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Antimicrobial Activity against Escherichia coli of Cu-Ni Nanoalloy and Combination of Ag Nanoparticles,Obtained by Different Method

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Journal of Pharmacy and Pharmacology 2021年第12期9卷 420-427页

作者： Cecilia A.Fernandez yamila aillanez Gaston Fernandez Marcelo R.Esquivel María de los ACangiano Research Institute of Chemical Technology(INTEQUI) National University of San Luis(UNSL)-CONICET.Almirante Brown 1455San Luis 5700Argentina School of Engineering and Farming Sciences(FICA) National University of San Luis(UNSL)Ruta 55 Ext.NorteVilla MercedesSan Luis5730Argentina School of Chemistry Biochemistry and PharmacyUNSLSan LuisArgentina School of Medical Sciences of the Catholic University of Cuyo San LuisArgentina Atomic Center of Bariloche(CNEA-CONICET) Avenida Bustillo km 95BarilocheRío Negro8400Argentina National University of Comahue(UNCo)-Bariloche Quintral 1250BarilocheRío Negro8400Argentina

Escherichia coli,is a pathogenic bacterium that causes serious infections,whose therapeutic treatment is threatened by the emergence of multiple resistance to conventional *** recent years,metal nanoparticles(NPs)have been studied for their antimicrobial capacity and their possible applications as an alternative to antibiotics against different *** also vary in synthesis techniques;either by chemical,physical and biological *** objective of this work was to study the possible antimicrobial capacity of Cu-Ni nanoalloys obtained by a method called *** antimicrobial capacity of the NPs mentioned above was evaluated in vitro by the agar diffusion *** of the NPs evaluated showed antibacterial activity against the strain of *** *** combining chemical and biological NP,synergistic effects are observed with an increase in antibacterial activity in some *** can conclude that NPs derived from chemical and biological synthesis could be used as antimicrobials against *** and when these are combined,antibacterial effects *** the future,these applications of nanomaterials could be used as an alternative to the use of antibiotics against infections that have limited treatments.

关键词： Nanoalloys Cu-Ni antibacterial activity human pathogens nanotechnology

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Neuroprotective effect of Neuro-EPO in neurodegenerative diseases:“Alea jacta est”

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Neural Regeneration Research 2019年第9期14卷 1519-1521页

作者： Ramón Rama Fernando Garzón yamila Rodríguez-Cruz Tangui Maurice Julio-César García-Rodríguez Department of Cell Biology Physiology and ImmunologyUniversity of BarcelonaBarcelonaSpain Department of Animal Health University of NarinoPastoNarinoColombia Department of Histology University of Medical SciencesHavanaCuba MMDN Univ MontpellierINSERMEPHEUMR_S1198MontpellierFrance CENPALAB National Center for Animals BreedingHavanaCuba

Our common home,planet Earth,is inhabited by more than 7 billion human *** average life expectancy currently estimated for men is^69 years,with strong differences among ***,neurodegenerative diseases are currently the leading cause of death and disability *** clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified.

关键词： Our common home neurodegenerative still unidentified

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Breast cancer:Muscarinic receptors as new targets for tumor therapy

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World Journal of Clinical Oncology 2021年第6期12卷 404-428页

作者： Alejandro Español Agustina Salem yamila Sanchez María Elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

The development of breast cancer is a complex process that involves the participation of different *** authors have demonstrated the overexpression of muscarinic acetylcholine receptors(mAChRs)in different tumor tissues and their role in the modulation of tumor biology,positioning them as therapeutic targets in *** conventional treatment for breast cancer involves surgery,radiotherapy,and/or *** latter presents disadvantages such as limited specificity,the appearance of resistance to treatment and other side *** prevent these side effects,several schedules of drug administration,like metronomic therapy,have been *** therapy is a type of chemotherapy in which one or more drugs are administered at low concentrations ***,two chemotherapeutic agents usually used to treat breast cancer have been considered able to activate *** combination of low concentrations of these chemotherapeutic agents with muscarinic agonists could be a useful option to be applied in breast cancer treatment,since this combination not only reduces tumor cell survival without affecting normal cells,but also decreases pathological neo-angiogenesis,the expression of drug extrusion proteins and the cancer stem cell *** this review,we focus on the previous evidences that have positioned mAChRs as relevant therapeutic targets in breast cancer and analyze the effects of administering muscarinic agonists in combination with conventional chemotherapeutic agents in a metronomic schedule.

关键词： Muscarinic receptors Drug therapy Breast cancer Drug combination Metronomic therapy Drug resistance

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Non Local Corrections to the Electronic Structure of Non Ideal Electron Gases: The Case of Graphene and Tyrosine

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Journal of Modern Physics 2013年第4期4卷 522-527页

作者： yamila García John Cuffe Francesc Alzina Clivia M. Sotomayor-Torres Catalan Institute of Nanotechnology (CIN2-CSIC) Campus UAB Bellaterra Spain

We introduce a formal definition of a non local functional and show that the non local exchange-correlation potential functional, derived within Density-Functional Theory, is non local in the space of electronic densities. A previously developed non local exchange-correlation potential term, is introduced to approach the exact density-functional potential. With this approach, the electronic structure of the graphene surface and the tyrosine amino acid are calculated.

关键词： Nonlocality Interfaces Exchange-Correlation Potential Graphene

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Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells

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World Journal of Clinical Oncology 2022年第6期13卷 505-519页

作者： Alejandro Español yamila Sanchez Agustina Salem Jaqueline Obregon Maria Elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

BACKGROUND Triple negative breast cancer is more aggressive than other breast cancer subtypes and constitutes a public health problem worldwide since it has high morbidity and mortality due to the lack of defined therapeutic *** to chemotherapy complicates the course of patients’*** authors have highlighted the participation of nicotinic acetylcholine receptors(nAChR)in the modulation of conventional chemotherapy treatment in cancers of the ***,in breast cancer,less is known about the effect of nAChR activation by nicotine on chemotherapy treatment in smoking *** To investigate the effect of nicotine on paclitaxel treatment and the signaling pathways involved in human breast MDA-MB-231 tumor *** Cells were treated with paclitaxel alone or in combination with nicotine,administered for one or three 48-h *** effect of the addition of nicotine(at a concentration similar to that found in passive smokers’blood)on the treatment with paclitaxel(at a therapeutic concentration)was determined using the 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** signaling mediators involved in this effect were determined using selective *** also investigated nAChR expression,and ATP“binding cassette”G2 drug transporter(ABCG2)expression and its modulation by the different treatments with Western *** effect of the treatments on apoptosis induction was determined by flow cytometry using annexin-V and 7AAD *** Our results confirmed that treatment with paclitaxel reduced MDA-MB-231 cell viability in a concentration-dependent manner and that the presence of nicotine reversed the cytotoxic effect induced by paclitaxel by involving the expression of functionalα7 andα9 nAChRs in these *** action of nicotine on paclitaxel treatment was linked to modulation of the protein kinase C,mitogen-activated protein kinase,extracellular signal-regulated kinase,and NF-κB signaling pathways,

关键词： Breast cancer Paclitaxel Nicotinic acetylcholine receptors Drug therapy Signal transduction Drug transporter

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Risk Assessment of an Environmental Liability in the Commercialization of Hydrocarbons-A Secondary Publication

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Journal of World Architecture 2024年第2期8卷 108-117页

作者： yamila Navarro Sosa JoséCarlos Rojas Acosta Lester Rivas Trasancos Carlos C.Cañete Pérez Yuletsis Díaz Rodríguez Center for Petroleum Research(CEINPET) HavanaCuba Technological University of Havana JoséAntonio Echeverría HavanaCuba

The risk analysis evaluates the probability of occurrence with the impact of said *** the hydrocarbon sector,an environmental liability is an improperly abandoned facility,soil contaminated by spills or *** objective of this work is to define a risk management *** characterization of the residue and the area was carried *** events were identified:overflow spill,soil contamination by infiltration,as well as radiant heat and suffocating and toxic fumes from a *** matrix method was applied considering the probability of occurrence against *** danger of infiltration implied a high level of *** risk management plan was drawn up,its main action being the liquidation of the pool and the sanitation of the area.

关键词： Hazardous events Environmental liability Waste Risk Vulnerability

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Production and Sensory Evaluation of Novel Cheeses Made with Prebiotic Substances:Inulin and Oligofructose

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Food and Nutrition Sciences 2015年第16期6卷 1489-1495页

作者： Laura M.Machuca yamila E.Rodriguez Daniela E.Guastavino Meneguini María E.Bruzzo María F.Acuna Ojeda Marcelo C.Murguía Institute of Scientific Research(IDIC) Faculty of Engineering and TechnologyUniversity of the Cuenca del Plata(UCP)CorrientesArgentina Laboratory of Applied Chemistry Faculty of Biochemistry and Biological SciencesNational University of the Litoral(UNL)Santa FeArgentina

In recent years, the processing and consumption of functional foods worldwide have greatly increased. These foods benefit the body functions which improve consumers’ health and also reduce the risk factors that cause the onset of disease. Furthermore, prebiotic substances favor the multiplication of beneficial intestinal bacteria rather than harmful ones. The purpose of this study was to conduct the sensory evaluation of two functional cheeses containing inulin and oligofructose as a distinctive ingredient, including testing a cheese made with conventional ingredients, called control cheese. Affective type tests, which measured the degree of liking or disliking, were conducted using a verbal 7-point hedonic scale. According to the inclusion and exclusion criteria, 57 untrained judges were selected. This study is a quantitative, analytic and experimental-cross design. Statistical analysis of the data was performed by ANOVA with repeated measures. The results show a similar average degree of liking for the three cheeses, above 5 on the scale or “like”. By analyzing the critical level and the result of the Mauchly’s sphericity test, it is concluded that there is no statistically significant difference in the degree of liking for the three cheeses. Therefore, the addition of prebiotics to artisanal cheeses achieves to satisfy consumers and provide them benefits superior to those provided by traditional foods.

关键词： Cheese Inulin Oligofructose Functional Foods

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