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Liposomal dual delivery systems in visceral leishmaniasis enhance the synergistic effects of combination therapy:A promise for the future

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 47-60页

作者： Raghunath Hazra amrita Kar Santanu Kar Mahapatra Department of Paramedical and Allied Health Sciences Biodiversity and Environmental Studies Research CentreMidnapore City CollegeKuturiyaBhadutalaPaschim Medinipur-721129West BengalIndia

Visceral leishmaniasis(VL)is a neglected tropical disease,and this review has summarized the current treatment scenario and its *** also highlights alternative approaches used by research groups in India and around the world to develop cutting-edge and potent anti-leishmanial *** though numerous medications could be utilized to treat VL,the limitations of current treatments including their toxicity,cost,route of administration,and duration of doses,have contributed to the emergence of *** therapy might be a better option due to its shorter duration,easier route of administration,and ability to extend the lifespan of individual ***,there is a risk of not delivering both the drugs to the target site together,which can be overcome by the liposomal entrapment of those drugs and at a time knock an opportunity to reduce the dosage of amphotericin B if the combination drug provides a synergistic effect with ***,this review presents a novel strategy to fight against VL by introducing dual drug-loaded liposomes.

关键词： Visceral leishmaniasis Liposomal anti-leishmanial drug Dual drug liposome

Novel wild edible mushroom Astraeus hygrometricus(Pers.)Morgan induces robust apoptosis on human acute lymphoblastic leukemia cells through a RONS-subsisted mitochondria-dependent pathway

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 67-77页

作者： amrita Pal Ribhu Ray Anirban Chouni Subhadip Hajra Santanu Paul Department of Botany University of CalcuttaKolkata 700019India Department of Cancer Chemoprevention Chittaranjan National Cancer InstituteKolkata 700026India

Objective:To explore the therapeutic effects of the novel wild edible mushroom Astraeus hygrometricus(Pers.)Morgan(***)on human acute lymphoblastic leukemia ***:Extensive screening of the antiproliferative and chemopreventive potential of different extracts from 5 wild mushrooms,***,Phallus sp.,Lentinus sp.,Tricholoma sp.,and Serpula *** performed against a panel of 6 cancer cell lines and normal cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** determination,cell cycle profiling,intracellular reactive oxygen species(ROS)and reactive nitrogen species(RNS),and mitochondrial membrane potential were analyzed by flow *** activity of caspases was measured colorimetrically,and the expression pattern of mitochondrial proteins was ***:The methanol extract of *** and MOLT-4 cells were identified as the most potent extract exhibiting antiproliferative activity and most sensitive cell line,*** mushroom extract induced robust selective apoptosis in MOLT-4 cells and arrested cell cycle progression at the G0/G1 *** extract disrupted the mitochondrial membrane potential and enhanced ROS production in MOLT-4 *** methanol extract induced apoptosis by downregulating the expression of Bcl-2,increasing the expression of Bax,and activating the caspase ***:The novel wild edible mushroom is a potential repository of biomolecules for the development of antileukemic drugs.

关键词： Mushroom Astraeus hygrometricus(Pers.)Morgan Apoptosis Antileukemic

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA amrita SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI MADHU GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

亚洲凤凰属物种：研究趋势、状态、分布、民族植物学和药理活性（英文）

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Journal of Resources and Ecology 2024年第5期15卷 1382-1392页

作者： Santosh AYER amrita BHUSAL Pratima CHHETRI Anuska SUBEDI 卡塔里农业与林业大学自然资源管理学院

凤凰属物种因其深远的生态、经济和文化意义而闻名,已在亚洲范围内引起了广泛关注。然而,在该地区对凤凰属物种的研究趋势、状态、分布、民族植物学和药理活性的研究仍然有限。本研究旨在为亚洲凤凰属物种收集相关信息。我们采用了系统... 详细信息

凤凰属物种因其深远的生态、经济和文化意义而闻名,已在亚洲范围内引起了广泛关注。然而,在该地区对凤凰属物种的研究趋势、状态、分布、民族植物学和药理活性的研究仍然有限。本研究旨在为亚洲凤凰属物种收集相关信息。我们采用了系统综述和荟萃分析的首选报告项目（PRISMA）方法,系统地审查了亚洲地区有关凤凰属物种的文献,分析了从2000年到2023年的亚洲凤凰属物种的研究趋势。结果共发现了42项相关研究,时间分布表明,多年来对凤凰属物种的关注度波动较大,显示出持续增长的研究兴趣, 2019年发表的文章数量达到了显著高峰。从地理分布上,研究的集中区域仅限于亚洲48个国家中的12个,鉴于凤凰属物种的广泛分布,因此需要进行更广泛的探索。目前研究的主题主要集中在药理学,其次是民族植物学、形态学、分类学、材料科学、环境工程和生态学。值得注意的是,研究不成比例地集中在Phoenix dactylifera属物种上,较少涉及其他物种。对研究重点、物种分布和地理代表性的分析强调了多样化研究主题的重要性,探索亚洲各地较少研究的凤凰属物种的生态、经济和文化意义,以揭示其在亚洲景观中的全部潜力和重要性。

关键词：凤凰属物种研究趋势民族植物学多功能植物亚洲

新型野生食用菌硬皮地星通过RONS介导线粒体依赖途径诱导人急性淋巴细胞白血病细胞的强凋亡（英文）

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Journal of Traditional Chinese Medical Sciences 2024年第1期 67-77+152页

作者： amrita Pal Ribhu Ray Anirban Chouni Subhadip Hajra Santanu Paul Department of Botany University of Calcutta Department of Cancer Chemoprevention Chittaranjan National Cancer Institute

目标:探讨新型野生食用菌硬皮地星（Astraeus hygrometricus）对人急性淋巴细胞白血病细胞的治疗作用。方法：采用3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐(MTT)试验，对5种野生菌类（硬皮地星、竹荪、香菇、口蘑和干朽菌）的提取物... 详细信息

目标:探讨新型野生食用菌硬皮地星（Astraeus hygrometricus）对人急性淋巴细胞白血病细胞的治疗作用。方法：采用3-(4,5-二甲基噻唑-2)-2,5-二苯基四氮唑溴盐(MTT)试验，对5种野生菌类（硬皮地星、竹荪、香菇、口蘑和干朽菌）的提取物针对6种癌细胞系和正常细胞的抗增殖及化学预防的潜力进行了广泛筛选。采用流式细胞术分析细胞凋亡、细胞周期、细胞内活性氧(ROS)和活性氮(RNS)以及线粒体膜电位进行检测。采用比色法测定半胱天冬酶活性，分析线粒体蛋白的表达模式。结果：硬皮地星甲醇提取物的抗增殖活性最强，且MOLT-4细胞系最为敏感。菌类提取物可诱导MOLT-4细胞的强选择性凋亡，并在G0/G1期阻滞细胞周期进程。提取物可破坏线粒体膜电位，增强MOLT-4细胞的ROS生成。甲醇提取物通过下调Bcl-2的表达，增加Bax的表达，以及激活caspase级联反应来诱导细胞凋亡。结论：这种新型野生食用菌为抗白血病药物的开发提供了潜在的生物分子库。

关键词：菌类硬皮地星细胞凋亡抗白血病

Bioactive compounds, nutritional profile and health benefits of colostrum: a review

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Food Production, Processing and Nutrition 2022年第1期4卷 319-339页

作者： amrita Poonia Shiva Department of Dairy Science and Food Technology Institute of Agricultural SciencesBanaras Hindu UniversityVaranasiUttar Pradesh 221005India

Bovine colostrum is defined as first milk by milching animals responsible for providing the innate immunity to the neonatal and possess many immunoglobulins for preventing the calf from diseases. Colostrum consist of many bioactive compounds like proteins, enzymes, growth factors, immunoglobulins and nucleotides that provides several benefits to human health. Numerous clinical and pre-clinical studies have demonstrated the therapeutic benefits of the bovine colostrum. This review focusses on bioactive compounds, their health benefits, potential of colostrum for developing several health foods and prevention of respiratory and gastrointestinal tract disorders. Processing can also be done to extend shelf-life and extraction of bioactive constituents either as encapsulated or as extracts. The products derived from bovine colostrum are high-end supplements possessing high nutraceutical value.

关键词： Colostrum Functional foods Bioactive compounds Health benefits Microbial infections

Strain induced changes in performance of strained-Si/strained-Si1-yGey/relaxed-Si1-xGex MOSFETs and circuits for digital applications

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Journal of Central South University 2017年第6期24卷 1233-1244页

作者： Kumar Subindu Kumari amrita Das Mukul K Department of Electronics Engineering Indian School of MinesDhanbad 826004India

Growing a silicon(Si) layer on top of stacked Si-germanium(Ge) compressive layer can introduce a tensile strain on the former, resulting in superior device characteristics. Such a structure can be used for high performance complementary metal-oxide-semiconductor(CMOS) circuits. Down scaling metal-oxide-semiconductor field-effect transistors(MOSFETs) into the deep submicron/nanometer regime forces the source(S) and drain(D) series resistance to become comparable with the channel resistance and thus it cannot be neglected. Owing to the persisting technological importance of strained Si devices, in this work, we propose a multi-iterative technique for evaluating the performance of strained-Si/strained-Si_(1-y)Ge_y/relaxed-Si_(1-x)Ge_x MOSFETs and its related circuits in the presence of S/D series resistance, leading to the development of a simulator that can faithfully plot the performance of the device and related digital circuits. The impact of strain on device/circuit performance is also investigated with emphasis on metal gate and high-k dielectric materials.

关键词： complementary metal-oxide-semiconductor (CMOS) high-k dielectric material inverter metal-oxide-semiconductor field-effect transistors (MOSFETs) SiGe series resistance strain

Finite element model to study the effect of exogenous buffer on calcium dynamics in dendritic spines

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International Journal of Modeling, Simulation, and Scientific Computing 2014年第2期5卷 1-12页

作者： amrita Jha Neeru Adlakha Department of Applied Mathematics and Humanities S.V.National Institute of Technology Surat Gujarat-395007

Dendritic spine plays an important role in calcium regulation in a neuron *** serves as a storage site for synaptic strength and receives input from a single synapse of *** order to understand the calcium dynamics in a neuron cell,it is crucial to understand the calcium dynamics in dendritic *** this paper,an attempt has been made to study the calcium dynamics due to the exogenous buffers,in dendritic spines with the help of a sectional *** compartments of dendritic spines are discretized using triangular *** boundary conditions have been *** element method has been employed to obtain the solution in the region for a two-dimensional unsteady state *** 7.11 is used for simulation of the problem and numerical *** numerical results have been used to study the effect of exogenous buffers on calcium distribution in dendritic spines.

关键词： Diffusion coefficient buffers variational form finite element method

Increased susceptibility of aging gastric mucosa to injury and delayed healing:Clinical implications

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World Journal of Gastroenterology 2018年第42期24卷 4721-4727页

作者： Andrzej S Tarnawski amrita Ahluwalia Department of Gastroenterology Research University of California Irvine and the Veterans Administration Long Beach Healthcare System

In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thrombotic action of aspirin, gastric mucosal injury and aging-related increased susceptibility of gastric mucosa to injury. Aspirin is widely used not only for the management of acute and chronic pain and arthritis, but also importantly for the primary and secondary prevention of cardiovascular events such as myocardial infarcts and strokes. Clinical trials have consistently shown that antiplatelet therapy with long term, low dose aspirin(LDA)-75 to 325 mg daily, dramatically reduces the risk of non-fatal myocardial infarcts, stroke and mortality in patients with established arterial diseases. However, such treatment considerably increases the risk of gastrointestinal(GI) ulcerations and serious bleeding by > 2-4 fold, especially in aging individuals. This risk is further increased in patients using LDA together with other antiplatelet agents, other nonsteroidal anti-inflammatory agents(NSAIDs) and/or alcohol, or in patients with Helicobacter pylori(H. pylori) infection. Previous studies by our group and others have demonstrated prominent structural and functional abnormalities in gastric mucosa of aging individuals(which we refer to as aging gastric mucosa or "aging gastropathy") compared to the gastric mucosa of younger individuals. Aging gastric mucosa has impaired mucosal defense, increased susceptibility to injury by a variety of noxious agents such as aspirin, other NSAIDs and ethanol, and delayed and impaired healing of injury. The mechanism underlying these abnormalities of aging gastric mucosa include reduced mucosal blood flowcausing hypoxia, upregulation of PTEN, activation of proapoptotic caspase-3 and caspase-9, and reduced survivin(anti-apoptosis protein), importin-α(nuclear transport protein), vascular endothelial growth factor, and nerve grow

关键词： Aging gastric mucosa Injury Low dose aspirin Platelets Cyclooxygenase-1 Cyclooxygenase-2 Thromboxane A-2