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Modulating the aggregation of amyloid proteins by macrocycles

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Aggregate 2022年第2期3卷 60-71页

作者： Gao li yan-mei li Fujian Engineering Research Center of New Chinese Lacquer Material College of Material and Chemical EngineeringMinjiang UniversityFuzhouChina Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijingChina Institute of Oceanography Minjiang UniversityFuzhouChina Beijing Institute for Brain Disorders BeijingChina Center for Synthetic and System Biology Tsinghua UniversityBeijingChina

The aggregation of amyloid proteins has been suggested to be the main cause of multiple human disorders;for example,amyloidβaggregates in Alzheimer’s disease andα-synuclein aggregates in Parkinson’s *** the search for therapeutic medicines,many molecules have been discovered and developed to modulate the aggregation of amyloid *** century has witnessed the flourishing growth of supramolecular chemistry,and some biocompatible macrocycles have been proven to inhibit the aggregation of some amyloid proteins via host-guest interactions and could thus be used for the prevention or treatment of related ***,we review the application of macrocycles in modulating the aggregation of amyloid proteins.

关键词： amyloid protein calixarene cucurbituril cyclodextrin inhibitor macrocycle

L^p(R^n)-Boundedness of certain commutators

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 185-191页

作者： DI yan-mei JIANG li-ya Department of Mathematics Zhejiang University of Technology Hangzhou 310023 China

In this paper, the LP（Rn）-boundedness of the commutators generalized by BMO（Rn） function and the singular integral operator T with rough kernel Ω∈ L log＋ L（Sn-1）is proved by using the Bony＇s formula for the... 详细信息

关键词： Commutators paraproduct littlewood-Paley theory.

Slime coating of kaolinite on chalcopyrite in saline water flotation

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International Journal of Minerals,Metallurgy and Materials 2018年第5期25卷 481-488页

作者： Zhi-li li Feng Rao Shao-xian Song yan-mei li Wen-biao liu CONACYT Instituto de Investigación en Metalurgiay Materiales Universidad Michoacana de San Nicolás de Hidalgo School of Resources and Environmental Engineering Wuhan University of Technology Departamento de Ingeniería en Minas Metalurgia y GeologíaUniversidad de Guanajuato Faculty of Land and Resource Engineering Kunming University of Science and Technology

In saline water flotation, the salinity can cause a distinguishable slime coating of clay minerals on chalcopyrite particles through its effect on their electrical double layers in aqueous solutions. In this work, kaolinite was used as a representative clay mineral for studying slime coating during chalcopyrite flotation. The flotation of chalcopyrite in the presence and absence of kaolinite in tap water, seawater, and gypsum-saturated water and the stability of chalcopyrite and kaolinite particles in slurries are presented. Zeta-potential distributions and scanning electron microscopy images were used to characterize and explain the different slime coating degrees and the different flotation performances. Kaolinite particles induced slime coating on chalcopyrite surfaces and reduced chalcopyrite floatability to the greatest extent when the p H value was in the alkaline range. At 0.24 wt% of kaolinite, the chalcopyrite floatability was depressed by more than 10% at alkaline p H levels in tap water. Salinity in seawater and gypsum-saturated water compressed the electrical double layers and resulted in extensive slime coating.

关键词： chalcopyrite clay minerals saline water flotation slime coating stability

Enhanced electrochemical property of FePO_4-coated liNi_(0.5)Mn_(1.5)O_4 as cathode materials for li-ion battery

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Science Bulletin 2017年第14期62卷 1004-1010页

作者： Ting-Feng Yi yan-mei li Xiao-Ya li Jing-Jing Pan Qianyu Zhang yan-Rong Zhu School of Chemistry and Chemical Engineering Anhui University of Technology Key Laboratory of Metallurgical Emission Reduction & Resources Recycling Ministry of Education Anhui University of Technology School of Environment and Civil Engineering Dongguan University of Technology

Pristine liNi0.5Mnl.5O4 and FePO4-coated one with Fd-3m space groups were prepared by a sol-gel method. The structure and performance were studied by X-ray diffraction （XRD） rietveld refinement, scanning electron microscopy （SEM）, high resolution transmission electron microscopy （HRTEM）, energy dispersive spectrometer （EDS） mapping, electrochemical impedance spectroscopy （EIS） and charge- discharge tests, respectively. The lattice parameters of all samples almost remain the same from the Rietveld refinement, revealing that the crystallographic structure has no obvious difference between pris- tine liNi0.5Mn1.5O4 and FePO4-coated one. All materials show similar morphologies with uniform particle distribution with small particle size, and FePO4 coating does not affect the morphology of liNi0.5Mnl05O 4 material. EDS mapping and HRTEM show that FePO4 may be successfully wrapped around the surfaces of ***.s04 particles, and provides an effective coating layer between the electrolyte and the surface of liNi0.5Mn1.5O4 particles. FePO4 （1 wt%）-coated ***.504 cathode shows the highest discharge capac- ity at high rate （2 C） among all samples. After 80 cycles, the reversible discharge capacity of FePO4 （1 wt%） coated liNi0.5Mn0.5O4 is 117 mAh g^-1, but the pristine one only has 50 mAh g^-1. FeP04 coating is an effec- tive and controllable way to stabilize the liNi0.5Mn1.5O4/electrolyte interface, and avoids the direct con- tact between liNi0.5Mn1.5O4 powders and electrolyte, then suppresses the side reactions and enhances the electrochemical performance of the liNi0.5Mn1.5O4.

关键词： liNi0.5Mn1.5O4 FePO4 coating Electrochemical property lithium-ion batteries

Investigation of Spontaneous Condensation of an Amino Acid Based Amphiphile on Cast Film by in situ Transmission FT-IR Spectroscopy

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Chinese Chemical Letters 2005年第12期16卷 1637-1640页

作者： Hai yan WANG yan mei li Yi XIAO Yu Fen ZHAO The Key Laboratory of Bioorganic Phosphorus Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084

The spontaneous condensation of the amphiphilic N-（O,O-dihexadecyl）phosphorylalanine on the cast film was observed by in situ investigation of transmission infrared spectroscopy The particular orientation and ordered packing of the monomers within the multilayers of the cast film is concluded to attribute to the spontaneous condensation between the monomers.

关键词： Amphiphile cast film condensation FT-IR N-(O O-dihexadecyl)phosphoryl alanine

Edge detection and mathematic fitting for corneal surface with Matlab software

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 336-342页

作者： Yue Di mei-yan li Tong Qiao Na Lu Department of Ophthalmology Shanghai Children’s HospitalShanghai Jiaotong University Department of Ophthalmology Eye & ENT Hospital Fudan Unversity Department of Radiology Huashan Hospital NorthFudan University

AIM：To select the optimal edge detection methods to identify the corneal surface,and compare three fitting curve equations with Matlab software. METHODS：Fifteen subjects were recruited. The corneal images from optical coherence tomography（OCT）were imported into Matlab software. Five edge detection methods（Canny,Log,Prewitt,Roberts,Sobel）were used to identify the corneal surface. Then two manual identifying methods（ginput and getpts）were applied to identify the edge coordinates respectively. The differences among these methods were compared. Binomial curve（y=Ax2＋Bx＋C）,Polynomial curve [p（x）=p1xn＋p2x（n-1）＋....＋pnx＋pn＋1] and Conic section（Ax2＋Bxy＋Cy2＋Dx＋Ey＋F=0）were used for curve fitting the corneal surface respectively. The relative merits among three fitting curves were analyzed. Finally,the eccentricity（e）obtained by corneal topography and conic section were compared with paired t-test. RESULTS：Five edge detection algorithms all had continuous coordinates which indicated the edge of the corneal surface. The ordinates of manual identifying were close to the inside of the actual edges. Binomial curve was greatly affected by tilt angle. Polynomial curve was lack of geometrical properties and unstable. Conic section could calculate the tilted symmetry axis,eccentricity,circle center,etc. There were no significant differences between ＇e＇ values by corneal topography and conic section（t=0.9143,P=0.3760 〉0.05）.CONCLUSION：It is feasible to simulate the corneal surface with mathematical curve with Matlab software. Edge detection has better repeatability and higher efficiency. The manual identifying approach is an indispensable complement for detection. Polynomial and conic section are both the alternative methods for corneal curve fitting. Conic curve was the optimal choice based on the specific geometrical properties.

关键词： Matlab software edge detection curve fitting mathematic simulation optical coherence tomography corneal topography

Tau Protein Associated Inhibitors in Alzheimer Disease

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Chinese Journal of Chemistry 2014年第10期32卷 964-968页

作者： Qian-Qian li Ting-Ting Chu Yong-Xiang Chen yan-mei li Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China

Neurofibrillary tangles composed of tau protein and senile plaque accumulated by amyloid-β(Aβ)are two hallmarks in Alzheimer disease(AD).In the patients with AD,tau is abnormally hyperphosphorylated,mutated or misfolding,which endows tau with stronger tendency to *** protein has the potency to mediate neuron toxicity of Aβ.The reduction of tau level ameliorates degeneration of neuron ***,many researches are exploring new methods to regulate tau *** review will mainly focus on small molecules that can directly inhibit tau fibrillation or control tau accumulation by regulating tau phosphorylation process.

关键词： tau protein post-translational modification Alzheimer disease aggregation inhibitors

A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

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Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-Hua Zhuo Jun-Jun Wu Lang Zhao Wen-Hao li Yu-Fen Zhao yan-mei li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the *** has led to a great demand for easy preparation and scalable vaccines,especially in low-income ***,we present an inhalable nanovaccine comprising chitosan and SARS-CoV-2 spike *** chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic *** addition,the enhanced adaptive immunity stimulated by chitosan showed potential protection against ***,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular *** inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine chitosan

Hydroxylation of 3-nitrotyrosine by hydroxyl radical

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Chinese Chemical Letters 2007年第5期18卷 542-544页

作者： Jun Chen Dong Wei Qun Shi Yu Fen Zhao yan mei li Key Laboratory of Bioorganic Phosphorous Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084 China

Hydroxylation of 3-nitrotyrosine （3-NT） and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and ^1H NMR spectrometry. The reactivity of 3-nitrotyrosine has been investigated using density functional theory （DFT） calculation.

关键词： 3-Nitrotyrosine Hydroxyl radical DFT Selective hydroxylation