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MULTI-LAYER PIEZOELECTRIC ACTUATOR AND ITS APPLICATION IN CONTROLLABLE CONSTRAINED DAMPING TREATMENT

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Chinese Journal of Mechanical Engineering 2007年第4期20卷 94-100页

作者： ZHANG Xinong XIE Shilin ZHANG yahong School of Aerospace Xi＇ an Jiaotong University Xi＇ an 710049. China

A kind of novel multi-layer piezoelectric actuator is proposed and integrated with controllable constrained damping treatment to perform hybrid vibration control. The governing equation of the system is derived based on the constitutive equations of elastic, viscoelastic and piezoelectric materials, which shows that the magnitude of control force exerted by multi-layer piezoelectric actuator is the quadratic function of the number of piezoelectric laminates used but in direct proportion to control voltage. This means that the multi-layer actuator can produce greater actuating force than that by piezoelectric laminate actuator with the same area under the identical control voltage. The optimal location placement of the multi-layer piezoelectric actuator is also discussed. As an example, the hybrid vibration control of a cantilever rectangular thin-plate is numerically simulated and carried out experimentally. The simulated and experimental results validate the power of multi-layer piezoelectric actuator and indicate that the present hybrid damping technique can effectively suppress the low frequency modal vibration of the experimental thin-plate structure.

关键词： Vibration control Multi-layer piezoelectric actuator Controllable constrained damping treatment Hybrid damping

A New Selection Criterion of Loop-free Alternate Interface for IP Fast Rerouting

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China Communications 2010年第3期7卷 91-98页

作者： Liu Jinhua Wang yahong Du Shuai Institute of Information Photonics and Optical Communications Beijing University of Posts and Telecommunica tions Beijing 100876 P. R. China Leadcore Technology Co. Ltd Shanghai 200233 P. R. China 3China Academy of Telecommunication Technologies Beijing 100083 P. R. China China Academy of Telecommunication Technologies Beijing 100083 P. R. China University of Science and Technology Beijing Beijing 100191 P. R. China

As the technology of IP Fast Rerouting (FRR) become mature and the related methods and specifi cation such as RFC5286 accepted as standard, it is expected that IP FRR will be deployed gradually and will enhance the survivability of IP network. This paper presents a different method for computing the Loop-free Alternate Interfaces. The new algorithm can be referred as "Next-Hop Cost Decrease (NHCD)" criterion. Compared with the RFC5286 LFA method, NHCD can handle both the simultaneous link failure and node failure, including multi-link failures. It has less computational complexity and can be used uniformly in the Traffi c Engineering and Network Recovery. However, NHCD is somewhat lower than the LFA method on recovery ratio of single link failure. After a formal description of NHCD criterion and a proof of loopfree alternates, the paper presents the simulation results of NHCD.

关键词： IP fast rerouting loop-free alternates descending cost for next-hop network survivability

数实融合下的新质生产力发展:发展优势、内在逻辑与实践方向

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China Economist 2024年第6期19卷 91-120页

作者：周亚虹郎旭华上海财经大学经济学院

实体经济和数字经济的深度融合(以下简称“数实融合”)发展,正在成为中国经济高质量发展的新动能、新增长极。数实融合下的新质生产力发展,具有要素提质增效、深化分工协作、拓宽市场空间和创新资源配置等四方面优势。它们贯穿从微观企... 详细信息

实体经济和数字经济的深度融合(以下简称“数实融合”)发展,正在成为中国经济高质量发展的新动能、新增长极。数实融合下的新质生产力发展,具有要素提质增效、深化分工协作、拓宽市场空间和创新资源配置等四方面优势。它们贯穿从微观企业生产过程到宏观经济运行机制革新的各个方面,为新质生产力发展提供内在动力。以产业高质量发展为主线,数实融合的这些独特优势贯穿于新质生产力发展逻辑始终,即在产业层面深化专业化生产、在产业链层面重构产业关联、在产业集群层面实现资源聚合,最终通过创新资源配置,形成更大范围、更强协同的现代化产业体系,从而构建起了一个相互串联、彼此贯通、结构立体的新质生产力发展体系。面对当前中国数实融合下新质生产力发展存在的问题,要着力通过完善要素市场化机制、产业创新机制、新产业与新业态投融资机制和相应的制度体系框架,充分释放数实融合发展的技术优势、系统优势、协同优势,为新质生产力的更好发展提供坚实支撑。

关键词：新质生产力数实融合发展优势实践方向

Design and test of cesium atomic concentration detection system based on TDLAS*1

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Optoelectronics Letters 2025年第3期 167-171页

作者： LIANG Lizhen LIU Shanhu WU Yong WEI Jianglong XIE yahong Hefei Institutes of Physical Science Chinese Academy of Sciences School of Science Shandong Jianzhu University School of Electronic and Information Engineering Anhui Jianzhu University

In order to better build the neutral beam injector with negative ion source (NNBI), the pre-research on key technologies has been carried out for the comprehensive research facility for fusion technology (CRFFT). Cesium seeding into negative-ion sources is a prerequisite to obtain the required negative hydrogen ion. The performance of ion source largely depends on the cesium conditions in the source. It is very necessary to quantitatively measure the amount of cesium in the source during the plasma on and off periods (vacuum stage).

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白细胞介素10工程化修饰人脐带间充质干细胞优效治疗炎症性肠病

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中国组织工程研究 2025年第23期29卷 4878-4887页

作者：冯乙芮高天芸王亚萍黄亚红王斌南京大学医学院附属鼓楼医院临床干细胞研究室南京大学生命科学学院江苏省南京市210008 南京大学医学院附属鼓楼医院临床干细胞研究室江苏省南京市210008 临床干细胞研究室南京鼓楼医院南京中医药大学鼓楼临床医学院江苏省南京市210008 南京大学生命科学学院江苏省南京市210008

背景:间充质干细胞来源广泛、易体外增殖,并可分泌一系列免疫调节因子抑制炎症、促进组织修复再生,广泛应用于各种疾病治疗研究。但是对于多种疾病,间充质干细胞的治疗效果有限。针对疾病特定发病机制或者干预靶点进行工程化修饰间充质... 详细信息

背景:间充质干细胞来源广泛、易体外增殖,并可分泌一系列免疫调节因子抑制炎症、促进组织修复再生,广泛应用于各种疾病治疗研究。但是对于多种疾病,间充质干细胞的治疗效果有限。针对疾病特定发病机制或者干预靶点进行工程化修饰间充质干细胞是未来细胞治疗的重要发展方向。目的:白细胞介素10是一种典型的抗炎细胞因子,有助于调节免疫反应并诱导巨噬细胞向抗炎表型极化,该研究探讨白细胞介素10基因工程化修饰人脐带间充质干细胞对炎症性肠病的治疗效果。方法:通过电转染建立稳定过表达人白细胞介素10基因的人脐带间充质干细胞,并基于细胞治疗产品标准筛选出临床级细胞。给予C57BL/6J小鼠自由饮用5%葡聚糖硫酸钠盐水溶液建立急性结肠炎模型,分别在造模前1 d(尾静脉途径)与造模后第4天(腹腔途径)注射空质粒转染的人脐带间充质干细胞或过表达人白细胞介素10基因的人脐带间充质干细胞(1×10~6个/只)。在造模后第6天取结肠组织进行苏木精-伊红染色评估组织学变化,免疫荧光染色检测增殖细胞核抗原与CD31的表达。结果与结论:构建的稳定过表达白细胞介素10的工程化人脐带间充质干细胞,满足临床级人脐带间充质干细胞质量标准;人脐带间充质干细胞对小鼠急性结肠炎具有修复效果,过表达白细胞介素10基因的人脐带间充质干细胞的治疗效果更加优效,更显著地抑制急性结肠炎小鼠的体质量下降(P<0.05)、结肠缩短(P<0.05)以及结肠组织损伤(P<0.05);过表达白细胞介素10基因人脐带间充质干细胞组结肠组织切片中增殖细胞核抗原阳性细胞与CD31阳性细胞显著多于人脐带间充质干细胞组,表明过表达白细胞介素10基因的人脐带间充质干细胞可能通过显著促进肠组织细胞增殖和血管再生进而促进结肠组织修复。

关键词：白细胞介素10 人脐带间充质干细胞工程化修饰间充质干细胞炎症性肠病再生修复细胞增殖肠再生

Research on emotion space of film and television scene images based on subjective perception

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The Journal of China Universities of Posts and Telecommunications 2019年第1期26卷 75-81,104页

作者： Su Zhibin Qian yahong Gu Yu Ren Hui School of Information and Communication Engineering Communication University of China School of Humanities and Social Sciences Beihang University

The premise of image emotion recognition is to determine its representative emotional adjectives and establish the quantifiable emotion space. In this paper, focusing on aroused emotion from film and television(TV) scene images, a method of selecting emotional adjectives and establishing the emotion space based on subjective perception experiment is proposed. Firstly, a special data set about film and TV scene images was established and a set of initial emotional adjectives was collected. Then the subjective perception experiment was designed to let subjects to evaluate the affection of all the initial adjectives during watching these scene images. Then the method of principal basis analysis was used for variable selection. Finally, the factor analysis was applied to accomplish the second dimension reduction to form a 5-dimensional(5 D) orthogonal emotion space. The optimized emotion space can explain more than 94% of original emotional adjectives, which greatly reduces the dimension of emotional adjectives and lays a foundation for the further research on image content and emotion recognition.

关键词： film and television scene images subjective perception emotion space principal basis analysis factor analysis

The Development of a Megawatt-Level High Current Ion Source

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Plasma Science and Technology 2012年第1期14卷 75-77页

作者： HU Chundong XIE yahong NBI team NBI team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

Neutral beam injection is one of the main plasma heating methods in nuclear fusion devices. In order to support the scientific study of the Experimental Advanced Superconducting Tokamak （EAST）, a megawatt-level high current ion source is designed and manufactured in the ASIPP, and the progress and preliminary test results will be presented in this paper.

关键词： NBI ion source megawatt high current

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen Qian Yixuan Sun Peishang Shi Xiuman zhou Qiongqiong Zhang Qingyu Dong Shengzhe Jin Lu Qiu Xiaoshuang Niu Xiaowen zhou Wenshan Zhao yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

Repair Effect of Hot Work Tool Steel by Laser-Melting Process

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Journal of Materials Science & Technology 2003年第z1期19卷 91-93页

作者： yahong SUN Satoshi HANAKI Hitoshi UCHIDA Hisakichi SUNADA Nobuhiro TSUJII Graduate School of Engineering Himeji Institute of Technology 2167ShoshaHimeji 671-2201Japan Technical Research Laboratories Sanyo Special Steel Co.LTD.3007NakajimaShikama-kuHimeji 672-8677Japan

Both wear and crack due to heat checking in hot work tool steel are major failure *** is desirable to find amethod to lengthen the tool life while reducing manufacturing *** paper suggests a method to improve toollife for hot work tool steel(SKD6)with crack by laser-melting *** method has been evaluated using theimpact and fatigue test *** is demonstrated that a repair of the crack by a laser-melting process is effectivefor life extension of the damaged tool.

关键词： Hot work tool steel Laser-melting process Impact test Fatigue test Fractography