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中华高血压杂志 2013年第6期21卷 598-598页

作者： Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu k Sakurai k Iwama N katagiri M yagihashi k Yaegashi N Mori S Suzuki M kuriyama S Imai Y 罗冬梅叶鹏

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。... 详细信息

妊娠高血压可导致分娩时产生严重的并发症，如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法：入选初产妇和经产妇共575名，评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值，参与者妊娠期间每日清晨在家自测血压。

关键词：妊娠高血压妊娠期间初产妇家庭诊室低出生体质量产前检查危险因素

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Human β-defensin-3 induction in H pylori-infected gastric mucosal tissues

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World Journal of Gastroenterology 2006年第36期12卷 5793-5797页

作者： k kawauchi A yagihashi N Tsuji N Uehara D Furuya D kobayashi N Watanabe Department of Clinical Laboratory Medicine Sapporo Medical University School of Medicine Sapporo Japan

AIM: To examine human β-defensin-3 (hBD-3) expression in inflamed gastric mucosal tissues or MkN45 gastric cancer cells with or without H pylori infection for better understanding the innate immune response to H pylori. METHODS: We used reverse transcription-polymerase chain reactions and immunohistochemistry to examine hBD-3 expression in inflamed gastric mucosal tissues or MkN45 gastric cancer cells with or without H pylori. Effects of hBD-3 against H pylori were also evaluated. RESULTS: The mean mRNA expression of hBD-3 in H pylori -positive specimens was significantly higher than that in H pylori-negative specimens (P = 0.0002, Mann-Whitney). In addition, unlike uninfected samples, 8 of 15 (53.33%) infected mucosal samples expressed hBD-3 protein. H pylori dose-dependently induced mRNA expression of hBD-3 in MkN45 cells, an effect inhibited by adding anti-toll-like receptor (TLR)-4 antibody. HBD-3 protein completely inhibited H pylori growth. CONCLUSION: Our results suggest that like hBD-2, hBD-3 may be involved in the pathophysiology of H pylori-induced gastritis.

关键词： Human β-defensin-2 Human β-defensin-3 Hpylori Gastric mucosa

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