检索结果-南通市图书馆

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

引用

Oncology Research 2025年第1期33卷 103-121页

作者： yan lu KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG luJI HUANG FU CHENG XINDAN SHENG XIN yanG MANZHAO OUyanG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ten Cases Treated by lu Shou-yan

引用

Journal of Acupuncture and Tuina Science 2009年第6期7卷 321-325页

作者：朱汝功陆焱垚崔学军 Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine

1 Stomachache 1.1 Case oneA 38-year-old male patient.

关键词： Acupuncture-moxibustion Therapy Stomachache Nausea Enuresis Goiter Deafiaess Medical Records

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于耦合界面键合效应的石墨烯磨损研究

引用

原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Principle and Progress of Dynamically Reconfigurable Computing Technologies

引用

Chinese Journal of Electronics 2020年第4期29卷 595-607页

作者： WEI Shaojun lu yan'an Institute of Microelectronics Tsinghua University

With the emergence of new applications and the increasing cost of new semiconductor manufacturing technology, high energy-efficiency and flexibility are both critical for *** reconfigurable computing architecture, which has the both characteristics, is one of the most promising architectures for future *** has shown notable advantages in many important application fields, compared to conventional ***, the fundamental reasons for the characteristics have never been deeply discussed in previous *** paper analyzes the reasons from the perspective of design *** technologies of dynamically reconfigurable computing are continually evolving, and some cheering results of application have been *** paper summarizes the latest progress in key technologies and provides an introduction of the application achievements.

关键词： Dynamically reconfigurable computing Principle Progress

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Upper crustal P-wave velocity structure beneath two volcanic areas in northern Iran

引用

Science China Earth Sciences 2017年第4期60卷 786-795页

作者： lu yan CHEN Ling Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China State Key Laboratory of Lithospherie Evolution Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101 China

Detailed information about the crustal structure is essential for better understanding the occurrence and mechanisms of earthquakes and *** we present a study of the upper crustal P-wave velocity structure of two seismically and volcanically active areas in northern Iran using the two-dimensional Pg travel time tomography *** imaging results suggest low velocities in the upper crust beneath the Damavand and Sahand-Sabalan volcanic areas in the central and western parts of northern Iran,*** upper crustal low velocities in these two areas roughly coincide with previously imaged low Pn velocity anomalies,suggesting that the Late Cenozoic volcanic activity was probably caused by the upwelling of hot materials from the *** image feature of the Pg velocity structure beneath the Sahand-Sabalan volcanic area further indicates that the hot materials stored in the upper crust beneath Sahand may be larger in size than those stored beneath *** of the Pg velocity images with the earthquake distribution in north Iran suggests that earthquakes mainly occur at moderately low velocity or low to high velocity boundary areas instead of significantly low or high velocity *** anisotropy results show that the Pg wave fast direction is consistent with the GPS direction at high Pg velocity areas and the fast direction is inconsistent with the GPS direction but consistent with the strike direction of faults at low velocity *** new upper crustal structural images provide the basic observation for better understanding of the regional seismicity and volcanism,and link the surface geological phenomena to deep crustal and mantle processes associated with the active tectonics in northern Iran.

关键词： Equatorial ionization anomaly Sudden stratospheric warming Ionosphere

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MODELING PHOTONIC CRYSTALS WITH COMPLEX UNIT CELLS BY DIRICHLET-TO-NEUMANN MAPS

引用

Journal of Computational Mathematics 2007年第3期25卷 337-349页

作者： Yuexia Huang Ya yan lu Department of Mathematics City University of Hong KongKowloonHong KongChina

For a photonic crystal （PhC） of finite size, it is important to calculate its transmission and reflection spectra. For two-dimensional （2-D） PhCs composed of a square lattice of circular cylinders, the problem can be solved by an efficient method based on the Dirichlet-to-Neumann （DtN） map of the unit cell and a marching scheme using a pair of operators. In this paper, the DtN operator marching method is extended to handle 2-D PhCs with complex unit cells and arbitrary lattice structures.

关键词： Photonic crystal Periodic structure Diffractive grating Dirichlet-to-Neumannmap Operator marching.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monitoring nearest neighbor queries with cache strategies

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 529-537页

作者： PAN Peng lu yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

The problem of continuously monitoring multiple K-nearest neighbor (K-NN) queries with dynamic object and query dataset is valuable for many location-based applications. A practical method is to partition the data space into grid cells, with both object and query table being indexed by this grid structure, while solving the problem by periodically joining cells of objects with queries having their influence regions intersecting the cells. In the worst case, all cells of objects will be accessed once. Object and query cache strategies are proposed to further reduce the I/O cost. With object cache strategy, queries remaining static in current processing cycle seldom need I/O cost, they can be returned quickly. The main I/O cost comes from moving queries, the query cache strategy is used to restrict their search-regions, which uses current results of queries in the main memory buffer. The queries can share not only the accessing of object pages, but also their influence regions. Theoretical analysis of the expected I/O cost is presented, with the I/O cost being about 40% that of the SEA-CNN method in the experiment results.

关键词： K-nearest neighbors (K-NNs) Continuous query Object cache Query cache

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3-D RIGID PLASTIC FEM SIMULATION OF EXTRUDING-BULGING PROCESS OF TEE TUBES

引用

中国有色金属学会会刊：英文版 1999年第2期9卷 45-50页

作者： Wang, Chenlu Shan, Debin lu, yan Harbin Inst of Technology Harbin China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｅｅｔｕｂｅｓａｒｅｗｉｄｅｌｙａｐｐｌｉｅｄａｓｉｍｐｏｒｔａｎｔｐｉｐｅｊｕｎｃｔｉｏｎｓｉｎｐｉｐａｇｅｉｎａｌｋｉｎｄｓｏｆｉｎｄｕｓｔｒｙｄｅｐａｒｔｍｅｎｔｓ．Ｗｉｔｈｔｈｅｄ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｅｅｔｕｂｅｓａｒｅｗｉｄｅｌｙａｐｐｌｉｅｄａｓｉｍｐｏｒｔａｎｔｐｉｐｅｊｕｎｃｔｉｏｎｓｉｎｐｉｐａｇｅｉｎａｌｋｉｎｄｓｏｆｉｎｄｕｓｔｒｙｄｅｐａｒｔｍｅｎｔｓ．Ｗｉｔｈｔｈｅｄｅｖｅｌｏｐｍｅｎｔｏｆｉｎｄｕｓ...

关键词： FEMextrudingbulging processtee tubes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A FOURTH ORDER DERIVATIVE-FREE OPERATOR MARCHING METHOD FOR HELMHOLTZ EQUATION IN WAVEGUIDES

引用

Journal of Computational Mathematics 2007年第6期25卷 719-729页

作者： Ya yan lu Department of Mathematics City University of Hong Kong Kowloon Hong Kong

A fourth-order operator marching method for the Helmholtz equation in a waveguide is developed in this paper. It is derived from a new fourth-order exponential integrator for linear evolution equations. The method improves the second-order accuracy associated with the widely used step-wise coupled mode method where the waveguide is approximated by segments that are uniform in the propagation direction. The Helmholtz equation is solved using a one-way reformulation based on the Dirichlet-to-Neumann map. An alternative version closely related to the coupled mode method is also given. Numerical results clearly indicate that the method is more accurate than the coupled mode method while the required computing effort is nearly the same.

关键词： Helmholtz equation Waveguides Dirichlet-to-Neumann map Operator marching.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional visualization and quantification of microporosity in aluminum castings by X-ray micro-computed tomography

引用

Journal of Materials Science & Technology 2021年第6期65卷 99-107页

作者： Cheng Gu yan lu Alan A.luo Department of Materials Science and Engineering The Ohio State University2041 College Rd N.ColumbusOhio 43210USA Department of Integrated Systems Engineering The Ohio State University1971 NeilAve.ColumbusOhio 43210USA

Porosity is a major issue in solidification processing of metallic *** this work,wedge die casting experiments were designed to investigate the effect of cooling rate on microporosity in an aluminum alloy *** information including dendrites and porosity were measured and observed by optical microscopy and X-ray micro-computed tomography(XMCT).The effects of cooling rate on secondary dendrite arm spacing(SDAS)and porosity were *** relationship between SDAS and cooling rate was established and validated using a mathematical ***-dimensional(3-D)porosity information,including porosity percentage,pore volume,and pore number,was determined by *** the cooling rate decreasing from a lower to a higher position of the wedge die,the observed pore number decreases,the porosity percentage increases,and the equivalent pore radius *** of the pores was discussed as an empirical criterion to distinguish the types of *** different cooling rates,the larger the equivalent pore radius is,the lower the sphericity of the *** research suggests that XMCT is a useful tool to provide critical 3-D porosity information for integrated computational materials engineering(ICME)design and process optimization of solidification products.

关键词： X-ray computed tomography Casting micropore Quantitative evaluation Al alloy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：