检索结果-南通市图书馆

2′-Fucosyllactose modulates the function of intestinal microbiota to reduce intestinal permeability in mice colonized by feces from healthy infants

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2023年

作者： Qingxue Chen Liu yang Fangqin Xiang Ignatius Man-Yau Szeto yalu yan Biao Liu Jinju Cheng Lu Liu Bailiang Li Sufang Duan Food College， Northeast Agricultural University National Center of Technology Innovation for Dairy Hohhot Inner Mongolia Yili Industrial Group， Co.Ltd.， Yili Maternal and Infant Nutrition Institute (YMINI) Key Laboratory of Dairy Science， Ministry of Education， Northeast Agricultural University

2′-Fucosyllactose (2’-FL) shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding. However， the effect and mechanism of 2’-FL in improving intestinal permeability are not clear. In this study， we constructed human microbiota-associated (HMA) mouse models by colonizing healthy infant feces in mice with antibiotic-depleted intestinal microbiota. The protective effect of 2’-FL on the intestinal permeability was explored using the HMA mouse models， and the combination of metagenomics was used to analyze the possible mechanisms by which the microorganisms reduced the intestinal permeability. The results showed that 2’-FL decreased the concentration of markers of intestinal permeability (enterotoxin and DAO) and increased the expression levels of tight junctions (occludin and claudin). Metagenomics revealed the enrichment of Bifidobacterium and increased the expression of glycoside hydrolases (GHs)， including GH31， GH28， and GH5. In conclusion， 2’-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.

关键词：

PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu Fangfang Zeng Mengshu Fan Kexuan Zhang Jingjing Duan yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang yan Huang yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric Diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

桥梁伸缩缝快硬聚合物水泥复合材料PCC研究

在线全文

学校读者我要写书评

暂无评论

江西建材 2024年第1期 72-74页

作者：阎敬文任雅露辽宁科技大学土木工程学院辽宁鞍山114000

在保证伸缩缝正常使用功能的基础上,为解决受损桥梁伸缩缝快速修复的问题,文中以硫铝酸盐水泥与普通硅酸盐水泥为胶凝材料,并加入聚合物胶粉,通过调节灰砂比、外加剂及矿物掺合料,制备一种快速硬化的水泥基砂浆材料,即快硬聚合物水泥复... 详细信息

在保证伸缩缝正常使用功能的基础上,为解决受损桥梁伸缩缝快速修复的问题,文中以硫铝酸盐水泥与普通硅酸盐水泥为胶凝材料,并加入聚合物胶粉,通过调节灰砂比、外加剂及矿物掺合料,制备一种快速硬化的水泥基砂浆材料,即快硬聚合物水泥复合材料(PCC,Polymer Cement Composite),经试验测试,其5 h抗压强度达到32 MPa,28 d抗压强度达到60 MPa以上,干缩率小于0.4‰,是一种理想的桥梁伸缩缝快速修补料。

关键词：快硬水泥聚合物桥梁伸缩缝

肺炎克雷伯菌噬菌体vB_KpnP_643的生物学特性及基因组分析

在线全文

学校读者我要写书评

暂无评论

中国兽医学报 2024年第2期44卷 298-304页

作者：路艳赵日虹徐莉冀亚路张梅梅顾敬敏韩文瑜吉林大学动物医学学院吉林长春130062 长春市动物疫病预防控制中心吉林长春130062

利用自临床分离的肺炎克雷伯菌从污水中分离得到1株新噬菌体vB_KpnP_643,并对其生物学特性和基因组进行了研究与分析。噬菌体vB_KpnP_643可在涂布有肺炎克雷伯菌平板上呈现出中心透亮且周围有晕环的噬菌斑。电镜观察结果显示,该噬菌体... 详细信息

利用自临床分离的肺炎克雷伯菌从污水中分离得到1株新噬菌体vB_KpnP_643,并对其生物学特性和基因组进行了研究与分析。噬菌体vB_KpnP_643可在涂布有肺炎克雷伯菌平板上呈现出中心透亮且周围有晕环的噬菌斑。电镜观察结果显示,该噬菌体属于短尾病毒科。一步生长曲线表明,噬菌体vB_KpnP_643的潜伏期约3 min,裂解周期约60 min。噬菌体vB_KpnP_643具有较好的热稳定性和酸碱耐受性,可适用于各种环境。此外,基于生物信息学分析,噬菌体vB_KpnP_643基因组全长43331 bp,包含编码64个开放阅读框(ORF),未发现与耐药、毒力及溶原相关的基因,DNA聚合酶的系统发育树分析表明该噬菌体在一个相对独立的分支。本研究结果表明噬菌体vB_KpnP_643有望成为抗击肺炎克雷伯菌感染的一种抗生素替代药物。

关键词：肺炎克雷伯菌噬菌体生物学特性基因组分析

Fabrication of NiCoP decorated TiO_(2)/polypyrrole nanocomposites for the effective photocatalytic degradation of tetracycline

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第5期33卷 2741-2746页

作者： yalu Wu Yinyin Xu yan Zhang Jingbo Feng Yuanyuan Li Jiaying Lan Xiuwen Cheng Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

Due to the massive discharge of antibiotics in water,it is an urgent matter to remove antibiotics from waste *** photocatalysts with high stability and activity have attracted extensive attention from *** an in-situ polymerization method,polypyrrole(PPy)was modified on the surface of TiO_(2)(named as TiO_(2)/PPy).By one-step reduction method,NiCoP was grafted on the surface of TiO_(2)/PPy(named as TiO_(2)/PPy/NiCoP)to synthesize the photocatalyst of TiO_(2)/PPy/NiCoP for degradation of tetra-cycline(TC)*** characterization results revealed that NiCoP was deposited on the surface of TiO_(2)/PPy *** photocatalytic experiment results illustrated that 83.2%of TC could be de-graded at natural pH with 20 mg of TiO_(2)/PPy/NiCoP in 50 mL of TC solution(10 mg/L)under visible light *** high catalytic activity is attributed to the attachment of NiCoP on the surface of TiO_(2)/PPy which can enlarge the light response range of TiO_(2)*** studies revealed that the degra-dation of TC was dominated by•O_(2)−and h+.The photodegradation efficiency of TC with TiO_(2)/PPy/NiCoP still reached over 74%after 5 consecutive cycles,indicating the potential applications in practical wastew-ater.

关键词： TiO_(2) NiCoP Polypyrrole Visible light photocatalytic Tetracycline

Association Between Physical Activity and Physical Fitness Among Adults Aged 40 to 79 Years—Beijing,China,2020–2021

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2022年第42期4卷 936-940页

作者： Xiaojin yan Heming Pei yalu Zhang Ning Kang Gong Chen Dongmin Wang Institute of Population Research Peking UniversityBeijingChina Department of Physical Education Peking UniversityBeijingChina

Summary What is already known about this topic?Physical fitness is well documented to be associated with physical activity among adults in the United *** China,research on this association places a heavier emphasis on the populations of children and *** is added by this report?Physical fitness was shown to be positively associated with physical activity among adults aged 40 to 79 years in *** populations with lower levels of physical fitness,this association was *** coefficients of the log-transformed metabolic equivalent value of physical activity(logPA)in quantile regression models at the 25th,50th,75th,and 90th percentile of the physical fitness indicators were 1.14,1.04,0.89,and 0.84,respectively.

关键词： Physical logP transformed

基于多元统计学分析^(60)Co-γ射线辐照对川芎挥发性成分的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辐射研究与辐射工艺学报 2024年第4期42卷 75-88页

作者：王艳孟爱莲贾鑫叶嘉伟徐攀张雁君邱娅璐何江毛腾霄高鹏四川省原子能研究院成都610101 辐照保藏四川省重点实验室成都610101 西南科技大学生命科学与工程学院绵阳621010 成都市药品检验研究院化学药品质量研究与控制重点实验室成都610045

川芎挥发性成分是其主要活性成分之一,也是评价川芎药用品质的重要指标。为探究^(60)Co-γ射线辐照对川芎挥发性成分的影响,本研究以不同吸收剂量处理川芎样品,采用电子鼻结合顶空固相微萃取-气相色谱-质谱技术(HS-SPME-GC-MS),通过主... 详细信息

川芎挥发性成分是其主要活性成分之一,也是评价川芎药用品质的重要指标。为探究^(60)Co-γ射线辐照对川芎挥发性成分的影响,本研究以不同吸收剂量处理川芎样品,采用电子鼻结合顶空固相微萃取-气相色谱-质谱技术(HS-SPME-GC-MS),通过主成分分析、线性判别分析、正交偏最小二乘法和聚类分析的多元统计学方法分析数据,以期了解川芎辐照前后挥发性成分的变化。电子鼻与GC-MS结果都表明:川芎气味主要由烷烃类、醇类、醛类、酮类贡献,10 kGy剂量以下的辐照处理对川芎挥发性气味成分影响不大;川芎经0 kGy(对照组)、3 kGy、7 kGy、10 kGy剂量辐照处理后,共鉴定出60种化合物,其中烃类23种,醇类12种,脂类10种,醛酮类4种,其他类11种;筛选到21种辐照前后的差异特征性指标物,它们在川芎挥发性成分中只占约12.92%,不是川芎的主要挥发性成分。经10 kGy剂量以下的辐照处理后,川芎中没有新生成的物质被鉴定出来。研究结果提示经10 kGy以下剂量处理川芎不会影响其主要挥发性成分。

关键词：川芎辐照挥发性成分顶空固相微萃取-气相色谱-质谱技术多元统计学分析

在线全文

学校读者我要写书评

暂无评论

高速公路收益权的资产证券化问题研究

金融研究 2016年第5期 111-123页

作者：闫妍顾亚露朱晓武中国科学院大学经济与管理学院北京100080 中国科学院大数据挖掘与知识管理重点实验室北京100080 中国政法大学商学院北京102249

本文研究了高速公路的资产证券化问题,设计以高速公路收益权作为基础资产的资产支持票据(ABN),并根据高速公路收费额的预期值和利率期限结构确定ABN的发行规模和票面利率。我们还对本文设计的ABN产品进行利率风险分析。

关键词：资产证券化资产支持票据高速公路

在线全文

学校读者我要写书评

暂无评论

大动态信号的高分辨采集电路设计方法

传感技术学报 2022年第2期35卷 148-153页

作者：邵亚璐王鉴庞存锁韩焱中北大学信息探测与处理山西省重点实验室山西太原030051 省部共建动态测试技术国家重点实验室山西太原030051

针对在数字采集中,受ADC的量化分辨力限制,大动态范围信号难以满足信号分辨力的要求的问题,提出了一种适应大动态范围信号高分辨力采集电路系统的设计方法。首先根据信号的动态范围、分辨力指标和关注度,将信号进行逆序分段放大到ADC的... 详细信息

针对在数字采集中,受ADC的量化分辨力限制,大动态范围信号难以满足信号分辨力的要求的问题,提出了一种适应大动态范围信号高分辨力采集电路系统的设计方法。首先根据信号的动态范围、分辨力指标和关注度,将信号进行逆序分段放大到ADC的输入动态范围,之后,根据各分段采集到的不同分辨力数据,进行数据加权合成,实现大动态范围信号的分段高分辨实时采集。仿真实验验证表明,此方法既可满足大动态范围信号的高分辨采集,同时可根据不同段信号的关注度,实现特定的分辨力采集,且误差率低于3%。

关键词：信号采集处理分段放大高分辨采集关注度大动态范围