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作者： yahya ibn ilias 泰山医学院

学位级别：硕士

目的:了解FGF23/Klotho水平与慢性血液透析患者血管壁钙化的关系。测定血液透析患者FGF23和Klotho水平。另一个目的是在患者组中通过无线电成像技术(CT扫描引导)检查血管壁。方法:慢性肾脏病(CKD)中与心血管并发症相关的死亡率很高。随... 详细信息

目的:了解FGF23/Klotho水平与慢性血液透析患者血管壁钙化的关系。测定血液透析患者FGF23和Klotho水平。另一个目的是在患者组中通过无线电成像技术(CT扫描引导)检查血管壁。方法:慢性肾脏病(CKD)中与心血管并发症相关的死亡率很高。随着慢性肾脏病(CKD)分期的进展,5D期患者血管钙化的发生率增加,并达到高峰。CKD分期5D的血液透析患者合并血管钙化时的发病率和死亡率成倍增加。最近一些临床和观察资料提出,成纤维细胞生长因子23(一种控制矿物质代谢的骨衍生激素)与心血管相关的死亡和血管钙化、左心室肥厚、血管内皮功能障碍等并发症相关。FGF23-Klotho信号轴异常是慢性肾脏病患者的特征性表现。这是一个基于医院的病例对照研究。本研究共纳入174例(95例,79例对照)。病例组男性49例(51.6%),女性46例(49.4%),对照组男性43例(54.4%),女性36例(45.6%)。从每个患者获得完整的人口统计学(年龄,性别,职业和婚姻状况)和临床病史(症状/症状,既往病史)。对照组患者还进行了全面的病史和体格检查。基线数据和结果是从医院记录获得的。本研究的目的和目的明确地解释给患者,然后产生书面知情同意。在SPSS(社会科学统计软件)25版和微软Excel 2016的帮助下,对数据进行处理和分析。所采用的统计方法有:独立简单t检验、Spearson秩分析和多元回归分析。结果:经预防和适当程序收集后,通过医院诊断服务对血样进行不同参数的测定,血样结果包括血清钙(2.68±0.14)、磷酸盐(1.67±0.18)、血清FGF23(150.52±22.12)、血清Klotho(284.5±42.2),血红蛋白(101.7±7.4)、血清肌酐(889.9±195.2)、甲状旁腺激素(62.37±22.5)、甘油三酯(1.62±0.57)总胆固醇(4.6±1.03)和血糖(5.4±1.2)。对照组男性43例(54.4%),女性36例(45.6%),记录年龄(56.35±10.92),血糖(4.72±0.61),血清胆固醇(4.01±0.5),甘油三酯(1.28±0.24),钙(0.24±),磷酸盐(1.25±0.15),血红蛋白(124.95±8.31),血清Klotho(403.67±21.29),血清FGF23(60.20±6.24)。维持性血液透析患者血清标本中FGF 23水平(150.52±22.19,P<0.01),血清Klotho(284.5±42.16,P<0.01),血清钙(2.68±0.14),磷酸盐(1.67±0.18)FGF 23与血清Klotho水平呈显著负相关(r=-0.702,P<0.01),FGF 23与血清磷酸盐呈显著正相关(r=0.894,P<0.01),血清磷酸盐(r=0.702,P<0.01),ACI(r=0.213,P<0.05)结论:·FGF23与血清Klotho呈显著负相关,与血清钙、磷、PTH水平及主动脉钙化指数呈正相关。·FGF23和Klotho可作为慢性HD患者血管钙化的预测指标和预后。·进一步揭示FGF23和Klotho在血管钙化中的作用机制及影响因素,并进行进一步的研究。·血清FGF23和Klotho水平测定应作为慢性HD患者CKD的预测指标。

关键词： FGF23 Klotho 血管钙化慢性肾脏病

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Optimizing Connections:Applied Shortest Path Algorithms for MANETs

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 787-807页

作者： Ibrahim Alameri Jitka Komarkova Tawfik Al-Hadhrami Abdulsamad Ebrahim yahya Atef Gharbi Faculty of Medical Sciences Jabir Ibn Hayyan Medical UniversityAlkufaNajaf54001Iraq Faculty of Economics and Administration University of PardubiceStudentskaPardubice53210Czech Republic Computer Science Department School of Science and TechnologyNottingham Trent UniversityNottinghamNG118NSUK Department of Information Technology College of Computing and Information TechnologyNorthern Border UniversityArar91431Saudi Arabia Department of Information System College of Computing and Information TechnologyNorthern Border UniversityArar91431Saudi Arabia

This study is trying to address the critical need for efficient routing in Mobile Ad Hoc Networks(MANETs)from dynamic topologies that pose great challenges because of the mobility of *** objective was to delve into and refine the application of the Dijkstra’s algorithm in this context,a method conventionally esteemed for its efficiency in static ***,this paper has carried out a comparative theoretical analysis with the Bellman-Ford algorithm,considering adaptation to the dynamic network conditions that are typical for *** paper has shown through detailed algorithmic analysis that Dijkstra’s algorithm,when adapted for dynamic updates,yields a very workable solution to the problem of real-time routing in *** results indicate that with these changes,Dijkstra’s algorithm performs much better computationally and 30%better in routing optimization than Bellman-Ford when working with configurations of sparse *** theoretical framework adapted,with the adaptation of the Dijkstra’s algorithm for dynamically changing network topologies,is novel in this work and quite different from any traditional *** adaptation should offer more efficient routing and less computational overhead,most apt in the limited resource environment of ***,from these findings,one may derive a conclusion that the proposed version of Dijkstra’s algorithm is the best and most feasible choice of the routing protocol for MANETs given all pertinent key performance and resource consumption indicators and further that the proposed method offers a marked improvement over traditional *** paper,therefore,operationalizes the theoretical model into practical scenarios and also further research with empirical simulations to understand more about its operational effectiveness.

关键词： Dijkstra’s algorithm optimization complexity analysis shortest path first comparative algorithm analysis nondeterministic polynomial(NP)-complete

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Enhancing Network Design through Statistical Evaluation of MANET Routing Protocols

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Computers, Materials & Continua 2024年第7期80卷 319-339页

作者： Ibrahim Alameri Tawfik Al-Hadhrami Anjum Nazir Abdulsamad Ebrahim yahya Atef Gharbi Faculty of Medical Sciences Jabir ibn Hayyan Medical UniversityAlkufa QuNajaf54001Iraq Computer Science Department School of Science and TechnologyNottingham Trent UniversityNottinghamNG118NSUK Department of Computing Faculty of Engineering Sciences&Technology(FEST)Hamdard UniversityKarachi74600Pakistan Department of Information Technology College of Computing and Information TechnologyNorthern Border UniversityArar91431Saudi Arabia Department of Information System College of Computing and Information TechnologyNorthern Border UniversityArar91431Saudi Arabia

This paper contributes a sophisticated statistical method for the assessment of performance in routing protocols salient Mobile Ad Hoc Network(MANET)routing protocols:Destination Sequenced Distance Vector(DSDV),Ad hoc On-Demand Distance Vector(AODV),Dynamic Source Routing(DSR),and Zone Routing Protocol(ZRP).In this paper,the evaluation will be carried out using complete sets of statistical tests such as Kruskal-Wallis,Mann-Whitney,and *** articulates a systematic evaluation of how the performance of the previous protocols varies with the number of nodes and the mobility *** study is premised upon the Quality of Service(QoS)metrics of throughput,packet delivery ratio,and end-to-end delay to gain an adequate understanding of the operational efficiency of each protocol under different network *** findings explained significant differences in the performance of different routing protocols;as a result,decisions for the selection and optimization of routing protocols can be taken effectively according to different network *** paper is a step forward in the general understanding of the routing dynamics of MANETs and contributes significantly to the strategic deployment of robust and efficient network infrastructures.

关键词： Routing protocols statistical approach friedman MANET

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Unordered rule discovery using Ant Colony Optimization

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Science China(Information Sciences) 2014年第9期57卷 189-203页

作者： KHAN Salabat BAIG Abdul Rauf ALI Armughan HAIDER Bilal KHAN Farman Ali DURRANI Mehr yahya ISHTIAQ Muhammad Department of Computer Science COMSATS Institute of Information TechnologyAttock CampusPakistan Department of Computer Science National University of Computer and Emerging SciencesIslamabadPakistan Al Imam Mohammad ibn Saud Islamic University (IMSIU) College of Computer and Information SciencesRiyadhSaudi Arabia

In this article,a novel unordered classification rule list discovery algorithm is presented based on Ant Colony Optimization(ACO).The proposed classifier is compared empirically with two other ACO-based classification techniques on 26 data sets,selected from miscellaneous domains,based on several performance *** opposed to its ancestors,our technique has the flexibility of generating a list of IF-THEN rules with unrestricted *** makes the generated classification model more comprehensible and easily *** results indicate that the performance of the proposed method is statistically significantly better as compared with previous versions of AntMiner based on predictive accuracy and comprehensibility of the classification model.

关键词： classification ant colony optimization data mining unordered rule set comprehensibility pattern recognition

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Intracochlear schwannoma: Imaging diagnosis

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Journal of Otology 2023年第2期18卷 101-103页

作者： Safaa Choayb yahya El Harras Meriem Fikri Najoua Ech-Cherif El Kettani Mohamed Jiddane Firdaous Touarsa Neuroradiology Department Ibn Sina University Hospital CenterRabatMorocco

Intralabyrinthine schwannomas(ILS)are rare benign tumors,often responsible for hearing *** is important in establishing the *** present the example of a 48-year-old lady who reported a 3-years history of right-sided sensorineural *** demonstrated a loss of the normal hypersignal of the second turn of the right cochlea compatible with intracochlear schwannoma.

关键词： Intracochlear schwannoma Intralabyrinthine schwannoma Sensorineural hearing loss

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