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Trilateral interaction between innervation,leukocyte,and adventitia:a new driver of atherosclerotic plaque formation

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2670-2672页

作者： yahya sohrabi Holger Reinecke Oliver Soehnlein Department of Cardiology I—Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzechia Institute of Experimental Pathology(ExPat) Center for Molecular Biology of Inflammation(ZMBE)University Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Department of Physiology and Pharmacology(FyFa) Karolinska InstitutetStockholmSweden

A recent study by Mohanta et *** a new understanding of neuroimmune interactions in *** atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic *** continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or *** disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood *** such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.

关键词： sympathetic acute hence

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The immune hunger games:the effects of fasting on monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1098-1100页

作者： Jorge Domínguez-Andrés Holger Reinecke yahya sohrabi Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Nijmegen Medical Centre6500HBNijmegenthe Netherlands Department of Cardiology I-Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzech Republic Department of Medical Genetics Third Faculty of MedicineCharles UniversityPragueCzech Republic

Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic ***,how these practices affect immune function is not well *** a recent study published in Immunity,Janssen et *** into the complex relationship among fasting,refeeding,and the immune *** fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].

关键词： becoming fasting she

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