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Evaluation of antimicrobial activity and bronchodialator effect of a polyherbal drug-Shrishadi

Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 905-909页

作者： Divya Kumari Kajaria Mayank Gangwar Dharmendra Kumar Amit Kumar Sharma Ragini Tilak Gopal Nath yamini bhusan tripathi JS tripathi SK Tiwari Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu UniversityVaranasi-221005(Uttar pradesh) Department of Microbiology Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Department of Medicinal Chemistry Institute of Medical SciencesBanaras Hindu UniversityVaranasi- 221005 (Uttar pradesh) Faculty of Aurveda Department of KayachikitsaInstitute of Medical SciencesBanaras Hindu University

Objective:To investigate antimicrobial and bronchodialator effect of hydroalcholic extract of polyherbal drug Shirishadi containing Shirisha(Albezzia lebbeck),Nagarmotha(Cyprus ratandus) & Kantakari(Solanum xanthocarpum).Methods:Antimicrobial activity was evaluated by discdiffusion method and MIC,MBC,MFC were calculated by micro dilution *** extract of this preparation was investigated for its phytochemical analysis,phenol and Oavonoid were determined by speclrophotometric method and in vivo bronchodilator effect was analysed by convulsion ***:The phytochemical tests revealed presence of alkaloids, anthraquinones,carbohydrates,flavonoids,saponins and *** antimicrobial result showed the MIC of 6.25 mg/*** Staphylococcus aureus and 12.5 mg/*** Escherichia coli and 12.5 mg/mL against remaining bacteria tested,with strong antifungal *** maximum inhibition zone is found against Pseudomonas aeruginosa with MIC 16 mg/mL Drug showed significant bronchodilator effect with 27.86%& 36.13%increase in preconvulsion time of guinea pigs prebeated with 100 & 200 mg/kg body weight of ***:The study reveals that the extracts possess antibacterial activity and antifungal activity in a dose dependent manner. This antimicrobial property may be due to presence of several saponins,further studies are highly needed for the drug development.

关键词： Shrishadi-polyherbal drug Phytochemical Phenolic & flavonoid content Candida species Bronchodilator

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Natural compounds as potential inhibitors of SARS-CoV-2 main protease: An insilico study

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 155-163页

作者： Amaresh Mishra yamini Pathak Anuj Kumar Surabhi Kirti Mishra Vishwas tripathi School of Biotechnology Gautam Buddha UniversityGreater Noida-201310India Bioinformatics Laboratory Uttarakhand Council for BiotechnologyBiotech BhawanPantnagarU.S.NagarUttarakhand-263145India Advanced Centre for Computational and Applied Biotechnology Uttarakhand Council for BiotechnologyDehradun-248007India School of Biotechnology Jawaharlal Nehru UniversityNew DelhiIndia

Objective:To explore natural compounds as potential inhibitors against main protease(Mpro)of ***:In the current study,systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and *** natural compounds were further validated using a combination of molecular dynamic(MD)simulations and molecular mechanic Poisson-Boltzmann surface area(MM/PBSA)free energy c alculation ***:Out of twenty natural compounds,four natural metabolites namely,amentoflavone,guggulsterone,puerarin,and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking *** MD simulations,all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro ***:Guggulsterone is a potential inhibitor of COVID-19 main protease *** in vitro and pre-clinical studies are needed.

关键词： SARS-CoV-2 COVID-19 Amentoflavone Guggulsterone Puerarin Piperine

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