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Hepatoprotective Effect of Costus Roots Extract against Carbon Tetrachloride （CCI4）-Induced Liver Injury in Guinea Pigs

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Journal of Life Sciences 2017年第4期11卷 176-184页

作者： Mohamed ali Hasan al-Duais yahya saleh Mohamed al-awthan Department of Biochemistry Faculty of Science University of Tabuk Tabuk 71491 Saudi Arabia Department of Biology Faculty of Science lbb University Ibb 70270 Yemen Department of Chemistry Faculty of Science Ibb University lbb 70270 Yemen

SC （Saussurea costus）（Asteraceae） is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous Indian systems of medicine. This study was undertaken to investigate the hepatoprotective effect of SC against liver injury induced by CC14 intoxication. Animals were divided into five groups. Group I, served as normal control. Group II received 2 mL CC14/kg b.w. diluted with olive oil, at 1：1 ratio on day 11. Groups III and IV were pre-treated orally respectively with 100 and 200 mg/kg b.w. aqueous roots extract of SC for 10 days followed by subcutaneous injection of CC14 （2 mL/kg b.w.）, once on day 11. Group V were orally given Liv-52 （100 mg/kg b.w.） once daily for 10 days followed by subcutaneous injection of CC14 （2 mL/kg b.w.）, once on day 11. Our results show that, the activity of serum hepatic enzymes （alT, AST, and alP） were significantly elevated in guinea pigs treated with CC14, while both the SC root extract and Liv-52 reduced significantly these enzymes activity. also, the levels of glucose, urea and cholesterol were decreased when compared with intoxicated control. Histopathological examination of intoxicated animals showed dilation, hemorrhage, vacuolization, inflammation and necrosis indicating liver damage, while the animals received SC or Liv-52 that showed less pathological effects or normal liver when compared to animals treated with CC14 alone. Biochemical and histological results confirm the hepatoprotective effect of aqueous extract of SC.

关键词： Saussurea costus CC14 hepatotoxi^ity extract Liv-52 histopathology biochemistry.

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The Hepatoprotective Effects of Solanum Incanum on Acetaminophen-lnduced Hepatotoxicity in Guinea Pigs

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Journal of Life Sciences 2010年第5期4卷 44-48页

作者： yahya saleh al-awthan Mohammed A. Salama Ahmed M. Helal Department of Biology Faculty of Science Ibb University Ibb 70270 Yemen Department of Zoology Faculty of Science Al-Azhar University Cairo 1150049 Egypt Department of Zoology Faculty of Science Al-Zaqaziq University Banha 44519 Egypt

Solanum incanum, a shrubby herb, is widely distributed and used as analgesic, antitoxic, and antispasmodic in folk medicine. In the present study, the protective effects of aqueous extract of S. incanum against acetaminophen induced acute liver damage were evaluated in guinea pigs. Animals were orally administered with S. incanum extract （50 and 100 mg/ kg bw） and silymarin （ 100 mg / kg bw） respectively for 6 days followed by acetaminophen administration （2 g / kg bw） at the 7th day. The results showed that the treatment with S. incanum extract significantly lowered the acetaminophen-induced serum levels of hepatic marker enzymes （AST, alT, and alP）, Liver histopathology also showed that S. incanum extract reduced the incidence of liver lesions including the swelling of hepatic cells, lymphocytes infiltration, nucleus condensation, and hepatic necrosis induced by acetaminophen treatment in guinea pigs. The S. incanum extract at a dose of 100 mg / kg bw was more effective in suppressing the oxidative damage than the extract at a dose of 50 mg / kg bw. Therefore, the results of this study suggest that S. incanum extract could protect liver against the acetaminophen-induced oxidative damage.

关键词： Solanum incanum extract acetaminophen hepatoprotection guinea pigs

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Enhancing Salt Leaching Efficiency of Saline-sodic Coastal Soil by Rice Straw and Gypsum Amendments in Coastal Area of Jiangsu,China

Enhancing Salt Leaching Efficiency of Saline-sodic Coastal S...

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作者： Ebrahim yahya saleh Khailah 扬州大学

学位级别：硕士

高盐度碱度对全球许多地区来说都是一个严重问题,它会对土壤的物理化学性质产生负面影响,例如低渗透性、通风不良和水资源可用性降低,并最终影响农业生产。为了改善土壤质量,通常需要通过淋滤降低盐分碱度;但较差的土壤性质,如低渗透性... 详细信息

高盐度碱度对全球许多地区来说都是一个严重问题,它会对土壤的物理化学性质产生负面影响,例如低渗透性、通风不良和水资源可用性降低,并最终影响农业生产。为了改善土壤质量,通常需要通过淋滤降低盐分碱度;但较差的土壤性质,如低渗透性,使盐浸过程非常无效。江苏新开垦沿海地区的高盐含量限制了其农业生产作用。通常需要几年的时间通过淋滤来改善这类土壤,以释放土壤中的可溶性盐。盐分随排水的淋溶缓慢,导致土壤结构不良。为此,为了加快土壤中盐分的淋溶效率,改善土壤结构,需要将有机质和化学改良剂结合起来。在这些改良剂中,石膏是一种常见的化学改良剂,被广泛用于改善盐碱土的物理化学性质,因为它含有足够的钙来去除根区的交换性钠,而且它相对便宜、普遍可用且易于使用。许多研究发现,电导率发生了积极的变化,大部分可交换钠从土壤中去除,增加了土壤渗透性,降低了容重,改善了絮凝作用,减少了粘土分散。施用钙(Ca+2)可以改善土壤的物理化学性质,并作为土壤改良剂,防止钠(Na+)的积累,而钠(Na+)与植物生长和作物产量直接相关。利用稻草可以将农业副产品转化为水稻产区宝贵且廉价的有机资源。将稻草还田并覆盖土壤表面,可以通过溶解土壤中的Ca+2化合物来帮助恢复盐碱土。它还可以有效地减少蒸发和盐分积累,保持土壤水分,增加土壤充足的持水能力,增加土壤通气量,降低土壤容重和总孔隙度。稻草降低了盐分,增加了 K+、Ca+2,显著影响了水稻的增产。多项研究表明,在石膏中添加稻草对降低ECe、pH、SAR和ESP的影响相对较大。在沿海地区和干旱地区改良盐碱土的研究较多,但在新开垦的沿海地区快速改良重盐碱土的研究较少。一些研究是在可控的实验室条件下进行的,使用渗滤柱定量测定渗滤液中可溶阳离子的浓度。由于在现场条件下很难量化溶质运动的空间和时间量化,使用渗滤柱的实验室实验在测量渗滤液水中溶解阳离子的浓度及其时间变化方面具有优势。本研究在中国扬州市扬州大学农业水土环境与生态实验室进行了渗透柱和实验。利用渗滤柱比较和评估了石膏和稻草作为单独和联合施用对提高新开垦沿海地区重盐碱土盐分淋洗效率的效果。这项研究假设,石膏和稻草的联合施用以及随后的水浸在提高盐浸效率方面更有效。通过渗滤柱实验,评价渗滤液溶液中EC和溶解阳离子(Ca2+、Mg2+、K+、Na+)的变化,以及土壤ECe、交换阳离子(Ca2+、Mg2+、K+、Na+)和土壤SAR的变化,本实验研究可为新开垦沿海地区的土壤盐渍化治理提供理论依据和技术支持。本论文的主要研究内容如下:1.通过研究样本土壤,评估施用石膏和稻草堆肥及其不同组合在盐碱土复垦中的潜力和有效性。2.确定改进浸出过程的最佳修正量。1.研究方法1)研究区和土壤性质在中国江苏省东台市济钢镇(北纬32°51′ 44″,东经120° 53′ 47″)两垛河与临海高等级公路交汇处东南侧的一个农业种植园中采集表层土样品(0-30cm)。这是一个平坦的地区,地面海拔约为海平面以上3.7米。该地区平均气温为14.8℃,年平均降雨量为1052.0毫米。重盐渍土具有粉壤土质地2)实验装置及步骤实验于2020年8月至2021年3月在中国扬州市扬州大学的水力与能源动力工程实验室进行。土壤样品风干,捣碎以粉碎土块,并在填充渗透柱之前通过2 mm的筛子。然后将土壤质地划分为粉壤土质地。在渗滤柱中填充土壤后,收集8个土壤样本(柱表面0-20厘米),每个样本约50克,然后测量电导率、pH值、交换性阳离子和土壤吸附率。使用八根直径为19厘米、高85厘米的PVC柱。底部设置一层5cm粗砂,以便于流动和防止堵塞,同时在过滤层上放置一根直径为50mm的波纹管,以帮助排水。塑料管是自下而上安装的,用来测量头部压力,随着时间的推移,塑料管在一定程度上有助于去除微小的气穴。本研究采用马尔可夫瓶法维持10cm恒定地表水,防止溢流。在填充到柱中之前,将土壤均匀混合并湿润,以获得1.30(g cm-3)的均匀堆积密度,并避开任何气穴。在填充之前,使用润滑剂使柱内壁粗糙,使土壤和柱壁紧密结合。在每根柱子中,设置一层密度为1.3的60 cm填充土,每20 cm搅拌和压实一次,并刷表面以防止分层。填充柱后,土壤高度为60cm,孔隙度约为50.9%。采用随机分组设计,共设计八个渗滤柱,每个柱有两个重复。采用了四种处理方法:1)对照(不施用石膏或稻草堆肥)(CT);2)稻草;3)石膏(GPS);4)石膏加稻草(GRS+RS)。石膏和稻草被混合到表层土中。每个土柱最初用20升2mol L/-1 NaCr溶液饱和,以确保盐度分布均匀。然后用淡水(EC=0.364 dS m-1)淋洗土壤。根据孔隙体积(PV)计算浸出水量:每个柱的孔体积为8.47 dm3。渗滤液样本收集在瓶子中进行分析。在每一次孔隙体积淋洗之间都会有一段休息时间,以便盐分

关键词：盐碱土土壤改良剂浸出效率石膏和有机改良剂盐分变化

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Rocket “Eruca sativa”:A salad herb with potential gastric anti-ulcer activity

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World Journal of Gastroenterology 2009年第16期15卷 1958-1965页

作者： saleh alqasoumi Mohammed al-Sohaibani Tawfeq al-Howiriny Mohammed al-yahya Syed Rafatullah Department of Pharmacognosy and Medicinal Aromatic and Poisonous Plants Research CenterCollege of PharmacyPO Box 2457King Saud University Department of Pathology (32) PO Box 2925King Khalid University HospitalKing Saud University

AIM： To validate gastric anti-ulcer properties of Rocket ＂Eruca sativa＂ on experimentally-induced gastric secretion and ulceration in albino rats. METHODS： Gastric acid secretion studies were undertaken using pylorus-ligated rats. Gastric lesions in the rats were induced by noxious chemicals including ethanol, strong alkalis, indomethacin and hypothermic restraint stress. The levels of gastric wall mucus （GWM）, nonprotein sulfhydryls （NP-SH） and malondialdehyde （MDA） were also measured in the glandular stomach of rats following ethanol administration. The gastric tissue was also examined histologically. The extract was used in two doses （250 and 500 mg/kg body weight） in all experiments. RESULTS： In pylorus-ligated Shay rats, the ethanolic extract of Rocket ＂Eruca sativa L.＂（EER） significantly and dose-dependently reduced the basal gastric acid secretion, titratable acidity and ruminal ulceration. Rocket extract significantly attenuated gastric ulceration induced by necrotizing agents （80% ethanol, 0.2 mol/L NaOH, 25% NaCl）, indomethacin and hypothermic restraint stress. The anti-ulcer effect was further confirmed histologically. On the other hand, the extract significantly replenished GWM and NP-SH levels, as well as the MDA level significantly reduced by extract pretreatment. CONCLUSION： Rocket extract possesses antisecretory, cytoprotective, and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect is possibly through prostaglandinmediated activity and/or through its anti-secretory and antioxidant properties.

关键词： Cytoprotection Eruca sativa Gastric ulcer and secretion Malondialdehyde Rocket Sulfhydryls

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An Efficient Text-Independent Speaker Identification Using Feature Fusion and Transformer Model

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Computers, Materials & Continua 2023年第5期75卷 4085-4100页

作者： Arfat Ahmad Khan Rashid Jahangir Roobaea alroobaea saleh yahya alyahyan Ahmed H.almulhi Majed alsafyani Chitapong Wechtaisong College of Computing Khon Kaen UniversityKhon Kaen40000Thailand Department of Computer Science COMSATS University IslamabadVehari CampusVehari61100Pakistan Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Computer Science Community College in DwadmiSharqa UniversityDawadmi17472Saudi Arabia School of Telecommunication Engineering Suranaree University of TechnologyNakhon Ratchasima30000Thailand

Automatic Speaker Identification(ASI)involves the process of distinguishing an audio stream associated with numerous speakers’*** common aspects,such as the framework difference,overlapping of different sound events,and the presence of various sound sources during recording,make the ASI task much more complicated and *** research proposes a deep learning model to improve the accuracy of the ASI system and reduce the model training time under limited computation *** this research,the performance of the transformer model is *** audio features,chromagram,Mel-spectrogram,tonnetz,Mel-Frequency Cepstral Coefficients(MFCCs),delta MFCCs,delta-delta MFCCs and spectral contrast,are extracted from the ELSDSR,CSTRVCTK,and Ar-DAD,*** evaluation of various experiments demonstrates that the best performance was achieved by the proposed transformer model using seven audio features on all *** ELSDSR,CSTRVCTK,and Ar-DAD,the highest attained accuracies are 0.99,0.97,and 0.99,*** experimental results reveal that the proposed technique can achieve the best performance for ASI problems.

关键词： Speaker identification signal processing Arabic deep learning transformer

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Optimal Deep Reinforcement Learning for Intrusion Detection in UAVs

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Computers, Materials & Continua 2022年第2期70卷 2639-2653页

作者： V.Praveena A.Vijayaraj P.Chinnasamy Ihsan ali Roobaea alroobaea saleh yahya alyahyan Muhammad Ahsan Raza Department of Computer Science and Engineering Dr.N.G.P Institute of TechnologyCoimbatore641048India Department of Information Technology Vignan’s Foundation for ScienceTechnology&ResearchGuntur522213India Department of Information Technology Sri Shakthi Institute of Engineering and TechnologyCoimbatore641062India Department of Computer System and Technology Faculty of Computer Science and Information TechnologyUniversity of MalayaKuala Lumpur50603Malaysia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science Community College in DwadmiShaqra University11961Saudi Arabia Department of Information Technology Bahauddin Zakariya UniversityMultan60000Pakistan

In recent years,progressive developments have been observed in recent technologies and the production cost has been continuously *** such scenario,Internet of Things(IoT)network which is comprised of a set of Unmanned Aerial Vehicles(UAV),has received more attention from civilian tomilitary *** network security poses a serious challenge to UAV networks whereas the intrusion detection system(IDS)is found to be an effective process to secure the UAV *** IDSs are not adequate to handle the latest computer networks that possess maximumbandwidth and data *** order to improve the detection performance and reduce the false alarms generated by IDS,several researchers have employed Machine Learning(ML)and Deep Learning(DL)algorithms to address the intrusion detection *** this view,the current research article presents a deep reinforcement learning technique,optimized by BlackWidow Optimization(DRL-BWO)algorithm,for UAV *** addition,DRL involves an improved reinforcement learning-based Deep Belief Network(DBN)for intrusion *** parameter optimization of DRL technique,BWO algorithm is *** helps in improving the intrusion detection performance of UAV *** extensive set of experimental analysis was performed to highlight the supremacy of the proposed *** the simulation values,it is evident that the proposed method is appropriate as it attained high precision,recall,F-measure,and accuracy values such as 0.985,0.993,0.988,and 0.989 respectively.

关键词： Intrusion detection UAV networks reinforcement learning deep learning parameter optimization

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Design, Fabrication and Experimentation of a Deep Drawing Machine

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Journal of Mechanics Engineering and Automation 2014年第10期4卷 804-812页

作者： Ahmed Ramahi yahya saleh Department of Industrial Engineering Faculty of Engineering An-Najah National University Nablus P.O. Box 7 Palestine

This paper presents the work implemented in designing, fabricating and operating a model of a cheap hydraulic DDM （deep drawing machine）, which is currently utilized in the manufacturing processes lab in the IED （Industrial Engineering Department） at An-Najah National University. The machine is used to conduct different experiments related to the deep drawing process. This work was implemented in three stages： the first was the design stage, in which all design calculations of the DDM elements were completed based on the specifications of the product （cup） to be drawn; the second was the construction stage, in which the DDM elements were fabricated and assembled at the engineering workshops of the university; the last was the operating and experimentation stage, in which the DDM was tested by conducting different experiments. The experience gained from designing and constructing such a mechanical lab equipment was found to be successful in terms of obtaining practical results that agree with those available in literature, cost-effective relative to the cost of a similar purchased equipment, as well as enhancing students＇ abilities in understanding the deep drawing process in particular and machine elements design concepts in general.

关键词： Deep drawing machine element design die design machine assembly and fabrication experimental investigation of drawforce and draw stroke.

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Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats

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World Journal of Gastroenterology 2009年第11期15卷 1373-1380页

作者： Salim S al-Rejaie Abdulaziz M aleisa Abdulaziz A al-yahya saleh A Bakheet Abdulmalik alsheikh Amal G Fatani Othman A al-Shabanah Mohamed M Sayed-Ahmed Department of Pharmacology College of PharmacyKing Saud UniversityPO Box 2457Kingdom of Saudi Arabia Department of Pathology College of MedicineKing Saud UniversityPO Box 2457 Kingdom of Saudi Arabia

AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each *** in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 *** in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 *** in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn *** in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group *** in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group ***:Administration of DENA resulted in a significant increase in alanine transaminase(alT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(alP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver *** the carnitine-depleted rat model,DENA induced a dramatic increase in serum alT,G-GT,alP and total bilirubin,as well as a progressive reduction in total carnitine content in liver ***, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control *** examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-

关键词： Carnitine deficiency D-carnitine L-carnitine Diethylnitrosamine Hepatic carcinogenesis

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Feasibility of developing composite action between concrete and cold-formed steel beam

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Journal of Central South University 2013年第12期20卷 3689-3696页

作者： S.O.Bamaga M.Md.Tahir T.C.Tan S.Mohammad N.yahya A.L.saleh M.Mustaffar M.H.Osman A.B.A.Rahman Construction Research Centre (UTM-CRC) Faculty of Civil EngineeringUniversiti Teknologi Malaysia

Cold-formed steel structures are steel structure products constructed from sheets or coils using cold rolling, press brake or bending brake method. These structures are extensively employed in building construction industry due to their light mass, ductility by economic cold forming operations, favorable strength-to-mass ratio and other factors. The utilization of cold formed steel sections with concrete as composite can hugely reduce the construction cost. However, the use of cold formed steel members in composite concrete beams has been very limited. A comprehensive review of developments in composite beam with cold formed steel sections was introduced. It was revealed that employing cold-formed steel channel section to replace reinforcement bars in conventional reinforced concrete beam results in a significant cost reduction without reducing strength capacity. The use of composite beam consisting of cold-formed steel open or close box and filled concrete could also reduce construction cost. Lighter composite girder for bridges with cold-formed steel of U section was introduced. Moreover, types of shear connectors to provide composite action between cold-formed steel beam and concrete slab were presented. However, further studies to investigate the effects of metal decking on the behavior of composite beam with cold-formed steel section and introduction of ductile shear connectors were recommended.

关键词： cold formed steel beam composite shear connection thin-wall composite girder

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Effects of Transformer DC Bias and the Relationship Between UHVDC Grounding Current and Grounding Resistances

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高电压技术 2008年第12期34卷 2530-2535页

作者： JIANG Wei WU Guang-ning XIAO Hua HUANG Zhen saleh yahya Muhammed GUAN Lan School of Electrical Engineering Southwest Jiaotong University Chengdu 610031 China Sichuan Electric Power Company Chengdu 610061 China

Recently years,UHVDC transmission system is paid more attention to in the field of China's power *** takes key part in the China electrical power development ***,many problems are caused by UHVDC system,such as DC bias,corrosion of metal underground and so *** bias is harm to the transformers nearby UHVDC grounding *** this paper,the influences of DC grounding current on transformer are introduced and some suggestions of DC bias solution were ***,the relationship between UHVDC Grounding Current and grounding Resistance of Substation was ***,two-part network circuit was used to equivalent the grounding ***,an analysis of rules was done between DC bias current and grounding ***,the conclusion is given that DC bias current rises fast as DC grounding resistance or AC grounding resistance *** drops when resistance of AC transmission line or interaction resistance between DC grounding system and AC grounding system *** AC grounding resistance and DC grounding resistance is important to restrain DC bias *** resistance of AC transmission line such as adding resistance into transformer neutral-point grounding is a useful way to limit DC bias current.

关键词： UHVDC 变压器直流偏磁接地电阻

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