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Solid-state characterization and impurities determination of fluconazol generic products marketed in Morocco

Journal of Pharmaceutical Analysis 2012年第6期2卷 412-421页

作者： Houda Bourichi Youness Brik Philipe Hubert yahia cherrah Abdelaziz Bouklouze Research Team of Pharmaceutical and Toxicological Analysis-Laboratory of Pharmacology and Toxicology Faculty of Medicine and Pharmacy Mohammed V University Soussi Rabat Morocco Physicochemical Service Drugs Quality Control Laboratory Division of Drugs and Pharmacy Ministry of Health Rabat Morocco Laboratory of Analytical Chemistry Department of Pharmacy CIRM (university of liège) B36-B40000 liège l Belgium

In this paper, we report the results of quality control based in pbysicochemical characteriza- tion and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were supplied by different pharmaceuticals companies. The sample A, as the discovered product, was supplied by Pfizer, while samples B and C （generics）, were manufactured by two different Indian industries. Solid-state characterization of the three samples was realized with different physicochemical methods as： X-ray powder diffraction, Fourier-transformation infrared spectroscopy, differential scanning calorimetry. High performance liquid chromatography was used to quantify the impurities in the different samples. The results from the physicochemical methods cited above, showed difference in polymorph structure of the three drug substances. Sample A consisted in pure polymorph II1, sample B consisted in pure polymorph I1, sample C consisted in a mixture of fluconazole Form Ili, form II and the monohydrate. This result was confirmed by differential scanning calorimetry. Also it was demonstrated that solvents used during the re-crystallization step were among the origins of these differences in the structure form. On the other hand, the result of the stability study under humidity and temperature showed that fluconazole polymorphic transformation could be owed to the no compliance with the conditions of storage. The HPLC analysis of these compounds showed the presence of specific

关键词： Generic productQuality control Fluconazole Polymorphism Impurities

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Integrative herbal treatments of diabetes in Beni Mellal region of Morocco

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Journal of Integrative Medicine 2019年第2期17卷 93-99页

作者： Hanae Naceiri Mrabti Nidal Jaradat Mohamed Reda Kachmar Abdelaziz Ed-Dra Abdelilah Ouahbi yahia cherrah Moulay El Abbes Faouzi Faculty of Medicine and Pharmacy Pharmacokinetic Team Laboratory of Pharmacology and Toxicology Université Mohammed V-Souissi Department of Pharmacy Faculty of Medicine and Health Sciences An-Najah National University Faculty of Sciences Health and Environment Laboratory Plant Protection Team Moulay Ismail University Faculty of Science Team of Microbiology and Health Laboratory of Chemistry-Biology Applied to the Environment Moulay Ismail University

Objectives: Diabetes is one of the most life-threatening chronic metabolic disorders and is considered a global health problem due to its prevalence and incidence. In Morocco, several herbal preparations are utilized to treat this disease. For this reason, the current study aimed to identify and to collect data about the medicinal plants utilized in folk medicine for the treatment of diabetes in the Beni Mellal region of ***: An ethnobotanical survey was carried out among 400 herbalists, competent villagers and traditional healers from the Beni Mellal region through direct interviews using a semistructured ***: Forty-five medicinal plants belonging to 25 families were identified for their use in diabetes treatment. Interview results showed that the most frequently used plants were Olea europaea, Salvia officinalis, Allium sativum and Trigonella foenum-graecum, with a relative frequency of citation values of24.3%, 23.0%, 22.5% and 20.5%, respectively. Moreover, in this study, the Fabaceae family was the most commonly reported plant family, and the leaves and roots were the most commonly used parts, for the treatment of ***: The Beni Mellal region of Morocco has an important floristic biodiversity of plants used to treat diabetes in traditional medicinal practice. This result provides a good database for pharmacological screenings in the search for plant-based antidiabetic medications.

关键词： Integrative medicine Medicinal plants Diabetes Beni Mellal Morocco Questionnaire

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Dependence of thermodynamic quantities at freeze-out on pseudorapidity and collision energy in p-p collisions at LHC energies

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Chinese Physics C 2024年第10期48卷 235-246页

作者： Murad Badshah yahia A.H.Obaidat Haifa I.Alrebdi M.Waqas Muhammad Ajaz Refka Ghodhbani Department of Physics Abdul Wali Khan University MardanMardan 23200Pakistan Department of Physics College of ScienceUniversity of BishaBisha 61922Saudi Arabia Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia School of Mathematics Physics and Optoelectronic EngineeringHubei University of Automotive TechnologyShiyan 442002China Department of Computer Sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafhaSaudi Arabia

The transverse momentum distributions of charged hadrons produced in proton-proton collisions at center-of-mass energies(√s)of 0.9 TeV and 2.36 TeV,as measured by the CMS detector at the Large Hadron Collider(LHC),have been analyzed within various pseudorapidity classes utilizing the thermodynamically consistent Tsallis *** fitting procedure resulted in the key parameters,namely,effective temperature(T),non-extensivity parameter(q),and kinetic freezeout volume(V).Additionally,the mean transverse momentum()and initial temperature(T_(i))of the particle source are determined through the fit function and string percolation method,*** alternative method is employed to calculate the kinetic freezeout temperature(T_(0))and transverse flow velocity(β_(T))from ***,thermodynamic quantities at the freezeout,including energy density(ε),particle density(n),entropy density(s),pressure(P),and squared speed of sound(C_(s)^(2)),are computed using the extracted T and *** is also observed that,with a decrease in pseudorapidity,all thermodynamic quantities except V and q *** trend is attributed to greater energy transfer along the mid pseudorapidity.q increases towards higher values of pseudorapidity,indicating that particles close to the beam axis are far from ***,V remains nearly independent of *** excitation function of these parameters(q)shows a direct(inverse)correlation with collision *** ε,n,s,and P show a strong dependence on collision energies at low *** verification of the thermodynamic inequality ε≥3P suggests the formation of a highly dense droplet-like Quark-Gluon Plasma(QGP).Additionally,the inequality T_(i)>T>T_(0)is explicitly confirmed,aligning with the evolution of the produced fireball.

关键词： charged hadrons tsallis statistics effective temperature non-extensivity parameter pseudorapidity kinetic freeze-out stage multiple freeze-out scenario QGP QCD matter squared speed of sound

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AI-Based Helmet Violation Detection for Traffic Management System

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 733-749页

作者： yahia Said YahyaAlassaf Refka Ghodhbani Yazan Ahmad Alsariera Taoufik Saidani Olfa Ben Rhaiem Mohamad Khaled Makhdoum Manel Hleili Department of Electrical Engineering College of EngineeringNorthern Border UniversityArar91431Saudi Arabia Department of Civil Engineering College of EngineeringNorthern Border UniversityArar91431Saudi Arabia Faculty of Computing and Information Technology Northern Border UniversityRafha91911Saudi Arabia College of Science Northern Border UniversityArar91431Saudi Arabia Department of Mathematics Faculty of Sciences of TabukUniversity of TabukTabuk71491Saudi Arabia

Enhancing road safety globally is imperative,especially given the significant portion of traffic-related fatalities attributed to motorcycle accidents resulting from non-compliance with helmet *** the critical role of helmets in rider protection,this paper presents an innovative approach to helmet violation detection using deep learning *** primary innovation involves the adaptation of the PerspectiveNet architecture,transitioning from the original Res2Net to the more efficient EfficientNet v2 backbone,aimed at bolstering detection *** rigorous optimization techniques and extensive experimentation utilizing the India driving dataset(IDD)for training and validation,the system demonstrates exceptional performance,achieving an impressive detection accuracy of 95.2%,surpassing existing ***,the optimized PerspectiveNet model showcases reduced computational complexity,marking a significant stride in real-time helmet violation detection for enhanced traffic management and road safety measures.

关键词： Non-helmet use detection traffic violation safety deep learning optimized PerspectiveNet

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Endoscopic Transcanal Excision of Glomus Tympanicum: A Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 305-310页

作者： Mohammed Atiah Alzahrani yahia Dhafer Alahmari Ali Jaber Asiry Ibrahem Hamad Erwe Ghada Ahmed Bin Abbas Department of Otorhinolaryngology Aseer Central Hospital Abha Saudi Arabia College of Medicine University of King Khalid Abha Saudi Arabia

Glomus tumors are extremely rare tumors that arise from paraganglionic cells, which are derived from neural crest cells. These tumors are benign, slow-growing, locally invasive, and destructive. Glomus tumors are the most common tumor of the middle ear cavity and the second most common tumor of the temporal bone. We present a case of a 49-year-old healthy female who, following diagnostic tools, received surgical intervention resulting in an excellent outcome. Our case report includes a comprehensive analysis of published cases in the literature.

关键词： Glomus Tympanicum Paragangliomas Endoscopic Transcanal

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Hematological Alterations in an Eastern Sudanese Chronic Kidney Disease Patient Population

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Open Journal of Urology 2024年第6期14卷 359-367页

作者： Mohammed Omer Abaker Gibreel Sundus Kamal Ibrahim Wijdan Abdel Aziz Hassan Manar yahia Mahjoub Leyla Mohammed Kheir Hamid Hibatellah Majzoub Abbas Nuha Fouzi Mohammed Secretariat of Academic Affairs Port Sudan Ahlia University Port Sudan Sudan Department of Hematology and Immunohematology College of Graduate Studies Port Sudan Ahlia University Port Sudan Sudan

Background: Chronic Kidney Disease (CKD), associated with a slow and progressive loss of kidney function over a period of several years, is an important clinical disaster with an increasing rate of morbidity and mortality especially in the least developed countries. Many hematological parameters are thought to alter dramatically during the course of the disease. These include white blood cells, red blood cells, and platelets. Methods: We tried, retrospectively, to evaluate the peripheral blood hematological alterations in a group of patients undergoing hemodialysis in an eastern Sudan dialysis center to add local medical information. Results: Anemia (Low hemoglobin and hematocrit) was detected in 94% of the patients’ group. Mean Erythrocyte count (3.32vs.4.76 (×109/L)), Hemoglobin concentration (9.4vs.13 (g/dl)), Hematocrit (28.7vs.38.7 (L/L)) and platelet count (296 vs. 238 (×109/L)) were significantly lower in the patients’ group than in the control group (P-values Conclusion: Five out of eight studied parameters (Red cell count, hemoglobin, hematocrit, mean cell hemoglobin concentration, and platelets count) have shown a significant alteration in CKD patients. As the complete blood count (CBC) test is the most utilized test in clinical laboratory practice, these alterations may be considered as early indicators for CKD. Furthermore, all patients with CKD must be routinely checked for these alterations.

关键词： Chronic Kidney Disease Chronic Renal Failure Hematological Alterations CBC Eastern Sudan Hemodialysis

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Assessment of Breast Cancer Prevention Practices among Women Attending Primary Health Care in Abha City, Aseer Region, Saudi Arabia

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International Journal of Clinical Medicine 2024年第2期15卷 31-54页

作者： Sabah Mohammed Asiri Sultan yahia Alfifii Tagreed Khairan Al-Rashidi Sager Misfer Alqahtani Faiz Abdulrahman Alshafa Fayez Mari Alamri Amal Mohammed Asiri Fatima Mohammed Ali Almagadi Thuraya Mohammed Asiri Department of Therapeutic Assistance Management General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Health Affairs General Directorate of Health Affairs Asser Region Abha Saudi Arabia Department of Kidney King Khaled Hospital Hail Saudi Arabia Department of Nursing Sarat Abida Hospital Aseer Saudi Arabia Department of Radiation Oncology King Faisal Medical City Abha Saudi Arabia Department of Health Affairs KSA MOH Department of Kidney Dialysis Centers General Directorate of Health Affairs Aseer Region Abha Saudi Arabia Department of Operation Ahad Rafidah Hospital General Directorate of Health Affairs in Asseer Region Abha Saudi Arabia South Qunfudah General Hospital Jizan Saudi Arabia Armed Forces Southern Region Hospital Aseer Saudi Arabia

Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for 15.9% of all cancers reported among Saudi nationals and 28.7% of all cancers reported among females of all ages. Early detection of breast cancer could decrease the risks, have a better prognosis, and have better outcomes/more successful treatments. Prevalence of breast cancer reached more than 25% of all diagnosed cancer in the kingdom among women. Aim: This study aims to assess the knowledge and performance of women attending primary care centers about breast self-examination and mammogram screening for prevention and early detection of breast cancer in Abha city primary healthcare centers, Kingdom of Saudi Arabia. Research Method: cross sectional design was conducted by using questionnaire, which was distributed to primary care center nurses. The collected data was statistically analyzed using the Statistical Package for Social Sciences, version 25. Results: The study found that participants had poor awareness and knowledge about breast self-examination, risk factors for breast cancer, and trends and practices in early diagnosis of breast cancer. Conclusion and Recommendations: It recommends increasing awareness campaigns and providing educational programs to improve knowledge and practices.

关键词： Assessment Breast Cancer Prevention Practices Women Attending Health Care Centers Abha City

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Effect of wind stress forcing on ocean dynamics at air-sea interface

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Frontiers of Information Technology & Electronic Engineering 2018年第8期19卷 1056-1062页

作者： Hussein yahia Veronique GARCON Joel SUDRE Christophe MAES Research Center INRIA Bordeaux-South West Talence 33405France CNRS LEGOS LaboratoryToulouse 31400France Brest University CNRSIRDIFREMERLOPSIUEMBrest 29238France

We evidence and study the differences in turbulence statistics in ocean dynamics carried by wind forcing at the air-sea interface. Surface currents at the air-sea interaction are of crucial importance because they transport heat from low to high latitudes. At first order, oceanic currents are generated by the balance of the Coriolis and pressure gradient forces(geostrophic current) and the balance of the Coriolis and the frictional forces dominated by wind stress(Ekman current) in the surface ocean layers. The study was conducted by computing statistical moments on the shapes of spectra computed within the framework of microcanonical multi-fractal formalism. Remotely sensed daily datasets derived from one year of altimetry and wind data were used in this study, allowing for the computation of two kinds of vector fields: geostrophy with and geostrophy without wind stress forcing. We explore the statistical properties of singularity spectra computed from velocity norms and vorticity data, notably in relation with kurtosis information to underline the differences in the turbulent regimes associated with both kinds of velocity fields.

关键词： Ocean dynamics Remote sensing Turbulence Signal processing Multi-fractal formalism

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An Intelligent Adaptive Dynamic Algorithm for a Smart Traffic System

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Computer Systems Science & Engineering 2023年第7期46卷 1109-1126页

作者： Ahmed Alsheikhy yahia Said Tawfeeq Shawly Electrical Engineering Department College of EngineeringNorthern Border UniversityArarSaudi Arabia Electrical Engineering Department Faculty of Engineering at RabighKing Abdulaziz UniversityJeddahSaudi Arabia

Due to excessive car usage,pollution and traffic have *** urban cities in Saudi Arabia,such as Riyadh and Jeddah,drivers and air quality suffer from traffic *** the government has implemented numerous solutions to resolve this issue or reduce its effect on the environment and residents,it still exists and is getting *** paper proposes an intelligent,adaptive,practical,and feasible deep learning method for intelligent traffic *** uses an Internet of Things(IoT)sensor,a camera,and a Convolutional Neural Network(CNN)tool to control traffic in real *** image segmentation algorithm analyzes inputs from the cameras installed in designated *** study considered whether CNNs and IoT technologies could ensure smooth traffic flow in high-speed,high-congestion *** presented algorithm calculates traffic density and cars’speeds to determine which lane gets high priority first.A real case study has been conducted on MATLAB to verify and validate the results of this *** algorithm estimates the reduced average waiting time during the red light and the suggested time for the green and red *** assessment between some literature works and the presented algorithm is also *** contrast to traditional traffic management methods,this intelligent and adaptive algorithm reduces traffic congestion,automobile waiting times,and accidents.

关键词： Smart traffic control artificial intelligence traffic congestion IoT CNN smart roads

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Effects of SARS-CoV-2 infection on pregnancy outcome:An overview

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Asian pacific Journal of Reproduction 2023年第4期12卷 155-161页

作者： yahia A.Amin Department of Theriogenology Faculty of Veterinary MedicineAswan UniversityAswanEgypt

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection may have harmful effects on expectant moms,labor,and newborns born to infected *** is a risk of the initiation of pregnancy with *** if the gametes are non-infected,pregnancies could be exposed later for infection by *** of COVID-19 during pregnancy highlighted the non-transmission or surprising transmission of SARS-CoV-2 to the ***,other studies have exhibited the potential mother-to-fetus *** this way,unanswered concerns about SARS-CoV-2 fetal transmission and the particular interface(s)controlling its pathogenesis throughout pregnancy *** review focuses on the potential effects of SARS-CoV-2 on vertical transmission,as well as the influence of the virus on pregnancy and placenta.

关键词： SARS-CoV-2 Hazard effects Pregnancy Placenta

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