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A New Selection Criterion of Loop-free Alternate Interface for IP Fast Rerouting

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China Communications 2010年第3期7卷 91-98页

作者： Liu Jinhua wang yahong Du Shuai Institute of Information Photonics and Optical Communications Beijing University of Posts and Telecommunica tions Beijing 100876 P. R. China Leadcore Technology Co. Ltd Shanghai 200233 P. R. China 3China Academy of Telecommunication Technologies Beijing 100083 P. R. China China Academy of Telecommunication Technologies Beijing 100083 P. R. China University of Science and Technology Beijing Beijing 100191 P. R. China

As the technology of IP Fast Rerouting (FRR) become mature and the related methods and specifi cation such as RFC5286 accepted as standard, it is expected that IP FRR will be deployed gradually and will enhance the survivability of IP network. This paper presents a different method for computing the Loop-free Alternate Interfaces. The new algorithm can be referred as "Next-Hop Cost Decrease (NHCD)" criterion. Compared with the RFC5286 LFA method, NHCD can handle both the simultaneous link failure and node failure, including multi-link failures. It has less computational complexity and can be used uniformly in the Traffi c Engineering and Network Recovery. However, NHCD is somewhat lower than the LFA method on recovery ratio of single link failure. After a formal description of NHCD criterion and a proof of loopfree alternates, the paper presents the simulation results of NHCD.

关键词： IP fast rerouting loop-free alternates descending cost for next-hop network survivability

New Interpretation of Postmodern Cultural School on Women＇s Social Status

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学术界 2016年第3期 275-280页

作者： Lu Dechun Qiu Zhongrong wang yahong college of foreign languages Chongqing Three Gorges University Chongqing 404100

Postmodern cultural school makes a deep exploration of women's social roles and values from the perspective of human beings' social naturalness,culture and social function,conducts deep introspection on women's social status from both macro and micro levels and carries out a brand newinterpretation of the impetus effect of critical thinking on women's social development. Postmodern cultural school overthrows the definitions and viewpoints expressed in traditional social constructivism and power theory by other cultural schools,explaining objectively the measuring standards of women's social status and refuting male chauvinism,thus promoting newattention to be paid to women's equality in social status.

关键词：现代文化社会角色妇女社会建构主义解读学派批判性思维人类社会

Three-dimensional reconstruction of systematic histological sections:application to observations on palatal shelf elevation

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International Journal of Oral Science 2021年第2期13卷 183-189页

作者： Weilong Liu Xiaoming wang Yinuo wang yahong wang Jing Zhang Bing Shi Chenghao Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cleft Lip and Palate Surgery West China School of StomatologySichuan UniversityChengduChina College of Electrical Engineering and information Technology Sichuan UniversityChengduChina

Normal mammalian secondary palate development undergoes a series of processes,including palatal shelf(PS)growth,elevation,adhesion and fusion,and palatal bone *** has been estimated that more than 90%of isolated cleft palate is caused by defects associated with the elevation ***,because of the rapidly completed elevation process,the entire process of elevation will never be easy to *** this article,we present a novel method for three-dimensional(3D)reconstruction of thick tissue blocks from two-dimensional(2D)histological *** established multiplanar sections of the palate and tongue in coronal and sagittal directions,and further performed 3D reconstruction to observe the morphological interaction and connection between the two components prior to and during *** method completes an imaging system for simultaneous morphological analysis of thick tissue samples using both synthetic and real *** new method will provide a comprehensive picture of reorientation morphology and gene expression pattern during the palatal elevation process.

关键词： histological shelf sections

Black Box Modeling Method and Its Application in Refractories Techniques

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China's Refractories 2012年第4期21卷 1-6页

作者： wang Jiezeng YUAN Lin YE yahong LI Penghai wang Juntao Ruitai Materials Technology Co. Ltd. Beijing 100024 China

Concept of black box, condition of modeling and control methods were introduced. Taking high purity silica brick as an example, the silica brick featured with high purity, low porosity, low true density and high strength was developed through problem analysis, test design, modeling and optimization. Using information technology to upgrade refractories industry was discussed.

关键词： black box modeling optimization techniques refractories

AKT/mTOR and C-Jun N-terminal Kinase(JNK) Signaling Pathways Are Required for Chrysotile Asbestos-Induced Autophagy

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AKT/mTOR and C-Jun N-terminal Kinase(JNK) Signaling Pathways...

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Ziying Ziying Lin yahong wang Gang Liu 广东医学院附属医院临床医学研究中心

Chrysotile asbestos is closely associated with excess mortality from pulmonary diseasessuch as lung cancer, mesothelioma, and asbestosis. Although multiple mechanisms inwhich chrysotile asbestos fibers induce pulmonary disease have been identified, the role ofautophagy in human lung epithelial cells has not been examined. In the present study, weevaluated whether chrysotile asbestos induces autophagy in A549 human lung epithelialcells, and then analyzed the possible underlying molecular mechanism. Chrysotile asbestos-induced autophagy in A549 cells based on a series of biochemical and microscopicautophagy markers. We observed that asbestos increased A549 cell microtubule-associated protein 2 light chains 3(LC3-II) expression, an autophagy marker, in conjunctionwith dephosphorylation of phospho-AKT, phosphomTOR, and phospho-P70s6 ***, AKT1/AKT2 double knockout(AKT DKO) murine embryonic fibroblasts(MEFs) hadnegligible asbestos-induced LC3-II expression supporting a crucial role for AKT *** asbestos also led to the phosphorylation/activation of Jun N-terminal kinase(JNK) and p38 MAPK. Pharmacologic inhibition of JNK, but not p38 MAPK, dramatically inhibitedthe protein expression of LC3-II. Moreover, JNK2-/- MEFs but not JNK1-/- MEFsblocked LC3-II levels induced by chrysotile asbestos. In addition, NAC, an antioxidant, attenuatedchrysotile asbestos-induced dephosphorylation of P-AKT and completely abolishedphosphorylation/activation of JNK. Finally, we demonstrated that chrysotile asbestos-induced apoptosis was not affected by the presence of the autophagy inhibitors 3-methyladenine(3-MA) or ATG5(autophagy-related gene 5) siRNA, indicating thatchrysotile asbestos-induced autophagy may be adaptive rather than prosurvival. Our findingsdemonstrate that AKT/mTOR and JNK2 signaling pathways are required for chrysotileasbestosinduced autophagy. These data provide a mechanistic basis for possible futureclinical applications targeting these signaling path

关键词： chrysotile asbestos autophagy LC3-Ⅱ pulmonary disease A549 cells

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旱地水窑开挖数值模拟与结构形状参数验证

农业工程学报 2007年第6期23卷 66-70页

作者：李宗利王亚红西北农林科技大学水利与建筑工程学院杨凌712100

旱地水窑是集雨蓄水,解决人畜饮水、发展节水灌溉的有效集雨蓄水工程。从水窑结构受力特性分析,水窑属于浅埋式非衬砌地下结构,其结构形状及尺寸是决定窑体稳定和安全的关键因素,而开挖阶段又是窑体最危险阶段之一。针对前期研究所拟定... 详细信息

旱地水窑是集雨蓄水,解决人畜饮水、发展节水灌溉的有效集雨蓄水工程。从水窑结构受力特性分析,水窑属于浅埋式非衬砌地下结构,其结构形状及尺寸是决定窑体稳定和安全的关键因素,而开挖阶段又是窑体最危险阶段之一。针对前期研究所拟定出的斜墙圆拱式窑体形状及参数,应用弹塑性非线性分析方法,分别采用两种不同开挖工序及过程进行开挖过程模拟研究,并从反映水窑体稳定性的位移、塑性区及拉应力3个方面分析了开挖卸荷对窑体稳定性的影响。数值模拟结果表明:不管采用上行法还是下行法开挖,水窑在开挖过程中土体是稳定的,从而验证了以前研究所推荐的水窑形状参数及拱曲线是合理的,所提出的计算理论和方法可以用于实际水窑的设计。

关键词：旱地水窑稳定开挖数值模拟验证

The JNK signaling pathway mediates chrysotile asbestos-inducedalveolar epithelial cell apoptosis

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The JNK signaling pathway mediates chrysotile asbestos-induc...

我国城乡居民收入差距监测预警研究——基于对重点区域的分析

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Gang Liu Ziying Lin yahong wang Jinfeng Tang Haili Huang 广东医学院附属医院临床医学研究中心

Chrysotile asbestos exposure is associated with excess mortality from pulmonary diseasessuch as lung cancer, mesothelioma, and asbestosis. Although multiple mechanisms bywhich chrysotile asbestos fibers induce pulmonary disease have been identified, the roleof apoptosis in human lung alveolar epithelial cells(AEC) has not been fully explored. Accumulatingevidence implicate AEC apoptosis as a crucial event in the development ofidiopathic pulmonary fibrosis(IPF) as well as asbestosis. The goal of this study was to determinewhether chrysotile asbestos induces mitochondria-regulated(intrinsic) AEC apoptosisand, if so, whether this occurs via activation of mitogen-activated protein kinases(MAPK). Using human A549 bronchoalveolar carcinoma-derived cells with alveolar epithelialtype II-like features, we show that chrysotile asbestos induces a dose/timedependentdecrease in cell viability, which is accompanied by the activation of the MAPKc-Jun N-terminal kinases(JNK), but not the MAPKs extracellular signal-regulated kinase(ERK)1/2 and p38. Chrysotile asbestos induces intrinsic AEC apoptosis as evidenced by theup-regulation of pro-apoptotic Bax and Bak along with activation of caspase-9, poly(ADPribose)polymerase(PARP), and cytochrome c release. Notably, SP600125, a specific JNKinhibitor, blocked chrysotile asbestos-induced JNK activation and apoptosis as assessed byboth caspase-9 cleavage and PARP activation. Our results demonstrate that chrysotile asbestosinduces intrinsic AEC apoptosis by a JNK-dependent mechanism and suggests apotential novel target for modulating chrysotile asbestos-related lung diseases.

关键词： chrysotile asbestos apoptosis c-Jun N-terminal kinases(JNK) mitochondriald ysfunction

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安徽农业科学 2011年第1期39卷 615-617页

作者：王亚红郑州大学旅游管理学院河南郑州450001

在对分析我国城乡居民收入差距的区域格局进的基础上,选择了12个重点省区进行分析和预警,旨在为针对性地解决问题,最终实现区域间、城乡间的协调发展创造条件。

关键词：城乡居民收入差距监测预警重点区域

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PM2.5 induces autophagy via inhibition of the PI3K/Akt/mTOR kinasesignaling pathway in human bronchial epithelial cells

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PM2.5 induces autophagy via inhibition of the PI3K/Akt/mTOR ...