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miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis

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Acta Pharmaceutica Sinica B 2022年第2期12卷 821-837页

作者： Tao su suchao Huang Yanmin Zhang yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao(SAR)999078China Department of Pharmacological and Pharmaceutical Sciences University of HoustonHoustonTX 77204USA

Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and *** overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical ***,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,***-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer *** data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 ***-β2 is a direct target of miR-7-5 *** reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung ***,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer ***,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’*** are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer *** study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)*** study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment.

关键词： Acidic tumor microenvironment miR-7-5p TGF-β2 Metastasis Lung cancer pH Invasion

Epigenetic Control in Development

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Epigenetic Control in Development

第二届全国发育生物学大会

作者： Juan Du Junzheng Zhang yajuan Li Tao He Ying su Alan Jian Zhu Peking-Tsinghua Center for Life Sciences School of Life SciencesPeking University

Polycomb(PC)repressive complexes(PRC)epigenetically repress the expression of developmentally important ***,not much is known about mechanisms that maintain PRC protein *** find that a novel gene,stuxnet(stux),controls PC protein stability,stux genetically interacts with Pc to pattern the developing Drosophila *** protein contains a ubiquitin-like domain that promotes PC protein degradation in the ***,heightened stux activity leads to homeotic transformation characteristic of reduced PRC ***,we show that mouse stux facilitates PC protein degradation in vertebrate cells,rescues stux-associated wing defect,and induces stereotypical homeotic transformation in *** together,our results uncover an evolutionarily conserved regulatory mechanism whereby Stux promotes PC protein degradation to reverse PRC-mediated epigenetic repression in development.

关键词： Polycomb epigenetic repression posttranslational modification development Drosophila

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基于“调态”方略的保健食品开发与评价

中国实验方剂学杂志 2022年第18期28卷 192-197页

作者：田雅娟苏洁王瑜高速吕圭源浙江中医药大学药学院杭州311402

随着老龄化进程的加快以及民众生活方式和生活环境的改变,我国慢性非传染性疾病(慢病)患病人数不断增加,已成为重大公共卫生问题,而处于亚健康状态的人群数量更为庞大且呈不断上升趋势。“治未病”思想是中医理论的核心内容之一,强调未... 详细信息

随着老龄化进程的加快以及民众生活方式和生活环境的改变,我国慢性非传染性疾病(慢病)患病人数不断增加,已成为重大公共卫生问题,而处于亚健康状态的人群数量更为庞大且呈不断上升趋势。“治未病”思想是中医理论的核心内容之一,强调未病先防、既病防变。中医将健康视作一种阴阳的动态平衡,擅长通过维持这种平衡来预防与治疗疾病。“调态”方略是在识“态”、辨“态”的基础上,通过调整偏盛或偏衰的状态来治疗疾病的一种方法,该方略对于中药保健食品的开发与评价具有重要的指导意义。保健食品在健康促进、慢病预防、生命质量提升等方面发挥着至关重要的作用,目前我国中药保健食品普遍缺乏中医理论的指导,未能充分体现中医药的优势与特色。该研究从“调态”的角度出发针对中药保健食品的开发策略、功能声称、评价方法及存在问题等内容进行了论述,并以糖尿病为例在产品开发与评价过程中引入“调态”方略,以期为推动具有中医药特色的保健食品的快速发展提供思路。

关键词：调态中医药保健食品开发与评价

Insulin sensitivity,βcell function,and adverse pregnancy outcomes in women with gestational diabetes

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Chinese Medical Journal 2022年第21期135卷 2541-2546页

作者： Yun Shen Yanwei Zheng Yingying su susu Jiang Xiaojing Ma Jiangshan Hu Changbin Li yajuan Huang Yincheng Teng Yuqian Bao Minfang Tao Jian Zhou Department of Endocrinology and Metabolism Shanghai Clinical Center for DiabetesShanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China Department of Gynecology and Obstetrics Shanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes MellitusShanghai Sixth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200233China

Background: The potential impact of β cell function and insulin sensitivity on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) remains uncertain. We aimed to investigate the association between β cell dysfunction, insulin resistance, and the composite adverse pregnancy ***: This observational study included 482 women diagnosed with GDM during pregnancy. Quantitative metrics on β cell function and insulin sensitivity during pregnancy were calculated using traditional equations. The association of β cell dysfunction and insulin resistance with the risk of the composite adverse pregnancy outcomes was investigated using multivariable-adjusted logistic regression ***: Multivariable-adjusted odds ratios (ORs) of adverse pregnancy outcomes across quartiles of homeostatic model assessment for insulin resistance (HOMA-IR) were 1.00, 0.95, 1.34, and 2.25, respectively (P for trend = 0.011). When HOMA-IR was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 1.34 (95% confidence interval 1.16-1.56) for each 1-unit increase in HOMA-IR. Multivariable-adjusted ORs of adverse pregnancy outcomes across quartiles of homeostatic model assessment for β cell function (HOMA-β) were 1.00, 0.51, 0.60, and 0.53, respectively (P for trend = 0.068). When HOMA-β was considered as a continuous variable, the multivariable-adjusted OR of adverse pregnancy outcomes was 0.57 (95% CI 0.24-0.90) for each 1-unit increase in HOMA-β. However, other quantitative metrics were not associated with the composite adverse pregnancy ***: We demonstrated a significant association of β cell function and insulin sensitivity with the risk of adverse pregnancy outcomes. We have provided additional evidence on the early identification of adverse pregnancy outcomes besides the glycemic values.

关键词： βcell function Insulin sensitivity Adverse pregnancy outcomes

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如何打造中国的CFO

职业时空 2005年第20期1卷 8-9页

作者：陈亚娟苏志浩廊坊师范学院

CFO(Chief Financial officer)意指公司首席财务执行官,是现代公司中最重要、最有价值的顶尖管理职位之一,是掌握着企业的神经系统(财务信息)和血液系统(现金资源)的灵魂人物,所以中国企业要想站在国际舞台上和世界顶尖级的企业竞争,就... 详细信息

CFO(Chief Financial officer)意指公司首席财务执行官,是现代公司中最重要、最有价值的顶尖管理职位之一,是掌握着企业的神经系统(财务信息)和血液系统(现金资源)的灵魂人物,所以中国企业要想站在国际舞台上和世界顶尖级的企业竞争,就必须建立自己强大的CFO队伍.随着中国市场经济的发展及经济全球一体化的推进,财务管理在企业集团管理中发挥着越来越重要的作用,中国CFO群体也随着形势的发展而出现、成长和壮大,面临新的机遇和挑战,中国CFO正在日渐崛起,但发展之路任重而道远.

关键词：中国 CFO 首席财务执行官企业管理市场经济财务管理

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一种考虑对齐不一致的短语翻译概率估计方法

中文信息学报 2011年第3期25卷 118-122页

作者：苏劲松刘群吕雅娟中国科学院计算技术研究所智能信息处理重点实验室北京100190 中国科学院研究生院北京100190

在统计机器翻译中,短语翻译概率特征对最终的翻译结果有着重大的影响。传统的估计方法只考虑了双语短语同时出现,满足对齐一致性的情况,而没有对其他情况进行统计,因而短语翻译概率的估计不够准确。该文中,我们修改了传统的短语概率计... 详细信息

在统计机器翻译中,短语翻译概率特征对最终的翻译结果有着重大的影响。传统的估计方法只考虑了双语短语同时出现,满足对齐一致性的情况,而没有对其他情况进行统计,因而短语翻译概率的估计不够准确。该文中,我们修改了传统的短语概率计算公式,在估计概率的过程中充分地考虑短语的各种出现情况。多个测试集上的实验结果证明了我们方法的有效性。

关键词：统计机器翻译对齐不一致短语翻译概率

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资源有限人工免疫系统的改进

计算机工程与应用 2011年第26期47卷 46-48,128页

作者：刘韬苏品刚刘亚娟江苏省现代企业信息化应用支撑软件工程技术开发研究中心江苏苏州215104 苏州职业大学江苏苏州215104 黑龙江工程学院机电工程系哈尔滨150050

分析了资源有限人工免疫系统的不足,提出了改进的资源有限人工免疫系统。改进的系统在演化过程中每一步都重新计算适应度阈值,更实际地反映了当时的抗体亲和度的状态;选取的刺激度函数充分体现了抗体距离较小时刺激值所应具有的优势,对... 详细信息

分析了资源有限人工免疫系统的不足,提出了改进的资源有限人工免疫系统。改进的系统在演化过程中每一步都重新计算适应度阈值,更实际地反映了当时的抗体亲和度的状态;选取的刺激度函数充分体现了抗体距离较小时刺激值所应具有的优势,对较小的距离又不过分敏感;同时选择可以使系统更合理地分配抗体的资源分配函数。仿真实验结果说明,改进的人工免疫系统在网络的进化速度、结构等方面获得了较优良的性能。

关键词：资源有限人工免疫系统适应度阈值刺激度函数资源分配函数

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陶瓷材料闪烧机理研究进展

硅酸盐学报 2020年第12期48卷 1872-1879页

作者：苏兴华吴亚娟安盖焦智华付梦莹长安大学材料科学与工程学院西安710061

闪烧是近年来发展出的一种新型的电场/电流辅助烧结技术,能在低温下极短时间内实现陶瓷材料的烧结致密化。研究者采用闪烧技术制备了多个体系的陶瓷材料,但是关于其闪烧机理并没有达成共识。本工作总结了目前已经提出的几种主要闪烧机理... 详细信息

闪烧是近年来发展出的一种新型的电场/电流辅助烧结技术,能在低温下极短时间内实现陶瓷材料的烧结致密化。研究者采用闪烧技术制备了多个体系的陶瓷材料,但是关于其闪烧机理并没有达成共识。本工作总结了目前已经提出的几种主要闪烧机理,包括Joule热、缺陷生成、电化学反应等,并结合已有的研究结果,探讨了各种机理的优势及存在的问题,最后提出了闪烧机理的研究方向。

关键词：闪烧机理 Joule热缺陷生成电化学反应

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拉萨光学湍流探空测量与模式分析

光学学报 2020年第6期40卷 12-19页

作者：韩亚娟吴晓庆罗涛苏昶东青春吴骕杨期科张坤中国科学院安徽光学精密机械研究所中国科学院大气光学重点实验室安徽合肥230031 中国科学技术大学研究生院科学岛分院安徽合肥230031

利用自行研制的湍流气象探空仪,对西藏拉萨的温度、风速、风向等常规气象参数廓线和C2n廓线进行探测。分析了湍流强度和常规气象参数随高度的变化趋势。比较了夜晚和早晨的湍流特征,发现8~15km处两者均出现强湍流层,且8km以上早晨的湍... 详细信息

利用自行研制的湍流气象探空仪,对西藏拉萨的温度、风速、风向等常规气象参数廓线和C2n廓线进行探测。分析了湍流强度和常规气象参数随高度的变化趋势。比较了夜晚和早晨的湍流特征,发现8~15km处两者均出现强湍流层,且8km以上早晨的湍流强度大于夜晚的湍流强度。同时基于Hufnagel-Vally 5/7模式,利用探空数据拟合得到符合拉萨湍流特征的拉萨C2n经验模式。对此经验模式进行统计分析,结果进一步证明拉萨C2n经验模式能有效估算拉萨的湍流强度。最后,将拉萨与高美谷的探空数据进行对比分析,发现拉萨的风速较小对天文观测有利,但湍流强度较强对天文观测有一定影响。该研究为后续拉萨湍流廓线和天文台选址的研究提供了参考,并为光电工程的应用提供了技术支持。

关键词：大气光学光学湍流湍流廓线探空测量拉萨