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Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

2008奥林匹克科学大会

作者： song,yajun JiningUniversity,China

Introduction This study explored the effect of nitric oxide(NO) in inducing catecholamine release in the endbrain of rats after acute endurance ***,the regulative function of Compound Chinese Herbal Medicine(CCHM) in this action was *** is anticipated that the results of this research will provide a basis for further studies of the mechanism and recovery of central fatigue. Methods

关键词： The influence of nitric oxide in inducing catecholamine release in the endbrain of rats following acute endurance exercise and its regulation by ingesting Chinese medicine

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Burns & Trauma 2019年第1期7卷 335-345页

作者： yajun song Yang Li Ya Xiao Wengang Hu Xu Wang Pei Wang Xiaorong Zhang Jiacai Yang Yong Huang Weifeng He Chibing Huang Department of Urology Xinqiao Hospitalthe Third Military Medical UniversityNo.83 Xinqiao StreetShapingba DistrictChongqing 400038China Institute of Burn Research Southwest HospitalState Key Laboratory of TraumaBurns and Combined Injurythe Third Military Medical UniversityNo.30 Gaotanyan StreetShapingba DistrictChongqing 400038China

Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory ***-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early ***-17A(IL-17A)plays a critical role in inflammatory ***,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly *** this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the ***:Mouse burn model was successfully established with infliction of 30%total body surface area scald *** histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without *** cytometry was used to detect the major source of IL-17A^(+)cells in the ***:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines *** addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this ***:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is ***,Vγ4^(+)T cells are identifi

关键词： IL-17A Burn Intestinal mucosa barrier Pro-inflammatory cytokines Vγ4+T cells Interleukin-17A

IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice

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Science Bulletin 2017年第15期62卷 1052-1063页

作者： Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han yajun song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang State Key laboratory of Pathogen and Biosecurity. Beijing Institute of MicrobiologY and Epidemiology Beijing 100071 China Key Laboratory of Cell Proliferation and Regulation Biology Ministry of Education Institute of Cell Biology College of Life Science Beijing Normal University Beijing 100875 China State Key Laboratory for Diagnosis and Treatment of Infectious Disease The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Hangzhou 310003 China Guangdong Provincial Key Laboratory of Gastroenterology Institute of Gastroenterology of Guangdong Province Department of Gastroenterology Nan fang Hospital Southern Medical University Guangzhou 510515 China Realbio Genomics Institute Shanghai 200050 China Key Laboratory of Dairy Biotechnology and Engineering Education Ministry of China Inner Mongolia Agricultural University Hohhot 010018 China

The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored, lnterleukin 17A （lL-17A）, a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet （HFD）, and the gut microbiota. Mice deficient in 1L-17A were resistant to diet-induced obesity and related diseases. Compared with the I1-17a^-/1 mice, wild-type （WT） mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Il-17a^-/- mice together signifi- cantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes. We also identified potentially beneficial and harmful species present during this period, and drew net- works of the most abundant species. A functional analysis indicated pathway changes in the WT and I1-17a^- /- mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17A in shaping and regulating the gut microbiota, which conversely, influences the host health.

关键词： Gut microbiota Obesity IL-17A Metagenomics

Different distribution pattern of 12 Virulence Genes in Legionella reference strains,Legionella strains Isolated from Environment Water and Patients in China

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Different distribution pattern of 12 Virulence Genes in Legi...

运用营养战略推迟运动性中枢神经系统疲劳的研究进展

中华医学会第十三次全国感染病学术会议

作者： XiaoYong Zhan ChaoHui HU yajun song RuiFu Yang QingYi Zhu Guangzhou Kingmed Center for Clinical Laboratory Institutes of Microbiology and Epidemiology Academy of Military Medical Science

The family of Legionella,a facultative gram-negative intracellular pathogen parasite,are ubiquitous worldwide in rivers and lakesas well as in artificial water systems such as eoolingtowers and *** the relatively short period,since *** was first identified as a human pathogen,more than 50 species of Legionellahave been recognized,and at least 24 of these havebeen associated with human disease although the vast majority cases of legionellosis are caused by Legionella pneumophila(***),mostly serogroup(SG)1

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中国体育科技 1999年第8期35卷 14-15,19页

作者：宋亚军山东济宁师专体育系济宁272125

近年来，运动性中枢神经系统（ＣＮＳ）疲劳的研究取得突破性进展。大量事实证明，大脑５－羟色胺（５－ＨＴ）是构成运动性疲劳的重要介质。有些研究者设计营养方法以削减大脑５－ＨＴ的合成，推迟运动性疲劳的出现，本文拟就这一领域... 详细信息

近年来，运动性中枢神经系统（ＣＮＳ）疲劳的研究取得突破性进展。大量事实证明，大脑５－羟色胺（５－ＨＴ）是构成运动性疲劳的重要介质。有些研究者设计营养方法以削减大脑５－ＨＴ的合成，推迟运动性疲劳的出现，本文拟就这一领域的研究现状做一综述。

关键词：疲劳中枢神经系统综述

The Establishment and Application of Mobile Electronic Surveillance System for Infectious Diseases with the Help of China—Sierra Leone,2016-Present

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China CDC weekly 2021年第36期3卷 763-768页

作者： Guangyu Zhao Haorong Chen Yanfeng Yan Jiafu Jiang Lei Lin Baogui Jiang Foday Sahr Stephen Sevalie Qiang Xu Jinjin Chen Henry Saidu Bangura Kandeh Bassie Kargbo yajun song Wei Liu Liqun Fang Yansong Sun State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina College of Life Science and Technology Beijing University of Chemical TechnologyBeijingChina College of Medicine and Allied Health Sciences University of Sierra LeoneFreetownSierra Leone Military Hospital WilberforceFreetownSierra Leone.

Introduction:Infectious disease surveillance has long been a challenge for low-income countries like Sierra *** approaches based on paper and Short Message Service(SMS)were subject to severe delays in obtaining,transmitting,and analyzing ***:During the China aid operation for fighting Ebola since the end of 2014,a mobile electronic surveillance system for infectious diseases(MESSID)was developed in collaboration with the Republic of Sierra Leone Armed Forces(RSLAF),which comprised an Android-based reporting system and a complementary web-based program designed by Active Server ***(***)with the main functions including surveillance,real-time reporting,and risk assessment of infectious ***:MESSID was successfully registered in June 2016 and had been used by all medical and health institutions in *** June 1,2016 to July 5,2021,34,419 cases were diagnosed with 47 infectious diseases of 5 categories,with a total of 42 clinical *** to traditional approaches based on paper and SMS,the MESSID showed flexibility,high efficiency,convenience,and ***:MESSID is an accessible tool for surveillance of infectious diseases in Sierra Leone and possibly in other African countries with similar needs,capable of improving timeliness of disease reporting,thus rendering a timely outbreak detection and response.

关键词： rendering Server Sierra

Computer-designed orthogonal RNA aptamers programmed to recognize Ebola virus glycoproteins

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Biosafety and Health 2019年第2期1卷 105-111页

作者： Teng Yue Liu Shuxia Yang Shan Guo Xiaocan Zhang Yanwen song yajun Cui Yujun State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Department of Computational Biology Beijing Computing CenterBeijing 100094China Massachusetts Institute of Technology 77 Massachusetts AvenueCambridgeMA 02139USA

Ebola virus (EBOV), a member of the filovirus family, is an enveloped negative-sense RNA virus that causes lethal infections in humans and primates. Thousands of people have died from the Ebola virus disease (EVD) in West Africa, and no specific antiviral medication and treatment have been approved for EVD. Although the development of an EBOV vaccine is promising, immunity to any vaccine is not immediate. Here, we computationally analysed the structure of EBOV glycoprotein GP2 (GP2EBOV) and designed RNA aptamers that recognize and inhibit it. The aptamers specifically bind to conserved arginine residues (Arg587 and Arg596) located in the C-terminal coiled-coil region of GP2EBOV. Molecular docking of the synthetic RNA aptamers with the ectodomain of GP2EBOV revealed that the optimized orthogonal RNA aptamers have strong binding affinities with the coiled-coil region of GP2EBOV. The characterized RNA aptamers may facilitate strategies to block replication of EBOV and related Filoviruses, and thus may serve as important antivirals to reduce mortality associated with these infections.

关键词： Ebola virus Glycoproteins RNA aptamers Molecular dynamic de novo design

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矩形翅片椭圆换热管束性能

同济大学学报（自然科学版） 2016年第7期44卷 1096-1100,1129页

作者：赵兰萍宋亚军杨志刚同济大学机械与能源工程学院上海201804 同济大学上海地面交通工具风洞中心上海201804

采用标准k-ε模型,就管排数和翅片间距等因素对矩形翅片椭圆换热管束流动换热性能的影响进行分析.得到管束各排翅片表面平均换热系数分布规律,并给出j因子和f因子与管排数的关系.结果表明:翅片间距主要通过阻力对管束性能产生影响,当翅... 详细信息

采用标准k-ε模型,就管排数和翅片间距等因素对矩形翅片椭圆换热管束流动换热性能的影响进行分析.得到管束各排翅片表面平均换热系数分布规律,并给出j因子和f因子与管排数的关系.结果表明:翅片间距主要通过阻力对管束性能产生影响,当翅片间距小于2.5 mm时,管束空气侧阻力对风速的敏感性显著增加;可以通过采用高导热系数翅片材料的方法来提升管束性能.

关键词：风洞换热器矩形翅片椭圆管束流动换热性能管排数翅片间距

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晋升激励、社会资本与企业财务治理效率

财会通讯（下） 2019年第5期 72-75页

作者：宋亚军田宇唐山学院

本文以我国A股2012-2017年上市企业为研究对象,深入探讨晋升激励、社会资本与企业财务治理效率之间的关系。研究发现:社会资本与企业财务治理效率之间存在显著正相关;晋升激励与企业财务治理效率之间存在显著正相关;晋升激励能够增强社... 详细信息

本文以我国A股2012-2017年上市企业为研究对象,深入探讨晋升激励、社会资本与企业财务治理效率之间的关系。研究发现:社会资本与企业财务治理效率之间存在显著正相关;晋升激励与企业财务治理效率之间存在显著正相关;晋升激励能够增强社会资本与企业财务治理效率之间的相关性。

关键词：晋升激励社会资本财务治理效率

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碳信息披露、盈余质量与重污染企业财务绩效

财会通讯（下） 2019年第1期 87-91页

作者：田宇宋亚军唐山学院

本文选取2011-2016年国内沪深两市A股上市重污染企业作为研究样本,对碳信息披露、盈余质量与企业财务绩效进行了分析。研究发现:随着企业盈余管理质量的提高,财务绩效会得到显著提升;随着企业披露碳信息质量的提高,财务绩效会得到显著提... 详细信息

本文选取2011-2016年国内沪深两市A股上市重污染企业作为研究样本,对碳信息披露、盈余质量与企业财务绩效进行了分析。研究发现:随着企业盈余管理质量的提高,财务绩效会得到显著提升;随着企业披露碳信息质量的提高,财务绩效会得到显著提升;盈余管理质量能够显著增强碳信息披露质量对企业财务绩效的影响作用。

关键词：碳信息披露盈余质量财务绩效重污染企业