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ECA39 is a novel distant metastasis-related biomarker in colorectal cancer

World Journal of Gastroenterology 2006年第36期12卷 5884-5889页

作者： Reigetsu Yoshikawa Hidenori Yanagi Chun-Shen Shen Yoshinori Fujiwara Masafumi Noda Toshihiko yagyu Makoto Gega Tsutomu Oshima Takehira Yamamura Haruki Okamura Yoshiro Nakano Tomonori Morinaga Tomoko Hashimoto-Tamaoki Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Dermatology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Genetics Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

AIM: To investigate the possible role of polysaccharide-K (PSK) -related markers in predicting distant metastasis and in the clinical outcome of colorectal cancer (CRC).METHODS: Firstly, we used protein microarrays to analyze the in vitro expression profiles of potential PSK-related markers in the human colorectal adenocarcinoma cell line SW480, which carries a mutant p53 gene. Then, we investigated the clinical implications of these markers in the prognosis of CRC patients. RESULTS: ECA39, a direct target of c-Myc, was identi-fied as a candidate protein affected by the anti-metastat-ic effects of PSK. Immunohistochemistry revealed that ECA39 was expressed at significantly higher levels in tumor tissues with distant metastases compared to those without (P < 0.00001). Positive ECA39 expression was shown to be highly reliable for the prediction of distant metastases (sensitivity: 86.7%, specificity: 90%, posi-tive predictive value: 86.7%, negative predictive value: 90%). A significantly higher cumulative 5-yr disease free survival rate was observed in the ECA39-negative patient group (77.3%) compared with the ECA39-positive patient group (25.8%) (P < 0.05). CONCLUSION: Our results suggest that ECA39 is a dominant predictive factor for distant metastasis in pa-tients with advanced CRC and that its suppression by PSK might represent a useful application of immuno-therapy as part of a program of integrated medicine.

关键词： ECA39 Distant metastasis Colorectal cancer Polysaccharide-K Integrated medicine

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Effect of Eating out on Quality and Quantity of Sleep among Japanese in Their 20s

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Health 2018年第9期10卷 1261-1269页

作者： Tomohide yagyu Kohei Akazawa Minami Ebihara Junta Ishikawa Ouchi Koichi Department of Health Informatics Suzuka University of Medical Science Suzuka Japan Department of Medical Informatics Niigata University Medical & Dental Hospital Niigata Japan

The purpose of this study was to analyze the effects of eating out or skipping meals on the quality or quantity of sleep in young Japanese adults. We analyzed 584 eligible subjects (283 men and 301 women) aged 20 - 29 years. Information on diet and individual lifestyle characteristics, including sleep quality, which was assessed by the Pittsburgh Sleep Quality Index Japanese version (PSQI-J), were obtained by participants completing an online questionnaire. Kendall’s tau coefficient was used to measure the ordinal association between diet and sleep quality. The Mann-Whitney U test was performed to evaluate differences in sleep quality by frequency of eating out and frequency of skipping meals. The results revealed a significant difference in sleep duration and PSQI-J score between people who eat out >2 times a week (“high restaurants group”) and those who do not (“low restaurants group”). Furthermore, whereas the mean sleep duration in the “high restaurants group” was 6.59 hours, the mean sleep duration in the “low restaurants group” was 6.90 hours (p = 0.007). The PSQI-J score was significantly higher in the “high restaurants group” than in the “low restaurants group” (4.91 versus 4.37, p = 0.006). Significant differences were also evident in the test’s component scores: C2, C3, and C7. No significant difference was found in sleep duration and PSQI-J score between the groups in terms of frequency of skipping meals (breakfast, lunch, and dinner). Our results suggested that excessive intake by eating out more than twice a week may lead to short sleep duration and high PSQI-J score.

关键词： Sleep Quality Dietary Habits Cross-Sectional Study Pittsburgh Sleep Quality Index Eating out

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Relationship of Lifestyle Habits with Sleep Quality among Japanese in Their 20s

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Health 2019年第1期11卷 1-8页

作者： Tomohide yagyu Kohei Akazawa Minami Ebihara Junta Ishikawa Koichi Ouchi Koji Kobayashi Kyoko Nakazawa Department of Health Informatics Suzuka University of Medical Science Suzuka Japan Department of Medical Informatics Niigata University Medical & Dental Hospital Niigata Japan Department of Medical Informatics and Statistics Niigata University Graduate School of Medical & Dental Sciences Niigata Japan

The purpose of this study was to analyze the effects of lifestyle on sleep quality in young Japanese adults. A cross-sectional study was conducted on the web. We analyzed 637 eligible subjects (316 men and 321 women) aged 20 - 29 years. Information on diet and individual lifestyle characteristics, including sleep quality, which was assessed using the Pittsburgh Sleep Quality Index Japanese version (PSQI-J). Results were obtained by participants completing an online questionnaire. The participants were divided into two groups based on whether they were students (“student group”) or not (“not student group”). The participants with a PSQI-J global score of 6 or higher were evaluated as low-sleep-quality. Logistic regression analyses were performed to evaluate associations of lifestyle habits with low-sleep-quality. Logistic regression analyses were applied for “student group” and “not student group”. The results showed that days of eating out at dinner (OR: 1.11, CI: 1.00 - 1.22) and skipping dinner (OR: 1.21, CI: 1.05 - 1.42) were significant and independent predictors for low-sleep-quality among the “not student group”. There were no significant and independent predictors for low-sleep-quality among “student group”. Our results suggested that excessive intake by eating out and deficient intake by skipping dinner might lead to a high PSQI-J score. It is necessary for young people to receive education on the importance of cooking their own meals for traditional and daytime eating. The implication of this study lies in the fact that we have analyzed the effects of lifestyle habits on quality of sleep.

关键词： Sleep Quality Eating Out Skipping Meal Cross-Sectional Study Pittsburgh Sleep Quality Index

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二尖瓣结构在左心室收缩过程中的重要作用

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心肺血管学报 1989年第1期 64-25页

作者： K.yagyu 程沛东京大学胸外科北京心肺血管中心安贞医院

理论上,二尖瓣置换术(MVR)后,瓣口功能面积大于单纯交界切开后的面积,但术后早期血液动力学检查证实,交界切开的效果却较(MVR)好。这说明左室功能除心肌因素外,二尖瓣结构也起着重要作用。采用改良二尖瓣置换术(mMVR)即保留二尖瓣后叶... 详细信息

理论上,二尖瓣置换术(MVR)后,瓣口功能面积大于单纯交界切开后的面积,但术后早期血液动力学检查证实,交界切开的效果却较(MVR)好。这说明左室功能除心肌因素外,二尖瓣结构也起着重要作用。采用改良二尖瓣置换术(mMVR)即保留二尖瓣后叶结构的换瓣方法,能够获得满意效果,尤其对心功能不佳的患者。

关键词：二尖瓣置换术收缩过程血液动力学左室功能二尖瓣关闭不全左心室心底部后叶二尖瓣叶后瓣

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这就是“靓丽可爱”女孩的典范！——真实LUCi GIRL的摩登LIFE

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国际服装技术 2006年第6期 80-83页

作者： Yoshiharu yagyu（摄影） Asako Fujita Jaky（翻译）

直击那些爱美的职业女性们真实的时尚生活！这次的实地调查向我们展现了与流行保持同步的日本女性对时尚品牌的关注。这也是“靓丽可爱”女孩们的扮靓秘诀哦！

关键词：女孩时尚生活职业女性

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线条优美的连衣裙、名媛风格的牛仔裤、极具分量感的裙子充满女人味的装扮让你成为Party主角！

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国际服装技术 2006年第6期 104-109页

作者： Katsuyuki Masuda（摄影） Yoshiharu yagyu（摄影） Masami Toshida Louisa（翻译）

婚宴、好友聚会……不管是正式的场合还是休闲的场合，能够直在变换出适合Party氛围的装扮，是可爱女孩的必备技巧。我们为大家介绍三种完全不同的风格，辅助以相应的化妆方法，让你成为派对上最受瞩目的可爱主角！

关键词：风格主角连衣裙牛仔裤优美线条裙子分量

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Bcr-Abl-mediated Raf kinase inhibitor protein suppression promotes chronic myeloid leukemia progenitor cells proliferation

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Stem Cell Discovery 2011年第3期1卷 54-66页

作者： Satoki Nakamura Tomohiro yagyu Tomonari Takemura Lin Tan Yasuyuki Nagata Daisuke Yokota Isao Hirano Kiyoshi Shibata Michio Fujie Shinya Fujisawa Kazunori Ohnishi 不详

The Ras/Raf-1/MEK/ERK pathway is constitutively activated in Bcr-Abl transformed cells, and Ras activity enhances the oncogenic ability of Bcr-Abl. On the hand, Raf kinase inhibitor protein (RKIP) inhibits activation of MEK by Raf-1 and its downstream signal transduction, resulting in blocking the MAP kinase pathway. Moreover, Raf-1 has been reported to regulate cell cycle progression. However, the mechanism by which Bcr-Abl promotes the cell cycle progression through Raf-1 is not completely understood. In the present study, we found that the expression of RKIP was suppressed in CML cells, and investigated the interaction between RKIP and Bcr-Abl in CML cells. In aldehyde dehydrogenase (ALDH)hi/CD34+ cells derived from CML patients, the inhibition of Bcr-Abl induced RKIP expression and reduced the phosphorylated-FOXM1 (pFOXM1) status, resulting in inhibited colony formation of Bcr-Abl+ progenitor cells. Moreover, overexpression of RKIP significantly decreased the colony numbers, reduced the pFOXM1 status, and reduced pFOXM-1 target genes such as Skp2, Cdc25B and KIS, and induced the expression of p27Kip1a and p21Cip1. Thus, Bcr-Abl represses the expression of RKIP, and continuously activates FOXM1, resulting in the proliferation of CML progenitor cells through the cell cycle modulation.

关键词： RKIP FOXM1 Bcr-Abl Progenitor cells Cell cycle

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