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《医宗金鉴·幼科杂病心法要诀》治未病思想初探

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中医儿科杂志 2024年第1期20卷 31-34页

作者：孟晓雨郜晓芹周亚东安徽中医药大学人文与国际教育交流学院安徽合肥230012

通过整理归纳《医宗金鉴·幼科杂病心法要诀》中对幼儿各发育阶段以及各类易感病证用药规律,从未雨绸缪,防病于先;见微知著,欲病救萌;已病早治,阻邪传经;瘥后防复,调护正气4个方面总结分析其中治未病思想的体现及运用,如在胎产护理方面... 详细信息

通过整理归纳《医宗金鉴·幼科杂病心法要诀》中对幼儿各发育阶段以及各类易感病证用药规律,从未雨绸缪,防病于先;见微知著,欲病救萌;已病早治,阻邪传经;瘥后防复,调护正气4个方面总结分析其中治未病思想的体现及运用,如在胎产护理方面,创造性地提出幼儿拭口、护脐方法,汤法浴儿具体措施;幼儿体质方面结合四诊法,注意清解胎毒;针对已病幼儿,主张用药平和,量儿大小选择用药;脾胃为先,预防传经等。诸多经典思想理论具有鲜明的治未病特色及时代先进性,为幼儿养生保健与临床诊疗提供了理论依据。

关键词：《医宗金鉴·幼科杂病心法要诀》治未病儿科理论探讨

Quaternized chitosan/Pluronic F127 thermosensitive hydrogel with high antibacterial properties for wound dressing

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Progress in Natural Science:Materials International 2023年第5期33卷 581-592页

作者： Kaiting Cheng Yiming Fang Liang Bai Feng Gui Junchi Ma Huimin gao yadong Zhao Xingtao Xu Marine Science and Technology College Zhejiang Ocean University Anhui Snow Dragon Fibre Technology CO. LTD. School of Food and Pharmacy Zhejiang Ocean University

In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small wounds.However, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multifunctional wound dressing. In this study, quaternized chitosan(QCS) with a high degree of substitution(107.84%) was successfully prepared and characterized using ultraviolet–visible(UV–vis) spectroscopy, Fourier transform infrared(FT-IR) spectroscopy, X-ray diffraction(XRD), and proton nuclear magnetic resonance(1H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperatureresponse characteristics are of great clinical research value as wound dressings.

关键词： Antibacterial activity Drug delivery Hemostasis Thermosensitive hydrogel Wound dressing

Hyper-Heuristic Task Scheduling Algorithm Based on Reinforcement Learning in Cloud Computing

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Intelligent Automation & Soft Computing 2023年第8期37卷 1587-1608页

作者： Lei Yin Chang Sun Ming gao yadong Fang Ming Li Fengyu Zhou School of Control Science and Engineering Shandong UniversityJinan250061ShandongChina School of Software Shandong UniversityJinan250101ShandongChina Academy of Intelligent Innovation Shandong UniversityShunhua RoadJinan250101ShandongChina Inspur Cloud Information Technology Co. Ltd.Inspur GroupJinan250101ShandongChina

The solution strategy of the heuristic algorithm is pre-set and has good performance in the conventional cloud resource scheduling process.However,for complex and dynamic cloud service scheduling tasks,due to the difference in service attributes,the solution efficiency of a single strategy is low for such problems.In this paper,we presents a hyper-heuristic algorithm based on reinforcement learning(HHRL)to optimize the completion time of the task sequence.Firstly,In the reward table setting stage of HHRL,we introduce population diversity and integrate maximum time to comprehensively deter-mine the task scheduling and the selection of low-level heuristic strategies.Secondly,a task computational complexity estimation method integrated with linear regression is proposed to influence task scheduling priorities.Besides,we propose a high-quality candidate solution migration method to ensure the continuity and diversity of the solving process.Compared with HHSA,ACO,GA,F-PSO,etc,HHRL can quickly obtain task complexity,select appropriate heuristic strategies for task scheduling,search for the the best makspan and have stronger disturbance detection ability for population diversity.

关键词： Task scheduling cloud computing hyper-heuristic algorithm makespan optimization

钙池操纵的钙通道在屋尘螨诱导哮喘小鼠气道上皮屏障破坏中的作用

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武汉大学学报（医学版） 2024年第1期45卷 19-24页

作者：钟剑王畅畅戚世权马如雪曹灿胡家倩李永帅高亚东武汉大学中南医院过敏反应科湖北武汉430071 武汉大学基础医学院免疫学系湖北武汉430071

目的:研究钙池操纵的钙内流(SOCE)在哮喘小鼠气道上皮屏障破坏中的作用及可能机制。方法:建立屋尘螨(HDM)致敏的C57BL/6急性过敏性哮喘小鼠模型,分为正常对照组、哮喘模型组和SOCE阻断剂BTP-2干预的哮喘模型组,剔除造模过程中死亡鼠和... 详细信息

目的:研究钙池操纵的钙内流(SOCE)在哮喘小鼠气道上皮屏障破坏中的作用及可能机制。方法:建立屋尘螨(HDM)致敏的C57BL/6急性过敏性哮喘小鼠模型,分为正常对照组、哮喘模型组和SOCE阻断剂BTP-2干预的哮喘模型组,剔除造模过程中死亡鼠和肺泡灌洗失败小鼠,每组10只。肺组织HE染色评估肺组织炎症,酶联免疫吸附试验(ELISA)检测支气管肺泡灌洗液(BALF)中IL-13和血清中IgE水平。右旋糖酐通透性实验评估屏障通透性,肺免疫荧光及肺组织化学染色评估连接蛋白(ZO-1和occludin)的分布和表达,RT-PCR和Western Blot评估肺组织中连接蛋白的表达。结果:与正常对照组相比,HDM致敏的小鼠气道炎症加重,肺组织ZO-1、occludin的mRNA和蛋白表达水平显著降低,同时右旋糖酐通透性增高(P<0.0001);与哮喘模型组相比,BTP-2干预组小鼠气道炎症减轻,ZO-1、occludin的mRNA和蛋白表达水平较哮喘组增高,右旋糖酐通透性亦明显下降(P<0.0001)。结论:SOCE及其介导的钙信号可能参与了HDM诱导的小鼠气道上皮屏障的破坏。

关键词：屋尘螨气道上皮屏障钙池操纵的钙通道哮喘气道炎症

构建适用于我国老年住院病人的新型谵妄筛查量表

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实用老年医学 2024年第1期38卷 28-33页

作者：刘亚东高浪丽吕娟葛宁岳冀蓉四川大学华西医院国家老年疾病临床医学研究中心四川省成都市610041 四川大学华西医院老年医学中心四川省成都市610041

目的构建适用于我国老年住院病人的谵妄筛查量表。方法通过查阅文献和专家小组讨论,制定诊断域和备选条目池。经过人群预实验,依照经典测量理论(CTT)方法进行条目删减。结合专家意见,修改量表结构,形成正式谵妄筛查量表中文版(DSI-CV... 详细信息

目的构建适用于我国老年住院病人的谵妄筛查量表。方法通过查阅文献和专家小组讨论,制定诊断域和备选条目池。经过人群预实验,依照经典测量理论(CTT)方法进行条目删减。结合专家意见,修改量表结构,形成正式谵妄筛查量表中文版(DSI-CV)。结果预实验共纳入730例病人,量表回收率为100%,条目空缺率为0。量表5个维度中,急性波动性、意识水平、注意力和认知水平的内部一致性系数分别为0.748、1.000、0.666和0.853,精神运动改变由于两个条目互斥的特殊性,不参与内部一致性讨论。经过CTT理论和专家小组讨论删减条目后,最终成型的DSI-CV包含5个维度共14个条目。结论基于CTT理论构建的DSI-CV在条目设置方面更符合我国文化特点,在使用情景方面充分考虑了老年住院病人的日常活动和与医护人员交互的情况。

关键词：谵妄老年医学筛查量表住院病人

Geological context and vents morphology in the ultramafic-hosted Tianxiu field, Carlsberg Ridge

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Acta Oceanologica Sinica 2023年第9期42卷 62-70页

作者： Jin Liang Chunhui Tao Xiangxin Wang Cheng Su Wei gao yadong Zhou Weikun Xu Xiaohe Liu Zhongjun Ding Key Laboratory of Submarine Geosciences Ministry of Natural ResourcesHangzhou 310012China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China National Deep Sea Center Qingdao 266237China School of Earth Sciences Zhejiang UniversityHangzhou 310027China Ocean College Zhejiang UniversityZhoushan 316021China

The Tianxiu hydrothermal field(TXHF) located on Carlsberg Ridge is one of the few active ultramafic-hosted venting systems known in the Indian Ocean. Despite numerous investigations, there is limited understanding of its sulfide structure morphology, and the factors controlling the formation of TXHF are poorly understood. In this study, we conducted detailed seafloor mapping using visual data obtained by dives using the human-occupied vehicle(HOV) Jiaolong. The TXHF is found to be an active, off-axis, ultramafic-hosted, high-temperature hydrothermal area in which serpentine peridotite is exposed. Two main hydrothermal sites were identified, i.e., P and Y, both of which feature a complex of chimneys and beehive diffusers constituting a “chimney jungle” and isolated large steep-sided structures developed on flat-lying sulfide mounds. In addition, some sporadic inactive chimneys and outcrops of hydrothermal deposits were noted. The chimneys are rich in Fe and Zn sulfide, and lack the central fluid channel formed by focused high-temperature fluid flow. Hydrothermal venting at TXHF is likely related to low-angle detachment faults that focus and transport hydrothermal fluids away from a heat source along the valley wall. Our results complement and expand upon previous works concerning sulfide chimney morphology and their corresponding mineral paragenesis in ultramafic-hosted hydrothermal systems in the Indian Ocean and further our understanding of modern seafloor hydrothermal systems.

关键词： hydrothermal activity sulfide accumulation morphology ultramafic-hosted Carlsberg Ridge

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中高温大曲表面霉菌分离鉴定与控制研究

中国酿造 2024年第3期43卷 90-94页

作者：王西邓小鹏万倩罗巍赵荣寿高占争张亚东张丹杨靖洲四川郎酒股份有限公司四川泸州646523 四川省古蔺郎酒厂(泸州)有限公司四川泸州646601

为针对性控制曲坯表面霉菌的生长,该研究在原有制曲工艺的基础上,对大曲生产过程中关键控制点进行合理调整,从曲坯表面分离出霉菌菌株并进行鉴定,同时通过研究安曲间距、覆盖物、一次翻曲时间以及霉菌擦拭等对曲坯表面霉菌生长情况以及... 详细信息

为针对性控制曲坯表面霉菌的生长,该研究在原有制曲工艺的基础上,对大曲生产过程中关键控制点进行合理调整,从曲坯表面分离出霉菌菌株并进行鉴定,同时通过研究安曲间距、覆盖物、一次翻曲时间以及霉菌擦拭等对曲坯表面霉菌生长情况以及曲坯感官和理化指标等的影响,摸索出控制冬春季中高温大曲表面霉菌生长的措施。结果表明,从曲坯表面分离纯化得到一株霉菌菌株L1,经鉴定为少根根霉(Rhizopus arrhizus)。在原有制曲工艺的基础上,保持安曲间距为2.0~2.5 cm、选择厚度为12~15 cm稻草作为覆盖物、调整一次翻曲时间为安曲后第3天,在此控制条件下,曲坯表面霉菌生长面积可降至50%,长度控制约为2 mm。一次翻曲时进行霉菌擦拭操作结果表明,断面菌丝更为明显和饱满,糖化力和酯化力指标略有提高,分别为783.3 mg/(g·h)、643 mg/(25 g·7 d),该研究对中高温大曲质量稳定和提升具有一定的参考意义。

关键词：中高温大曲霉菌分离鉴定控制措施

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LaB_(6)阴极的制备、应用与展望

电子显微学报 2024年第2期43卷 240-250页

作者：徐跃凡茹亚东左婷婷伍岳王鹏飞刘俊标高召顺韩立肖立业中国科学院电工研究所北京100190 中国科学院大学北京100049

六硼化镧(LaB_(6))阴极作为一种优异的热发射电子源,应用领域广泛,是高端电子束仪器及设备的关键元器件。本文系统介绍了LaB_(6)材料的制备和加工方法、阴极常见的装卡方式,总结了其在各领域应用现状,并对其发展前景进行了展望。

关键词： LaB_(6) 单晶阴极器件电子束设备

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预裂爆破孔间距设计在冲击地压防治中的应用

陕西煤炭 2024年第2期43卷 34-38页

作者：董亚东魏晓虎高昊锐王团李梓豪鄂尔多斯市伊化矿业资源有限责任公司内蒙古鄂尔多斯017300

伊化矿业30209工作面在回采期间出现强矿压显现现象,为解决强矿压显现的问题,引入顶板深孔预裂爆破手段进行卸压。以理论推导为基础,分析96 kg炸药爆破时裂隙区的范围,结合数值模拟手段对孔间距为8 m、10 m及15 m分别进行模拟,研究不同... 详细信息

伊化矿业30209工作面在回采期间出现强矿压显现现象,为解决强矿压显现的问题,引入顶板深孔预裂爆破手段进行卸压。以理论推导为基础,分析96 kg炸药爆破时裂隙区的范围,结合数值模拟手段对孔间距为8 m、10 m及15 m分别进行模拟,研究不同孔间距下的塑性区发育范围,并将新的参数设计方案在现场进行试验。通过微震监测数据统计结果,对比不同孔间距时的卸压效果,验证了设计的参数方案具有更好的卸压效果。

关键词：冲击地压预裂爆破孔间距参数设计微震监测