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The WRKY46–MYC2 module plays a critical role in E-2-hexenal-induced anti-herbivore responses by promoting flavonoid accumulation

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Plant Communications 2024年第2期5卷 228-242页

作者： Xin Hao Shuyao Wang Yu Fu yahui Liu Hongyu Shen Libo jiang Eric SMcLamore Yingbai Shen National Engineering Research Center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China State Key Laboratory of Animal Biotech Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China University of Illinois at Urbana-Champaign ChampaignIL 61820USA Department of Agricultural Sciences Clemson UniversityClemsonSC 29634USA

Volatile organic compounds(VOCs)play key roles in plant–plant communication,especially in response to pest attack.E-2-hexenal is an important component of VOCs,but it is unclear whether it can induce endog-enous plant resistance to ***,we show that E-2-hexenal activates early signaling events in Ara-bidopsis(Arabidopsis thaliana)mesophyll cells,including an H2O2 burst at the plasma membrane,the directedflow of calcium ions,and an increase in cytosolic calcium *** of wild-type Arabidopsis plants with E-2-hexenal increases their resistance when challenged with the diamond-back moth Plutella xylostella L.,and this phenomenon is largely lost in the wrky46 ***,E-2-hexenal induces the expression of WRKY46 and MYC2,and the physical interaction of their encoded proteins was verified by yeast two-hybrid,firefly luciferase complementation imaging,and in vitro pull-down *** WRKY46–MYC2 complex directly binds to the promoter of RBOHD to promote its expres-sion,as demonstrated by luciferase reporter,yeast one-hybrid,chromatin immunoprecipitation,and electrophoretic mobility shift *** module also positively regulates the expression of E-2-hexenal-induced naringenin biosynthesis genes(TT4 and CHIL)and the accumulation of totalflavonoids,thereby modulating plant tolerance to ***,our results highlight an important role for the WRKY46–MYC2 module in the E-2-hexenal-induced defense response of Arabidopsis,providing new in-sights into the mechanisms by which VOCs trigger plant defense responses.

关键词： E-2-hexenal early signaling events WRKY46–MYC2 RBOHD naringenin

Fast Verification of Network Configuration Updates

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Computers, Materials & Continua 2023年第1期74卷 293-311页

作者： jiangyuan Yao Zheng jiang Kaiwen Zou Shuhua Weng Yaxin Li Deshun Li yahui Li Xingcan Cao Scool of Computer Science and Technology Hainan UniversityHaikou570228China School of Cyberspace Security Hainan UniversityHaikou570228China School of Software Engineering Jilin UniversityChangchun130012China School of Software Beijing Jiaotong UniversityBeijing100091China University of British Columbia VancouverV5K1K5Canada

With the expansion of network services,large-scale networks have progressively become *** network status changes rapidly in response to customer needs and configuration changes,so network configuration changes are also very ***,no matter what changes,the network must ensure the correct conditions,such as isolating tenants from each other or guaranteeing essential *** changes occur,it is necessary to verify the after-changed ***,for the verification of large-scale network configuration changes,many current verifiers show poor *** order to solve the problem ofmultiple global verifications caused by frequent updates of local configurations in large networks,we present a fast configuration updates verification tool,FastCUV,for distributed control *** aims to enhance the efficiency of distributed control plane verification for medium and large networks while ensuring *** paper presents a method to determine the network range affected by the configuration *** present a flow model and graph structure to facilitate the design of verification algorithms and speed up *** scheme verifies the network area affected by obtaining the change of the Forwarding Information Base(FIB)before and *** supports rich network attributes,meanwhile,has high efficiency and correctness *** experimental verification and result analysis,our method outperforms the state-of-the-art method to a certain extent.

关键词： Network verification configuration updates network control plane forwarding information base

A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications

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Chinese Chemical Letters 2020年第11期31卷 2955-2959页

作者： Kaijie Wang Dazhou Xi Chuantao Liu yahui Chen Hao Gu Long jiang Xiaoqiang Chen Fang Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China

A ratiometric probe(HBT-HBZ)bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid(HClO)with high selectivity and sensitivity is reported in this *** fluorescence intensity ratios(I470nm/I572nm)of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in *** detection limit of 24 nmol/L suggests that the sensor is very sensitive to *** to the series of performed experiments,HBT-HBZ has practical applications,such as the detection of HClO residues in tap water,which has been rarely *** addition,confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells.A ratiometric probe(HBT-HBZ)for sensing HClO with high selectivity and sensitivity is reported in this *** probe exhibited high selectivity for HClO among other ROS,RNS and *** addition,HBTHBZ has some practical applications such as the analysis of the HClO content in tap ***,confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells.

关键词： HClO Benzothiazole Fluorescence probe Tap water Bioimaging

重庆市基层群众急救技能受训情况的调研与分析

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中国急救复苏与灾害医学杂志 2023年第7期18卷 963-967页

作者：王心一姜雅慧孟心语赵蒙龙清艳龙俊杰陈锦菲重庆医科大学第二临床学院重庆400010

目的探究重庆市基层群众常见急救技能受训及应用情况,为“重庆市公众卫生应急技能提升行动”开展基层群众急救培训提供最新依据。方法实地走访,通过发放院前急救基线调查问卷及随机采访两种方式开展调研。结果基层群众对常见急救知识技... 详细信息

目的探究重庆市基层群众常见急救技能受训及应用情况,为“重庆市公众卫生应急技能提升行动”开展基层群众急救培训提供最新依据。方法实地走访,通过发放院前急救基线调查问卷及随机采访两种方式开展调研。结果基层群众对常见急救知识技能掌握度欠佳、受训度不足,专业急救技能培训的接触机会极少;同时,群众对理论知识学习兴趣不高,而对实操需求较大。宣传力度不够、培训体系不完善等诸多因素导致现今群众急救技能学习能力差,既往培训有效转化率低等问题,急救技能培训亟需开展。结论目前基层群众急救技能培训主要以基层社区青壮年为主体,通过简化趣味化理论讲解、加强实操练习,围绕关键几项基础急救技能,有效提高培训有效率与急救技能实际运用水平。

关键词：基层群众急救技能急救培训院前急救急救宣传调研分析

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

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Frontiers of Medicine 2007年第3期1卷 269-273页

作者： LI yahui LI Huaixing DONG Shiyuan YU Chao jiang Yu SUN Shuhan Institute for Nutritional Science Shanghai Institute for Biological SciencesChinese Academy of ScienceShanghai 200031China Center for Healthy Food Evaluation State Food and Drug AdministrationBeijing 100061China Department of Medical Genetics College of Basic Medical ScienceSecond Military Medical UniversityShanghai 200433China

The aim of this article was to investigate the influence and the related mechanism of the Retn gene on glucose uptake and insulin resistance in 3T3-L1 *** was used to determine glucose uptake in 3T3-L1 cells with different Retn gene expression levels,whether cells were stimulated by insulin or ***-PCR and real-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3-L1 cells with different Retn gene expression levels,including insulin receptor substrate-1(IRS-1),phosphatidylinositol 3-kinase(PI-3K),AKT-2,glucose transporter-4(GLUT-4),p38 mitogen-activated protein kinase(p38MAPK)and glycogen synthase kinase-3b(GSK-3b).The glucose uptake decreased with the increase in Retn gene expression in 3T3-L1 cells,which was independent of whether the cells were stimulated by insulin or *** mRNA expression of two signal proteins PI-3K and AKT-2 decreased and the other two signal proteins,GSK-3b and p38MAPK,increased with Retn overexpression in 3T3-L1 *** could induce insulin resistance in adipocytes,which might be related to the changes of some proteins in PI-3K and Ras pathways.

关键词： Resistin Retn gene insulin glucose uptake 3T3-L1 cells

Analyses on the tectonic thermal evolution and influence factors in the deep-water Qiongdongnan Basin

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Acta Oceanologica Sinica 2014年第12期33卷 107-117页

作者： WANG Zhenfeng SHI Xiaobin YANG Jun HUANG Baojia SUN Zhen WANG yahui jiang Haiyan YU Chuanhai YANG Xiaoqiu Zhanjiang Branch of China National Offshore Oil Corporation (CNOOC) Limited Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences University of Chinese Academy of Sciences

To reveal the tectonic thermal evolution and influence factors on the present heat flow distribution, based on 154 heat flow data, the present heat flow distribution features of the main tectonic units are first analyzed in detail, then the tectonic thermal evolution histories of 20 profiles are reestablished crossing the main deep-water sags with a structural, thermal and sedimentary coupled numerical model. On the basis of the present geothermal features, the Qiongdongnan Basin could be divided into three regions： the northern shelf and upper slope region with a heat flow of 50-70 mW/m^2, most of the central depression zone of 70-85 mW/m^2, and a NE trending high heat flow zone of 85-105 mW/m^2 lying in the eastern basin. Numerical modeling shows that during the syn-rift phase, the heat flow increases generally with time, and is higher in basement high area than in its adjacent sags. At the end of the syn-rift phase, the heat flow in the deep-water sags was in a range of 60-85 mW/m^2, while in the basement high area, it was in a range of 75-100 mW/m^2. During the post-rift phase, the heat flow decreased gradually, and tended to be more uniform in the basement highs and sags. However, an extensive magmatism, which equivalently happened at around 5 Ma, has greatly increased the heat flow values, and the relict heat still contributes about 10-25 mW/m^2to the present surface heat flow in the central depression zone and the southern uplift zone. Further analyses suggested that the present high heat flow in the deep-water Qiongdongnan Basin is a combined result of the thermal anomaly in the upper mantle, highly thinning of the lithosphere, and the recent extensive magma-tism. Other secondary factors might have affected the heat flow distribution features in some local regions. These factors include basement and seafloor topography, sediment heat generation, thermal blanketing, local magmatic injecting and hydrothermal activities related to faulting and overpressure.

关键词： northern continental margin South China Sea surface heat flow magmatism

CFD simulation on the generation of turbidites in deepwater areas: a case study of turbidity current processes in Qiongdongnan Basin, northern South China Sea

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Acta Oceanologica Sinica 2014年第12期33卷 127-137页

作者： jiang Tao ZHANG Yingzhao TANG Sulin ZHANG Daojun ZUO Qianmei LIN Weiren WANG yahui SUN Hui WANG Bo Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education China University of Geosciences Kochi Institute for Core Sample Research Japan Agency for Marine-Earth Science and Technology Zhanjiang Branch of China National Offshore Oil Corporation (CNOOC) Limited

Turbidity currents represent a major agent for sediment transport in lakes, seas and oceans. In particu-lar, they formulate the most significant clastic accumulations in the deep sea, which become many of the world＇s most important hydrocarbon reservoirs. Several boreholes in the Qiongdongnan Basin, the north-western South China Sea, have recently revealed turbidity current deposits as significant hydrocarbon res-ervoirs. However, there are some arguments for the potential provenances. To solve this problem, it is es-sential to delineate their sedimentary processes as well as to evaluate their qualities as reservoir. Numerical simulations have been developed rapidly over the last several years, offering insights into turbidity current behaviors, as geologically significant turbidity currents are difficult to directly investigate due to their large scale and often destructive nature. Combined with the interpretation of the turbidity system based on high-resolution 3D seismic data, the paleotophography is acquired via a back-stripping seismic profile integrated with a borehole, i.e., Well A, in the western Qiongdongnan Basin; then a numerical model is built on the basis of this back-stripped profile. After defining the various turbidity current initial boundary conditions, includ-ing grain size, velocity and sediment concentration, the structures and behaviors of turbidity currents are investigated via numerical simulation software ANSYS FLUENT. Finally, the simulated turbidity deposits are compared with the interpreted sedimentary bodies based on 3D seismic data and the potential provenances of the revealed turbidites by Well A are discussed in details. The simulation results indicate that a sedimen-tary body develops far away from its source with an average grain size of 0.1 mm, i.e., sand-size sediment. Taking into account the location and orientation of the simulated seismic line, the consistence between normal forward simulation results and the revealed cores in

关键词： turbidity current CFD simulation 3D seismic interpretation sedimentary process

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

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Acta Pharmaceutica Sinica B 2022年第1期12卷 424-436页

作者： Lei Luo Yiming Qi Hong Zhong Shinan jiang Hu Zhang Hao Cai yahui Wu Zhongwei Gu Qiyong Gong Kui Luo Huaxi MR Research Center(HMRRC) Department of RadiologyFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China College of Pharmaceutical Sciences Southwest UniversityChongqing 400716China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041China Amgen Bioprocessing Centre Keck Graduate InstituteClaremontCA 91711USA

Precisely delivering combinational therapeutic agents has become a crucial challenge for anti-tumor treatment. In this study, a novel redox-responsive polymeric prodrug(molecular weight,MW: 93.5 k Da) was produced by reversible addition-fragmentation chain transfer(RAFT) polymerization. The amphiphilic block polymer-doxorubicin(DOX) prodrug was employed to deliver a hydrophobic photosensitizer(PS), chlorin e6(Ce6), and the as-prepared nanoscale system [NPs(Ce6)] was investigated as a chemo-photodynamic anti-cancer agent. The glutathione(GSH)-cleavable disulfide bond was inserted into the backbone of the polymer for biodegradation inside tumor cells, and DOX conjugated onto the polymer with a disulfide bond was successfully released intracellularly. NPs(Ce6) released DOX and Ce6 with their original molecular structures and degraded into segments with low MWs of 41.2 k Da in the presence of GSH. NPs(Ce6) showed a chemo-photodynamic therapeutic effect to kill 4 T1 murine breast cancer cells, which was confirmed from a collapsed cell morphology, a lifted level in the intracellular reactive oxygen species, a reduced viability and induced apoptosis. Moreover, ex vivo fluorescence images indicated that NPs(Ce6) retained in the tumor, and exhibited a remarkable in vivo anticancer efficacy. The combinational therapy showed a significantly increased tumor growth inhibition(TGI,58.53%). Therefore, the redox-responsive, amphiphilic block polymeric prodrug could have a great potential as a chemo-photodynamic anti-cancer agent.

关键词： Stimuli responsiveness Polymeric prodrug Photodynamic therapy Combinational therapy Nanomedicine

Effectiveness of Xinglouchengqi decoction on constipation in patients with acute ischemic stroke: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2020年第1期40卷 112-120页

作者： Chen Pei jiang Lan Geng Hualei Han Xiao Xu Yinping Chen Yan Guo Jinbin Wu Shuang Wang yahui Yan Ruyu Ren Yi ZouYihuai Department of Neurology Dongzhimen Hospital affiliated to Beijing University of Chinese MedicineBeijing 100700China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical University&Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100088China Department of Neurology Beijing Pinggu Hospital of Traditional Chinese MedicineBeijing 101200China Department of Neurology Beijing Changping Hospital of Traditional Chinese MedicineBeijing 102200China Department of Neurology Hospital affiliated to Changzhi Academy of Chinese Medical SciencesChangzhi 046000China Department of Emergency Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

OBJECTIVE:To evaluate the effectiveness of traditional Chinese herbal Xinglouchengqi(XLCQ)decoction for the treatment of constipation in acute ischemic stroke patients,and figure out the role that bowel movements play in the treatment of acute ischemic ***:A total of 317 eligible patients were recruited and randomized to the XLCQ group(211 patients)or the control group(106 patients).In addition to conventional standard medical care and rehabilitation,participants in the XLCQ group received XLCQ decoction,while the control group received clysis therapy using glycerin enemas or lactulose oral *** groups were given treatment for 3 to 6 d,during which they received daily visits to record defecation features and accompanying *** assessments using the National Institutes of Health Stroke Scale(NIHSS)were conducted before and 1 month after ***:Patients in the XLCQ group had lower aggregate constipation scores compared with the control group on days 3 and 5(P<0.05).Spontaneous bowel movements tended to reappear more rapidly after taking the XLCQ decoction than after conventional laxative *** the average aggregate constipation score and the time taken to achieve spontaneous bowel movements showed positive correlations with NIHSS scores before and1 month after treatment(P<0.01).CONCLUSION:Treatment with XLCQ decoction effectively alleviated the overall symptoms of constipation in acute ischemic stroke *** status of bowel movements in acute ischemic stroke can reflect the severity of neurological impairment and predict neurological outcomes at 1 month.

关键词： Stroke Constipation Xinglouchengqi decoction Randomized controlled trial