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左归饮加减对小鼠肝细胞内SOD的影响

泰山医学院学报 1995年第2期16卷 86-87页

作者：王洪海马培珍高慧英安蔚崔海庆李亚鲁泰山医学院中医学教研室

本试验选用昆明种小鼠３２只，其中老年小鼠（１８月～２２个月）２４只，分为Ａ、Ｂ两组，Ｃ组为青年小鼠（２个月）８只，以中药方剂左归饮加减的水煎液给Ａ组小鼠自由饮用。７５天后，与Ｂ组相比活力增加，毛色光亮，肝细胞内ＳＯＤ... 详细信息

本试验选用昆明种小鼠３２只，其中老年小鼠（１８月～２２个月）２４只，分为Ａ、Ｂ两组，Ｃ组为青年小鼠（２个月）８只，以中药方剂左归饮加减的水煎液给Ａ组小鼠自由饮用。７５天后，与Ｂ组相比活力增加，毛色光亮，肝细胞内ＳＯＤ活性明显升高（Ｐ＜０．０５）。实验证明，以左归饮为主的水煎液，可增强肝细胞内ＳＯＤ的活性，因此有明显的抗氧化、抗衰老的作用。

关键词：左归饮抗衰老小鼠超氧化物歧化酶药理

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一种考虑传感器位置误差的改进源定位算法

航空学报 2014年第7期35卷 1992-1998页

作者：曹亚陆彭力江南大学物联网工程学院江苏无锡214122

在无线传感器网络的定位问题中,通过移动目标与传感器之间的到达时差(TDOA)与到达频差(FDOA)测量量可以估计目标的位置和速度。但是,当传感器自身信息存在误差时,传统的定位方法将失去精确的定位效果。针对带有传感器误差的源定位问题,... 详细信息

在无线传感器网络的定位问题中,通过移动目标与传感器之间的到达时差(TDOA)与到达频差(FDOA)测量量可以估计目标的位置和速度。但是,当传感器自身信息存在误差时,传统的定位方法将失去精确的定位效果。针对带有传感器误差的源定位问题,基于极大似然(ML)法获取一个封闭的近似解。提出了一种改进的近似极大似然(AML)算法,更新带有传感器误差的代价函数,不仅能实现实时定位,而且保证全局收敛。仿真结果表明,本文算法在存在传感器误差场景下依然可以达到克拉美-罗下限(CRLB),比已有的改进两步加权最小二乘(2-step WLS)法更有效。

关键词：传感器位置误差近似极大似然算法源定位到达时差到达频差

Study on the relationship of iodine nutritional status with thyroid function and autoantibodies in pregnant women in Baotou

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Discussion of Clinical Cases 2020年第1期7卷 3-7页

作者： Yuanyuan Fan yalu Wang Chenhui li Ziling li Department of Endocrinology Baogang HospitalBaotouInner MongoliaChina The Second Military Medical University ShanghaiChina

Objective:To investigate the relationship of iodine nutritional status with thyroid function in pregnant women in Baotou,and provide a scientific basis for the guide of reasonable iodine ***:By use of As-Ce catalysis spectrophotometry,the urinary iodine concentration was determined in 90 women during different periods of pregnancy admitted to Baogang Hospital of Inner Mongolia from January 2017 to December *** determination of thyroid function and the autoantibody level was carried out by electro-chemiluminescence immunoassay(ECliA).Results:In the early trimester of pregnancy,pregnant women with iodine deficiency,iodine sufficiency and iodine excess accounted for 36.67%,40.00%and 23.33%respectively;in the middle trimester of pregnancy,they accounted for 66.67%,26.67%and 6.66%respectively;they made up 40.00%,40.00%and 20.00%respectively in the late trimester of *** rate of iodine deficiency in women in the middle trimester of pregnancy was significantly higher than that in women in the early and the late trimesters of pregnancy respectively,and the difference was statistically significant(plin *** matter in the pregnant women with iodine deficiency or with iodine excess,the abnormality rate of thyroid function and autoantibodies was significantly higher than that in the pregnant women with iodine *** difference was statistically significant(plity rate of thyroid

关键词： Iodine nutritional status Pregnancy Urinary iodine Thyroid function

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan yalu Tan Panlin liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang Yan Huang Yangzhou Zhang Jia-Da li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as liMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

2′-Fucosyllactose modulates the function of intestinal microbiota to reduce intestinal permeability in mice colonized by feces from healthy infants

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Food Science and Human Wellness 2023年

作者： Qingxue Chen liu Yang Fangqin Xiang Ignatius Man-Yau Szeto yalu Yan Biao liu Jinju Cheng Lu liu Bailiang li Sufang Duan Key Laboratory of Dairy Science， Ministry of Education， Northeast Agricultural University Food College， Northeast Agricultural University National Center of Technology Innovation for Dairy Hohhot Inner Mongolia Yili Industrial Group， Co.Ltd.， Yili Maternal and Infant Nutrition Institute (YMINI)

2′-Fucosyllactose (2’-FL) shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding. However， the effect and mechanism of 2’-FL in improving intestinal permeability are not clear. In this study， we constructed human microbiota-associated (HMA) mouse models by colonizing healthy infant feces in mice with antibiotic-depleted intestinal microbiota. The protective effect of 2’-FL on the intestinal permeability was explored using the HMA mouse models， and the combination of metagenomics was used to analyze the possible mechanisms by which the microorganisms reduced the intestinal permeability. The results showed that 2’-FL decreased the concentration of markers of intestinal permeability (enterotoxin and DAO) and increased the expression levels of tight junctions (occludin and claudin). Metagenomics revealed the enrichment of Bifidobacterium and increased the expression of glycoside hydrolases (GHs)， including GH31， GH28， and GH5. In conclusion， 2’-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.

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两性离子自组装仿生表面的制备、表征及抗黏附性能

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高等学校化学学报 2014年第7期35卷 1484-1491页

作者：吴雅露李光吉刘云鸿陈达杨华南理工大学材料科学与工程学院广州510640

设计与合成了磺酸甜菜碱型的两性离子化合物:N,N-二甲基氨甲酸乙酯基丙基三乙氧基硅烷磺酸内盐(SiNNS),利用红外光谱(FTIR)和氢核磁共振波谱(1H NMR)对其分子组成与结构进行了表征.通过自组装技术将SiNNS分子构筑在玻璃基材表面,形成了... 详细信息

设计与合成了磺酸甜菜碱型的两性离子化合物:N,N-二甲基氨甲酸乙酯基丙基三乙氧基硅烷磺酸内盐(SiNNS),利用红外光谱(FTIR)和氢核磁共振波谱(1H NMR)对其分子组成与结构进行了表征.通过自组装技术将SiNNS分子构筑在玻璃基材表面,形成了模拟细胞外层膜的仿生表面.利用原子力显微镜(AFM)、X光电子能谱(XPS)和接触角测量仪对表面的形貌特征、化学组成和润湿性进行了表征.以空白玻璃为对照样品,研究了这一表面的防雾性能和抗细菌黏附性能.结果表明,所制备的两性离子自组装仿生表面具有超亲水性和水下超疏油特性,其水滴接触角为9.2°,水下油滴接触角接近180°;与对照样品相比,两性离子自组装表面具有优异的防雾性与抗细菌黏附性.

关键词：甜菜碱型两性离子自组装仿生表面超亲水抗细菌黏附性

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双面珠地网眼面料的设计与生产

针织工业 2008年第7期 3-4页

作者：雷励宋雅路成都纺织高等专科学校四川成都611731

对双面珠地网眼组织的形成原理进行了介绍。以实例阐述了双面珠地网眼面料的设计方法,包括常规结构设计、变化结构设计、抽针结构设计、功能面料的设计,给出了它们的编织图及工艺参数,并对面料风格进行了评价,同时分析了相关的生产工艺... 详细信息

对双面珠地网眼组织的形成原理进行了介绍。以实例阐述了双面珠地网眼面料的设计方法,包括常规结构设计、变化结构设计、抽针结构设计、功能面料的设计,给出了它们的编织图及工艺参数,并对面料风格进行了评价,同时分析了相关的生产工艺要点。

关键词：双面珠地网眼形成原理结构设计工艺

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高温化学非平衡湍流边界层直接数值模拟

航空学报 2022年第1期43卷 236-247页

作者：刘朋欣袁先旭孙东傅亚陆李辰中国空气动力研究与发展中心空气动力学国家重点实验室绵阳621000 中国空气动力研究与发展中心计算空气动力研究所绵阳621000

高超声速飞行器在特定工况下飞行时,其表面会存在湍流与化学非平衡耦合作用,但考虑化学反应的高温湍流边界层的研究工作还十分有限。选取高超声速楔形体头部斜激波后的流动状态,分别采用热完全气体模型、空气化学反应模型开展直接数值模... 详细信息

高超声速飞行器在特定工况下飞行时,其表面会存在湍流与化学非平衡耦合作用,但考虑化学反应的高温湍流边界层的研究工作还十分有限。选取高超声速楔形体头部斜激波后的流动状态,分别采用热完全气体模型、空气化学反应模型开展直接数值模拟(DNS)研究,对比分析了化学非平衡效应对湍流统计量、湍流脉动量的影响趋势,并研究了高温湍流边界层标度律。计算结果表明,以吸热离解反应为主的化学非平衡效应会使边界层平均温度和脉动温度显著降低,但对平均速度剖面、速度脉动、雷诺应力的影响较小;在高温化学非平衡湍流边界层的对数区,各流动参数的拓展自相似理论的相对标度指数基本符合标度律。

关键词：高超声速流动高温化学非平衡湍流边界层直接数值模拟标度律

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介孔金属膦酸盐杂化材料研究进展

化学学报 2014年第5期72卷 521-536页

作者：刘亚录朱运培李敏袁忠勇南开大学化学学院先进能源材料化学教育部重点实验室天津化学化工协同创新中心天津300071

介孔金属有机膦酸盐杂化材料由于同时结合了无机和有机组分的性质,可作为一种环境友好的多功能材料而备受关注.介孔金属有机膦酸盐中的有机和无机组分不是简单的物理混合,而是在分子尺度上的融合.合成膦酸盐所需有机前驱体主要为有机多... 详细信息

介孔金属有机膦酸盐杂化材料由于同时结合了无机和有机组分的性质,可作为一种环境友好的多功能材料而备受关注.介孔金属有机膦酸盐中的有机和无机组分不是简单的物理混合,而是在分子尺度上的融合.合成膦酸盐所需有机前驱体主要为有机多聚膦酸及其相应的盐和酯类化合物,种类繁多,使得各种有机官能团被均匀地引入进金属膦酸盐的骨架中,呈现多功能作用,有效地扩展了其应用领域.本文系统地综述了介孔金属有机膦酸盐的合成及在吸附、分离、催化、生物传感和药物控释等领域应用研究进展,并对介孔金属膦酸盐材料的发展方向和应用前景进行了展望.

关键词：介孔金属膦酸盐有机-无机杂化吸附催化