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Analysis of the Immune Response by Standardized Whole‑Blood Stimulation with Metabolism Modulation

Phenomics 2024年第1期4卷 81-89页

作者： Jialin Zhao Xuling Han Helian Li yali luo Yan Fang Yun Wang Jian Gao Yiran Zhao Jingxuan Han Feng Qian State Key Laboratory of Genetic Engineering ShanghaiPublic Health Clinical CenterHuman PhenomeInstituteZhangjiang Fudan International InnovationCenter and School of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of ContemporaryAnthropology School of Life SciencesFudan UniversityShanghai 200438China Institute of Immunophenome International Human PhenomeInstitutes(Shanghai)Shanghai 200433China

The immune system defends the body from infection and plays a vital role in a wide range of health *** afects a series of physiological processes,including those linked to the function of human immune *** metabolism modulates immune cell activation and cytokine *** the relationship between metabolism and immune response has important implications for the development of immune-based ***,the deployment of large-scale functional assays to investigate the metabolic regulation of immune response has been limited by the lack of standardized ***,we present a protocol for the analysis of immune response using standardized whole-blood stimulation with metabolism *** immune stimuli including pattern recognition receptor(PRR)ligands and microbial stimuli were incubated with fresh human whole *** metabolic inhibitors were used to modulate metabolic status in the immune *** variable immune responses after metabolic interventions were *** described in detail the main steps involved in the whole-blood stimulation and cytokines quantifcation,namely,collection and treatment of whole blood,preparation of samples and controls,cytokines detection,and stimulation with metabolic *** metabolic inhibitors for anabolic pathways and catabolic pathways exert selective efects on the production of cytokines from immune *** addition to a robust and accurate assessment of immune response in cohort studies,the standardized whole-blood stimulation with metabolic regulation might provide new insights for modulating immunity.

关键词： Immune response Whole blood stimulation Cytokines Immunometabolism

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强力枇杷膏(蜜炼)治疗肺结核引发的咳嗽疗效观察

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科技与健康 2024年第16期3卷 69-72页

作者：罗雅莉六盘水市第三人民医院感染一科贵州六盘水553001

研究针对肺结核引发咳嗽的患者应用强力枇杷膏(蜜炼)治疗的临床疗效。选择六盘水市第三人民医院2022年10月—2023年10月收治的80例因肺结核引发咳嗽的患者为研究对象,使用抽签法将其分为比对组(n=40,应用化疗药物抗结核治疗联合乙酰半... 详细信息

研究针对肺结核引发咳嗽的患者应用强力枇杷膏(蜜炼)治疗的临床疗效。选择六盘水市第三人民医院2022年10月—2023年10月收治的80例因肺结核引发咳嗽的患者为研究对象,使用抽签法将其分为比对组(n=40,应用化疗药物抗结核治疗联合乙酰半胱氨酸颗粒治疗)、试验组[n=40,于化疗药物抗结核治疗基础上联合应用强力枇杷膏(蜜炼)治疗],比较两组患者的治疗效果。结果显示,治疗后,试验组治疗有效率高于比对组,入睡时间短于比对组,夜间咳嗽次数少于比对组,治疗时间、咳嗽停止时间短于比对组,咳嗽、咳痰等症状好转情况优于比对组,并发症发生率低于比对组,各项生活质量指标评分高于比对组,上述指标对比,差异均有统计学意义(P<0.05)。研究发现,临床针对肺结核引发咳嗽的患者,在化疗药物抗结核治疗基础上联合应用强力枇杷膏(蜜炼)治疗,可缓解患者咳嗽、咳痰等症状,缩短患者咳嗽停止时间,且治疗的安全性高,并发症发生率低,有利于提高患者生活质量。

关键词：强力枇杷膏(蜜炼) 肺结核咳嗽

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苏沪城市群区域出梅后期对流初生客观识别方法及其时空分布特征

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气象学报 2024年第3期82卷 275-288页

作者：曹林兮吴梦雯罗亚丽陈锋南京信息工程大学气象灾害教育部重点实验室/气象灾害预报预警与评估协同创新中心/大气科学学院/天气与气象技术研究院南京210044 浙江省气象科学研究所杭州310051 福建省灾害天气重点实验室/中国气象局海峡灾害天气重点开放实验室福州350007

研发了一套利用天气雷达观测资料对流初生(CI)客观识别算法。该算法定义“对流块”为雷达反射率因子达到35 dBz的连续强回波区域,如果某一对流块的前30 min、周边一定范围内没有任何对流块,且它维持超过20 min,则该对流块被识别为CI。... 详细信息

研发了一套利用天气雷达观测资料对流初生(CI)客观识别算法。该算法定义“对流块”为雷达反射率因子达到35 dBz的连续强回波区域,如果某一对流块的前30 min、周边一定范围内没有任何对流块,且它维持超过20 min,则该对流块被识别为CI。将这套CI客观识别算法应用于苏-沪城市群区域出梅后期(从梅雨季结束到8月底,且排除热带气旋影响)CI识别,构建了该地区2019—2022年出梅后期高时、空分辨率(10 min、1 km)CI数据库,通过个例和统计研究,分析了CI识别结果对算法中两个参数的敏感性。判断对流回波是否为首次出现,当区域半径(R)设为10 km时,对流块最小面积设为4 km^(2)(Test1)或2 km^(2)(Test2)对CI识别结果的影响不大,两个试验都能识别出CI连续发生和相邻发生的复杂情况,Test1能够识别出Test2的83%CI事件,二者识别出的CI日数、逐日CI数、CI高频区分布、CI频次日变化等统计特征基本一致;当R设为30 km、对流块最小面积为4 km^(2)(Test3)时,仅能识别出Test1的36%CI事件,其识别的CI数目不足,导致CI发生频次的空间分布和日变化的分析结果明显不同于Test1和Test2。识别结果表明,分析区域内有CI发生频次较高的3个子区域:沿长江的“上海—苏锡常—南京”城市带、从南通北部到黄海近海、分析区域西南侧的天目山系部分区域,CI频次日变化呈现午间(11—14时,北京时)主峰特征。

关键词：对流初生客观算法数据库构建时空分布

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敦煌方大补肺汤联合顺铂对Lewis肺腺癌荷瘤小鼠的干预作用及分子机制

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中国实验方剂学杂志 2024年第17期30卷 95-104页

作者：肖孟勇骆亚莉齐晓风罗晶马琳娜阮琳峰连妮妮甘肃中医药大学兰州730000 甘肃省中医药防治慢性疾病重点实验室兰州730000

目的:探讨敦煌方大补肺汤联合顺铂对Lewis肺腺癌荷瘤小鼠的干预作用及相关分子机制。方法:C57BL/6J小鼠50只,随机挑选10只作为空白组(不造模),40只皮下接种Lewis细胞,复制Lewis肺腺癌荷瘤小鼠模型,随机分为模型组(等量生理盐水)、顺铂组... 详细信息

目的:探讨敦煌方大补肺汤联合顺铂对Lewis肺腺癌荷瘤小鼠的干预作用及相关分子机制。方法:C57BL/6J小鼠50只,随机挑选10只作为空白组(不造模),40只皮下接种Lewis细胞,复制Lewis肺腺癌荷瘤小鼠模型,随机分为模型组(等量生理盐水)、顺铂组(5 mg·kg^(-1))、大补肺汤组(14.35 g·kg^(-1)·d^(-1))、大补肺汤联合顺铂组(大补肺汤14.35 g·kg^(-1)·d^(-1)+顺铂5 mg·kg^(-1)),每组10只,连续治疗14 d。观察小鼠一般状况,记录体质量变化,计算抑瘤率、脾指数、胸腺指数,血常规检测外周血白细胞(WBC)、血小板(PLT)、血红蛋白(HGB),流式细胞术检测脾脏CD4^(+)CD25^(+)FoxP3^(+)调节性T细胞(Treg)、自然杀伤(NK)细胞表达,蛋白免疫印迹法(Western blot)及实时荧光定量聚合酶链式反应(Real-time PCR)测定肿瘤组织内磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路相关蛋白及mRNA的表达。结果:与空白组比较,模型组体质量降低(P<0.05),脾指数、胸腺指数明显降低(P<0.05),脾脏中NK细胞百分比明显下降(P<0.05),Treg细胞百分比明显升高(P<0.05),WBC、PLT、HGB数量均明显下降(P<0.05);与模型组比较,大补肺汤组肿瘤生长明显抑制,体质量升高,瘤质量明显降低(P<0.05),NK细胞百分比明显升高(P<0.05),Treg细胞比例明显降低(P<0.05),WBC、PLT、HGB数量明显升高(P<0.05),顺铂组肿瘤生长明显抑制,体质量明显降低(P<0.05),瘤质量明显降低(P<0.05),胸腺指数、脾指数明显降低(P<0.05),Treg细胞百分比明显降低(P<0.05),WBC、PLT、HGB数量明显下降(P<0.05),大补肺汤联合顺铂组肿瘤生长明显抑制,瘤质量明显降低(P<0.05),各给药组肿瘤组织中PI3K、Akt、mTOR蛋白磷酸化及mRNA水平明显降低(P<0.05);与顺铂组比较,大补肺汤联合顺铂组肿瘤生长明显抑制,瘤质量明显降低(P<0.05),体质量明显升高(P<0.05),脾指数、胸腺指数明显升高(P<0.05),NK细胞明显升高(P<0.05),Treg细胞百分比明显降低(P<0.05),WBC、PLT、HGB数量明显增多(P<0.05),PI3K、Akt、mTOR磷酸化及mRNA水平明显降低(P<0.05)。结论:大补肺汤联合顺铂具有增效减毒作用,可有效调节免疫功能,增加NK细胞比例,降低Treg细胞比例,改善骨髓抑制,下调PI3K/Akt/mTOR信号通路抑制Lewis肺腺癌荷瘤小鼠的肿瘤生长。

关键词：大补肺汤顺铂 Lewis肺腺癌免疫细胞磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路

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Analysis of Paths and Sources of Moisture for the South China Rainfall during the Presummer Rainy Season of 1979–2014

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Journal of Meteorological Research 2018年第5期32卷 744-757页

作者： Yangruixue CHEN yali luo State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 University of Chinese Academy of Sciences Beijing 100049 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044

The paths and sources of moisture supplied to South China during two periods of the presummer rainy season （April-June） of 1979-2014, i.e., before and after the onset of the summer monsoon over the South China Sea （SCS）, are investigated by using the Hybrid Single-Particle Lagrangian Integrated Trajectory （HYSPLIT） model. During the premonsoon-onset period, the moisture transport trajectories are clustered into 6 groups, with four ocean-originating paths providing 83.9% and two continent-originating paths （originating over Lake Baikal and the Persian Gulf） con- tributing the remaining 16.1% of the total moisture. The two Pacific-originating paths, from the western Pacific Ocean and the East China Sea, combined account for about 46%, the SCS-originating path contributes about 24.3%, while the Bay of Bengal-originating path accounts for 13.6% of the total moisture over South China. The trajectories during the postmonsoon-onset period are clustered into 4 groups, with three southwesterly paths （from the Arabian Sea, the central Indian Ocean, and the western Indian Ocean, respectively） accounting for more than 76% and the sole Pacific-originating path accounting for 23.8% of the total moisture. The formation of the moisture transport tra-jectories is substantially affected by the topography, especially the Tibetan Plateau and the Indian and Indo-China Peninsulas. The SCS region contributes the most moisture during both periods （35.3% and 31.1%）. The Pacific Ocean is ranked second during the former period （about 21.0%） but its contribution is reduced to 5.0% during the lat-ter period, while the contribution from the Bay of Bengal and the Indian Ocean combined increases from 17.1% to 43.2%.

关键词： presummer rainy season South China the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model water vapor path moisture source

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PDCA循环管理在西药配药中的应用效果及对降低配药内部差错发生率的影响

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临床医学研究与实践 2024年第18期9卷 183-186页

作者：高鹏侠罗雅莉宝鸡市人民医院陕西宝鸡721000

目的探讨PDCA循环管理在西药配药中的应用效果及对降低配药内部差错发生率的影响。方法随机选择2020年2月至2022年2月我院开具的80张西药处方单,以非同周期法将其分为对照组和观察组,每组40张。对照组实施常规管理,观察组实施PDCA循环... 详细信息

目的探讨PDCA循环管理在西药配药中的应用效果及对降低配药内部差错发生率的影响。方法随机选择2020年2月至2022年2月我院开具的80张西药处方单,以非同周期法将其分为对照组和观察组,每组40张。对照组实施常规管理,观察组实施PDCA循环管理。管理前、后西药房共计12名工作人员。比较两组的配药差错发生情况、整体管理质量、配药用时、取药等候时间及满意度。结果观察组的配药差错总发生率低于对照组,差异具有统计学意义(P<0.05)。观察组的存放管理、制度落实、标志管理、培训评分高于对照组,差异具有统计学意义(P<0.05)。观察组的配药用时、取药等候时间短于对照组,差异具有统计学意义(P<0.05)。观察组的满意度高于对照组,差异具有统计学意义(P<0.05)。结论PDCA循环管理在西药配药中的应用效果明显,可降低配药差错发生率,缩短配药用时、取药等候时间,提升整体管理质量及患者满意度,值得临床进一步推广和应用。

关键词： PDCA循环管理西药配药配药差错管理质量工作效率

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Characteristics of Pre-summer Daytime Cloud Regimes over Coastal South China from the Himawari-8 Satellite

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Advances in Atmospheric Sciences 2022年第12期39卷 2008-2023,I0001-I0015页

作者： Mingxin LI yali luo Min MIN State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSun Yat-sen UniversityGuangzhou 519082China

Using the high spatiotemporal resolution(2 km-and-10 min)data from the Advanced Himawari Imager onboard the Himawari-8 satellite,this study documents the fine-scale characteristics of daytime cloud regimes(CRs)over coastal South China during the pre-summer rainy season(April–June).Six CRs(CR1–CR6)are identified based on the joint frequency distribution of cloud top brightness temperature and cloud optical thickness,namely,the optically thin-to-moderate cloud mixture,optically thin warm clouds with cirrus,optically thick warm clouds,weak convective cloud mixture,strong convective clouds,and extreme,deep convective *** optically thick warm clouds are the major CR during April and May,with higher frequencies over land,especially along the urban agglomeration,rather than the offshore which may be an indicator of the higher aerosol concentrations being a contributing factor over the *** CRs with weak convective cloud mixtures and strong convective clouds appear more frequently over the land,while the two CRs with optically thinner clouds occur mainly *** flow patterns(SPs)are objectively identified and examined focusing on those favoring the two major rainproducing CRs(CR5 and CR6)and the highly reflective CR with optically thick warm clouds(CR3).The two SPs favoring CR5 and CR6 are characterized by abundant moisture with low-level jets after monsoon onset,and a northwest highsoutheast low pattern with strong dynamic convergence along the coastline,*** non-convective CR3 with high reflectance is related to a SP that features the western North Pacific subtropical high extending more westward,leading to a moderate moisture supply and a wide range of convective available potential energy,but also,large convective inhibition.

关键词： cloud regime monsoon onset synoptic pattern satellite data spatiotemporal distribution

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Classification and Diurnal Variations of Precipitation Echoes Observed by a C-band Vertically-Pointing Radar in Central Tibetan Plateau during TIPEX-Ⅲ 2014-IOP

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Journal of Meteorological Research 2018年第6期32卷 985-1001页

作者： Ruoyun MA yali luo Hui WANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology Key Laboratory for Cloud Physics and Weather Modification of China Meteorological Administration Chinese Academy of Meteorological Sciences

This study investigates classification and diurnal variations of the precipitation echoes over the central Tibetan Plateau based on the observations collected from a C-band vertically-pointing frequency-modulated continuous-wave(C-FMCW)radar during the Third Tibetan Plateau Atmospheric Scientific Experiment(TIPEX-Ⅲ)2014-Intensive Observation Period(2014-IOP).The results show that 51.32%of the vertical profiles have valid echoes with reflectivity>–10 dBZ,and 35.06% of the valid echo profiles produce precipitation at the ground(precipitation profiles);stratiform precipitation with an evident bright-band signature,weak convective precipitation,and strong convective precipitation account for 52.03%,42.98%,and 4.99% of the precipitation profiles,*** 59.84% of the precipitation occurs in the afternoon to midnight,while 40.16% of the precipitation with weaker intensity is observed in the nocturnal hours and in the *** variation of occurrence frequency of precipitation shows a major peak during 2100–2200 LST(local solar time)with 59.02%being the stratiform precipitation;the secondary peak appears during 1300–1400 LST with 59.71% being the weak convective precipitation;the strong convective precipitation occurs mostly(81.83%)in the afternoon and evening with two peaks over 1200–1300 and 1700–1800 LST,*** from approximately 1100 LST,precipitation echoes develop with enhanced vertical air motion,elevated echo top,and increasing radar *** upward air motion occurs most frequently in 1700–1800 LST with a secondary peak in 1100–1400 LST,while the tops of precipitation echoes and intense upward air motion reach their highest levels during 1600–1800 *** atmospheric conditions in the early morning are disadvantageous for convective initiation and *** noon,the convective available potential energy(CAPE)increases markedly,convective inhibition(CIN)is generally small,and a super-dry-adiabatic layer is prese

关键词： TIPEX-Ⅲ vertically-pointing radar precipitation echoes diurnal variation

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Mesoscale Observational Analysis of Lifting Mechanism of a Warm-Sector Convective System Producing the Maximal Daily Precipitation in China Mainland during Pre-Summer Rainy Season of 2015

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Journal of Meteorological Research 2016年第5期30卷 719-736页

作者： WU Mengwen luo yali State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science ＆Technology Nanjing 210044

A long-lived, quasi-stationary mesoscale convective system （MCS） producing extreme ramtall （maximum of 542 mm） over the eastern coastal area of Guangdong Province on 20 May 2015 is analyzed by using high-resolution surface observations, sounding data, and radar measurements. New convective ceils are continuously initiated along a mesoscale boundary at the surface, leading to formation and maintenance of the quasi-linear-shaped MCS from about 2000 BT 19 to 1200 BT 20 May. The boundary is originally formed between a cold dome generated by previous convection and southwesterly flow from the ocean carrying higher equivalent potential temperature （θe） air. The boundary is subsequently maintained and reinforced by the contrast between the MCS-generated cold outflow and the oceanic higher-θe air. The cold outflow is weak （wind speed ≤ 5 m s-1）, which is attributable to the characteristic environmental conditions, i.e., high humidity in the lower troposphere and weak horizontal winds in the middle and lower troposphere. The low speed of the cold outflow is comparable to that of the near surface southerly flow from the ocean, resulting in very slow southward movement of the boundary. The boundary features temperature contrasts of 2-3℃ and is roughly 500-m deep. Despite its shallowness, the boundary appears to exert a profound influence on continuous convection initiation because of the very low level of free convection and small convection inhibition of the near surface oceanic air, building several parallel rainbands （of about 50-kin length） that move slowly eastward along the MCS and produce about 80% of the total rainfall. Another MCS moves into the area from the northwest and merges with the local MCS at about 1200 BT. The cold outflow subsequently strengthens and the boundary moves more rapidly toward the southeast, leading to end of the event in 3 h.

关键词： pre-summer rainy season of South China coastal warm-sector heavy rainfall mesoscale con- vective system mesoscale boundary convection-generated cold outflow

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深圳市宝安区乙肝联合免疫时间与乙肝母婴阻断效果

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中国艾滋病性病 2024年第8期30卷 856-860页

作者：罗雅丽王利玲吕鼎言陈佳虹王维深圳市宝安区妇幼保健院广东深圳518100 深圳市宝安区中心医院广东深圳518100

目的分析2017-2021年深圳市宝安区乙肝暴露儿童接种首剂乙肝疫苗(HepB1)和注射乙肝免疫球蛋白(HBIG)的执行情况,并探讨联合免疫执行时间对乙肝母婴传播阻断效果的影响。方法收集2017-2021年在宝安区18家助产医院分娩的HBV感染产妇及其... 详细信息

目的分析2017-2021年深圳市宝安区乙肝暴露儿童接种首剂乙肝疫苗(HepB1)和注射乙肝免疫球蛋白(HBIG)的执行情况,并探讨联合免疫执行时间对乙肝母婴传播阻断效果的影响。方法收集2017-2021年在宝安区18家助产医院分娩的HBV感染产妇及其所生儿童信息,获取乙肝暴露儿童免疫后血清学检测结果,进行统计学分析。结果共7396对HBsAg阳性产妇-乙肝暴露儿童纳入研究,HepB1及时接种率由2017年的77.74%上升至2021年的99.69%;HBIG及时注射率由2017年的76.62%上升至2021年的98.77%。乙肝母婴传播率为0.31%,免疫成功率为98.42%。在0~<6 h执行联合免疫的情况下,相较于参照组(≥12 h),乙肝母婴传播的(OR=0.11,95%CI:0.02~0.53)。此外产妇HBeAg阳性也是发生母婴传播的危险因素(OR=28.50,95%CI:6.55~123.97)。结论及早执行联合免疫是预防母婴传播的保护因素,对于HBV DNA检测和抗病毒治疗条件不成熟的地区,可考虑对乙肝暴露儿童进行极早期联合免疫(出生后6 h内),以进一步降低乙肝母婴传播风险。

关键词：乙型肝炎病毒乙肝疫苗乙肝免疫球蛋白联合免疫母婴传播

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