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Proceedings of Anticancer Research 2023年第2期7卷 12-17页

作者： Jinjin Qin Chenyuan Cao yakun zhao Jing Wang Hongli Wu Bei Wang Affiliated Hospital of Hebei University Baoding 071000Hebei ProvinceChina

Objective:To observe the changes in insulin resistance in patients with gestational diabetes mellitus(GDM)based on the detection of serum microRNA-372-3p and glucose transporter protein 4(GLUT4)***:We conducted a retrospective cohort study of 42 patients who were diagnosed with GDM and hospitalized in our hospital during the period from January 2017 to December 2021 and another 42 patients who had normal pregnancy during the same period by collecting their clinical *** analyzed their serum microRNA expression profiles and miR-372-3p levels to study the relationship between GDM and insulin ***:The relative expression of miR-372-3p in the serum of patients in the GDM group was significantly higher than that of patients in the control group,but the GLUT 4 level of the GDM group was significantly lower than that of the control group(P<0.05).Compared with the control group,the GDM group had significantly higher levels of fasting blood glucose(FBG),fasting insulin(FINS),2-hour postprandial blood glucose(2h-BG),total cholesterol(TC),triglyceride(TG),and homeostatic model assessment for insulin resistance(HOMA-IR)index but significantly lower homeostasis model assessment ofβ-cell function(HOMA-β)index(P<0.05).The relative expression of miR-372-3p in serum was independently and positively correlated with HOMA-IR,while the level of GLUT4 was independently and negatively correlated with HOMA-IR(P<0.05).Conclusion:Glycosylated hemoglobin test in the early stages of pregnancy(12–13 weeks of gestation)is important to ensure the health of pregnant women and *** screening and intervention for elevated glucose in pregnant women act as a guideline for the treatment of *** with insulin resistance and related complications such as hyperinsulinemia and hypoglycemia should be given priority.

关键词： Gestational diabetes mellitus microRNA-372-3p Glucose transporter Insulin resistance

Detection and Clinical Significance of Th17/Treg Cell-Related Factors in Patients with Gestational Diabetes Mellitus

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Proceedings of Anticancer Research 2023年第6期7卷 102-107页

作者： Jinjin Qin Bei Wang Chenyuan Cao yakun zhao Jing Wang Hongli Wu Department of Obstetrics Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To investigate the detection of Th17/Treg cell-related factors in patients with gestational diabetes mellitus(GDM)and its clinical ***:In this study,a retrospective cohort research method was used to collect the clinical data of 42 patients who were hospitalized in the Affiliated Hospital of Hebei University and received the diagnosis of GDM from January 2018 to December 2022,as well as 42 patients with normal pregnancies during the same *** Th17/Treg expression levels and metabolism-related indexes in the peripheral blood of patients were detected by ***:The relative expression of Th17 in the serum of patients in the GDM group was significantly higher than that of the control group,and the level of Treg was significantly lower than that of the control group(P<0.05);the levels of FBG,FINS,2hBG,TC,TG and HOMA-IR of the patients in the GDM group were significantly higher than that of the control group,and the level of HOMA-βwas significantly lower than that of the control group(P<0.05).Conclusion:The imbalance of the Th17/Treg cell ratio in patients with GDM may be related to their disease progression and prognosis,providing new ideas and strategies for the clinical treatment of GDM.

关键词： Gestational diabetes mellitus Th17/Treg cells Cytokines Clinical significance

Epidemiological Survey on Vitamin A,D,E Levels of Pregnant Women in Baoding

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Journal of Clinical and Nursing Research 2023年第4期7卷 57-62页

作者： Bei Wang yakun zhao Hongli Wu Ling Liang Wenli Kang Yan An Jie Cui Department of Obstetrics Affiliated Hospital of Hebei UniversityBaoding 073000China

Objective:To understand the vitamin levels in pregnant women and its influencing factors and provide a basis for formulating scientific and reasonable vitamin supplement plans for pregnant ***:Pregnant women with a pregnancy period of 12 weeks to 36 weeks in Baoding area were selected as the research subjects using the random sampling *** sample size is estimated to be 5,000 people,and the diversity of the research subjects,such as age,education level,pregnancy,etc.,were recorded through a *** content of the survey included the personal information of the research subjects,pregnancy conditions,eating habits,vitamin supplements taken,*** the same time,blood tests were carried out on the research subjects to detect indicators such as vitamin ***:The results of serum measurement showed that the vitamin A level of pregnant women was 0.38±0.12 mg/L,the vitamin E level was 13.51±3.17 mg/L,and the vitamin D level was 17.82±4.18 ng/L;the level of vitamin A of pregnant women in the first trimester was significantly lower than those in the second and third trimesters,and the level of vitamin E of pregnant women in second trimester was significantly higher than those in the first and third trimesters,with statistically significant differences(P<0.05).The rate of vitamin A deficiency in the early stage was significantly higher than that in the middle and late stages of pregnancy,(P<0.05);vitamin D deficiency existed in all pregnant ***:Pregnant women should maintain a reasonable diet and eat more vitamin-rich foods,such as vegetables,fruits,etc.;besides,pregnant women should take vitamin supplements under the guidance of doctors or professionals according to their own conditions;moreover,the publicity and education for pregnant women should be improved with more emphasis on vitamin supplementation.

关键词： Vitamins Pregnant women Epidemiology

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负载感知的太赫兹纳米传感网的TDMA协议

同济大学学报（自然科学版） 2018年第11期46卷 1568-1574页

作者：徐娟赵雅坤张茸阚佳丽同济大学电子与信息工程学院上海201804

针对基于TS-OOK(time spread on-off keying)调制的通信系统存在数据传输连续碰撞的问题,考虑到实际应用场景具备负载不均衡的特点,提出负载感知的TDMA (LATDMA)协议.该协议根据网络中源节点数目、源节点业务量大小以及太赫兹信道的传... 详细信息

针对基于TS-OOK(time spread on-off keying)调制的通信系统存在数据传输连续碰撞的问题,考虑到实际应用场景具备负载不均衡的特点,提出负载感知的TDMA (LATDMA)协议.该协议根据网络中源节点数目、源节点业务量大小以及太赫兹信道的传输特性,在传统TDMA协议基础上实现动态分配时隙.仿真结果表明:该协议是能量高效的,在时延和平均吞吐量方面均具有明显的优势,因此可以应用于时延要求较苛刻的网络场景中.

关键词：纳米网太赫兹带介质访问控制负载感知

装配式L形截面夹芯组合剪力墙节点抗震性能试验

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土木工程学报 2022年第S01期55卷 49-55页

作者：马少春赵亚坤郭成超鲍鹏河南大学开封市工程修复与材料循环工程技术研究中心河南开封475004 郑州大学河南郑州450001

为研究装配式L形截面夹芯组合剪力墙节点的整体工作性能,设计了由环形水平钢筋连接试件及水平贯通钢筋连接试件共两类。详细考察了试件的工作状态、破坏机理、滞回性能、刚度退化及耗能等变化规律,并对其延性性能进行了评价。结果表明:... 详细信息

为研究装配式L形截面夹芯组合剪力墙节点的整体工作性能,设计了由环形水平钢筋连接试件及水平贯通钢筋连接试件共两类。详细考察了试件的工作状态、破坏机理、滞回性能、刚度退化及耗能等变化规律,并对其延性性能进行了评价。结果表明:试件发生了典型的弯剪破坏,主要集中在腹板脚部混凝土被拉裂或压碎、钢筋拉长或压弯。通过对比分析发现,环形水平钢筋连接试件的开裂、屈服、峰值荷载及相应的变形均得到大幅度的提高;通过对耗能性能进行评估,得出的结论一致等。说明环形钢筋可以有效增强腹板与暗柱、翼缘与暗柱之间的连接,有助于综合提高试件的抗震能力。

关键词：夹芯剪力墙节点抗震试验装配式滞回及骨架曲线刚度

Effect of Mitochondrial Function of Ovarian Granulosa Cells on In Vitro Fertilization and Embryo Transfer Outcomes in Obese Polycystic Ovary Syndrome Patients

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Proceedings of Anticancer Research 2023年第3期7卷 1-6页

作者： Jing Wang Yana Gao Hongli Wu Gaijing Wang Jie Cui Jinjin Qin Lulu Wang yakun zhao Rui Li Affiliated Hospital of Hebei University Baoding 071000Hebei ProvinceChina

Objective:To investigate the effect of abnormal ovarian granulosa cell metabolism on in vitro fertilization and embryo transfer(IVF-ET)outcomes in obese polycystic ovary syndrome(PCOS)***:Patients with PCOS who met the study criteria were screened according to the inclusion criteria.A total of 32 patients with obese PCOS were recruited into the study group,and 39 patients with non-obese PCOS were recruited into the control *** general data(age,body mass index,and years of infertility),insulin resistance index(HOMA-IR),follicle-stimulating hormone(FSH),luteinizing hormone(LH),granulosa cell mitochondrial function,and IVF-ET outcome of patients in the study group and control group were retrospectively ***:The differences in age and years of infertility between the study group and the control group were insignificant(P>0.05),and the body mass index(BMI)of the study group and control group was 30.5±1.24 kg/m2 and 22.3±1.12 kg/m2,respectively,in which the difference was statistically significant(P0.05);the rate of IVF-ET failure was significantly higher in the study group than in the control ***:PCOS is a complex endocrine disorder,and obesity is one of the independent risk factors for the development of PCOS.

关键词： Polycystic ovary syndrome Mitochondrial function Ovarian granulosa cell In vitro fertilization and embryo transfer

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市政埋地供水管网抗寒潮服务可靠度分析

自然灾害学报 2024年第3期33卷 122-129页

作者：梁建文赵雅坤肖笛天津大学建筑工程学院天津300350 南开大学管理科学与工程系天津300071

提出了市政埋地供水管网抗寒潮服务可靠度分析的一个方法。针对寒潮期气温变化对供水管道温度应力和管道周围土体冰冻应力的影响,建立管道接头渗漏状态的供水管网水力分析模型,采用一次二阶矩方法计算市政埋地供水管网抗寒潮服务可靠度... 详细信息

提出了市政埋地供水管网抗寒潮服务可靠度分析的一个方法。针对寒潮期气温变化对供水管道温度应力和管道周围土体冰冻应力的影响,建立管道接头渗漏状态的供水管网水力分析模型,采用一次二阶矩方法计算市政埋地供水管网抗寒潮服务可靠度。以某城市供水管网为例进行分析,分别给出了在蓝色、黄色、橙色和红色寒潮预警下供水管网的服务可靠度。研究表明,寒潮期气温变化对市政埋地供水管网服务可靠度具有明显影响,有必要开展市政埋地供水管网寒潮可靠度分析,寒潮强度、管道接头性能、管网拓扑结构等是市政埋地供水管网服务可靠度的影响因素。研究对于市政埋地供水管网抗灾设计具有一定参考价值。

关键词：市政供水管网抗寒潮服务可靠度温度应力管道接头变形管道渗漏

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大数据时代学习者权利的保障

河北广播电视大学学报 2015年第2期20卷 36-39页

作者：赵雅琨河北广播电视大学河北石家庄050071

大数据构成了当代教育的技术背景之一,必然对包括学习者权利在内的教育要素产生深刻影响,学习资源、学习过程、学习评价以及学习者的地位因此发生了深刻的变化。学习者从被动的受教育者,成为了知识的建构者,人力资源的再造者,教育管理... 详细信息

大数据构成了当代教育的技术背景之一,必然对包括学习者权利在内的教育要素产生深刻影响,学习资源、学习过程、学习评价以及学习者的地位因此发生了深刻的变化。学习者从被动的受教育者,成为了知识的建构者,人力资源的再造者,教育管理的参与者,学习型社会的建设者。因此,有必要对大数据时代的学习者权利加以特殊关照,并讨论其权利保障的基础。

关键词：学习者权利大数据权利保障终身学习

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公司僵局司法救济的法理基础

河北广播电视大学学报 2013年第5期18卷 71-74页

作者：赵雅琨河北广播电视大学河北石家庄050071

对公司僵局进行司法救济的前提是公司僵局之不可回避、不可自救,由此获得司法干预的法理基础:亟需填补的法律漏洞、公司自力救济不能、其他救济途径用尽,是司法救济的必要性所在;维护股东权利、实现实质正义、满足期待利益,这是司法救... 详细信息

对公司僵局进行司法救济的前提是公司僵局之不可回避、不可自救,由此获得司法干预的法理基础:亟需填补的法律漏洞、公司自力救济不能、其他救济途径用尽,是司法救济的必要性所在;维护股东权利、实现实质正义、满足期待利益,这是司法救济的正当性所在;司法介入应遵循几项基本原则,这是司法救济的适当性所在。同时,思考公司自治与司法介入的关系,希望在对国家强制保持警惕的同时信任司法救济,最终达到平衡各方利益的善果。

关键词：公司僵局自力救济司法救济法理基础