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Journal of Traditional Chinese Medicine 2024年第1期44卷 222-223页

作者： XIng Yunqi li.Junxiang YUAN yali MAO Tangyou Gastroenterology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Department of Hepatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

To the Editors:We read with great interest the study recently publi.hed by Sun et al 1 entitled“Electroacupuncture at Tianshu(ST25)and Zusanli.ST36)alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor”in which the microbial details of electroacupuncture(EA)-induced protection in irritable bowel syndrome(IBS)were investigated.

关键词： releasing treatment details

Emerging mechanisms of ferroptosis and its impli.ations in lung cancer

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Chinese Medical Journal 2024年第7期137卷 818-829页

作者： Qian li.Qibin Song Huadong Pei yali Chen Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashington D.C.20057USA State Key Laboratory of Medical Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Lung cancer is one of the most common mali.nancies and has the highest number of deaths among all *** continuous advances in medical strategies,the overall survival of lung cancer patients is still low,probably due to disease progression or drug *** is an iron-dependent form of regulated cell death triggered by the lethal accumulation of li.id peroxides,and its dysregulation is impli.ated in cancer *** evidence has shown that targeting the ferroptosis pathway could be a potential strategy for improving lung cancer treatment *** this review,we summarize the underlying mechanisms and regulatory networks of ferroptosis in lung cancer and highli.ht ferroptosis-targeting precli.ical attempts to provide new insights for lung cancer treatment.

关键词： Lung cancer Ferroptosis Ferroptosis regulators Ferroptosis inducers Cancer treatment

A stepwise approach to enhancing flotation of low-grade zinnwaldite through the cationic/DL-2-octanol/anionic reagent combinations: Behavior and mechanism analysis

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International Journal of Mining Science and Technology 2024年第6期34卷 881-891页

作者： Zhonghua Xue yali Feng Haoran li.Jinrong Ju Xingquan Dua School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In order to alleviate the pressure on the supply of li.hium resources,this research proposes the use of binary/ternary collectors with high selectivity and collecting abili.y to enhance the flotation purification of low-grade zinnwaldite *** binary collector is a mixture of dodecylamine polyoxyethylene ether and DL-2-octanol.A binary collector is added first,followed by sodium oleate,known as a ternary *** acidic conditions,the recovery of li.O in the concentrate was increased by 8.26%with the binary collector and 13.70%with the ternary collector,compared to the dodecylamine polyoxyethylene *** binary collector enhanced the dispersibili.y of the single collector,while co-adsorption strengthened the hydrophobic nature of the zinnwaldite ***,zinnwaldite particles,after the appli.ation of binary collector,displayed inter-particle flocculation and attachment to bubbles within 60109 m compared to other *** collector exhibited the capacity to lower critical micelle concentration and surface tension,subsequently inducing a denser and thicker hydrophobic layer through electrostatic forces,hydrophobic interactions,and chemical *** objective of this research is to facili.ate the recovery of li.hium resources from low-grade ores in order to meet the needs of sustainable development.

关键词： Zinnwaldite Molecular dynamics simulation Flotation Ternary collector Extended DLVO theory

Facile synthesis of NiMn2S4 nanoflakes on nickel foam for high-performance aqueous asymmetric supercapacitors

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Science China(Technological Sciences) 2024年第2期67卷 499-508页

作者： ADIL Emin li.yali GAO Zhe DOng YunXia li.DongHao CHEN YongChao FU YuJun HE DeYan li.JunShuai LOngi Institute of Future Technology and School of Materials&EnergyLanzhou UniversityLanzhou 730000China

Supercapacitors display promising electrochemical performance with high power density and excellent cycle ***,their low energy density li.its their advancement in a broader range of *** enhance their energy density,we proposed self-assembled spinel NiMn2S4nanoflakes grown on nickel foam which we successfully prepared by a facile hydrothermal *** NiMn2S4electrode deli.ers a high capacitance of 2096.7 F g^(-1)at 1.0 A g^(-1),with an exceptional rate capabili.y(~720.6 F g^(-1)at a very high current density of 100 A g^(-1))and good cycle stabili.y(~85.1%retention of the initial capacitance after 7000 cycles with the Coulombic efficiency around 100%).The as-fabricated asymmetric supercapacitors based on NiMn2S4nanoflakes//active carbon demonstrate an energy density of 73.6 W h kg^(-1)at 800.5 W kg^(-1)and adequate cycli.g performance of~84.6%capacitance retention at 15 A g^(-1)after 10000 *** results reveal that the nanostructured NiMn2S4is an excellent electrode material for high-performance energy storage appli.ations.

关键词： NiMn2S4 nanostructure high capacitance aqueous supercapacitors long cycle stabili.y high energy density

Molecular compositions and sources of organic aerosols at a rural site on the Guanzhong Plain,Northwest China:The importance of biomass burning

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Particuology 2024年第6期89卷 44-56页

作者： yali li. Minxia Shen Haijiao li. Wenting Dai Weining Qi Yifan Zhang Lu li.Yue Cao Xin Wang Xiao Guo Yingkun Jiang Jianjun li State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National Observation and Research Station of Regional Ecological Environment Change and Comprehensive Management in the Guanzhong Plain ShaanxiChina

The concentration of PM_(2.5)has considerably reduced in recent years,but remains relatively high in *** particular,the increasing contribution of organic compounds to PM_(2.5)generates popular pressure for further reductions,resulting in an urgent need to study organic aerosol(OA).To investigate the molecular composition and source contribution of OA in the rural area of the Guanzhong Plain,Northwest China,PM_(2.5)samples were collected during 3–23 August 2016 and 5–20 January 2017 and studied for more than 100 organic tracer *** mean concentration of total measured organic compounds is 662±296 ng/m^(3)in summer and 3258±1925 ng/m^(3)in *** is the most abundant single compound found throughout the sampli.g period,which is a crucial tracer for biomass burning emissions,preli.inary suggesting that biomass burning is an essential source of *** summer,organic compounds such as li.id compounds,sugar compounds,and polycycli. aromatic hydrocarbons(PAHs),more come from higher plants,wood burning,vehicle exhausts,plastic waste,and other direct emission *** PAHs(OPAHs),nitrophenols,and phthali. acids more come from the atmosphere through the oxidation reaction of aromatic precursors,especially photochemical ***,in winter,most of the increases in concentrations of organic compounds are attributed to biomass *** analysis of a haze event(14–19 January 2017)during the winter sampli.g period shows that the increases in the concentration of organic compounds are unaccompanied by strong secondary formation under lower relative humidity(49.1%±13.5%).The main reason for the growth of OA in this haze event is the accumulation of primary OA(POA).The source apportionment by the positive matrix factorization(PMF)model shows that biomass burning(37.1%)is the primary source of OA in the rural regions of the Guanzhong Plain,especially in winter(40.6%).The contribution of secondary formation decreases from 26.0%in summer t

关键词： Organic aerosol Molecular composition Seasonal variation Source apportionment Guanzhong Plain

Preli.inary report of coseismic surface rupture(part)of Türkiye's M_(W)7.8 earthquake by remote sensing interpretation

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Earthquake Research Advances 2024年第1期4卷 4-13页

作者： yali Guo Haofeng li.Peng li.ng Renwei Xiong Chaozhong Hu Yueren Xu Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing100036China

Both M_(W) 7.8 and M_(W) 7.5 earthquakes occurred in southeastern Türkiye on February 6,2023,resulting in numerous buildings collapsing and serious *** the distribution of coseismic surface ruptures and secondary disasters surrounding the epicentral area is important for post-earthquake emergency and disaster ***-resolution Maxar and GF-2 satelli.e data were used after the events to extract the location of the rupture surrounding the first epicentral *** results show that the length of the interpreted surface rupture zone(part of)is approximately 75 km,with a coseismic sinistral dislocation of 2-3 m near the epicenter;however,this reduced to zero at the tip of the southwest section of the East Anatoli. Fault ***,dense soil li.uefaction pits were triggered along the rupture *** events are in the western region of the Eurasian Seismic Belt and result from the subduction and colli.ion of the Arabian and African Plates toward the Eurasian *** western region of the Chinese mainland and its adjacent areas are in the eastern section of the Eurasian Seismic Belt,where seismic activity is controlled by the colli.ion of the Indian and Eurasian *** China and Türkiye have independent tectonic histories.

关键词： 2023 Türkiye M_(w)7.8 earthquake Coseismic surface rupture East anatoli.n fault zone Eurasian seismic zone Remote sensing interpretation

Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang Tao Luo Fuyu li.yali Jiang Jinke Wang Weizhong Zhang Yunfei Bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili.Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several ***,the heterogeneity of eccDNA is largely *** this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron *** discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization

Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metaboli. syndrome but not cognitive decli.e in centenarians

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Genes & Diseases 2024年第3期11卷 106-108页

作者： Long Feng Hongqi Huo Qun li.Tao Yang yali Zhao Pei Zhang Ping Ping Shihui Fu Department of Anesthesiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Nuclear Medicine Department Handan Central HospitalHandanHebei056001China Department of Neurosurgery Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Central Laboratory Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China School of li.e Science Beijing Institute of TechnologyBeijing 100081China General Station for Drug and Instrument Supervision and Control Joint Logistic Support Force of Chinese People's LiberationArmyBeijing 100071China Department of Cardiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Geriatric Cardiology Chinese People's Liberation Army General HospitalBeijing 100853China

Approximately 20%-25%of adults encounter metaboli. syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decli.e(CD)*** with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidyli.ositol 3-hydroxy kinase family.

关键词： ATM development cognitive

Exploring the multicomponent synergy mechanism of Zuogui Wan(左归丸) on postmenopausal osteoporosis by a systems pharmacology strategy

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Journal of Traditional Chinese Medicine 2024年第3期44卷 489-495页

作者： FEng Yanchen li. yali DAng Xue li. Zixuan ZHAng Yunke CHE Zhiying li.Xiang PAN Xiaolong li. Feixiang ZHEng Pan Traditional Chinese Medicine (Zhong Jing) School Henan University of Chinese Medicine Hospital of Encephalopathy the First Affiliated Hospital of Henan University of Chinese Medicine State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineResearch Units of Infectious Disease and MicroecologyChinese Academy of Medical Sciences

OBJECTIVE: To explore the multi-component synergistic mechanism of Zuogui Wan(左归丸, ZGW) in treating postmenopausal osteoporosis(PMOP). METHODS: The main components and target genes of ZGW were screened via the Traditional Chinese Medicine Systems Pharmacology(TCMSP). In addition, the target gene sets of PMOP were derived from the Gene Cards and Onli.e Mendeli.n Inheritance in Man databases. The search tool for recurring instances of neighbouring genes(STRIng) 11.0 software was used to analyze the interaction among intersecting genes. Cytoscape 3.6.1 software and the Matthews correlation coefficient(MCC) algorithm were used to screen the core genes. Fifty Sprague-Dawley female rats were randomly divided into the sham-operated(Sham) group and the four ovariectomized(OVX) subgroups. Rats subjected to Sham or OVX were administered with the vehicle(OVX, 1 m L water/100 g weight), 17β-estradiol(E2, 50 μg·kg-1·d-1), and lyophili.ed powder of ZGW at a low dose of 2.3(ZGW-L) and high dose of 4.6(ZGW-H) g·kg-1·d-1 for three months. The bone density and bone strength were assessed using dual-energy X-ray and three-point bending tests, respectively. Furthermore, enzyme-li.ked immunosorbent assay, Hematoxyli.-eosin staining, and western blot analysis were used to determine the potential pharmacological mechanisms of action of ZGW in PMOP. RESULTS: A total of 117 active compounds of ZGW were screened from the TCMSP. Furthermore, 108 intersecting genes of drugs and diseases were identified. Using STRIng software and the MCC algorithm, ten core genes, including C-X-C chemokine li.ing 8(CXCL8), C-C chemokine receptor type 2(CCR2), alpha-2a active receptor(ADRA2A), melatonin receptor type 1B(MTNR1B), and amyloid-beta A4 protein(APP), were identified. The anti-osteoporosis regulation network of ZGW was constructed using the Cytoscape software. The animal experiments demonstrated that ZGW groups significantly reduced the serum levels of β-C-terminal telopeptide of type I collagen(β-CTX

关键词： Zuogui Wan network pharmacology osteoporosis, postmenopausal

The influence of patterned microporous layer on the proton exchange membrane fuel cell performances

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Nano Research 2024年第7期17卷 6095-6101页

作者： Shunzhong Wang Kadi Hu Wei Chen yali Cao li.an Wang Zhichang Wang li.ui Cui Mingzheng Zhou Wei Zhu Hui li.Zhongbin Zhuang State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China State Power Investment Corporation Hydrogen Energy Company Ltd.Beijing 102600China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Energy Environmental Catalysis Beijing University of Chemical TechnologyBeijing 100029China

The ordered membrane electrode assembly(MEA)has gained much attention because of its potential in improving mass ***,a comprehensive study was conducted on the influence of the patterned microporous layer(MPL)on the proton exchange membrane fuel cell *** patterned MPL is employed,grooves are generated between the catalyst layer and the gas diffusion *** is found that the grooves do not increase the contact resistance,and it is beneficial for water *** the MEA works under low humidity scenarios,the MEA with patterned MPL illustrated higher performance,due to the reduced inner resistance caused by improved water retention,leading to increased ionic ***,when the humidity is higher than 80%or working under high current density,the generated water accumulated in the grooves and hindered the oxygen mass transport,leading to a reduced MEA performance.

关键词： microporous layer patterned proton exchange membrane fuel cell mass transport humidity water reduction