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Global trends in diabetic eye disease research from 2012 to 2021

Neural Regeneration Research 2024年第10期19卷 2310-2320页

作者： Yuan Yuan Shangli Ji yali song Zhaodi Che Lu Xiao Shibo Tang Jia Xiao Aier School of Ophthalmology Central South UniversityChangshaHunan ProvinceChina Changsha Aier Eye Hospital ChangshaHunan ProvinceChina Aier Eye Institute ChangshaHunan ProvinceChina Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina

Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.

关键词： clinical trials diabetic cataracts diabetic eye disease diabetic glaucoma diabetic macular edema diabetic retinopathy drug development global research publication research grant

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Emerging mechanisms of ferroptosis and its implications in lung cancer

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中华医学杂志(英文版) 2024年第7期137卷 818-829页

作者： Li Qian song Qibin Pei Huadong Chen yali USA State Key Laboratory of Medical Proteomics National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing 102206 Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology Georgetown Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington D.C. 20057

Lung cancer is one of the most common malignancies and has the highest number of deaths among all cancers. Despite continuous advances in medical strategies, the overall survival of lung cancer patients is still low, probably due to disease progression or drug resistance. Ferroptosis is an iron-dependent form of regulated cell death triggered by the lethal accumulation of lipid peroxides, and its dysregulation is implicated in cancer development. Preclinical evidence has shown that targeting the ferroptosis pathway could be a potential strategy for improving lung cancer treatment outcomes. In this review, we summarize the underlying mechanisms and regulatory networks of ferroptosis in lung cancer and highlight ferroptosis-targeting preclinical attempts to provide new insights for lung cancer treatment.

关键词： Lung cancer Ferroptosis Ferroptosis regulators Ferroptosis inducers Cancer treatment

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Interdecadal changes in the western Siberian summer mean and extreme rainfall during 1982-2021

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 37-41页

作者： yali Zhu Fangwu song Dong Guo Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjingChina Carbon Neutrality Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

本文研究发现,西西伯利亚夏季降水在1995年后显著增加,2012年后又有所减少,极端降水日数和强度呈现一致的变化特征.伴随这两次降水的年代际增加/减少,西西伯利亚上空出现异常气旋/反气旋和水汽幅合/幅散.极端降水发生时的区域环流特征... 详细信息

本文研究发现,西西伯利亚夏季降水在1995年后显著增加,2012年后又有所减少,极端降水日数和强度呈现一致的变化特征.伴随这两次降水的年代际增加/减少,西西伯利亚上空出现异常气旋/反气旋和水汽幅合/幅散.极端降水发生时的区域环流特征在三个时段基本一致:西西伯利亚低空出现气旋性异常,高空为西北-东南向的异常气旋-反气旋偶极子型.1995-2011年期间,极端降水日数更多,强度更强,上述异常环流型也更强.

关键词：西伯利亚夏季降水年代际变化乌拉尔高压北大西洋波流相互作用

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双网互嵌:基层社会矛盾纠纷协同治理的逻辑理路和实践进路——以T市矛盾纠纷多元化解模式为例

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天津行政学院学报 2024年第2期26卷 65-74页

作者：郝雅立宋沂霏天津商业大学天津300134

基层社会矛盾纠纷的协同化解需要行政调解网络与社会调解网络的要素协作与功能耦合,双维网络的互嵌逻辑为破解矛盾纠纷调解障碍、实现协同治理增量提供新路径。矛盾纠纷协同治理的生成理路包括三大核心节点:重组协同治理理论要件,追踪... 详细信息

基层社会矛盾纠纷的协同化解需要行政调解网络与社会调解网络的要素协作与功能耦合,双维网络的互嵌逻辑为破解矛盾纠纷调解障碍、实现协同治理增量提供新路径。矛盾纠纷协同治理的生成理路包括三大核心节点:重组协同治理理论要件,追踪挖掘矛盾纠纷化解多元模式的实践行动与运行机制,以及形成社会矛盾纠纷协同治理共同体。协同调解网络的互嵌融合有赖于共识塑造、制度设计、能力建构、条块结合等治理要素的共同作用,矛盾纠纷的多元调解机制及运行模式推动治理方式优化、网络关系重塑与多维空间缔结,激活并优化了全方位多层次的协同调解体系。互嵌化的思维和行动方式为重建协同秩序、畅通多元化纠纷解决模式与协同治理的融合通道提供了新的实践进路。

关键词：矛盾纠纷行政调解网络社会调解网络双网互嵌矛调中心

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Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation

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Acta Pharmaceutica Sinica B 2023年第1期13卷 100-112页

作者： Zhaodi Che yali song Chengfang Xu Wei Li Zhiyong Dong Cunchuan Wang Yixing Ren Kwok-Fai So George L.Tipoe Fei Wang Jia Xiao Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China Department of Obstetrics the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Faculty of Pharmaceutical Sciences Toho UniversityChiba 2748510Japan Department of General Surgery and Institute of Hepato-Biliary-Pancreas and Intestinal DiseaseAffiliated Hospital of North Sichuan Medical CollegeNanchong 637000China GMH Institute of CNS Regeneration Guangdong Medical Key Laboratory of Brain Function and DiseasesJinan UniversityGuangzhou 510632China School of Biomedical Sciences LKS Faculty of Medicinethe University of Hong KongHong KongChina Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China

Chronic alcohol consumption causes liver steatosis,cell death,and inflammation.Melatonin(MLT)is reported to alleviate alcoholic liver disease(ALD)-induced injury.However,its direct regulating targets in hepatocytes are not fully understood.In the current study,a cell-based screening model and a chronic ethanol-fed mice ALD model were used to test the protective mechanisms of MLT.MLT ameliorated ethanol-induced hepatocyte injury in both cell and animal models(optimal doses of 10μmol/L and 5 mg/kg,respectively),including lowered liver steatosis,cell death,and inflammation.RNA-seq analysis and loss-of-function studies in AML-12 cells revealed that telomerase reverse transcriptase(TERT)was a key downstream effector of MLT.Biophysical assay found that epidermal growth factor receptor(EGFR)on the hepatocyte surface was a direct binding and regulating target of MLT.Liver specific knock-down of Tert or Egfr in the ALD mice model impaired MLT-mediated liver protection,partly through the regulation of nuclear brahma-related gene-1(BRG1).Long-term administration(90 days)of MLT in healthy mice did not cause evident adverse effect.In conclusion,MLT is an efficacious and safe agent for ALD alleviation.Its direct regulating target in hepatocytes is EGFR and downstream BRG1-TERT axis.MLT might be used as a complimentary agent for alcoholics.

关键词： Alcoholic liver disease Melatonin Binding receptor TERT EGFR BRG1 Biophysics Safety

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Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

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Protein & Cell 2024年第2期15卷 121-134页

作者： Hui Sun Tingting Deng yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Vaccines for Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China Xiang An Biomedicine Laboratory Xiamen 361102China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSchool of MedicineSouthem University of Science and TechnologyShenzhen 518112China The Second Affliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.

关键词： SARS-CoV-2 broad neutralizing antibody rearrangement synergistic neutralization

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基于卷积神经网络的肌电信号人体运动模式识别技术

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兵工学报 2024年第7期45卷 2144-2158页

作者：刘亚丽鲁妍池马勋举宋遒志北京理工大学机电学院北京100081 北京理工大学前沿技术研究院外骨骼技术研发中心山东济南250300

随着外骨骼机器人等肌电控制设备的快速发展,表面肌电信号此类非平稳、非周期信号在高性能运动识别系统中的应用已成为相关研究领域的重点。为实现肌电信号跨域特征融合,提出一种基于肌电信号的双卷积链神经网络模型,采集7块关键肌肉的... 详细信息

随着外骨骼机器人等肌电控制设备的快速发展,表面肌电信号此类非平稳、非周期信号在高性能运动识别系统中的应用已成为相关研究领域的重点。为实现肌电信号跨域特征融合,提出一种基于肌电信号的双卷积链神经网络模型,采集7块关键肌肉的原始肌电信号,经特征提取,转化为能量核相图和离散小波变换系数特征图,分别输入双卷积链神经网络的卷积神经网络分支和MobileNetV2分支,利用融合模块提取高层隐藏特征并进行充分交互。制备包括以上两种特征图像和传统肌电信号图谱在内的3种数据集。3组交叉实验结果表明:所提方法对6种自测下肢运动的平均识别准确率达94.19%,显著优于其他特征组合与网络架构;在ENABL3S开源数据集识别7种下肢运动中取得98.32%的稳态识别准确率,进一步验证了所提方法优良的肌电特征捕捉能力和模式识别准确性。

关键词：外骨骼机器人表面肌电信号运动模式识别双卷积链神经网络能量核小波变换分析

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A GAN-based deep enhancer for quality enhancement of retinal images photographed by a handheld fundus camera

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 38-46页

作者： Junxia Fu Lvchen Cao Shihui Wei Ming Xub yali song Huiqi Li Yuxia You Beijing Aier Intech Eye Hospital BeijingChina Aier Eye Hospital Group HunanChina Department of Ophthalmology The Chinese People's Liberation Army General HospitalBeijingChina School of Artificial Intelligence Henan UniversityZhengzhouChina School of Information and Electronics Beijing Institute of TechnologyBeijingChina

Objective:Due to limited imaging conditions,the quality of fundus images is often unsatisfactory,especially for images photographed by handheld fundus cameras.Here,we have developed an automated method based on combining two mirror-symmetric generative adversarial networks(GANs)for image enhancement.Methods:A total of 1047 retinal images were included.The raw images were enhanced by a GAN-based deep enhancer and another methods based on luminosity and contrast adjustment.All raw images and enhanced images were anonymously assessed and classified into 6 levels of quality classification by three experienced ophthalmologists.The quality classification and quality change of images were compared.In addition,imagedetailed reading results for the number of dubiously pathological fundi were also compared.Results:After GAN enhancement,42.9% of images increased their quality,37.5%remained stable,and 19.6%decreased.After excluding the images at the highest level(level 0)before enhancement,a large number(75.6%)of images showed an increase in quality classification,and only a minority(9.3%)showed a decrease.The GANenhanced method was superior for quality improvement over a luminosity and contrast adjustment method(P<0.001).In terms of image reading results,the consistency rate fluctuated from 86.6%to 95.6%,and for the specific disease subtypes,both discrepancy number and discrepancy rate were less than 15 and 15%,for two ophthalmologists.Conclusions:Learning the style of high-quality retinal images based on the proposed deep enhancer may be an effective way to improve the quality of retinal images photographed by handheld fundus cameras.

关键词： Generative adversarial networks(GANs) Retinal image Quality Handheld fundus cameras

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高黎贡山北段土壤中虫生真菌物种多样性及垂直分布特征

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云南农业大学学报（自然科学版） 2024年第2期39卷 1-9页

作者：张翼飞徐玲陈凯杨连涛宋娅丽陈自宏保山学院高黎贡山研究院云南保山678000 西南林业大学生态与环境学院云南昆明650224

【目的】探讨高黎贡山北段虫生真菌的物种多样性及其在不同海拔的分布特征,为该区域虫生真菌资源的保护和利用奠定基础。【方法】在高黎贡山北段沿海拔梯度(1900~4300 m)采集土壤样品,分离虫生真菌菌株,根据菌株的形态特征和多基因系统... 详细信息

【目的】探讨高黎贡山北段虫生真菌的物种多样性及其在不同海拔的分布特征,为该区域虫生真菌资源的保护和利用奠定基础。【方法】在高黎贡山北段沿海拔梯度(1900~4300 m)采集土壤样品,分离虫生真菌菌株,根据菌株的形态特征和多基因系统发育分析进行物种鉴定;将样区划分为5个海拔梯度带(Ⅰ~Ⅴ),对虫生真菌的物种多样性及垂直分布特征进行分析。【结果】在高黎贡山北段土壤中共获得1135株虫生真菌,分属于4科7属19种;优势属为绿僵菌属(Metarhizium,8种816株)、白僵菌属(Beauveria,4种214株),优势种依次为棕色绿僵菌(M.brunneum)、球孢白僵菌(B.bassiana)和蝙蝠蛾鳞翅虫草(Samsoniella hepiali)。所有海拔梯度土壤中都有虫生真菌分布,随着海拔升高,虫生真菌的物种丰富度和菌株数量均呈下降趋势,但多样性指数呈增加趋势。中海拔梯度带(I)的虫生真菌物种丰富度(13种)和菌株数(265株)最高;最高海拔梯度带(Ⅴ)的物种丰富度(9种)和菌株数(139株)最低,Simpson多样性指数(0.576)、Shannon-Wiener多样性指数(1.272)和Pielou’s均匀度指数(0.579)最高,优势度(0.424)最低。【结论】高黎贡山北段土壤中虫生真菌资源丰富,广泛分布于所有海拔梯度中,中海拔区域的物种和菌株数量较多,高海拔区域的多样性指数较高。

关键词：虫生真菌高黎贡山北段海拔物种多样性垂直分布

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生态塘-潜表流复合人工湿地对抚仙湖入湖河流水质净化效应及途径

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环境科学研究 2024年第3期37卷 572-585页

作者：苏孟白王克勤宋娅丽胡淳王帅兵赵昌彬西南林业大学生态与环境学院云南昆明650224 云南经贸外事职业学院云南昆明650224 玉溪师范学院云南玉溪653100 云阳县国有四十八槽林场重庆云阳404500

为探明人工湿地在流域面源污染治理和高原湖泊及临湖流域水生态环境保护中的效用,本研究以尖山河流域生态塘-潜表流复合人工湿地11级功能区和4种植物为研究对象,通过测定2021年雨季6场典型降雨后各功能区污染物负荷、一个刈割周期内植... 详细信息

为探明人工湿地在流域面源污染治理和高原湖泊及临湖流域水生态环境保护中的效用,本研究以尖山河流域生态塘-潜表流复合人工湿地11级功能区和4种植物为研究对象,通过测定2021年雨季6场典型降雨后各功能区污染物负荷、一个刈割周期内植物各器官及其对应土壤的氮磷含量,分析其氮磷积累量、富集系数和迁移系数的变化特点,深入探讨系统对不同面源污染物的去除效应及途径.结果表明:①生物沉砂塘对悬移质的沉积率范围为27.75%~55.00%,且逐级递减,系统对面源污染物的去除率在44.40%~78.87%之间,末端分区效果更为显著.②植物根区土壤作用(贡献率为59%~74%)是人工湿地氮去除的主要途径,植物吸收转化(贡献率为32%~42%)是磷去除的主要途径,在高污染负荷输入条件下悬移质削减率及污染物净化效应更优.③人工湿地植物营养元素的富集和株内迁移能力具有阶段性,氮、磷元素富集系数(分别为2.29~3.53、1.07~2.92)均大于1且向上迁移活跃,有利于修复环境污染.④单位面积氮磷去除速率均表现为表流湿地>潜流带状湿地,最优植物配置分别为再力花+旱伞草和香蒲+旱伞草.研究显示,合理调配土壤与植物比例及组合,高效利用不同植物配置路线对元素的敏感差异性,对入湿水体进行预处理和采用多功能、多塘系结合的人工湿地设计可稳定发挥水质净化效用.

关键词：人工湿地生态塘-潜表流串联模式水质净化面源污染抚仙湖

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