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Molecular compositions and sources of organic aerosols at a rural site on the Guanzhong Plain,Northwest China:The importance of biomass burning

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Particuology 2024年第6期89卷 44-56页

作者： yali liu Minxia Shen Haijiao liu Wenting Dai Weining Qi Yifan Zhang Lu Li Yue Cao Xin Wang Xiao Guo Yingkun Jiang Jianjun Li State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National Observation and Research Station of Regional Ecological Environment Change and Comprehensive Management in the Guanzhong Plain ShaanxiChina

The concentration of PM_(2.5)has considerably reduced in recent years,but remains relatively high in *** particular,the increasing contribution of organic compounds to PM_(2.5)generates popular pressure for further reductions,resulting in an urgent need to study organic aerosol(OA).To investigate the molecular composition and source contribution of OA in the rural area of the Guanzhong Plain,Northwest China,PM_(2.5)samples were collected during 3–23 August 2016 and 5–20 January 2017 and studied for more than 100 organic tracer *** mean concentration of total measured organic compounds is 662±296 ng/m^(3)in summer and 3258±1925 ng/m^(3)in *** is the most abundant single compound found throughout the sampling period,which is a crucial tracer for biomass burning emissions,preliminary suggesting that biomass burning is an essential source of *** summer,organic compounds such as lipid compounds,sugar compounds,and polycyclic aromatic hydrocarbons(PAHs),more come from higher plants,wood burning,vehicle exhausts,plastic waste,and other direct emission *** PAHs(OPAHs),nitrophenols,and phthalic acids more come from the atmosphere through the oxidation reaction of aromatic precursors,especially photochemical ***,in winter,most of the increases in concentrations of organic compounds are attributed to biomass *** analysis of a haze event(14–19 January 2017)during the winter sampling period shows that the increases in the concentration of organic compounds are unaccompanied by strong secondary formation under lower relative humidity(49.1%±13.5%).The main reason for the growth of OA in this haze event is the accumulation of primary OA(POA).The source apportionment by the positive matrix factorization(PMF)model shows that biomass burning(37.1%)is the primary source of OA in the rural regions of the Guanzhong Plain,especially in winter(40.6%).The contribution of secondary formation decreases from 26.0%in summer t

关键词： Organic aerosol Molecular composition Seasonal variation Source apportionment Guanzhong Plain

Slc43a2^(+)T cell metastasis from spleen to brain in RGNNV infected teleost

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Science China(Life Sciences) 2024年第4期67卷 733-744页

作者： Qing Wang yali liu Minlin Zhang Min Yang Jiantao Liang Xiaoling Zuo Shaowen Wang Xianze Jia Huihong Zhao Han Jiang Qiang Lin Qiwei Qin College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Nansha-South China Agricultural University Fishery Research Institute Guangzhou 511457China Joint University Laboratory of Guangdong Province Hong Kong and Marco Region on Marine Bioresource Conservation and ExploitationGuangzhou 510642China University of Chinese Academy of Sciences Beijing 100101China

The origin of T cells in the teleost's brain is *** viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral ***,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing *** viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2^(+)T cells synchronously increased in the spleen and *** the infection tests in asplenic zebrafish(tlx1^▲zebrafish model),no increase in the number of slc43a2^(+)T cells was observed in the ***-cell transcriptomic analysis indicated that slc43a2^(+)T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune *** study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

关键词： central nervous system slc43a2^(+)T cell RGNNV T cell migration teleost

Exploring the multicomponent synergy mechanism of Zuogui Wan(左归丸) on postmenopausal osteoporosis by a systems pharmacology strategy

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Journal of Traditional Chinese Medicine 2024年第3期44卷 489-495页

作者： FENG Yanchen liu yali DANG Xue LIN Zixuan ZHANG Yunke CHE Zhiying LI Xiang PAN Xiaolong liu Feixiang ZHENG Pan Traditional Chinese Medicine(Zhong Jing)School Henan University of Chinese MedicineZhengzhou 450046China Hospital of Encephalopathy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineResearch Units of Infectious Disease and MicroecologyChinese Academy of Medical SciencesHangzhou 31000China

OBJECTIVE: To explore the multi-component synergistic mechanism of Zuogui Wan(左归丸, ZGW) in treating postmenopausal osteoporosis(PMOP). METHODS: The main components and target genes of ZGW were screened via the Traditional Chinese Medicine Systems Pharmacology(TCMSP). In addition, the target gene sets of PMOP were derived from the Gene Cards and Online Mendelian Inheritance in Man databases. The search tool for recurring instances of neighbouring genes(STRING) 11.0 software was used to analyze the interaction among intersecting genes. Cytoscape 3.6.1 software and the Matthews correlation coefficient(MCC) algorithm were used to screen the core genes. Fifty Sprague-Dawley female rats were randomly divided into the sham-operated(Sham) group and the four ovariectomized(OVX) subgroups. Rats subjected to Sham or OVX were administered with the vehicle(OVX, 1 m L water/100 g weight), 17β-estradiol(E2, 50 μg·kg-1·d-1), and lyophilized powder of ZGW at a low dose of 2.3(ZGW-L) and high dose of 4.6(ZGW-H) g·kg-1·d-1 for three months. The bone density and bone strength were assessed using dual-energy X-ray and three-point bending tests, respectively. Furthermore, enzyme-linked immunosorbent assay, Hematoxylin-eosin staining, and western blot analysis were used to determine the potential pharmacological mechanisms of action of ZGW in PMOP. RESULTS: A total of 117 active compounds of ZGW were screened from the TCMSP. Furthermore, 108 intersecting genes of drugs and diseases were identified. Using STRING software and the MCC algorithm, ten core genes, including C-X-C chemokine living 8(CXCL8), C-C chemokine receptor type 2(CCR2), alpha-2a active receptor(ADRA2A), melatonin receptor type 1B(MTNR1B), and amyloid-beta A4 protein(APP), were identified. The anti-osteoporosis regulation network of ZGW was constructed using the Cytoscape software. The animal experiments demonstrated that ZGW groups significantly reduced the serum levels of β-C-terminal telopeptide of type I collagen(β-CTX

关键词： osteoporosis postmenopausal network pharmacology Zuogui Wan

Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

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The Innovation 2024年第2期5卷 42-50页

作者： yali liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Pan Gu Yanbin Hao Kai Xue Hongbo Duan Anquan Xia Yi Hu Zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and Entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for Environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2)it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

ChatGPT-AIGC用户风险感知维度识别与治理研究——基于扎根理论的探索性分析

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情报理论与实践 2024年第3期47卷 121-129页

作者：刘亚丽范逢春四川大学公共管理学院四川成都610065

[目的/意义]识别ChatGPT-AIGC用户风险感知维度属性,为数字智能时代有效实现风险治理、推动新一代人工智能技术健康可持续发展提供价值参考。[方法/过程]结合已有风险感知维度研究成果,通过面对面访谈和线上访谈收集数据,借鉴扎根理论... 详细信息

[目的/意义]识别ChatGPT-AIGC用户风险感知维度属性,为数字智能时代有效实现风险治理、推动新一代人工智能技术健康可持续发展提供价值参考。[方法/过程]结合已有风险感知维度研究成果,通过面对面访谈和线上访谈收集数据,借鉴扎根理论研究思路对访谈文本进行三级编码,构建ChatGPT-AIGC用户风险感知影响机理APCO模型。[结果/结论]结果发现个人风险感知能力影响用户产生不同的风险感知维度,而用户风险感知维度属性又进一步对使用意愿产生影响。基于此,从技术研发、信息监管、法律监督三方面提出风险治理策略。

关键词：扎根理论 ChatGPT 人工智能生成内容风险感知治理策略

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青年群体阅读焦虑影响因素及消解策略研究

图书馆学研究 2024年第3期 22-34页

作者：刘亚丽范逢春四川大学公共管理学院

分析青年群体阅读焦虑现象产生的原因并提出应对策略,对塑造全民阅读健康生态具有重要意义。借鉴扎根理论研究思路提取、确定青年群体阅读焦虑影响因素,利用ISM和MICMAC探索、揭示各个因素之间的层级关系和影响程度。根据计算结果发现,M... 详细信息

分析青年群体阅读焦虑现象产生的原因并提出应对策略,对塑造全民阅读健康生态具有重要意义。借鉴扎根理论研究思路提取、确定青年群体阅读焦虑影响因素,利用ISM和MICMAC探索、揭示各个因素之间的层级关系和影响程度。根据计算结果发现,MICMAC中的依赖群因素与ISM中直接层因素相同,独立群因素与ISM中根源层大部分因素相同,自发群因素与ISM中间层因素相同,表明ISM与MICMAC计算结果存在内部交互性和关联性。最后从政府引导、媒介融合、个体需求以及内容优化等方面提出消解策略,以期为全民阅读质量的提升提供价值参考。

关键词：阅读焦虑扎根理论影响因素 ISM-MICMAC 消解策略

基于卷积神经网络的肌电信号人体运动模式识别技术

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兵工学报 2024年第7期45卷 2144-2158页

作者：刘亚丽鲁妍池马勋举宋遒志北京理工大学机电学院北京100081 北京理工大学前沿技术研究院外骨骼技术研发中心山东济南250300

随着外骨骼机器人等肌电控制设备的快速发展,表面肌电信号此类非平稳、非周期信号在高性能运动识别系统中的应用已成为相关研究领域的重点。为实现肌电信号跨域特征融合,提出一种基于肌电信号的双卷积链神经网络模型,采集7块关键肌肉的... 详细信息

随着外骨骼机器人等肌电控制设备的快速发展,表面肌电信号此类非平稳、非周期信号在高性能运动识别系统中的应用已成为相关研究领域的重点。为实现肌电信号跨域特征融合,提出一种基于肌电信号的双卷积链神经网络模型,采集7块关键肌肉的原始肌电信号,经特征提取,转化为能量核相图和离散小波变换系数特征图,分别输入双卷积链神经网络的卷积神经网络分支和MobileNetV2分支,利用融合模块提取高层隐藏特征并进行充分交互。制备包括以上两种特征图像和传统肌电信号图谱在内的3种数据集。3组交叉实验结果表明:所提方法对6种自测下肢运动的平均识别准确率达94.19%,显著优于其他特征组合与网络架构;在ENABL3S开源数据集识别7种下肢运动中取得98.32%的稳态识别准确率,进一步验证了所提方法优良的肌电特征捕捉能力和模式识别准确性。

关键词：外骨骼机器人表面肌电信号运动模式识别双卷积链神经网络能量核小波变换分析

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外骨骼机器人助力效能测试方法及应用综述

兵工学报 2024年第8期45卷 2497-2519页

作者：刘亚丽鲁妍池徐小龙宋遒志北京理工大学机电学院北京100081 北京理工大学前沿技术研究院外骨骼技术研发中心山东济南250300

外骨骼机器人在军事、医疗及工业等领域展现出广阔的应用前景,迫切需要一套科学的外骨骼助力效能测试评估体系,以实现对外骨骼研发、产品迭代及实际使用的指导与规范。为全面把握现有性能测试方法,进行CiteSpace可视化科学知识图谱分析... 详细信息

外骨骼机器人在军事、医疗及工业等领域展现出广阔的应用前景,迫切需要一套科学的外骨骼助力效能测试评估体系,以实现对外骨骼研发、产品迭代及实际使用的指导与规范。为全面把握现有性能测试方法,进行CiteSpace可视化科学知识图谱分析与数据统计,围绕代谢成本评估、生物电信号评估、运动学与动力学参数评估、工况表现评估和综合评价模型5类常见评估方法进行综述,总结其关键指标与技术局限,并从评估理论深入与测试方法、候选评估集合建立方法、综合评价模型结构设计与指标赋权方法、多场景测试方法4个方面,对外骨骼效能评估技术的未来发展提出展望,对完善外骨骼评估体系、实现技术横向比较具有实际意义。

关键词：外骨骼机器人助力效能测试代谢成本生物电信号人体生物力学综合评价模型

一种改进YOLOv5的CT图像肺结节检测方法

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计算机科学 2024年第S01期51卷 575-580页

作者：邬春明刘亚丽东北电力大学电气工程学院吉林吉林132000

针对YOLOv5算法对CT图像中的肺结节检测效果较差的问题,提出基于改进YOLOv5的肺结节检测方法。将YOLOv5网络中Neck部分的特征金字塔改进为加权双向特征金字塔网络;在YOLOv5网络中的Backbone部分加入高效通道注意力机制与坐标注意力机制... 详细信息

针对YOLOv5算法对CT图像中的肺结节检测效果较差的问题,提出基于改进YOLOv5的肺结节检测方法。将YOLOv5网络中Neck部分的特征金字塔改进为加权双向特征金字塔网络;在YOLOv5网络中的Backbone部分加入高效通道注意力机制与坐标注意力机制。在LIDC-IDRI数据集上进行实验,结果表明,检测的平均精度可达80.2%,召回率可达90.75%,因此该方法能够有效检测肺结节。相较于YOLOv5算法,改进后的算法在mAP上提高了7.7%,在召回率上提高了5.5%。

关键词：肺结节检测深度学习特征金字塔注意力机制