检索结果-南通市图书馆

Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation

Regenerative Biomaterials 2024年第2期3卷 137-146页

作者： Qirong Xu Chen Li Xiangyan Meng Xinghong Duo yakai feng School of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007PR China Key Laboratory of National Ethnic Affairs Commission of Resource Chemistry and Ecological Environment Protection on Qinghai-Tibet Plateau Xining 810007PR China institute of Disaster and Emergency Medicine Tianjin UniversityTianjin 300072PR China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350PR China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072PR China

Endothelial cell proliferation plays an important role in angiogenesis and treatment of related *** aim of this study was to evaluate the effect of polyethylenimine(PEI)-modified graphene quantum dots(GQDs)gene vectors on endothelial cell *** GQDs-cationic polymer gene vectors were synthesized by amidation reaction,and used to deliver pzNF580 gene to Human umbilical vein endothelial cells(HUVECs)for promoting their *** chemical modification of GQDs can ad-just gene vectors'surface properties and charge distribution,thereby enhancing their interaction with gene molecules,which could effectively compress the pZNF580 *** CCK-8 assay showed that the cell viability was higher than 80%at higher vector concentration(40μg/mL),demonstrating that the GQDs-cationic polymer gene vectors and their gene complex nanoparticles(NPs)having low *** results of the live/dead cell double staining assay were consistent with those of the CCK-8 assay,in which the cell viability of the A-GQDs/pZNF580(94.38±6.39%),C-GQDs-PEI-polylactic acid-co-polyacetic acid(PLGA)/pZNF580(98.65±6.60%)and N-GQDs-PEI-PLGA/pZNF580(90.08±1.60%)groups was significantly higher than that of the Lipofectamine 2000/pzNF580(71.98±3.53%)positive treatment *** results of transfection and western blot experiments showed that the vector significantly enhanced the delivery of plasmid to HUVECs and increased the expression of pZNF580 in *** addition,the gene NPs better promote endothelial cell migration and *** cell migration rate and proliferation ability of C-GQDs-PEI-PLGA/pZNF580 and N-GQDs-PEI-PLGA/pZNF580 treatment groupS were higher than those of Lipofectamine 2000/pDNA treatment *** GQDs possess the potential to serve as efficient gene *** tightly bind gene molecules through charge and other non-covalent interactions,significantly improving the effciency of gene delivery and ensuring the smooth release of genes with

关键词： graphene quantum dots polyethylenimine ZNF580 gene endothelial cell proliferation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

0il bleed from elastomeric thermal silicone conductive pads

引用

Frontiers of Chemical Science and Engineering 2016年第4期10卷 509-516页

作者： Yuqi Chen yakai feng Jingqi Zhao Jingbo Shen Menghuang feng School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Chemical Engineering (Tianjin) Tianjin 300072 China Tianjin Laird Electronic Material Co. Ltd. Tianjin 300457 China

Oil bleed is a serious problem in elastomeric thermal silicone conductive pads. The components of the oil bleed and the effect of the silicone chemical parameters on the amount ofoil bleed have been determined. The main components of oil bleeds are the uncrosslinked silicones in the cured resins, which include the unreacted silicone materials and the macromolecular substances produced by the hydrosilylation reaction. Cured resins with a high crosslinking density and a high molecular weight of vinyl silicone residues had a lower amount of oil bleed. In addition, a low Si-H content also reduced the amount ofoil bleed.

关键词： oil bleed crosslinking density molecularweight vinyl silicones hydrosilicones

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Investigation of High-Efficiency Antibacterial Liquid Dishwashing Detergent

引用

Transactions of Tianjin University 2019年第4期25卷 322-329页

作者： Mingxue Dai Jintang Guo Xuexue Xue yakai feng School of Chemical Engineering and Technology Tianjin University

A high-effi ciency liquid dishwashing detergent was prepared by using oregano essential oil as an antibacterial agent. The surface cleaning and antibacterial property of the detergent resolved its unifunctionality problem. The antibacterial activities of the detergent were demonstrated through a disk diff usion assay and wipe experiments with Escherichia coli and Staphylococcus aureus . Results showed that the prepared detergent was highly eff ective against E. coli and S. aureus . The results of chemical accelerated tests indicated that the detergent would be eff ective for at least 1 year. The antibacterial property and detergency performance of the high-effi ciency antibacterial liquid dishwashing detergent were compared with those of a commercial antibacterial detergent containing 0.02% o -phenylphenol. The detergency performance of the high-effi ciency detergent reached 97.8% and was superior to that of the commercial antibacterial detergent.

关键词： Oregano essential oil Dishwashing detergent Antibacterial property Detergency performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrospinning of polycarbonate urethane biomaterials

引用

Frontiers of Chemical Science and Engineering 2011年第1期5卷 11-18页

作者： yakai feng Fanru MENG Ruofang XIAO Haiyang ZHAO Jintang GUO School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Polycarbonate urethane(PCU)nano-fibers were fabricated via electrospinning using N,Ndimethylformamide(DMF)and tetrahydrofuran(THF)as the mixed *** effect of volume ratios of DMF and THF in the mixed solvent on the fiber structures was *** results show that nano-fibers with a narrow diameter distribution and a few defects were obtained when mixed solvent with the appropriate volume ratio of DMF and THF as 1∶*** the proportion of DMF was more than 75%in the mixed solvent,it was easy to form many beaded *** applied voltage in the electrospinning process has a significant influence on the morphology of *** the electric voltage was set between 22 and 32 kV,the average diameters of the fibers were found between 420 and 570 *** electron microscopy(SEM)images showed that fiber diameter and structural morphology of the electrospun PCU membranes are a function of the polymer solution *** the concentration of PCU solution was 6.0 wt-%,a beaded-fiber microstructure was *** increasing the concentration of PCU solutions above 6.0 wt-%,beaded fiber decreased and finally ***,when the PCU concentration was over 14.0 wt-%,the average diameter of fibers became large,closed to 2μm,because of the high solution *** average diameter of nanofibers increased linearly with increasing the volume flow rate of the PCU solution(10.0 wt-%)when the applied voltagewas 24 *** results show that the morphology of PCU fibers could be controlled by electrospinning parameters,such as solution concentration,electric voltage and flow rate.

关键词： electrospinning polycarbonate urethane process parameter average diameter morphology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel reprocessable chloroprene rubber based on dynamic disulfide metathesis

引用

International Journal of Smart and Nano Materials 2024年第1期15卷 42-61页

作者： Jianliang Jiang Junxue Zhai Yanqing Chen Dongqi Zhao yakai feng School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin)Tianjin UniversityTianjinChina R&D Department of China(Yangzhou) Material Handling Tech-Engineering LtdYangzhouChina Key Laboratory of Rubber Plastics of Ministry of Education/Shandong Province (QUsT)School of Polymer Science&EngineeringQingdao University of Science&TechnologyQingdaoChina R&D Department of Tianjin Joaboa Technology Co.Ltd TianjinP.R.China Frontiers Science Center for Synthetic Biology Tianjin UniversityTianjinChina Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjinChina

For sustainable application of chloroprene rubber(CR),a new technology is developed by the vulcanization of CR using 2,2'-dithiodipyridine(DPD)as a cross-linking agent with the repro-cessing performance owing to disulfde *** DPD was incorporated into CR vulcanization,the Menschutkin reac-tion between allyl chloride group and pyridine group occurred with a maximum exothermic peak at 184°*** number of effective cross-linking bond at o.5 phr DPD vulcanizate was higher than that at high DPD *** vulcanizate showed high tensile strength(11.12 MPa)and elongation at break(1253±120%)owing to the exchangeable disulfide bond in the *** the catalysis of triphenylphosphine,the metathesis of disulfide compound was improved obviously,which endowed CR/DPD vulcanizates with good recyclability *** cross-linkage maintains its stability at low temperature,thus ensuring the mechanical stability of CR/DPD vulcanizate under the ambient *** and reprocessing of CR/DPD vulcanizate can be conducted with common industrial rubber processing *** reprocessable chloroprene rubber could have potential appli-cation in CR industry,also serve to significantly improve envir-onmental sustainability.

关键词： Chloroprene rubber reprocessable Menschutkin reaction disulfide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

引用

Frontiers of Chemical Science and Engineering 2010年第3期4卷 372-381页

作者： yakai feng Haiyang ZHAO Li ZHANG Jintang GUO School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Thrombus formation and blood coagulation are serious problems associated with blood contacting products,such as catheters,vascular grafts,artificial hearts,and heart *** progresses and strategies to improve the hemocompatibility of biomaterials by surface modification using photochemical immobilization and photograft polymerization are reviewed in this *** approaches to modify biomaterial surfaces for improving the hemocompatibility,i.e.,bioinert surfaces,immobilization of anticoagulative substances and biomimetic surfaces,are *** biomimetic amphiphilic phosphorylcholine and Arg-Gly-Asp(RGD)sequence are the most effective and most often employed biomolecules and peptide sequence for improving hemocompatibility of material *** RGD sequence can enhance adhesion and growth of endothelial cells(ECs)on material surfaces and increase the retention of ECs under flow shear stress *** surface modification is a promising strategy for biomaterials especially for cardiovascular grafts and functional tissue engineered blood vessels.

关键词： anticoagulative biomimetic biomaterials hemocompatibility phosphorylcholine photochemical immobilization photograft polymerization photolinker surface modification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of depsipeptides from L-amino acids and lactones

引用

Frontiers of Chemical Science and Engineering 2011年第4期5卷 409-415页

作者： Hongfei CAO yakai feng Heyun WANG Li ZHANG Musammir KHAN Jintang GUO School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative MedicineTianjin 300072ChinaTeltow 14513Germany

By using the corresponding L-amino acid sodium as initiator,ε-caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions ofε-caprolactone(CL)with L-alanine and L-leucine,respec-tively,and p-dioxanone-depsipeptide(PDO-Leu)was prepared by the reaction of p-dioxanone(PDO)with *** poly(ε-caprolactone)oligomers(PCL-Ala and PCL-Leu)of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of L-amino acid sodium and *** presence of the depsipeptide structure in these obtained products was conﬁrmed by 1H NMR spectra and the molecular weight of the poly(ε-caprolactone)oligomers was measured by gel permeation chromatography(GPC).These products con-tain a hydroxyl group and a carboxyl group in one molecule,which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight *** this way,the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures.

关键词： ε-caprolactone p-dioxanone L-alanine L-leucine depsipeptide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation

引用

Frontiers of Chemical Science and Engineering 2020年第5期14卷 889-901页

作者： Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb yakai feng School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China School of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007China Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin) Tianjin 300350China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Department of Hepatopancreatobiliary and Splenic Medicine Afiliated HospitalLogistics University of People's Amed Police ForceTianjin 300162China Department of Physiology and Pathophysiology Logistics University of People's Armed Police ForceTianjin 300162China Institute of Drug Research(IDR) School of Pharmacy Faculty of MedicineThe Hebrew University of JerusalemJerusalem 91905Israel

Gene therapy has drawn great attention in the treatments of many diseases,especially for cardiovascular ***,the development of gene carriers with low cytotoxicity and multitargeting function is still a ***,the multitargeting REDV-G-TATG-NLS peptide was conjugated to amphiphilic cationic copolymer poly(e-caprolactone-co-3(S)-methyl-morpho-line-2,5-dione)-g-polyethyleneimine(PCLMD-g-PEI)via a heterobifunctional orthopyridyl disulfde-poly(ethylene glycol)-N-hydroxysuccinimide(OPSS-PEG-NHS)linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop the gene carriers with low cytotoxicity and high transfection *** multitargeting micelles were prepared from PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers by self-assembly method and used to load pEGFP-ZNF580 plasmids(pDNA)to form gene complexes for enhancing the proliferation and migration of endothelial cells(ECs).The loading pDNA capacity was proved by agarose gel electrophoresis *** multitargeting gene com-plexes exhibited low cytotoxicity by 3-(4,-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide *** high internalization efficiency of these gene complexes was confirmed by flow *** results of in vitro transfection demonstrated that these multitargeting gene complexes possessed relatively high transfection *** rapid migration of ECs transfected by these gene complexes was verified by wound healing *** to ECs-targeting ability,cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS pep-tide,the multitargeting polycationic gene carrier with low cytotoxicity and high transfection efficiency has great potential in gene therapy.

关键词： gene carriers multitargeting function ECs transfection efficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modification of polycarbonateurethane surface with poly （ethylene glycol） monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet adhesion

引用

Frontiers of Chemical Science and Engineering 2014年第2期8卷 188-196页

作者： Jing YANG Juan LV Bin GAO Li ZHANG Dazhi YANG Changcan SHI Jintang GUO Wenzhong LI yakai feng School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Tianjin University-Helmholtz-Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine Tianjin 300072 China Key Laboratory of Systems Bioengineering Ministry of Education Tianjin University Tianjin 300072 China University of Rostock Department of Cardiac Surgery Reference & Translation Center for Cardiac Stem Cell Therapy Schillingallee 69 D-18057 Rostock Germany

Poly（ethylene glycol） monoacrylate （PEGMA） is grafted onto polycarbonateurethane （PCU） surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly（PEGMA） on the surface react with one NCO group of isophorone diisocyanate （IPD1） and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly（PEGMA）. Our synergic modification method using both PEG and phosphorylcho- line may be applied in surface modification of bloodcontacting biomaterials and some relevant devices.

关键词： poly(ethylene glycol) monoacrylate phos-phorylcholine polycarbonateurethane surface modifica-tion anti-platelet adhesion biomaterials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fabrication and characterization of electrospun biocompatible PU/PEGMA hybrid nanofibers by in-situ UV photopolymerization

引用

Science China(Physics,Mechanics & Astronomy) 2012年第7期55卷 1189-1193页

作者： WANG HeYun feng yakai YUAN WenJie ZHAO HaiYang FANG ZiChen KHAN Musammir GUO JinTang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin 300072China

Poly（ethylene glycol） methacrylate （PEGMA） was introduced into a polyurethane （PU） solution in order to prepare hemocom- patible electrospun membranes for potential application as small diameter vascular scaffolds. Crosslinked PU/PEGMA hybrid nanofibers were fabricated by a reactive electrospinning process with N,N＇-methylenebisacrylamide （MBAm） as erosslinker and benzophenone （BP） as photoinitiator. The photoinduced polymerization and crosslinking reaction took place simultane- ously during the electrospinning process. No significant difference in the membrane morphology was found by SEM when PEGMA content was less than 20 wt%. The crosslinked fibrous membranes of PU/PEGMA exhibit higher hydro- philicity and mechanical strength than PU membrane. These nanofibrous membranes are potential substitutes for artificial vascular scaffolds.

关键词： electrospinning crosslink photopolymerization polyurethane poly(ethylene glycol) methacrylate.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：