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羟基红花黄色素A减轻双环己酮草酰二腙小鼠髓鞘脱失的机制

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中国组织工程研究 2025年第25期29卷 5311-5319页

作者：陈莹刘健梁亚杰李彦青宋丽娟黄建军尉杰忠王青马存根山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心山西省晋中市030619 国药同煤集团总医院神经外科/山西省卫健委神经疾病防治研究重点实验室山西省大同市037003 山西大同大学脑科学研究所/大同市第五人民医院山西省大同市037009

背景:在中枢神经系统脱髓鞘疾病的发生发展过程中,小胶质细胞导致的神经炎症是主要病理特征,因此抑制炎症反应对缓解髓鞘脱失非常重要。羟基红花黄色素A有保护血脑屏障、抑制神经元的凋亡、改善神经功能的作用。目的:探究羟基红花黄色素... 详细信息

背景:在中枢神经系统脱髓鞘疾病的发生发展过程中,小胶质细胞导致的神经炎症是主要病理特征,因此抑制炎症反应对缓解髓鞘脱失非常重要。羟基红花黄色素A有保护血脑屏障、抑制神经元的凋亡、改善神经功能的作用。目的:探究羟基红花黄色素A抑制双环己酮草酰二腙诱导的小鼠髓鞘脱失的作用机制。方法:①体内实验:将30只健康雄性C57BL/6小鼠随机分为正常组、双环己酮草酰二腙组和羟基红花黄色素A组3组,后2组小鼠喂养含0.2%双环己酮草酰二腙的饲料6周建立脱髓鞘小鼠模型,正常组小鼠喂养正常饲料;在第4周末,给予羟基红花黄色素A组小鼠腹腔注射20 mg/(kg·d)羟基红花黄色素A,正常组和双环己酮草酰二腙组小鼠腹腔注射生理盐水,持续2周。旷场实验、高架十字迷宫实验评价小鼠的行为学变化;黑金染色和髓鞘碱性蛋白、降解髓鞘碱性蛋白免疫荧光染色检测胼胝体髓鞘脱失情况;离子钙结合接头分子1免疫荧光染色和ELISA法分别检测小胶质细胞的活化和炎症因子的表达;Western Blot法检测各组小鼠脑中Toll样受体4、髓样分化因子88、核因子κB p65蛋白的表达水平;②体外实验:采用脂多糖诱导建立BV2小胶质细胞炎症模型。将BV2细胞分为正常组、脂多糖组(1μg/mL)和脂多糖(1μg/mL)+羟基红花黄色素A(25μmol/L)组,采用ELISA法检测细胞上清中肿瘤坏死因子α和白细胞介素6的表达水平。结果与结论:①对比正常组,双环己酮草酰二腙组小鼠焦虑情况严重、自主运动能力异常,胼胝体区髓鞘大量脱失,髓鞘碱性蛋白平均荧光强度显著降低,降解髓鞘碱性蛋白平均荧光强度显著升高,离子钙结合接头分子1阳性小胶质细胞数量增多,脑内白细胞介素1β、肿瘤坏死因子α、白细胞介素6水平升高,Toll样受体4、髓样分化因子88、核因子κB p65的蛋白表达水平明显升高。羟基红花黄色素A治疗后,小鼠上述症状和各项指标均发生相反的变化。②羟基红花黄色素A显著抑制由脂多糖诱导的BV2小胶质细胞炎症因子肿瘤坏死因子α和白细胞介素6的表达。③上述结果说明羟基红花黄色素A能够显著改善双环己酮草酰二腙诱导的小鼠髓鞘脱失,作用机制与Toll样受体4/髓样分化因子88/核因子κB p65信号通路抑制小胶质细胞活化介导的炎症反应有关。

关键词：羟基红花黄色素A 双环己酮草酰二腙炎症髓鞘脱失小胶质细胞小鼠

Development of superconducting microcalorimeters for the HUBS mission

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Superconductivity 2022年第4期4卷 29-40页

作者： Sifan Wang Guole Wang Naihui Chen Yanling Chen Wei Cui Jiao Ding Fajun Li yajie liang Qian Wang Yeru Wang Low Temperature Detector Lab Department of AstronomyTsinghua UniversityHaidian DistrictBeijing 100084China

Hot Universe Baryon Surveyor(HUBS)is a proposed space‐borne observatory for X‐ray *** primary scientific objectives of the mission are to fill a void in probing the ecosystem of galaxies and thus to advance our understanding of galaxy formation and evolution,which is of fundamental importance in *** specifically,HUBS aims at directly detecting soft X‐ray emission from diffuse gas of temperature exceeding 106 K,which is theoretically postulated to permeate the large structures in the cosmic web and also fill the extended halo of ***,although some indirect evidence exists,the presence of such hot gas has yet to be well established observationally,due to the lack of effective tools to probe *** this paper,we describe the design of HUBS,focusing on its scientific payload,which employs superconducting technologies in the detector system,and particularly on progress in the development of superconducting microcalorimeters.

关键词： Transition‐edge sensor(TES) Microcalorimeter Non‐dispersive X‐ray spectrometer X‐ray detector

Extraction of straight field roads between farmlands based on agricultural vehicle-mounted LiDAR

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International Journal of Agricultural and Biological Engineering 2022年第5期15卷 155-162页

作者： Lili Yang Yuanyuan Xu yajie liang Jia Qin Yuanbo Li Xinxin Wang Weixin Zhai Long Wen Zhibo Chen Caicong Wu College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Key Laboratory of Agricultural Machinery Monitoring and Big Data Applications Ministry of Agriculture and Rural AffairsBeijing 100083China

The application of autonomous agricultural vehicles is gaining popularity as a way to increase production efficiency and lower operational *** achieve high performance,perception tasks(such as obstacle detection,road extraction,and drivable area extraction)are of great *** with structured roads,field roads between farmlands,including unstructured roads and semi-structured roads,are unfavorable for autonomous agricultural vehicle driving due to their bumpiness and unstructured *** study proposed an extraction method for the straight field roads between *** proposed method was based on the point cloud data acquired by LiDAR(Velodyne VLP-16)mounted on a John Deere 12046B-1204 *** proposed method has three aspects:Euclidean Clustering-based extraction,boundary-based extraction,and road point cloud curve segment ***,Euclidean Clustering with K-Dimensional(KD)-Tree data structure was adopted to extract the road curve segments close to the LiDAR composed of road ***,the boundary lines constraint was constructed to extract the distant road curve ***,the local distance ratio was used to modify the extracted road curve *** average extraction accuracy for both semi-structured and unstructured roads exceeded 98%,and the false positive rate(FPR)was less than 0.5%.These experimental findings demonstrated that the proposed road extraction method was precise and *** proposed method of this study can be applied to enhance the perception ability of autonomous agricultural vehicles thereby increasing the efficiency and safety of field road driving.

关键词： road extraction straight field road autonomous agricultural vehicle LiDAR farmland

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

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国际感染病学（电子版） 2017年第2期6卷 33-41页

作者： Mingxing Su Congsong Sun Haiying Wang Chunyu Yuan Ruixia Guo yajie liang Qiang Wang Liu Chao Institute of Disease Control and Prevention of the Chinese People's Liberation Army Beijing 100071 China Medical University of Anhui Anhui Hefei 230000 China Beijing University of Chinese Medicine Beijing 100029 China Shanxi Medical University Shanxi Taiyuan 030000 China

Objective: The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Method: Wistar rats were randomly divided into four study groups that were treated with saline(control) or arsenic trioxide at a low(0.1 mg/mL), medium(1 mg/mL), or high(10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Results: Compared with the control group, the red blood cell distribution width decreased significantly in each exposure group and then gradually recovered. The red blood cell count only increased in the high-dose group, and the hemoglobin levels did not differ significantly between the groups. Significant decreases in the platelet count and mean platelet volume were observed in each arsenic-exposed group. White blood cell countsalso decreased significantly and then gradually recovered; this was associated with an increased percentage of lymphocytes and a decreased percentage of neutrophils. The blood cell parameter changes were related to the arsenic trioxide concentration and the observation time. Conclusion: Intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.

关键词： dynamic changes blood toxicity arsenic trioxide correlation

3D printing-based frugal manufacturing of glass pipettes for minimally invasive delivery of therapeutics to the brain

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Neuroprotection 2023年第1期1卷 58-65页

作者： Guanda Qiao David Gulisashvili Anna Jablonska Guiling Zhao Miroslaw Janowski Piotr Walczak yajie liang Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA Laboratory of Molecular Cardiology Department of PhysiologyCenter for Biomedical Engineering and TechnologyUniversity of Maryland School of MedicineBaltimoreMarylandUSA

Objective:Intracerebral delivery of agents in liquid form is usually achieved through commercially available and durable metal ***,their size and texture may contribute to mechanical brain *** pipettes with a thin tip may significantly reduce injection-associated brain damage but require access to prohibitively expensive programmable pipette *** study is to remove the economic barrier to the application of minimally invasive delivery of therapeutics to the brain,such as chemical compounds,viral vectors,and ***:We took advantage of the rapid development of free educational online resources and emerging low-cost 3D printers by designing an affordable pipette puller(APP)to remove the cost ***:We showed that our APP could produce glass pipettes with a sharp tip opening down to 20μm or less,which is sufficiently thin for the delivery of therapeutics into the brain.A pipeline from pipette pulling to brain injection using low-cost and open-source equipment was established to facilitate the application of the ***:In the spirit of frugal science,our device may democratize glass pipette-puling and substantially promote the application of minimally invasive and precisely controlled delivery of therapeutics to the brain for finding more effective therapies of brain diseases.

关键词： 3D-printable brain injection frugal science glass pipette pulling

盐雾环境中玻璃纤维/不饱和聚酯复合材料腐蚀深度对弯曲性能的影响

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复合材料学报 2016年第6期33卷 1223-1233页

作者：方园梁亚杰刘伟庆黄杨霍瑞丽南京工业大学土木工程学院南京211816

采用中性盐雾加速老化试验模拟海洋大气环境,对玻璃纤维/不饱和聚酯复合材料在盐雾环境中的弯曲性能进行了研究。通过玻璃纤维/不饱和聚酯复合材料经盐雾加速老化后的吸湿率、玻璃化转变温度、巴氏硬度和弯曲性能的变化,结合金相显微镜... 详细信息

采用中性盐雾加速老化试验模拟海洋大气环境,对玻璃纤维/不饱和聚酯复合材料在盐雾环境中的弯曲性能进行了研究。通过玻璃纤维/不饱和聚酯复合材料经盐雾加速老化后的吸湿率、玻璃化转变温度、巴氏硬度和弯曲性能的变化,结合金相显微镜观测得到的腐蚀深度,研究腐蚀深度对玻璃纤维/不饱和聚酯复合材料耐久性的影响。结果表明:老化初期玻璃纤维/不饱和聚酯复合材料的吸湿率随时间增长较快,随后增长逐渐趋于稳定。玻璃纤维/不饱和聚酯复合材料的玻璃化转变温度呈现先增加后下降的趋势,老化180d后玻璃化转变温度增加了2.1%;老化180d后玻璃纤维/不饱和聚酯复合材料的巴氏硬度与老化前相比降低了17.6%,弯曲强度损失率为10%。基于金相显微镜分析得到老化后玻璃纤维/不饱和聚酯复合材料的腐蚀深度,建立了腐蚀深度与弯曲强度之间的关系。

关键词：玻璃纤维不饱和聚酯复合材料盐雾弯曲性能腐蚀深度

高校应用技术转型之电商专业《程序设计语言》课改研析

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电子测试 2016年第9期27卷 96-97页

作者：梁亚杰北京邮电大学世纪学院经济管理系 102101

为促进应用技术型人才培养,各高校越来越重视计算机基础课程的教学。电子商务专业作为一个集"IT"与"商务"为一体的交叉综合性专业,《程序设计语言》课程作为电子商务专业基础必修课,其教学效果将对学生学习后续技术类课程及就业产生重... 详细信息

为促进应用技术型人才培养,各高校越来越重视计算机基础课程的教学。电子商务专业作为一个集"IT"与"商务"为一体的交叉综合性专业,《程序设计语言》课程作为电子商务专业基础必修课,其教学效果将对学生学习后续技术类课程及就业产生重要影响。根据学科性质,调查学生学习情况,结合电子商务专业学生特点,分析学生学习过程中存在的问题及原因,改进教学方式方法,提高教学效率,强化学生学习效果,对培养应用型人才及促进高校应用技术转型改革具有重要的战略意义。

关键词：程序设计语言电子商务课程改革

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东盟:2021年回顾与2022年展望

东南亚纵横 2022年第1期 45-55页

作者：梁雅洁罗圣荣云南大学外国语学院云南大学“一带一路”研究院暨国际关系研究院

2021年,国际形势复杂多变,COVID-19变异毒株持续蔓延,东盟各国暴发新一轮疫情,加之面临愈发紧迫的非传统安全威胁,维护地区和平与稳定任重道远。东盟以“我们关心,我们准备,我们繁荣”为主题,致力于构建以人为本、共同发展的东盟共同体... 详细信息

2021年,国际形势复杂多变,COVID-19变异毒株持续蔓延,东盟各国暴发新一轮疫情,加之面临愈发紧迫的非传统安全威胁,维护地区和平与稳定任重道远。东盟以“我们关心,我们准备,我们繁荣”为主题,致力于构建以人为本、共同发展的东盟共同体,努力协调解决缅甸危机,并在多领域加强可持续发展。展望2022年,东盟将以“东盟:共同应对挑战”为主题,维护东盟的内部团结,深化公共卫生合作,共同应对国际形势中的机遇与挑战,促进成员国与外部合作伙伴之间的互联互通,推动东盟的可持续发展。

关键词：东盟东盟共同体缅甸危机

共同应对内外挑战努力维护“中心地位”——东盟2022年回顾与2023年展望

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东南亚纵横 2023年第2期 1-12页

作者：梁雅洁罗圣荣云南大学外国语学院云南大学国际关系研究院云南大学区域国别研究院

2022年,由于国际形势复杂多变,新冠疫情持续肆虐,乌克兰危机升级,东盟面临一系列内外风险和挑战。东盟轮值主席国柬埔寨以“东盟:共同应对挑战”为主题,以推动政治安全、经济和社会文化三大共同体建设为核心事项,继续致力维护地区和平... 详细信息

2022年,由于国际形势复杂多变,新冠疫情持续肆虐,乌克兰危机升级,东盟面临一系列内外风险和挑战。东盟轮值主席国柬埔寨以“东盟:共同应对挑战”为主题,以推动政治安全、经济和社会文化三大共同体建设为核心事项,继续致力维护地区和平稳定与发展繁荣,统筹疫情防控与经济发展,构建以人为本、共同发展的东盟共同体,维护东盟统一性和“中心性”。这一年,东盟多次派特使访问缅甸,积极推动缅甸和平进程。原则上同意接纳东帝汶成为第11个东盟成员国,实现东盟扩容。经济上基本克服疫情影响,重视旅游业和数字经济发展潜力,加强国际和区域经济合作,努力促进经济全面复苏。对外关系上积极应对大国博弈,进一步巩固与中国的政治、经济和人文交流等各领域合作,将东盟与美国、印度的关系升级为全面战略伙伴关系,加强成员国与外部合作伙伴之间的联系,努力构建以东盟为中心的外交网络。展望2023年,东盟轮值主席国印度尼西亚将以“东盟事务:增长的中心”为主题,聚焦东盟内部事务及经济增长中心两大方面,加强东盟能力和有效性、维护东盟的团结及东盟中心地位,促进东盟经济发展。东盟将共同应对国际形势中的机遇和挑战,推动东盟共同体建设和可持续发展,提升东盟在地区和世界上的地位和影响力。

关键词：东盟东盟共同体东盟峰会 “印太经济框架” 中国—东盟合作

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