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circ2CBA: prediction of circRNA-RBP binding sites combining deep learning and attention mechanism

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Frontiers of Computer Science 2023年第5期17卷 217-225页

作者： yajing guo Xiujuan LEI Lian LIU Yi PAN School of Computer Science Shaanxi Normal UniversityXi’an 710119China Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Circular RNAs(circRNAs)are RNAs with closed circular structure involved in many biological processes by key interactions with RNA binding proteins(RBPs).Existing methods for predicting these interactions have limitations in feature *** view of this,we propose a method named circ2CBA,which uses only sequence information of circRNAs to predict circRNA-RBP binding *** have constructed a data set which includes eight ***,circ2CBA encodes circRNA sequences using the one-hot ***,a two-layer convolutional neural network(CNN)is used to initially extract the *** CNN,circ2CBA uses a layer of bidirectional long and short-term memory network(BiLSTM)and the self-attention mechanism to learn the *** AUC value of circ2CBA reaches *** of circ2CBA with other three methods on our data set and an ablation experiment confirm that circ2CBA is an effective method to predict the binding sites between circRNAs and RBPs.

关键词： circRNAs RBPs CNN BiLSTM self-attention mechanism

Evaluating damage in optical elements using an amplified spontaneous emission beam

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High Power Laser Science and Engineering 2015年第4期3卷 25-30页

作者： Qiong Zhou Jiangfeng Wang yajing guo Dean Liu Jianqiang Zhu National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences University of Chinese Academy of Science

A method to evaluate damage in optical elements with the near field of an amplified spontaneous emission(ASE) beam has been developed. Local peak intensities are generally distributed randomly in the near field of a laser beam. The partial coherence of the ASE source results in a very smooth beam profile. The coherence time of ASE is much less than the pulse width. Small-scale intensity modulations can be smoothed out rapidly within the time of a pulse *** the experiments, ASE is generated from a multifunctional high-performance Nd:glass system, with a pulse duration of 3 ns, a spectral width(full width at half maximum, FWHM) of 1 nm and an adjustable energy range from 1 to 10 *** damage thresholds of samples induced by ASE are two to three times higher than those induced by a laser with the same size of test spot. Furthermore, the ASE beam has great potential for the detection of defects over a large area and the conditioning of optical elements.

关键词： amplified spontaneous emission damage threshold test partially coherence uniform intensity distribution

Laser-induced damage tests based on a marker-based watershed algorithm with gray control

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High Power Laser Science and Engineering 2014年第3期2卷 31-36页

作者： yajing guo Shunxing Tang Xiuqing Jiang Yujie Peng Baoqiang Zhu Zunqi Lin Joint Laboratory on High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences University of Chinese Academy of Sciences

An effective damage test method based on a marker-based watershed algorithm with gray control(MWGC) is proposed to study the properties of damage induced by near-field laser irradiation for large-aperture laser *** tests were performed on fused silica samples and information on the size of damage sites was obtained by this new algorithm,which can effectively suppress the issue of over-segmentation of images resulting from non-uniform illumination in darkfield *** analysis and results show that the lateral damage growth on the exit surface is exponential,and the number of damage sites decreases sharply with damage site size in the damage site distribution *** average damage growth coefficients fitted according to the experimental results for Corning-7980 and Heraeus-Suprasil312 samples at 351 nm are 1.10 ± 0.31 and 0.60 ± 0.09,respectively.

关键词： damage growth laser-induced damage marker-based watershed algorithm with gray control

主权评级负向调整对股票市场影响的实证分析——基于发达经济体和新兴经济体的比较分析

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征信 2013年第3期31卷 71-76页

作者：郭亚静中央财经大学金融学院北京100081 新疆财经大学金融学院新疆乌鲁木齐830026

在不同时期主权评级下调对股票市场的影响存在差异表现,市场受影响的波动幅度,随经济发展逐渐减弱,整体而言股票市场对主权评级下调的反应是超短期的,基本都在2天内迅速消化该影响信息。"顺周期"评级调整行为,会强化后期的信息预期;"逆... 详细信息

在不同时期主权评级下调对股票市场的影响存在差异表现,市场受影响的波动幅度,随经济发展逐渐减弱,整体而言股票市场对主权评级下调的反应是超短期的,基本都在2天内迅速消化该影响信息。"顺周期"评级调整行为,会强化后期的信息预期;"逆周期"评级调整行为,则导致后期滞后反应。

关键词：主权评级股票市场波动差异

密度泛函理论研究Al_(24)N_(24)几何结构、芳香性和光谱性质

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重庆大学学报 2024年第11期47卷 112-119页

作者：郭雅晶李秀燕太原师范学院物理系山西晋中030619 太原理工大学物理学院太原030024

通过密度泛函理论(density functional theory,DFT)结合B3LYP/6-31g(d)基组对Al_(24)N_(24)团簇的几何电子结构进行全面优化和物理化学性质模拟分析。研究结果表明,Al_(24)N_(24)团簇的4种基态稳定结构点群依次为S_(4)、C_(2)、S_(8)、O;4种Al_(24)N_(24)团簇气相下既非p型输运材料,亦非n型输运材料,也不存在双极性传递性质,但是这些团簇有利于空穴传输;在优化好的Al_(24)N_(24)团簇气相结构下,研究了它们的核独立化学位移值(nuclear independent chemical shift value,NICS),由NICS得出4种同分异构体均具有芳香性;这4种同分异构体的红外和拉曼分子振动谱表明,各分子内部振动模式对红外和拉曼振动峰值的分布具有重要的影响,随着体系内八元环数量的增多,红外谱出现轻微蓝移现象,拉曼谱中未观测到此现象;特别是对称性为O的Al_(24)N_(24)分子,内部含有6个八元环,这也导致它的振动谱不同于其他三者。

关键词：芳香性光谱性质密度泛函理论

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Effects of acupuncture and moxibustion on chromatin remodeling-related enzymes in the colon tissue of rats with Crohn disease

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Journal of Acupuncture and Tuina Science 2024年第5期22卷 353-362页

作者： LI Yanting guo yajing ZHAO Jimeng SUN Yi guo Sen SHI Yin Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200137China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China

Objective:To investigate the regulatory effects of acupuncture and moxibustion on chromatin remodeling complex core catalytic subunit of Brahma-related gene 1(Brg1),histone deacetylase(HDAC)3,HDAC9,and males absent on the first(MOF)in the colon tissue of rats with Crohn disease(CD).Methods:Using the random number table method,60 male Sprague-Dawley rats were divided into 5 groups,including a normal group,a model group,an acupuncture group,a medicinal cake-insulated moxibustion group,and an acupuncture-moxibustion group,with 12 rats in each *** rat models were prepared using 2,4,6-trinitrobenzene sulfonic acid(TNBS)in all groups except the normal *** normal and model groups received no *** the acupuncture group,rats were intervened with acupuncture at bilateral Zusanli(ST36)and Shangjuxu(ST37),20 min/session,once a *** medicinal cake-insulated moxibustion group received medicinal cake-insulated moxibustion at Qihai(CV6)and bilateral Tianshu(ST25)with 2 cones per point per session,once a *** acupuncture-moxibustion group received both acupuncture and moxibustion interventions *** intervention was performed for 10 consecutive *** included general condition,disease activity,macroscopic damage,and pathological changes in the rat’s colon *** fluorescence quantitative polymerase chain reaction was used to measure the mRNA expression of chromatin remodeling-related enzymes Brg1,HDAC3,and HDAC9,while Western blotting detected the protein expression of Brg1,HDAC3,HDAC9,and MOF in rat’s colon ***:The model group showed significantly increased diarrhea score,occult blood score,macroscopic damage score of colon tissue,and colon macroscopic damage index(CMDI)score,as well as elevated mRNA expression levels of HDAC3 and HDAC9,protein expression levels of HDAC3,HDAC9,and MOF,and decreased mRNA and protein expression levels of Brg1 compared to the normal group(P<0.01).In contrast,compared to the mod

关键词： Acupuncture Therapy Moxibustion Therapy Medicinal Cake-insulated Moxibustion Crohn Disease Inflammatory Bowel Diseases Chromatin Remodeling Rats

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基于双焦透镜的双踪远场自动准直

中国激光 2024年第6期51卷 94-99页

作者：宗楠唐顺兴郭亚晶中国科学院上海光学精密机械研究所高功率激光物理联合实验室上海201800 上海交通大学 IFSA协同创新中心上海200240

在光束传输控制中,反馈系统需要具有较高的角度分辨率,以达到自动准直的精度要求,此外还需要具备一定的角视场,以降低对初始安装和调试的精度要求。提出了一种基于双焦透镜的双踪远场自动准直方案,在同一光学系统中实现了高精度和大视... 详细信息

在光束传输控制中,反馈系统需要具有较高的角度分辨率,以达到自动准直的精度要求,此外还需要具备一定的角视场,以降低对初始安装和调试的精度要求。提出了一种基于双焦透镜的双踪远场自动准直方案,在同一光学系统中实现了高精度和大视场两种角度分辨率的远场图像反馈系统。基于矩阵光学理论对远场图像反馈系统进行数值分析,给出了双焦透镜的等效传输矩阵,并分析了双焦透镜的角度分辨率和视场特性。设计并开展实验对基于双焦透镜的双踪远场自动准直方案进行了性能演示,实验结果表明,高精度下的角度分辨率约为大视场下角度分辨率的6.9倍,与设计值(6.6倍)基本相符。

关键词：光学设计高功率激光自动准直远场成像矩阵光学

农业无人机智能机器学习系统——基于人工智能和深度学习

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农机化研究 2023年第3期45卷 237-240,259页

作者：郭亚静洛阳职业技术学院河南洛阳471003

为了提高农业无人机作业时的自主学习能力,基于人工智能技术将深度学习算法应用到了无人机机器学习系统的设计上,并提出了基于神经网络深度学习的农业无人机智能识别系统,有效提高了无人机的自动学习和识别能力。以采摘机器人的设计为例... 详细信息

为了提高农业无人机作业时的自主学习能力,基于人工智能技术将深度学习算法应用到了无人机机器学习系统的设计上,并提出了基于神经网络深度学习的农业无人机智能识别系统,有效提高了无人机的自动学习和识别能力。以采摘机器人的设计为例,对智能机器学习系统的可靠性进行了验证,并对不同学习算法果实识别的准确性进行了测试。测试结果表明:基于神经网络的深度学习算法在果实的成熟度识别方面具有明显的优势,从而验证了算法的可靠性。

关键词：农业无人机人工智能深度学习机器学习神经网络

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基于图像处理与计算机辅助的物理机械播种装置研究

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农机化研究 2019年第10期41卷 219-223页

作者：郭亚静洛阳职业技术学院河南洛阳471003

采用计算机辅助中的虚拟设计技术,设计了一套物理机械播种装置。为了实现对该装置性能的检测,基于图像处理技术,采用大津法、中值法和二值法,设计和开发了一种播种装置性能参数检测方法,能够在条播、穴播和精密播种3种方式下实现对机械... 详细信息

采用计算机辅助中的虚拟设计技术,设计了一套物理机械播种装置。为了实现对该装置性能的检测,基于图像处理技术,采用大津法、中值法和二值法,设计和开发了一种播种装置性能参数检测方法,能够在条播、穴播和精密播种3种方式下实现对机械播种装置播种量、重播量和播种率的准确计算。

关键词：机械播种图像处理计算机辅助大津法中值法二值法