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Quantitative Biology 2024年第2期12卷 197-204页

作者： yahan Li Xinrui Cai Junliang Shang Yuanyuan Zhang Jin-Xing Liu School of Computer Science Qufu Normal UniversityRizhaoChina School of Information and Control Engineering Qingdao University of TechnologyQingdaoChina School of Health and Life Sciences University of Health and Rehabilitation SciencesQingdaoChina

Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex *** data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data *** this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data *** of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different *** results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.

关键词： high-order epistasis model penetrance table resampling strategy simulation single nucleotide polymorphisms

新时代高等职业院校“大思政课”实践育人体系建构的探索——四川工程职业技术大学“传火·铸魂”思政育人品牌的实践

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装备制造与教育 2024年第1期38卷 13-17页

作者：杨雅涵倪波唐鹏唐咏春四川工程职业技术大学四川德阳618000

近年来,四川工程职业技术大学以习近平总书记关于思政课建设的重要论述、关于“大思政课”的重要指示批示为指导,从问题导向出发,逐一破解教学难题,继而系统规划统筹育人资源,逐步构建起以“课程-平台-项目-品牌-基地-队伍”六维聚力的... 详细信息

近年来,四川工程职业技术大学以习近平总书记关于思政课建设的重要论述、关于“大思政课”的重要指示批示为指导,从问题导向出发,逐一破解教学难题,继而系统规划统筹育人资源,逐步构建起以“课程-平台-项目-品牌-基地-队伍”六维聚力的“传火·铸魂”大思政课实践育人体系。打造了“理想信念之识-青春奋斗之能-民族复兴之志”进阶目标课程,锻造了一支把专业教育与思政实践深入结合的团队,建成“传火铸魂”实践教育基地,孵化“传火铸魂”创新行动项目,以“传理想信念之火,传青春奋斗之火,传民族复兴之火,铸时代新人之魂”的理念贯穿多场域、全链条育人过程,凝炼出“大思政课”实践育人的品牌。

关键词：大思政课实践教学育人目标

Chemical warfare agent countermeasures based on macrocycle supramolecular chemistry

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Science China Chemistry 2024年

作者： Junyi Chen yahan Zhang Chunju Li Qingbin Meng State Key Laboratory of National Security Specially Needed Medicines Beijing Institute of Pharmacology and Toxicology Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of Chemistry Tianjin Normal University

Given that chemical warfare agents(CWAs) pose some of the largest threats to humankind, social stability, and world peace,considerable attention has been drawn to the development of the corresponding detection, decontamination, and treatment techniques. The versatile functionality and distinctive recognition potency of macrocycles enable their customized design for specific tasks, such as chemical sensing, catalysis, or separation. Hence, supramolecular materials are well suited for the establishment of CWA countermeasures. Herein, we summarize the recent progress in the development of macrocycle-based materials for counteracting several representative CWAs, including nerve, blister, blood, incapacitating, choking, and irritating agents, providing a foundation for further advances in this field and fostering practical translational terms.

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Expert recommendation on collection,storage,annotation,and management of data related to medical artificial intelligence

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智慧医学(英文) 2023年第2期3卷 144-149页

作者： yahan yang Ruiyang Li Yifan Xiang Duoru Lin Anqi Yan Wenben Chen Zhongwen Li Weiyi Lai Xiaohang Wu Cheng Wan Wei Bai Xiucheng Huang Qiang Li Wenrui Deng Xiyang Liu Yucong Lin Pisong Yan Haotian Lin Chinese Association of Artificial Intelligence Medical Artificial Intelligence Branch of Guangdong Medical Association Zhongshan Ophthalmic Center Sun Yat-sen UniversityState Key Laboratory of OphthalmologyGuangzhouGuangdong 510623China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510080China Nanjing University of Aeronautics and Astronautics NanjingJiangsu 210016China Institute of Software Engineering School of Computer Science and TechnologyXidian UniversityXi’anShaanxi 710071China Cloud Intelligent Care Tech.Ltd. GuangzhouGuangdong 510115China Centre for Precision Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510080China 不详

Medical artificial intelligence(AI)and big data technology have rapidly advanced in recent years,and they are now routinely used for image-based *** has a massive amount of medical ***,a uniform criteria for medical data quality have yet to be ***,this review aimed to develop a standardized and detailed set of quality criteria for medical data collection,storage,annotation,and management related to medical *** would greatly improve the process of medical data resource sharing and the use of AI in clinical medicine.

关键词： Artificial intelligence Big data Intelligent medicine Data collection Data storage Data annotation Data management

An Improved Non-coupled PCNN Model for Image Segmentation

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An Improved Non-coupled PCNN Model for Image Segmentation

作者： Xiangyu Deng yahan yang Wenjuan Qin College of Physics and Electronic Engineering Northwest Normal University

Pulse-coupled neural network（PCNN） model is widely used in digital image processing,but it is always a difficult problem to set network parameters and determine the optimal *** analyzing the firing characteristics and network parameters setting for the non-coupled linking PCNN,we propose an improved non-coupled linking PCNN for image *** model introduce the coupling effect of neighboring neurons into the dynamic threshold subsystem,and using a combination of DNN network,manual adjusting on step length for setting the dynamic threshold initial *** the dynamic threshold initial value is adjusted properly,the optimal segmentation for the image can be *** the proposed algorithm in image segmentation of Lena and mammographic images,the segmentation effect similar to that of the traditional model can be obtained by less iteration,and it shows faster speed and better robustness.

关键词： Non-coupled PCNN model Network parameters Coupling effect of neighbor DNN prediction

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地方政府竞争促进了地区碳排放强度吗?

经济与管理评论 2022年第2期38卷 136-146页

作者：李治国杨雅涵赵园春中国石油大学(华东)经济管理学院山东青岛266580 悉尼大学商学院新南威尔士州悉尼2006

碳排放强度是低碳发展模式的重要衡量标准之一,降低碳强度已成为中国亟待解决的重要问题,政府干预是解决这一问题的重要手段。通过构建“古诺竞争模型”,运用数理模型提出假说,进一步基于我国2006-2019年的省级面板数据,运用中介效应与... 详细信息

碳排放强度是低碳发展模式的重要衡量标准之一,降低碳强度已成为中国亟待解决的重要问题,政府干预是解决这一问题的重要手段。通过构建“古诺竞争模型”,运用数理模型提出假说,进一步基于我国2006-2019年的省级面板数据,运用中介效应与门槛效应分析地方政府竞争对碳排放强度的影响。研究发现:地方政府竞争直接导致了地区碳排放强度的增加,且通过环境规制影响碳强度的传导路径存在,地方政府竞争通过降低环境规制强度从而增加了地区碳排放强度;随着地方政府竞争水平的降低,环境规制对碳排放强度的影响呈倒N型关系。

关键词：地方政府竞争环境规制碳排放强度中介效应门槛回归

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大景深光子多普勒测速仪设计及高超试验应用

光子学报 2022年第6期51卷 19-26页

作者：郝歌扬罗庆杨雅涵焉兆超吴国俊黄洁中国科学院西安光学精密机械研究所西安710119 中国科学院大学北京100049 中国空气动力学研究与发展中心超高速空气动力研究所四川绵阳621000 青岛海洋科学与技术试点国家实验室山东青岛266200

受限于炮口尺寸较小、激光能量衰减严重和测速系统作用距离有限等因素,超高速试验中的内弹道速度变化历程数据获取困难。针对该问题设计了一种大景深光子多普勒测速仪,并在超高速弹道靶上多次重复获取了内弹道速度变化历程数据。试验过... 详细信息

受限于炮口尺寸较小、激光能量衰减严重和测速系统作用距离有限等因素,超高速试验中的内弹道速度变化历程数据获取困难。针对该问题设计了一种大景深光子多普勒测速仪,并在超高速弹道靶上多次重复获取了内弹道速度变化历程数据。试验过程中,大景深光子多普勒测速仪分别记录了发射弹丸由静止加速至约2 km/s和7 km/s的速度变化历程,最高速度6.89 km/s。试验结果表明,大景深光子多普勒测速仪在超高速内弹道研究中具有较高的可行性和稳定性。

关键词：物理光学超高速弹道靶光子多普勒测速仪激光多普勒效应内弹道速度

Highly selective growth of(6,5)single-walled carbon nanotubes from sigma phase alloy catalyst

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Nano Research 2024年第3期17卷 1999-2003页

作者： Liantao Xin Chen Ma Qianru Wu Shaokang Liu Linhai Li Xiuyun Zhang Liu Qian Maoshuai He Dong Li Fangqian Han Shulan Hao Lihu Feng yahan Li Huaping Liu Lili Zhang Chang Liu Jin Zhang College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Physics Science and Technology Yangzhou UniversityYangzhou 225002China Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The chirality structure of a single-walled carbon nanotube(SWNT)strongly depends on the composition of catalyst used in the chemical vapor deposition *** this study,we develop a porous magnesia supported manganese-rhenium(MnRe/MgO)catalyst for chirality-selective synthesis of *** characterizations reveal that(6,5)tubes with a selectivity higher than 70%are grown from the Re-rich MnRe/MgO *** comparing the SWNT growth results with those of monometallic Mn or Re,the formation of sigma phase,an intermetallic compound occurring in transition-metal alloy systems,is revealed to be crucial for the dominant synthesis of(6,5)*** work not only extends the application of sigma phase alloy for catalytic synthesis of SWNTs,but also sheds lights on the growth of SWNTs with a high chirality selectivity.

关键词： single-walled carbon nanotubes sigma phase manganese-rhenium catalyst selective growth transition-metal alloy

Highly Stable Nonhydroxyl Antisolvent Polymer Dielectric:A New Strategy towards High-Performance Low-Temperature Solution-Processed Ultraflexible Organic Transistors for Skin-Inspired Electronics

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Research 2021年第1期2021卷 1615-1626页

作者： Mingxin Zhang Cong Zhang yahan yang Hang Ren Junmo Zhang Xiaoli Zhao Yanhong Tong Qingxin Tang Yichun Liu Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory of UV-Emitting Materials and Technology Ministry of EducationNortheast Normal UniversityChangchun 130024China

Scarcity of the antisolvent polymer dielectrics and their poor stability have significantly prevented solution-processed ultraflexible organic transistors from low-temperature,large-scale production for applications in low-cost skin-inspired ***,we present a novel low-temperature solution-processed PEI-EP polymer dielectric with dramatically enhanced thermal stability,humidity stability,and frequency stability compared with the conventional PVA/c-PVA and c-PVP dielectrics,by incorporating polyethyleneimine PEI as crosslinking sites in nonhydroxyl epoxy *** PEI-EP dielectric requires a very low process temperature as low as 70℃ and simultaneously possesses the high initial decomposition temperature(340℃)and glass transition temperature(230℃),humidity-resistant dielectric properties,and frequency-independent *** into the solution-processed C8-BTBT thin-film transistors,the PEI-EP dielectric enables the device stable operation in air within 2 months and in high-humidity environment from 20 to 100%without significant performance *** PEI-EP dielectric transistor array also presents weak hysteresis transfer characteristics,excellent electrical performance with 100%operation rate,high mobility up to 7.98 cm^(2)V^(-1)s^(-1)(1 Hz)and average mobility as high as 5.3 cm^(2)V^(-1)s^(-1)(1 Hz),excellent flexibility with the normal operation at the bending radius down to 0.003 mm,and foldable and crumpling-resistant *** results reveal the great potential of PEI-EP polymer as dielectric of low-temperature solution-processed ultraflexible organic transistors and open a new strategy for the development and applications of next-generation low-cost skin electronics.

关键词： dielectric humidity stability

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脱水诱导基因RD特性及功能

中国科学院大学学报（中英文） 2022年第2期39卷 154-164页

作者：龚束芳初明洋杨雅涵乔坤王金刚东北农业大学园艺园林学院哈尔滨150030

脱水诱导基因(Responsive to Dehydration,RD)是一类能够调节植物脱水的基因,对植物脱水胁迫具有一定耐受性,有些成员还对低温、高盐等非生物胁迫具有不同程度的响应。RD成员分属于不同家族,在结构和功能方面存在差异。归纳不同RD的结... 详细信息

脱水诱导基因(Responsive to Dehydration,RD)是一类能够调节植物脱水的基因,对植物脱水胁迫具有一定耐受性,有些成员还对低温、高盐等非生物胁迫具有不同程度的响应。RD成员分属于不同家族,在结构和功能方面存在差异。归纳不同RD的结构组成、蛋白保守基序、调控机理以及应对生物以及非生物胁迫时的功能,以及RD基因启动子区域中不同的顺式作用元件在基因应对非生物胁迫时发挥的作用,可为今后对RD基因的研究提供相关参考。

关键词：脱水诱导 RD 结构特点基因功能