KF)algorithm in correcting Raman-based models during cell ***,partial least squares(PLS)models for different components were constructed using data from manually fed-batch cultures,and the predictive performance of these models was ***,various correction methods including the PLS-KF-KF method proposed in this study were employed to refine the PLS ***,a case study involving the auto-control of glucose concentration demonstrated the application of optimal model correction *** results indicated that the original PLS models exhibited differential performance between manually fed-batch cultures and Raman-controlled *** glucose,the root mean square error of prediction(RMSEP)of manually fed-batch culture and Raman-controlled culture was 0.23 and 0.40 g·L^(-1).With the implementation of model correction methods,there was a significant improvement in model performance within Raman-controlled *** RMSEP for glucose from updating-PLS,KF-PLS,and PLS-KF-KF was 0.38,0.36 and 0.17 g·L^(-1),***,the proposed PLS-KF-KF model correction method was found to be more effective and stable,playing a vital role in the automated nutrient feeding of cell cultures.

关键词： Raman spectroscopy Model correction Algorithm Model-predictive control Bioprocess

Effect of direct charging of hot recycled slag on hot metal pretreatment dephosphorization in a dephosphorization furnace

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Journal of Iron and Steel Research International 2020年第2期27卷 148-159页

作者： Xue-feng Bai yan-hui sun Lei Luo Chang-liang Zhao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Shougang Jingtang United Iron&Steel Co. Ltd.Tangshan 063200HebeiChina

Industrial experiments were carried out to investigate the effect of the direct charging of hot recycled slag(DCHRS)on hot metal pretreatment dephosphorization in a dephosphorization *** bulk compositions of semi-steel and slag show that a better dephosphorization effect could be achieved by applying the DCHRS process in the dephosphorization *** with the bulk compositions in normal heats,the mean contents of phosphorus in the semi-steel and total Fe in the final slag were decreased by 0.006 and 1.93 wt.%,respectively,with an increase of approximately 6°C in the semisteel *** to mineralogical observations,the dephosphorization slags in normal heats and test heats were similar in petrographic constituents,but the metal loss was markedly decreased in the DCHRS *** calculations show that even though the dephosphorization slag in the DCHRS process had the same dephosphorization capacity as that in the normal refining process,the phosphorus distribution between slag and hot metal in the new process was slightly higher and closer to the reaction ***,proper operating conditions,including slag basicity,total Fe content in the final slag,bath temperature,slag formation and slag volume,were optimized to improve the dephosphorization efficiency under the condition of the DCHRS *** consumption of lime,light-burnt dolomite and oxygen during blowing was significantly decreased by the DCHRS process.

关键词： Dephosphorization Hot slag Slag recycling Dephosphorization furnace Thermodynamics

Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal

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Neuroscience Bulletin 2020年第10期36卷 1095-1106页

作者： Xin-yan Zhang Qing Li Ye Dong Wei yan Kun Song Yong-Qin Lin yan-Gang sun Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of the Chinese Academy of Sciences Beijing 100049China

Although opioids still remain the most powerful pain-killers,the chronic use of opioid analgesics is largely limited by their numerous side-effects,including opioid ***,the mechanism underlying this dependence is largely *** this study,we used the withdrawal symptoms precipitated by naloxone to characterize opioid dependence in *** determined the functional role of mu-opioid receptors(MORs)expressed in different subpopulations of neurons in the development of morphine *** found that conditional deletion of MORs from glutamatergic neurons expressing vesicular glutamate transporter 2(Vglut2^+)largely eliminated the naloxone-precipitated withdrawal *** contrast,conditional deletion of MORs expressed in GABAergic neurons had a limited effect on morphine ***,mice with MORs deleted from Vglut2^+glutamatergic neurons also showed no morphine-induced locomotor ***,morphine withdrawal and morphine-induced hyperactivity were not significantly affected by conditional knockout of MORs from dorsal spinal *** together,our data indicate that the development of morphine withdrawal is largely mediated by MORs expressed in Vglut2^+glutamatergic neurons.

关键词： Morphine Mu-opioid receptor Naloxoneprecipitated withdrawal Dorsal spinal cord Locomotor hyperactivity

A NEW METHOD FOR THE UNCERTAIN RESPONSE ANALYSIS OF STRUCTURES WITH UNCERTAIN PARAMETERS

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Acta Mechanica Solida Sinica 2003年第1期16卷 47-51页

作者： Xie Jun sun yan Guan Gang Dept.Of Engineering Mechanics Shanghai Jiaotong UniversityShanghai 200240China College of Civil Engineering Zhengzhou UniversityZhengzhou 450002China

A computing method for estimating the upper and lower bounds of the response of structures with uncertainties is presented. The uncertain parameters are described by the convex model. A numerical example of the frame ... 详细信息

关键词： convex model structures with uncertainties upper and lower bounds of response

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-yan sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin