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Harmful evaluation of heavy metals from soil layer to the groundwater: Take the Jilin Hunchun Basin as an example

China Geology 2024年第1期7卷 116-124页

作者： Xiao-Dong guo Qiang Liu Hui-Rong Zhang Xu-Fei Shi chuan-Yu Qin Zhi-Qiang Zhang Shenyang Geological Survey Center China Geological SurveyMinistry of Natural ResourcesShenyang 110034China Key Laboratory of Black Land Evolution and Ecological Effects Shenyang 110034China New Energy and Environment College Jilin UniversityChangchun 130026China Jilin Hydrogeological Survey Institute Changchun 130026China

The continuous enrichment of heavy metals in soils has caused potential harm to *** methods to evaluate the harm of heavy metals in soil to groundwater are lacked in previous *** on the theory of groundwater circulation and solid-liquid equilibrium,a simple and easy-touse flux model of soil heavy metals migrating to groundwater is *** on groundwater environmental capacity,an innovative method for evaluating the harm of heavy metals in soil to groundwater is proposed,which has been applied in Hunchun Basin,Jilin Province,*** results show that the fluxes of soil heavy metals into groundwater in the study area are Zn,Cu,As,Pb,Cd,Ni,and Hg in descending *** content of heavy metals in groundwater(As,Hg,Cu,Pb,Zn,Ni,and Cd)in most areas has not risen to the threshold of environmental capacity within 10 *** harm levels of soil heavy metals to groundwater in the most townships soils are at the moderate level or *** evaluation method can quantify the flux of soil heavy metals into groundwater simply and quickly,determine the residual capacity of groundwater to heavy metals,evaluate the harm level of soil heavy metals to groundwater,provide support for relevant departments to carry out environmental protection of soil and groundwater,and provide a reference to carry out similar studies for related scholars.

关键词： Soil heavy metals As+Hg+Cu+Pb+Zn+Ni+Cd Environmental capacity Groundwater Hazard degree Migration flux model Agricultural geological survey engineering Hunchun Basin Jilin Province

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Nutrient enrichment driven by canopy rainfall redistribution:Mechanism,quantification,and pattern

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Science China Earth Sciences 2024年第5期67卷 1529-1544页

作者： chuan YUAN Xiaoping YUE Yafeng ZHANG Yu ZHANG Yanting HU Qiang TANG Li guo Shuai WANG Xingwu DUAN Wenhua XIANG Xiaohua WEI Xiaoyan LI College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhou 311300China Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqing 400715China Shapotou Desert Research and Experiment Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Geographical Sciences Hebei Normal UniversityShijiazhuang 050024China Faculty of Life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Yunnan Key Laboratory of Soil Erosion Prevention and Green Development Institute of International Rivers and Eco-securityYunnan UniversityKunming 650091China Department of Earth Environmental and Geographic SciencesUniversity of British Columbia(Okanagan)KelownaBritish Columbia V1V 1V7Canada

Vegetation canopies intercept and redistribute rainfall into throughfall and stemflow,which transfer substantial amounts of elements into the soil,influencing soil microbial community,plant survival,and plant community *** advancements in ecohydrological research,the implication of nutrient enrichment resulting from this redistribution of rainfall by canopies remains largely *** address this gap,we conducted a systematic review of 1020 papers published between 2000 and 2022,gathering data on nutrient concentration and enrichment for critical ions(including K^(+),Na^(+),Ca^(2+),Mg^(2+),NH_(4)^(+),Cl^(-),NO_(3)^(-)and SO_(4)^(2-))from the Web of Science and Chinese Knowledge Infrastructure *** aimed to synthesize the mechanisms,quantify the enrichments,and identify global patterns of nutrient enrichment in stemflow and throughfall across climate zones,and vegetation types and *** results of this study indicate that stemflow exhibits,on average,2.1times greater ion concentration(6.13 mg L^(-1))compared to *** particular,among the investigated ions,SO_(4)^(2-)(12.45and 6.32 mg L^(-1))for stemflow and throughfall,respectively,and Cl^(-)(9.21 and 4.81 mg L^(-1))exhibit the highest concentrations in both rainfall redistribution components,while K^(+)(13.7 and 5.8)and Mg^(2+)(5.6 and 2.8)have the highest enrichment *** climate zones,throughfall and stemflow show the lowest ion concentrations but the highest enrichment factors in extremely humid *** the temperature gradient,ion concentrations are the highest in cold climates with no clear patterns observed for enrichment factors with increasing *** addition,shrubs,conifers,mixed forests,and artificial ecosystems demonstrate enrichment factors 1.1 to 3.0 times greater than those of trees,broad-leaved plants,pure forests,and natural *** findings emphasize the need for increased attentions to artificial ecosystems,such as urban

关键词： Ecohydrology Rainfall redistribution Nutrients transport Enrichment characteristics Climate zones

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Mandarin fish von Hippel-Lindau protein regulates the NF-κB signaling pathway via interaction with IκB to promote fish ranavirus replication

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Zoological Research 2024年第5期45卷 990-1000页

作者： Zhi-Min Li Xiao-Wei Qin Qi Zhang Jian He Min-Cong Liang chuan-Rui Li Yang Yu Weng-Hui Liu Shao-Ping Weng Jian-guo He Chang-Jun guo School of Marine Sciences State Key Laboratory for BiocontrolSouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Guangdong Province Key Laboratory of Aquatic Economic Animals&Guangdong Provincial Observation and Research Station for Marine Ranching of the Lingdingyang BaySun Yat-sen UniversityGuangzhouGuangdong 510275China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouGuangdong 510640China

The von Hippel-Lindau tumor suppressor protein(VHL),an E3 ubiquitin ligase,functions as a critical regulator of the oxygen-sensing pathway for targeting hypoxia-inducible *** evidence suggests that mammalian VHL may also be critical to the NF-κB signaling pathway,although the specific molecular mechanisms remain ***,the roles of mandarin fish(Siniperca chuatsi)VHL(scVHL)in the NF-κB signaling pathway and mandarin fish ranavirus(MRV)replication were *** transcription of scVHL was induced by immune stimulation and MRV infection,indicating a potential role in innate ***-luciferase reporter gene assays and reverse transcription quantitative PCR(RT-qPCR)results demonstrated that scVHL evoked and positively regulated the NF-κB signaling *** with NF-κB signaling pathway inhibitors indicated that the role of scVHL may be mediated through scIKKα,scIKKβ,scIκBα,or ***-immunoprecipitation(Co-IP)analysis identified scIκBαas a novel target protein of ***,scVHL targeted scIκBαto catalyze the formation of K63-linked polyubiquitin chains to activate the NF-κB signaling *** MRV infection,NF-κB signaling remained activated,which,in turn,promoted MRV *** findings suggest that scVHL not only positively regulates NF-κB but also significantly enhances MRV *** study reveals a novel function of scVHL in NF-κB signaling and viral infection in fish.

关键词： VHL NF-κB IκBα Ranavirus Mandarin fish

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Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-Xia Liao chuan-He Zhang Jian-guo Huang Wei Chen Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this *** were randomly assigned to receive either aflibercept or a combination of aflibercept and *** once a month for a total of three *** macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly ***:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both ***:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and ***,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

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Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4149-4163页

作者： Xinyun Jian Cheng Wang Shijuan Wu guo Sun chuan Huang Chengbing Qiu Yuanzheng Liu Peter FLeadlay Dong Liu Zixin Deng Fuling Zhou Yuhui Sun Department of Hematology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(Ministry of Education) Wuhan UniversityWuhan 430071China School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China School of Life Sciences Co-Innovation Center of NeuroregenerationNantong Laboratory of Development and DiseasesNantong UniversityNantong 226019China Department of Biochemistry University of CambridgeCambridge CB21GAUK Department of Biochemistry and Molecular Biology Biomedicine Discovery InstituteMonash UniversityClayton VIC 3800Australia ARC Centre of Excellence for Innovations in Protein and Peptide Science Monash UniversityClayton VIC 3800Australia

Aminoglycosides(AGs)are a class of antibiotics with a broad spectrum of ***,their use is limited by safety concerns associated with nephrotoxicity and ototoxicity,as well as drug *** address these issues,semi-synthetic approaches for modifying natural AGs have generated new generations of AGs,however,with limited types of modification due to significant challenges in *** study explores a novel approach that harness the bacterial biosynthetic machinery of gentamicins and kanamycins to create hybrid *** was achieved by glycodiversification of gentamicins via swapping the glycosyltransferase(GT)in their producer with the GT from kanamycins biosynthetic pathway and resulted in the creation of a series of novel AGs,therefore referred to as genkamicins(GKs).The manipulation of the hybrid biosynthetic pathway enabled the targeted accumulation of different GK species and the isolation and characterization of six GK *** compounds display retained antimicrobial activity against a panel of World Health Organization(WHO)critical priority pathogens,and GK-C2a,in particular,demonstrates low ototoxicity compared to clinical drugs in zebrafish *** study provides a new strategy for diversifying the structure of AGs and a potential avenue for developing less toxic AG drugs to combat infectious diseases.

关键词： Antibiotic Aminoglycoside biosynthesis Biosynthetic engineering Ototoxicity

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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： chuan-Zhen Li Yu-Hang Liu Deng Pan Meng-Hao Xia Qiang Zhang Yu-chuang Li guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

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PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts

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Journal of Genetics and Genomics 2024年第2期51卷 243-251页

作者： Xinran Dong Yulan Lu Lanting guo chuan Li Qi Ni Bingbing Wu Huijun Wang Lin Yang Songyang Wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang Center for Molecular Medicine Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Department of Bioinformatics Hangzhou Nuowei Information Technology Co.LtdHangzhouZhejiang 310000China The Third Research Institute of the Ministry of Public Security Shanghai 200031China Xiamen Campus of Children's Hospital of Fudan University XiamenFujian 361006China Institutes for Systems Genetics West China HospitalChengduSichuan 610041China Shanghai Putuo People's Hospital Tongji UniversityShanghai 200060China

The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://***:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.

关键词： Privacy protecti on Rare diseases in children Genetic testing Web system Trusted executi on envir onment

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PriChain: Efficient Privacy-preserving Finegrained Redactable Blockchains in Decentralized Settings

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Chinese Journal of Electronics 2024年

作者： Hongchen guo Weilin GAN Mingyang ZHAO chuan ZHANG Tong WU Liehuang ZHU Jingfeng XUE School of Computer Science and Technology Beijing Institute of Technology School of Cyberspace Science and Technology Beijing Institute of Technology School of Computer and Communication Engineering University of Science and Technology Beijing

Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data redaction. However, the development of redactable blockchain is now obstructed by three limitations, which are data privacy breaches, high communication overhead, and low searching efficiency, respectively. In this paper, we propose PriC hain, the first efficient privacy-preserving fine-grained redactable blockchain in decentralized settings. PriChain provides data owners with rights to control who can read and redact on-chain data while maintaining downward compatibility, ensuring the one who can redact will be able to read. Specifically, inspired by the concept of multi-authority attribute-based encryption, we utilize the isomorphism of the access control tree, realizing fine-grained redaction mechanism, downward compatibility, and collusion resistance. With the newly designed structure, PriChain can realize O（n） communication and storage overhead compared to prior O（n2） schemes. Furthermore, we integrate multiple access trees into a tree-based dictionary, optimizing searching efficiency. Theoretical analysis proves that PriC hain is secure against the chosen-plaintext attack and has competitive complexity. The experimental evaluations show that PriChain realizes 10× efficiency improvement of searching and 100× lower communication and storage overhead on average compared with existing schemes.

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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu chuan-Lin Feng guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

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平台封禁的反不正当竞争法应对——以《反不正当竞争法》的修订为背景

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当代法学 2024年第2期38卷 65-76页

作者：郭传凯山东大学法学院

平台封禁是指数字企业利用技术手段关闭面向特定经营者的应用程序接口,致使特定经营者无法使用平台设施的竞争行为,具体表现为屏蔽软件功能、禁止外部链接直连或接入某项业务等方面。该行为很可能破坏竞争秩序,阻碍数字经济健康发展。... 详细信息

平台封禁是指数字企业利用技术手段关闭面向特定经营者的应用程序接口,致使特定经营者无法使用平台设施的竞争行为,具体表现为屏蔽软件功能、禁止外部链接直连或接入某项业务等方面。该行为很可能破坏竞争秩序,阻碍数字经济健康发展。鉴于反垄断法难以充分回应平台封禁,适用反不正当竞争法规制平台封禁成为维护数字竞争秩序的可行选择。在《反不正当竞争法》修订的背景下,平台封禁应当参照恶意不兼容予以处理。认定平台封禁是否构成恶意不兼容应以“妨碍、破坏其他经营者合法提供的网络产品或者服务正常运行”为主要标准,兼顾“恶意”的主观心态。为应对平台封禁,《反不正当竞争法》的“网络条款”需要修订,执法机制应予以优化,司法裁判需作出相应变革。

关键词：平台封禁恶意不兼容反不正当竞争法互联互通

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