检索结果-南通市图书馆

HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation

Cellular & Molecular Immunology 2023年第4期20卷 404-418页

作者： Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu yaguang Zhang Yiru Fang Jinfang Zhu Bing sun state Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai 200031China College of Life Sciences Jiangxi University of Chinese MedicineNanchang 330004China Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqingChina Department of Allergy Chongqing General HospitalChongqingChina Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Laboratory of Immune System Biology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892USA CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China.

Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune ***,specific drug targets on lung ILC2s have rarely been *** studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to ***,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with ***,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 *** data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human ***,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in *** with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of *** conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s.

关键词： Serotonin(5-HT) HTR2A DOl Group 2 innate lymphoid cell Type 2 lung inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lactate anions participate in T cell cytokine production and function

引用

Science China(Life Sciences) 2021年第11期64卷 1895-1905页

作者： Jing Wen Shipeng Cheng yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling Liyan Ma Xinghao Ai Bing sun School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China School of Life Science University of Science and Technology of ChinaHefei 230026China Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function.

关键词： lactate glycolysis TCR activation immunometabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

电动汽车大功率充电堆集中监控与运营系统

引用

青岛科技大学学报（自然科学版） 2020年第3期41卷 104-110页

作者：高德欣孙亚光青岛科技大学自动化与电子工程学院山东青岛266061

充电堆是一种大功率直流箱式充电设备,能够适应不同功率电动汽车的充电需求,并可为多辆电动汽车同时充电。本研究基于.NET平台,开发了一套电动汽车大功率充电堆集中监控与运营系统。首先,设计了系统结构,分为通讯层、设备层和监控层;其... 详细信息

充电堆是一种大功率直流箱式充电设备,能够适应不同功率电动汽车的充电需求,并可为多辆电动汽车同时充电。本研究基于.NET平台,开发了一套电动汽车大功率充电堆集中监控与运营系统。首先,设计了系统结构,分为通讯层、设备层和监控层;其次,通过CAN总线采集充电堆与电动汽车充电过程的各种数据,并将其传输到上位机数据服务器中进行解析;然后,利用C#语言开发了系统人机界面,实现了对大功率充电堆充电过程的实时监控和充电运营数据的统计和分析。经现场运行表明,系统可靠、有效。

关键词：电动汽车充电堆集中监控 CAN总线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quasi-freestanding, striped WS2 monolayer with an invariable band gap on Au（001）

引用

Nano Research 2017年第11期10卷 3875-3884页

作者： Min Hong Xiebo Zhou Jianping Shi Yue Qi Zhepeng Zhang Qiyi Fang yaguang Guo Yajuan sun Zhongfan Liu Yuanchang Li Qian Wang Yanfeng Zhang Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Center for Nanochemistry(CNC) Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China State Key Laboratory of Coal-based Low-carbon Energy ENN Group Co. Ltd. Langfang 065001 China National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100190 China Center for Applied Physics and Technology Peking University Beijing 100871 China

Revealing the structural/electronic features and interfacial interactions of monolayer MoS2 and WS2 on metals is essential to evaluating the performance of related *** this study,we focused on the atomic-scale features of monolayer WS2 on Au（001） synthesized via chemical vapor *** tunneling microscopy and spectroscopy reveal that the WS2/Au（001） system exhibits a striped superstructure similar to that of MoS2/Au（001） but weaker interfacial interactions,as evidenced by experimental and theoretical ***,the WS2/Au（001） band gap exhibits a relatively intrinsic value of ～ 2.0 ***,the band gap can gradually decrease to ～ 1.5 eV when the sample annealing temperature increases from ～370 to 720 ℃.In addition,the doping level （or Fermi energy） of monolayer WS2/Au（001） varies little over the valley and ridge regions of the striped patterns because of the homogenous distributions of point defects introduced by ***,this work provides an in-depth investigation into the interfacial interactions and electronic properties of monolayer MX2 on metal substrates.

关键词： WS2 Au(001) striped superstructure interfacial interaction STM/STS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer metabolism and tumor microenvironment:fostering each other?

引用

Science China(Life Sciences) 2022年第2期65卷 236-279页

作者： Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing sun Shi-Min Zhao Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Molecular and Cell Biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West China School of Basic Medical Sciences&Forensic Medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and Molecular Biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China School of Medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua University School of Life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

引用

Cellular & Molecular Immunology 2020年第6期17卷 621-630页

作者： Chunyan Yi Xiaoyu sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of Sciences200031 ShanghaiChina School of Life Science and Technology ShanghaiTech University201210 ShanghaiChina Shanghai Public Health Clinical Center Fudan University201508 ShanghaiChina Key Laboratory of Special Pathogens Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of Sciences430071 WuhanChina Shanghai Institute of Biological Products 200052 ShanghaiChina

Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health *** viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral *** SARS-CoV-2 and SARS-CoV share this *** we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing *** in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two *** finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or *** is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize ***,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing ***,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable.

关键词： SARS-CoV-2 spike protein receptor binding motif cross-neutralizing antibody substitution mutation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Directly modulated 25 Gbaud/s tunable in-series DFB laser array for WDM systems

引用

Chinese Optics Letters 2023年第1期21卷 85-90页

作者：孙振兴王亚光肖如磊王磊磊龚洋洋邱逸仁陈向飞 Key Laboratory of Intelligent Optical Sensing and Manipulation of the Ministry of Education&Nanjing University-Tongding Joint Lab for Large-scale Photonic Integrated Circuits&National Laboratory of Solid-State Microstructures&College of Engineering and Applied Science&Institute of Optical Communication Engineering Nanjing UniversityNanjing 210093China Department of Photonics and Institute of Electro-Optical Engineering Taiwan Sun Yat-sen UniversityKaohsiung 80424China

In this Letter,we proposed and experimentally demonstrated a directly modulated tunable laser based on the multi-wavelength distributed feedback(DFB)laser *** lasers are placed in series to avoid the usage of an optical combiner and additional power loss.A three-section design is utilized to reduce the interference from other lasers and improve the electro-optic response ***,the reconstruction-equivalent-chirp technique is used to simplify the grating fabrication and precisely control the grating *** realized 12 channels with 100 GHz spacing with high side mode suppression ratios of above 50 *** output power of all the channels is above 14 *** 3 dB electro-optic bandwidth is above 20 GHz at a bias current of 100 mA for all four lasers.A 25 Gb/s data transmission over a standard single-mode fiber of up to 10 km is demonstrated for all 12 channels,and 50 Gb/s data per wavelength is obtained through the four-level pulse amplitude *** proposed directly modulated tunable in-series DFB laser array shows the potential for a compact and low-cost light source for wavelength division multiplexing(WDM)systems,such as next-generation front-haul networks and passive optical networks.

关键词： tunable laser directly modulated laser laser array wavelength division multiplexing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients

引用

Cellular & Molecular Immunology 2020年第8期17卷 878-880页

作者： yaguang Zhang Xiaojing Wang Xuezhen Li Dong Xi Ruizhi Mao Xiaohui Wu Shipeng Cheng Xiaoyu sun Chunyan Yi Zhiyang Ling Liyan Ma Qin Ning Yiru Fang Bing sun Di Wu State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of Sciences320 Yueyang Road200031ShanghaiChina Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030WuhanChina Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine200030ShanghaiChina

Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after *** of immunity in COVID-19 patients has been considered as one of the fatal factors for patients,especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However,the mechanism of cytokine-induced lymphopenia in COVID-19 is very ***-2 is critical for the proliferation,differentiation,and function of T cells,including Tregs,CD4+,and CD8+effector cells.6 Here,we reported the negative relationship between the concentration of soluble IL-2 receptor(sIL-2R)and T-cell number in blood from COVID-19 *** vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling,which could be rescued by strong IL-2 *** data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients.

关键词： patients lympho immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于机器学习的中央空调的优化控制策略

引用

青岛科技大学学报（自然科学版） 2019年第1期40卷 111-118页

作者：瞿叶奇高德欣孙亚光青岛科技大学自动化与电子工程学院山东青岛266061

针对中央空调时变、大滞后、非线性、模型复杂度高的问题,提出了一种基于机器学习的优化控制策略。首先,建立中央空调系统的物理模型,根据系统采集的数据信息,进行分类和预处理;其次,利用机器学习的相关算法,建立采集数据之间的机器学... 详细信息

针对中央空调时变、大滞后、非线性、模型复杂度高的问题,提出了一种基于机器学习的优化控制策略。首先,建立中央空调系统的物理模型,根据系统采集的数据信息,进行分类和预处理;其次,利用机器学习的相关算法,建立采集数据之间的机器学习模型,并验证模型的精度;然后,根据构造的机器模型,设计了一种优化控制策略,解决中央空调实际运行中存在的问题,并给出控制算法;最后,用Python进行了仿真,验证了方法的有效性。

关键词：机器学习中央空调大数据随机森林算法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

叶片/叶盘摩擦阻尼结构的非线性模态分析综述

引用

航空动力学报 2022年第10期37卷 2167-2187页

作者：孙业凯吴亚光王兴范雨袁杰张大义中国航发商用航空发动机有限责任公司上海200241 北京航空航天大学能源与动力工程学院北京102206 中山大学航空航天学院广东深圳518107 思克莱德大学卓越航空航天中心英国格拉斯哥G11XQ

概述了非线性模态的理论基础以及非线性动力学分析的一般数值方法;进而针对含干摩擦非线性环节的结构,总结了阻尼非线性模态的相关研究进展;在此基础上,重点综述了国内外近十年来采用阻尼非线性模态数值方法在航空发动机带冠叶片、缘板... 详细信息

概述了非线性模态的理论基础以及非线性动力学分析的一般数值方法;进而针对含干摩擦非线性环节的结构,总结了阻尼非线性模态的相关研究进展;在此基础上,重点综述了国内外近十年来采用阻尼非线性模态数值方法在航空发动机带冠叶片、缘板阻尼器、叶根阻尼与干摩擦阻尼环分析与设计中的应用;列举了目前用于验证非线性模态的先进试验技术。提出了非线性模态在干摩擦阻尼结构动力学分析中亟需解决和关注的若干问题。研究表明:非线性模态逐渐从理论研究阶段过渡到工程应用阶段。结合模型降维技术,阻尼非线性模态已经可用于提取带干摩擦阻尼叶片/叶盘高保真有限元模型的模态特征。拓展能量平衡法与非线性模态综合法搭建了非线性模态与稳态响应的桥梁,可以显著提升基于响应的参数分析效率。非线性模态试验技术的研究处于起步阶段,尚无法应用于工程复杂结构。

关键词：非线性振动阻尼非线性模态干摩擦阻尼器叶片叶盘

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：