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Arterial stiffness and stroke:de-stiffening strategy,a therapeutic target for stroke

Stroke & Vascular Neurology 2017年第2期2卷 65-72页

作者： yajing chen Fanxia Shen Jianrong Liu Guo-Yuan Yang Department of Neurology Ruijin Hospital and Ruijin Hospital NorthShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Neuroscience and Neuroengineering Center Med-X Research Institute and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina

Stroke is the second leading cause of mortality and morbidity worldwide.Early intervention is of great importance in reducing disease burden.Since the conventional risk factors cannot fully account for the pathogenesis of stroke,it is extremely important to detect useful biomarkers of the vascular disorder for appropriate intervention.Arterial stiffness,a newly recognised reliable feature of arterial structure and function,is demonstrated to be associated with stroke onset and serve as an independent predictor of stroke incidence and poststroke functional outcomes.In this review article,different measurements of arterial stiffness,especially pressure wave velocity,were discussed.We explained the association between arterial stiffness and stroke occurrence by discussing the secondary haemodynamic changes.We reviewed clinical data that support the prediction role of arterial stiffness on stroke.Despite the lack of long-term randomised double-blind controlled therapeutic trials,it is high potential to reduce stroke prevalence through a significant reduction of arterial stiffness(which is called de-stiffening therapy).Pharmacological interventions or lifestyle modification that can influence blood pressure,arterial function or structure in either the short or long term are promising de-stiffening therapies.Here,we summarised different de-stiffening strategies including antihypertension drugs,antihyperlipidaemic agents,chemicals that target arterial remodelling and exercise training.Large and well-designed clinical trials on de-stiffening strategy are needed to testify the prevention effect for stroke.Novel techniques such as modern microscopic imaging and reliable animal models would facilitate the mechanistic analyses in pathophysiology,pharmacology and therapeutics.

关键词： therapeutic prevention stiffness

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Roles of the fibroblast growth factor signal transduction system in tissue injury repair

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Burns & Trauma 2022年第1期10卷 618-638页

作者： Keyang chen Zhiheng Rao Siyang Dong yajing chen Xulan Wang Yongde Luo Fanghua Gong Xiaokun Li School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of breast surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of neurology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Research Units of Clinical Translation of Cell Growth Factors and Diseases Research Chinese Academy of Medical ScienceWenzhou Medical UniversityWenzhouZhejiang 325000China

Following injury,tissue autonomously initiates a complex repair process,resulting in either partial recovery or regeneration of tissue architecture and function in most organisms.Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors,cytokines and other signaling molecules under normal conditions.However,under chronic traumatic or pathological conditions,the reparative or regenerative process of most tissues in different organs can lose control to different extents,leading to random,incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function,accompanied by the development of fibrosis,scarring or even pathogenesis that could cause organ failure and death of the organism.Ample evidence suggests that the various combinatorial fibroblast growth factor(FGF)and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis.In this review,we attempt to provide a brief update on our current understanding of the roles,the underlying mechanisms and clinical application of FGFs in tissue injury repair.

关键词： Tissue injury Repair Regeneration Cell growth Fibroblast growth factor Signal transduction

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自我表达与他者叙述——以关紫兰自画像及陈抱一、中川纪元《关紫兰像》为中心的中日美术交流

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美术学报 2024年第1期 78-86页

作者：陈雅婧中央美术学院湖南科技大学

关紫兰是近代中国最早一批现代主义女性艺术家,毕业于中华艺术大学、日本文化学院,师从陈抱一、中川纪元等人。在关紫兰的画作中自画像占比非常大,皆展露出率真而肆意的自我表达;同时陈抱一和中川纪元也为其画过多幅肖像,是以男性师友... 详细信息

关紫兰是近代中国最早一批现代主义女性艺术家,毕业于中华艺术大学、日本文化学院,师从陈抱一、中川纪元等人。在关紫兰的画作中自画像占比非常大,皆展露出率真而肆意的自我表达;同时陈抱一和中川纪元也为其画过多幅肖像,是以男性师友眼光进行的他者叙述。围绕关紫兰自画像,陈抱一、中川纪元《关紫兰像》的中日美术交流,折射出西方现代主义艺术从日本进入中国的具体路径,以及近代中国艺术家对日式西洋画的接受、探索与创新。

关键词：关紫兰陈抱一中川纪元自画像中日美术交流

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穴位贴敷配合磁电联合治疗慢传输型便秘伴焦虑30例疗效观察

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中国民族民间医药 2024年第9期33卷 107-112页

作者：陈雅静唐昆安徽中医药大学安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

目的:观察穴位贴敷配合磁电联合治疗慢传输型便秘伴焦虑的临床疗效。方法:将60例慢传输型便秘患者按照随机分组的原则,分为对照组和观察组,对照组予单纯穴位贴敷治疗;观察组予穴位贴敷配合磁电联合治疗。每组治疗2个疗程。观察两组的便... 详细信息

目的:观察穴位贴敷配合磁电联合治疗慢传输型便秘伴焦虑的临床疗效。方法:将60例慢传输型便秘患者按照随机分组的原则,分为对照组和观察组,对照组予单纯穴位贴敷治疗;观察组予穴位贴敷配合磁电联合治疗。每组治疗2个疗程。观察两组的便秘症状评分、SAS评分、以及肠道菌群(大肠杆菌、乳酸杆菌、双岐杆菌)治疗前后的变化。结果:治疗前两组便秘症状评分、SAS评分、肠道菌群计数差异无统计学意义(P>0.05);治疗后,两组便秘症状评分、SAS评分、大肠杆菌计数均较前下降,观察组效果更显著(P<0.05);乳酸杆菌、双歧杆菌计数较前升高,观察组效果优于对照组(P<0.05)。结论:穴位贴敷配合磁电联合治疗慢传输型便秘有效,且可缓解患者焦虑状态,值得临床推广。

关键词：穴位贴敷磁电联合慢传输型便秘焦虑肠道菌群

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陕西医学杂志 2024年第3期53卷 357-360页

作者：冯克娜张淼陈雅静保定市第二医院内分泌科河北保定071000

目的:探讨2型糖尿病(T2DM)患者血清C1q肿瘤坏死因子相关蛋白5(CTRP5)、脂联素(APN)水平与颈动脉粥样硬化(CAS)的关系。方法:选择T2DM患者96例为观察组,选择体检健康者108例为对照组。采用酶联免疫吸附(ELISA)法检测血清CTRP5、APN水平... 详细信息

目的:探讨2型糖尿病(T2DM)患者血清C1q肿瘤坏死因子相关蛋白5(CTRP5)、脂联素(APN)水平与颈动脉粥样硬化(CAS)的关系。方法:选择T2DM患者96例为观察组,选择体检健康者108例为对照组。采用酶联免疫吸附(ELISA)法检测血清CTRP5、APN水平。根据超声检查将T2DM患者分为CAS组和无CAS组,并比较两组一般资料及血清生化指标。分析T2DM患者发生CAS的影响因素,并进行相关性分析。结果:观察组血清CTRP5水平高于对照组,APN水平低于对照组(均P<0.05)。T2DM患者中,40例出现CAS,56例无CAS。CAS组患者年龄、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、CTRP5水平较无CAS组升高,APN水平较无CAS组下降(均P<0.05)。HbA1c、TG、LDL-C、CTRP5为CAS发生的独立危险因素,APN是CAS的独立保护因素(均P<0.05)。血清CTRP5与HbA1c、TG、LDL-C水平呈正相关,血清APN与HbA1c、TG、LDL-C水平呈负相关(均P<0.05)。结论:T2DM患者发生CAS后CTRP5水平升高,APN水平下降,CTRP5为CAS发生的独立危险因素,APN为CAS发生的独立保护因素。

关键词： 2型糖尿病 C1q肿瘤坏死因子相关蛋白5 脂联素颈动脉粥样硬化危险因素关系

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Integrative regulatory mechanisms of stomatal movements under changing climate

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Journal of Integrative Plant Biology 2024年第3期66卷 368-393页

作者： Jingbo Zhang Xuexue chen yajing Song Zhizhong Gong State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesNational Academy of Agriculture Green DevelopmentChina Agricultural UniversityBeijing 100193China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100094China Institute of Life Science and Green Development School of Life SciencesHebei UniversityBaoding 071001China

Global climate change-caused drought stress,high temperatures and other extreme weather profoundly impact plant growth and development,restricting sustainable crop production.To cope with various environmental stimuli,plants can optimize the opening and closing of stomata to balance CO_(2)uptake for photosynthesis and water loss from leaves.Guard cells perceive and integrate various signals to adjust stomatal pores through turgor pressure regulation.Molecular mechanisms and signaling networks underlying the stomatal movements in response to environmental stresses have been extensively studied and elucidated.This review focuses on the molecular mechanisms of stomatal movements mediated by abscisic acid,light,CO_(2),reactive oxygen species,pathogens,temperature,and other phytohormones.We discussed the significance of elucidating the integrative mechanisms that regulate stomatal movements in helping design smart crops with enhanced water use efficiency and resilience in a climate-changing world.

关键词： environmental stress guard cell plant regulatory mechanisms stomatal movements

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高层次科技人才计划对人才引培影响的调查研究

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科技广场 2024年第1期 13-18页

作者：贾清萍黄星月陈雅静南昌大学公共政策与管理学院江西南昌330031

实施高层次科技人才计划是实现高端人才引培量质齐升和科技强省的重要手段。本文通过对中部A省科技创新高层次人才的调查,发现高层次科技人才计划对入选人才的科技创新能力、职务职称晋升、个人地位和成长空间等都有显著影响。但高层次... 详细信息

实施高层次科技人才计划是实现高端人才引培量质齐升和科技强省的重要手段。本文通过对中部A省科技创新高层次人才的调查,发现高层次科技人才计划对入选人才的科技创新能力、职务职称晋升、个人地位和成长空间等都有显著影响。但高层次科技人才计划实施中也存在不足,应从以下方面着手:优化人才遴选程序、放宽人才遴选限制条件;构建科学精准的人才评价机制;构建彰显价值的人才激励制度;营造一流的人才生态环境。

关键词：人才计划科技创新高层次人才人才引培

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多维驱动融合冰山理论干预联合Snyder希望理论在再生障碍性贫血患者中的应用效果

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中国医药导报 2024年第3期21卷 171-174页

作者：苏婷李金芳陈雅静孙蓉江苏省淮安市第一人民医院治疗室江苏淮安223300 江苏省淮安市第一人民医院护理部江苏淮安223300

目的探讨多维驱动融合冰山理论干预联合Snyder希望理论在再生障碍性贫血患者生理及心理的影响。方法以便利抽样法对江苏省淮安市第一人民医院血液科2020年4月至2022年4月收治的100例再生障碍性贫血患者为研究对象,以随机数字表法将其... 详细信息

目的探讨多维驱动融合冰山理论干预联合Snyder希望理论在再生障碍性贫血患者生理及心理的影响。方法以便利抽样法对江苏省淮安市第一人民医院血液科2020年4月至2022年4月收治的100例再生障碍性贫血患者为研究对象,以随机数字表法将其分为对照组与观察组,各50例。对照组予以Snyder希望理论护理,观察组在对照组的基础上予以多维驱动融合冰山理论干预,比较两组干预前后凝血功能、生活质量情况。结果干预后,两组癌症患者生命质量测定量表共性模块评分高于干预前,且观察组高于对照组(P<0.05);两组Herth希望指数高于干预前,且观察组高于对照组(P<0.05)。结论多维驱动融合冰山理论干预联合Snyder希望理论能够有效改善再生障碍性贫血患者心理状态,进而提高生活质量。

关键词：多维驱动融合冰山理论 Snyder希望理论再生障碍性贫血希望指数生活质量

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Analysis of York Pigs Feeding Behavior Using Stepwise Regression and Principal Component Regression

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Agricultural Biotechnology 2021年第2期10卷 78-83页

作者： Xuelin FU yajing chen Manting WU Junyong HU Wanghong LIU The Breeding Swine Quality Supervision and Testing Center Ministry of Agriculture and Rural Affairs(Wuhan)Wuhan 437770China National Engineering Research Center for Livestock Wuhan 437770China

A statistical analysis was conducted on the feeding behavior of 106 York breeding pigs.Pearson correlation analysis,principal component correlation analysis and multiple stepwise regression equation methods were applied to establish regression equations of the York breeding pigs total feed intake per time and average feed intake per time with corrected fat thickness,feed conversion rate,and corrected daily gain.The results showed that:①there were three peak feed intake periods for the pigs,and the correlation coefficient between the feed intake and the corrected fat thickness of the pigs in the 24 h period was positive or negative,that is,increasing the number of feeding times and the feed intake was not necessarily conducive to the fat thickness accumulation,but the breeding goal of fat thickness could be achieved by controlling the feeding times and feed intake;②the average feed intake of pigs in the 60-90 kg body weight stage was 30%-50%higher than that of the 30-60 kg body weight stage,but the number of feeding times decreased,the peak feeding time was more concentrated,and the feeding duration per time was 3.0 min longer,indicating that as the weight of pigs increased,the feed intake increased significantly;and③the stepwise regression equations and the principal component equations showed that the feeding behavior of York pigs in the 30-90 kg growth stage was not only affected by the feeding time within 24 h,but also by environmental factors such as temperature and humidity.The feeding behavior of York pigs is a complex process of interaction between environmental factors and animal factors.

关键词： Feed intake Corrected daily weight gain Feed conversion ratio Corrected fat thickness Stepwise regression Principal component regression

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Process of Analyzing Pig Inbreeding Coefficient Using SAS Program

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Agricultural Biotechnology 2021年第3期10卷 59-62,86页

作者： Xuelin FU Junyong HU yajing chen Tingting WU Wanghong LIU The Breeding Swine Quality Supervision and Testing Center Ministry of Agriculture(Wuhan)Wuhan 437770China

The paternity index is one of the important parameters which paternity determination depends on.Inbreeding is an indispensable and effective means to improve herds and breeds and breed new strains and breeds.It can fix good traits and improve herd genetic uniformity.The INBREED module of SAS statistical analysis software can be used to calculate the inbreeding coefficients of the offspring and their parents in the pig herd pedigree.In this study,we used actual data as an example to compile and operate an SAS program for calculating the inbreeding coefficients of a pig herd.Compared with the dedicated software for calculating inbreeding coefficients developed in recent years,such as BASIC+database dBASE,Visual Basic+database SQ L Serve method,DFREMLI,MTDF EMLI,VCE,ASREML,DMU,GBS and Herdsman,calculating inbreeding coefficients with SAS programs has the advantages of low cost,simple programming language,and easy operation.For livestock breeders who are not provided with special computing software,the use of SAS to calculate the inbreeding coefficients of pigs is of great significance to planned breed selection and assortative mating.

关键词： Pig herd Inbreeding Coefficient SAS

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