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The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 222-223页

作者： XING Yunqi li Junxiang YUAN yali MAO Tangyou Gastroenterology Department Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China Department of Hepatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

To the Editors:We read with great interest the study recently published by Sun et al 1 entitled“Electroacupuncture at Tianshu(ST25)and Zusanli(ST36)alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor”in which the microbial details of electroacupuncture(EA)-induced protection in irritable bowel syndrome(IBS)were investigated.

关键词： releasing treatment details

Asymmetric Deep Hashing for Person Re-Identifications

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Tsinghua Science and Technology 2022年第2期27卷 396-411页

作者： yali Zhao yali li Shengjin Wang Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

The person re-identification(re-ID)community has witnessed an explosion in the scale of data that it has to handle.On one hand,it is important for large-scale re-ID to provide constant or sublinear search time and dramatically reduce the storage cost for data points from the viewpoint of efficiency.On the other hand,the semantic affinity existing in the original space should be preserved because it greatly boosts the accuracy of re-ID.To this end,we use the deep hashing method,which utilizes the pairwise similarity and classification label to learn deep hash mapping functions,in order to provide discriminative representations.More importantly,considering the great advantage of asymmetric hashing over the existing symmetric one,we finally propose an asymmetric deep hashing(ADH)method for large-scale re-ID.Specifically,a two-stream asymmetric convolutional neural network is constructed to learn the similarity between image pairs.Another asymmetric pairwise loss is formulated to capture the similarity between the binary hashing codes and real-value representations derived from the deep hash mapping functions,so as to constrain the binary hash codes in the Hamming space to preserve the semantic structure existing in the original space.Then,the image labels are further explored to have a direct impact on the hash function learning through a classification loss.Furthermore,an efficient alternating algorithm is elaborately designed to jointly optimize the asymmetric deep hash functions and high-quality binary codes,by optimizing one parameter with the other parameters fixed.Experiments on the four benchmarks,i.e.,DukeMTMC-reID,Market-1501,Market-1501+500 k,and CUHK03 substantiate the competitive accuracy and superior efficiency of the proposed ADH over the compared state-of-the-art methods for large-scale re-ID.

关键词： person re-identification deep hashing asymmetric hashing large-scale

Identification and global characterization of eccDNA reveals hallmarks in iron nanoparticles-treated breast cancer cells

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Genes & Diseases 2024年第2期11卷 532-534页

作者： Wenxiang Lu Ying Wang Tao Luo Fuyu li yali Jiang Jinke Wang Weizhong Zhang Yunfei Bai State Key Lab of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China The Friendship Hospital of Ili Kazakh Autonomous Prefecture Ili & Jiangsu Joint Institute of HealthYiningXinjiang 835000China Department of Ophthalmology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

The biogenesis and functions of extrachromosomal circular DNA(eccDNA)have been studied for several decades.However,the heterogeneity of eccDNA is largely ignored.In this study,we purified and sequenced eccDNA and RNA using a method that simultaneously extracts DNA and RNA from cultured cells treated with iron nanoparticles.We discovered that the characteristics of eccDNA are altered by iron stress,particularly on genic and CpG islands regions,suggesting a biogenesis mechanism induced by transcription.

关键词： breast nanoparticles characterization

Facile synthesis of NiMn2S4 nanoflakes on nickel foam for high-performance aqueous asymmetric supercapacitors

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Science China(Technological Sciences) 2024年第2期67卷 499-508页

作者： ADIL Emin li yali GAO Zhe DONG YunXia li DongHao CHEN YongChao FU YuJun HE DeYan li JunShuai LONGi Institute of Future Technology and School of Materials&EnergyLanzhou UniversityLanzhou 730000China

Supercapacitors display promising electrochemical performance with high power density and excellent cycle stability.However,their low energy density limits their advancement in a broader range of applications.To enhance their energy density,we proposed self-assembled spinel NiMn2S4nanoflakes grown on nickel foam which we successfully prepared by a facile hydrothermal method.The NiMn2S4electrode delivers a high capacitance of 2096.7 F g^(-1)at 1.0 A g^(-1),with an exceptional rate capability(~720.6 F g^(-1)at a very high current density of 100 A g^(-1))and good cycle stability(~85.1%retention of the initial capacitance after 7000 cycles with the Coulombic efficiency around 100%).The as-fabricated asymmetric supercapacitors based on NiMn2S4nanoflakes//active carbon demonstrate an energy density of 73.6 W h kg^(-1)at 800.5 W kg^(-1)and adequate cycling performance of~84.6%capacitance retention at 15 A g^(-1)after 10000 cycles.The results reveal that the nanostructured NiMn2S4is an excellent electrode material for high-performance energy storage applications.

关键词： NiMn2S4 nanostructure high capacitance aqueous supercapacitors long cycle stability high energy density

Preliminary report of coseismic surface rupture(part)of Türkiye's M_(W)7.8 earthquake by remote sensing interpretation

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Earthquake Research Advances 2024年第1期4卷 4-13页

作者： yali Guo Haofeng li Peng liang Renwei Xiong Chaozhong Hu Yueren Xu Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing100036China

Both M_(W) 7.8 and M_(W) 7.5 earthquakes occurred in southeastern Türkiye on February 6,2023,resulting in numerous buildings collapsing and serious casualties.Understanding the distribution of coseismic surface ruptures and secondary disasters surrounding the epicentral area is important for post-earthquake emergency and disaster assessments.High-resolution Maxar and GF-2 satellite data were used after the events to extract the location of the rupture surrounding the first epicentral area.The results show that the length of the interpreted surface rupture zone(part of)is approximately 75 km,with a coseismic sinistral dislocation of 2-3 m near the epicenter;however,this reduced to zero at the tip of the southwest section of the East Anatolia Fault Zone.Moreover,dense soil liquefaction pits were triggered along the rupture trace.These events are in the western region of the Eurasian Seismic Belt and result from the subduction and collision of the Arabian and African Plates toward the Eurasian Plate.The western region of the Chinese mainland and its adjacent areas are in the eastern section of the Eurasian Seismic Belt,where seismic activity is controlled by the collision of the Indian and Eurasian Plates.Both China and Türkiye have independent tectonic histories.

关键词： 2023 Türkiye M_(w)7.8 earthquake Coseismic surface rupture East anatolian fault zone Eurasian seismic zone Remote sensing interpretation

Molecular compositions and sources of organic aerosols at a rural site on the Guanzhong Plain,Northwest China:The importance of biomass burning

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Particuology 2024年第6期89卷 44-56页

作者： yali liu Minxia Shen Haijiao liu Wenting Dai Weining Qi Yifan Zhang Lu li Yue Cao Xin Wang Xiao Guo Yingkun Jiang Jianjun li State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National Observation and Research Station of Regional Ecological Environment Change and Comprehensive Management in the Guanzhong Plain ShaanxiChina

The concentration of PM_(2.5)has considerably reduced in recent years,but remains relatively high in China.In particular,the increasing contribution of organic compounds to PM_(2.5)generates popular pressure for further reductions,resulting in an urgent need to study organic aerosol(OA).To investigate the molecular composition and source contribution of OA in the rural area of the Guanzhong Plain,Northwest China,PM_(2.5)samples were collected during 3–23 August 2016 and 5–20 January 2017 and studied for more than 100 organic tracer compounds.The mean concentration of total measured organic compounds is 662±296 ng/m^(3)in summer and 3258±1925 ng/m^(3)in winter.Levoglucosan is the most abundant single compound found throughout the sampling period,which is a crucial tracer for biomass burning emissions,preliminary suggesting that biomass burning is an essential source of OA.In summer,organic compounds such as lipid compounds,sugar compounds,and polycyclic aromatic hydrocarbons(PAHs),more come from higher plants,wood burning,vehicle exhausts,plastic waste,and other direct emission sources.Oxygenated PAHs(OPAHs),nitrophenols,and phthalic acids more come from the atmosphere through the oxidation reaction of aromatic precursors,especially photochemical oxidation.However,in winter,most of the increases in concentrations of organic compounds are attributed to biomass burning.The analysis of a haze event(14–19 January 2017)during the winter sampling period shows that the increases in the concentration of organic compounds are unaccompanied by strong secondary formation under lower relative humidity(49.1%±13.5%).The main reason for the growth of OA in this haze event is the accumulation of primary OA(POA).The source apportionment by the positive matrix factorization(PMF)model shows that biomass burning(37.1%)is the primary source of OA in the rural regions of the Guanzhong Plain,especially in winter(40.6%).The contribution of secondary formation decreases from 26.0%in summer to 16.9%in winter,and the contribution of fossil

关键词： Organic aerosol Molecular composition Seasonal variation Source apportionment Guanzhong Plain

Mutant rs189037 in ataxia-telangiectasia mutated gene had a negative association with metabolic syndrome but not cognitive decline in centenarians

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Genes & Diseases 2024年第3期11卷 106-108页

作者： Long Feng Hongqi Huo Qun li Tao Yang yali Zhao Pei Zhang Ping Ping Shihui Fu Department of Anesthesiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Nuclear Medicine Department Handan Central HospitalHandanHebei056001China Department of Neurosurgery Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Central Laboratory Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China School of life Science Beijing Institute of TechnologyBeijing 100081China General Station for Drug and Instrument Supervision and Control Joint Logistic Support Force of Chinese People's LiberationArmyBeijing 100071China Department of Cardiology Hainan Hospital of Chinese People's Liberation Army General HospitalSanyaHainan 572013China Department of Geriatric Cardiology Chinese People's Liberation Army General HospitalBeijing 100853China

Approximately 20%-25%of adults encounter metabolic syndrome(MetS)worldwide,and MetS is a riskfactorfor cognitive decline(CD)development.Patients with MetS have an 11.48-fold increased incidence of CD compared with those without Mets.^(1) Ataxia-telangiectasia mutated(ATM)gene encodes ATM kinase,which belongs to the phosphatidylinositol 3-hydroxy kinase family.

关键词： ATM development cognitive

PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment

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Virologica Sinica 2024年第2期39卷 235-250页

作者： Qiang Zhang Hanzhe Ye Cong liu Haiwu Zhou Mingbin He Xiaodong liang Yu Zhou Kun Wang yali Qin Zhifei li Mingzhou Chen State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan430072China Taikang Center for life and Medical Sciences Wuhan UniversityWuhan430072China Hubei Jiangxia Laboratory Wuhan430200China

Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and viral mRNAs are concentrated.However,the mechanism of IBAG formation and the physiological function of IBAGs are unclear.Here,we found that the internal structures of RSV IBs are actual M2-1-free viral messenger ribonucleoprotein(mRNP)condensates formed by secondary LLPS.Mechanistically,the RSV nucleoprotein(N)and M2-1 interact with and recruit PABP to IBs,promoting PABP to bind viral mRNAs transcribed in IBs by RNArecognition motif and drive secondary phase separation.Furthermore,PABP-eIF4G1 interaction regulates viral mRNP condensate composition,thereby recruiting specific translation initiation factors(eIF4G1,eIF4E,eIF4A,eIF4B and eIF4H)into the secondary condensed phase to activate viral mRNAs for ribosomal recruitment.Our study proposes a novel LLPS-regulated translation mechanism during viral infection and a novel antiviral strategy via targeting on secondary condensed phase.

关键词： Respiratory syncytial virus(RSV) Inclusion bodies(IBs) Biomolecular condensates liquid-liquid phase separation(LLPS) Secondary condensed phase mRNA activation

Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

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Science China(life Sciences) 2024年第1期67卷 113-121页

作者： Hui Zhu Taishun li Peizhen Xu lijun Ding Xianghong Zhu Bin Wang Xiaoqiu Tang Juan li Pengfeng Zhu Huiyan Wang Chenyan Dai Haixiang Sun Jianwu Dai yali Hu Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Biostatistics Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Gynecology Changzhou Maternal and Child Health Care HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Clinical Center for Stem Cell Research Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Department of Hematology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe intrauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5%)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2%)(RR=1.52,95%CI 1.08–2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9%(41/72)vs.control group 38.2%(26/68),RR=1.49,95%CI 1.04–2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse effects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively

关键词： intrauterine adhesion Asherman’s syndrome uterine infertility autologous bone marrow stem cells transplantation endometrial regeneration ongoing pregnancy rate