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SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

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Acta Pharmaceutica Sinica B 2021年第1期11卷 89-99页

作者： Yanying Zhou Xiaomei Fan Tingying Jiao Wenzhou Li Panpan Chen Yiming jiang Jiahong Sun Yixin Chen Pan Chen Lihuan Guan yajie Wen Min Huang Huichang Bi School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Baoan Women’s and Children’s Hospital Jinan UniversityShenzhen 518102China Department of Pharmacy the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Acetaminophen(APAP)overdose is the leading cause of drug-induced liver injury,and its prognosis depends on the balance between hepatocyte death and *** 6(SIRT6)has been reported to protect against oxidative stress-associated DNA *** whether SIRT6 regulates APAPinduced hepatotoxicity remains *** this study,the protein expression of nuclear and total SIRT6 was up-regulated in mice liver at 6 and 48 h following APAP treatment,***6 knockdown in AML12 cells aggravated APAP-induced hepatocyte death and oxidative stress,inhibited cell viability and proliferation,and downregulated CCNA1,CCND1 and CKD4 protein ***6 knockdown signifi-cantly prevented APAP-induced NRF2 activation,reduced the transcriptional activities of GSTm andNQO1 and the m RNA levels of Nrf2,Ho-1,Gsta and ***,SIRT6 showed potential protein interaction with NRF2 as evidenced by co-immunoprecipitation(Co-IP)***,the protective effect of P53 against APAP-induced hepatocytes injury was *** Sirt6 m RNA was significantly down-regulated in P53à/àmice.P53 activated the transcriptional activity of SIRT6 and exerted interaction with *** results demonstrate that SIRT6 protects against APAP hepatotoxicity through alleviating oxidative stress and promoting hepatocyte proliferation,and provide new insights in the function of SIRT6 as a crucial docking molecule linking P53 and NRF2.

关键词： Acetaminophen Hepatotoxicity SIRT6 NRF2 P53

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6个甜樱桃品种(系)物候期及花器特征研究

绿色科技 2024年第13期26卷 79-83,89页

作者：张亚杰位杰谢宏江崔龙蒋媛肖欢贾存花姚文英新疆生产建设兵团第二师农业科学研究所新疆铁门关841005

以6个甜樱桃品种(系)为试材,观察物候期和花器结构特征,并采用血球计数器法测定花粉量。结果表明:在满足各品种休眠需冷量的条件下,甜樱桃物候期规律为:芽膨大期到始花期8~10 d,始花期到盛花始期1~3 d,盛花始期到盛花末期结束6~9 d,盛... 详细信息

以6个甜樱桃品种(系)为试材,观察物候期和花器结构特征,并采用血球计数器法测定花粉量。结果表明:在满足各品种休眠需冷量的条件下,甜樱桃物候期规律为:芽膨大期到始花期8~10 d,始花期到盛花始期1~3 d,盛花始期到盛花末期结束6~9 d,盛花末期到末花期2~4 d,物候期会受栽培环境因素影响而上下浮动。‘齐早’‘马什哈德’‘桑提娜’‘波兰8号’‘波兰9号’‘5-S4’这6个甜樱桃品种均为单瓣花,圆形白色花瓣,花瓣5枚、花萼5片、雌蕊1枚、雄蕊26~37枚,花瓣顶端形状微凹,盛开花瓣着生状态分离,花序类型均为伞形花序,花序轴均无,萼片状态均为反折,仅花萼筒形状和萼筒、萼片长度比略有差异;不同品种(系)花序花朵数、单花雄蕊数、花冠直径、花瓣纵横径方面有不同程度的差异,供试品种花序花朵数均在3~5朵花;本研究将甜樱桃品种的单药花粉量分为6类,生产上配置授粉树时可供参考,‘齐早’‘马什哈德’‘波兰8号’的花粉量类型为极多,‘桑提娜’‘波兰9号’‘5-S4’的花粉量类型为多;‘齐早’‘波兰8号’‘5-S4’这3个品种在该地区表现较好,可作为新疆地区温室种植的主推品种。研究为新疆地区设施甜樱桃栽培品种选择与配置提供了参考。

关键词：甜樱桃物候期花器特征花粉量品种

细胞外信号调节激酶1在甲状腺素诱导的母源性甲状腺功能亢进仔鼠心肌中的差异表达

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解剖学杂志 2022年第5期45卷 422-425,490页

作者：李斌陈晶张聿杨静姜雅洁杨浩天奇佳欣刘玥欣马添颖赵孟乙高灏包头医学院基础医学与法医学院包头014040 包头医学院包头014040

目的:研究甲状腺素诱导的母源性甲状腺功能亢进(甲亢)对新生仔鼠心以及心肌肥厚信号通路关键酶表达的影响。方法:建立妊娠合并甲亢模型,取母源性甲亢和对照仔鼠心,进行解剖学检查以及心肌组织光、电镜检查,采用实时定量PCR法检测心房钠... 详细信息

目的:研究甲状腺素诱导的母源性甲状腺功能亢进(甲亢)对新生仔鼠心以及心肌肥厚信号通路关键酶表达的影响。方法:建立妊娠合并甲亢模型,取母源性甲亢和对照仔鼠心,进行解剖学检查以及心肌组织光、电镜检查,采用实时定量PCR法检测心房钠肽(ANP)、脑钠肽(BNP)、β-肌球蛋白重链(β-MHC)、细胞外信号调节激酶1(ERK1)、钙调素依赖型蛋白激酶Ⅱ(CaMK-Ⅱ)、信号传导与转录激活因子(STAT)-3、磷脂酰肌醇3-激酶(PI3K)的表达,采用免疫印迹检测ERK1、CaMK-Ⅱ、STAT-3、PI3K的表达。结果:母源性甲亢仔鼠出现心肌细胞体积增大,线粒体大小不均、形态不规则;实时定量PCR显示母源性甲亢仔鼠心肌中ANP、BNP、β-MHC均高表达,实时定量PCR和Western blot结果显示母源性甲亢仔鼠心肌中ERK1的表达上调,而CaMK-Ⅱ、STAT-3、PI3K与同期对照组的表达无统计学差异。结论:甲状腺素诱导的母源性甲亢对新生仔鼠心肌组织有一定的影响,并引起了ERK1的差异表达。

关键词：母源性甲状腺功能亢进仔鼠心细胞外信号调节激酶1

Polylysine-decorated macroporous microcarriers laden with adipose-derived stem cells promote nerve regeneration in vivo

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Bioactive Materials 2021年第11期6卷 3987-3998页

作者： Yi Sun Xiaoqi Chi Haoye Meng Mengjiao Ma Jing Wang Zhaoxuan Feng Qi Quan Guodong Liu Yansen Wang yajie Xie Yudong Zheng jiang Peng School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083PR China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Lab of Musculoskeletal Trauma&War InjuriesPLANo.28 Fuxing RoadBeijing100853PR China Qingdao National Laboratory for Marine Science and Technology Qingdao266237PR China Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu Province226007PR China

Cell transplantation is an effective strategy to improve the repair effect of nerve guide conduits(NGCs).However,problems such as low loading efficiency and cell anoikis undermine the *** are efficient 3D cell culture scaffolds,which can also prevent cell anoikis by providing substrate for adhesion during ***,we demonstrate for the first time microcarrier-based cell transplantation in peripheral nerve *** first prepared macroporous chitosan microcarriers(CSMCs)by the emulsion-phase separation method,and then decorated the CSMCs with polylysine(pl-CSMCs)to improve cell *** then loaded the pl-CSMCs with adipose-derived stem cells(ADSCs)and injected them into electrospun polycaprolactone/chitosan NGCs to repair rat sciatic nerve *** ADSCs-laden pl-CSMCs effectively improved nerve regeneration as demonstrated by evaluation of histology,motor function recovery,electrophysiology,and gastrocnemius *** efficient cell transplantation,convenient operation,and the multiple merits of ADSCs,the ADSCs-laden pl-CSMCs hold good potential in peripheral nerve repair.

关键词： Chitosan microcarriers Polylysine Adipose-derived stem cells Peripheral nerve repair Cell transplantation

The characteristic properties of PEDOT nano-particle based on reversed micelle method

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Science China(Technological Sciences) 2010年第9期53卷 2355-2362页

作者： ZHENG HuaJing,jiang YaDong,XU JianHua & YANG yajie State Key Laboratory of Electronic Thin Films & Integrated Devices,School of Optoelectronic Information,University of Electronic Science and Technology of China,Chengdu 610054,China State Key Laboratory of Electronic Thin Films & Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu China

Based on the study of a new type of conducting polymer poly (3,4-ethylenedioxythiophene) (PEDOT),this paper focuses on the preparation and the materials properties of PEDOT nanoparticles made by reversed micelle *** on optical,electrical and the thermal stability of PEDOT nanoparticles were carried *** main results were as follows: The small-sized PEDOT nanoparticles were prepared by different methods,such as ultraviolet/visible (UV-Vis) spectroscopy,fourier-transform infrared (FT-IR) spectrum,scanning electron microscopy (SEM) and so *** Bragg peaks of nanoparticles at 6.7°,12.7°,25° were observed by XRD and the good orientation of molecular chain was attributed to the effective doping of toluene-p-sulfonic acid,which also resulted in an enhancement of thermal stability of nanoparticles compared with the conventional ***,the gas sensitivity of nanoparticles deposited on quartz crystal microbalance (QCM) was studied and the nanopartices deposited device exhibited excellent sensitivity to HCl gas at low *** sensitivity of the nanoparticles by the reverse micelle was better than that of the common PEDOT particles.

关键词： poly (3 4-ethylenedioxythiophene) conducting polymer reversed micelle n-particle photoelectric properties thermal stability

In-situ artificial retina with all-in-one reconfigurable photomemristor networks

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npj Flexible Electronics 2023年第1期7卷 265-273页

作者： Yichen Cai Yizhou jiang Chenxu Sheng Zhiyong Wu Luqiu Chen Bobo Tian Chungang Duan Shisheng Xiong Yiqiang Zhan Chunxiao Cong Zhi-Jun Qiu yajie Qin Ran Liu Laigui Hu School of Information Science and Technology Fudan UniversityShanghai 200433China Key Laboratory of Polar Materials and Devices(MOE) Department of ElectronicsEast China Normal UniversityShanghai 200241China Yiwu Research Institute of Fudan University Yiwu CityZhejiang 322000China

Despite that in-sensor processing has been proposed to remove the latency and energy consumption during the inevitable data transfer between spatial-separated sensors,memories and processors in traditional computer vision,its hardware implementation for artificial neural networks(ANNs)with all-in-one device arrays remains a challenge,especially for organic-based *** the advantages of biocompatibility,low cost,easy fabrication and flexibility,here we implement a self-powered in-sensor ANN using molecular ferroelectric(MF)-based photomemristor *** ferroelectric depolarization was intentionally introduced into the ANN,which enables reconfigurable conductance and *** photoresponsivity as synaptic weight,the MFbased in-sensor ANN can operate analog convolutional computation,and successfully conduct perception and recognition of white-light letter images in experiments,with low processing energy *** Chinese digits are also recognized and regressed by a large-scale array,demonstrating its scalability and potential for low-power processing and the applications in MF-based in-situ artificial retina.

关键词： artificial networks ferroelectric

Ramulus Cinnamomi Intelligence Quality Assessment Based on Knowledge Reduction

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Ramulus Cinnamomi Intelligence Quality Assessment Based on K...

补中益气汤改善CPZ诱导的脱髓鞘小鼠神经行为缺陷及促进髓鞘再生

2010 3rd International Conference on Computer and Electrical Engineering(ICCEE 2010)

作者： Jianyang Lin Mingyan jiang yajie Xu Zhoumi Kan Department of Pharmacy The First Hospital of China Medical University

According to the traditional morphological classification divide the quality of traditional Chinese medicine Ramulus Cinnamomi into first grade and second grade. Disperse the chromatogram data Ramulus Cinnamomi obtained by criterion inspect and make knowledge reduction. Then it will get the largest liner irrespective vector group. It will get every clustering centre data of Ramulus Cinnamomi with adaptive weight PSO and POWELL optimization. Make the criterion data of Ramulus Cinnamomi as Weibull distribution and make the sample as Normal distribution to calculate similar and ensure the finial similar with similarity ratio. It used lobato integral and Hermite interpolation. This investigation makes good evaluation to the Ramulus Cinnamomi in Guangdong Guangxi Yunnan and Vietnam and high delicacy and anti-jamming.

关键词： Quality Assessment Distributed Clustering Ramulus Cinnamomi Knowledge Reduction

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山西中医药大学学报 2024年第8期25卷 880-886页

作者：杨琬芳刘健梁亚杰陈莹陶悦郭羽李保珍姜维佳杨智超王青马存根山西中医药大学基础医学院山西晋中030619

目的:探究补中益气汤(BYD)对双环己酮草酰二腙(CPZ)诱导的脱髓鞘小鼠行为缺陷的改善作用及促进髓鞘再生的机制。方法:30只C57BL/6雄性小鼠随机分为对照组、模型组和BYD组,每组10只。对照组正常饲养,模型组和BYD组0.2%CPZ喂饲;第29日起,... 详细信息

目的:探究补中益气汤(BYD)对双环己酮草酰二腙(CPZ)诱导的脱髓鞘小鼠行为缺陷的改善作用及促进髓鞘再生的机制。方法:30只C57BL/6雄性小鼠随机分为对照组、模型组和BYD组,每组10只。对照组正常饲养,模型组和BYD组0.2%CPZ喂饲;第29日起,BYD组灌胃BYD,30 g/kg,2次/d,对照组和模型组灌胃等量生理盐水。第42日,各组进行旷场和高架十字迷宫试验检测行为学变化,取脑组织切片行TrueGold染色及MBP和GFAP免疫荧光染色,观察海马胼胝体髓鞘脱失情况;EILSA法检测小鼠脑组织中炎症相关细胞因子IL-6、IL-10、IL-1β和TNF-α表达水平。结果:与模型组比较,BYD组明显改善小鼠在迷宫和旷场试验中的运动活性及胼胝体髓鞘脱失,减少星形胶质细胞损伤,降低促炎细胞因子IL-6和IL-1β表达,提高抑炎细胞因子IL-10表达,差异均有统计学意义(P<0.05,P<0.01)。结论:BYD可能通过免疫调节,减轻脑组织炎症反应,改善CPZ模型小鼠的髓鞘再生及神经行为。

关键词：多发性硬化免疫炎症补中益气汤脱髓鞘 CPZ

Analysis on the Characteristic Properties of PEDOT Nano-particle Based on Reversed Micelle Method

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Journal of Wuhan University of Technology(Materials Science) 2011年第3期26卷 422-428页

作者：郑华靖 State Key Laboratory of Electronic Thin Films&Integrated Devices School of Optoelectronic InformationUniversity of Electronic Science and Technology of China

Based on the study of a new type of conducting polymer poly （3,4-ethylenedioxythiophene）（PEDOT）,we focussed on the preparation and characteristics of PEDOT nanoparticles made by reversed micelle ***,we deeply investigated the optical,electrical and the thermal stability of PEDOT *** main results are as follows： the small-sized PEDOT nanoparticles were prepared and utilized by different methods,such as ultraviolet/visible （UV-Vis） spectroscopy,Fourier-transform infrared （FT- IR） spectrum,scanning electron microscopy（SEM） and so *** results show that the amount of oxidizer,ultrasonic treatment,polymerizing temperature and doping degree can influent morphology,electrical ability and gas sensitivity of PEDOT *** Bragg peaks of nanoparticles at 6.7°,12.7°,25° were observed by XRD and the better orientation of molecular chain was attributed to the effective doping of toluene-p-sulfonic acid,which also resulted in an enhancement of thermal stability of nanoparticles than conventional PEDOT.

关键词： poly (3 4-ethylenedioxythiophene) conducting polymer reversed micelle nano-particle photoelectric properties thermal stability