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Dingxin recipe alleviates atherosclerosis injury in Apo E-knockout mice via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response

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Journal of Traditional Chinese Medicine 2020年第6期40卷 938-946页

作者： Cui Xiaobing Huang Zhiyong Lou Linjie Cheng Saibo zhang Yu zhang yaxin Jia Yuhua Zhou Fenghua School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Integrated Hospital of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510310China The Third Affiliated Hospital Southern Medical UniversityGuangzhou 510630China Department of Traditional Chinese Medicine the First Affiliated Hospital of Wenzhou Medical CollegeWenzhou 325000China Department of Traditional Chinese Medicine Xinyang Central HospitalXinyang 464000China

OBJECTIVE:To further elucidate the mechanism underlying the anti-atherosclerotic effect of Dingxin recipe(DXR).METHODS:Fifty 6-week-old male Apo E^-/-mice were randomly divided into the following groups:model,simvastatin(5 mg·kg^-1·d^-1),DXR low-dose(9.30 g·kg^-1·d^-1),DXR middle-dose(18.59 g·kg^-1·d^-1)and DXR high-dose(37.18 g·kg^-1·d^-1)(n=10).Ten male C57BL/6J mice were used as the control *** Apo E^-/-mice were fed a high-fat diet(HFD)and the control mice received a common *** HFD for 12 weeks,the mice were treated with DXR or simvastatin for another 12 *** expression of inflammatory cytokines and visfatin was determined in serum and atherosclerotic lesions by enzyme-linked immunosorbent *** expression was also assessed in aortic atherosclerotic *** vessel endothelial cells(VECs)were pretreated with DXR sera prior to *** effects of DXR were analyzed to elucidate its protective mechanism against visfatin-induced inflammation in ***:DXR regulated blood lipids and reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecules-1(ICAM-1),vascular cell adhesion molecule-1(VCAM-1)and visfatin expression in Apo E^-/-mice,particularly at the higher *** areas of atherosclerotic lesions in the DXR groups were significantly smaller than those in the model *** alleviated visfatin-induced VEC injury via downregulation of TNF-α,IL-6,ICAM-1 and VCAM-1 through mitogen-activated protein kinase ***:DXR alleviated atherosclerosis injury via downregulation of visfatin expression and inhibition of the visfatin-induced inflammatory response in VECs.

关键词： Atherosclerosis Nicotinamide phosphoribosyltransferase Inflammation Mitogen-activated protein kinases Dingxin recipe

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A systematic review of the inequality of health burdens related to climate change

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 137-153页

作者： Xinke Song Shihui zhang Hai Huang Qun Ding Fang Guo yaxin zhang Jin Li Mingyu Li Wenjia Cai Can Wang State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Department of Earth System Science Tsinghua UniversityBeijing100084China

Climate change significantly impacts human health,exacerbating existing health inequalities and creating new *** study addresses the lack of systematic review in this area by analyzing 2440 publications,focusing on four key terms:health,disparities,environmental factors,and climate *** inclusion criteria limited the selection to English-language,peer-reviewed articles related to climate health hazards,ensuring the relevance and rigor of the synthesized *** process synthesized 65 relevant *** investigation revealed that recent research,predominantly from developed countries,has broadened its scope beyond temperature-related impacts to encompass diverse climate hazards,including droughts,extreme weather,floods,mental health issues,and the intersecting effects of Coronavirus Disease *** has highlighted exposure as the most studied element in the causal chain of climate change-related health inequalities,followed by adaptive capability and inherent *** most significant vulnerabilities were observed among populations with low socioeconomic status,ethnic minorities,and *** study further reveals research biases and methodological limitations,such as the paucity of attention to underdeveloped regions,a narrow focus on non-temperature-related hazards,challenges in attributing climate change effects,and a deficit of large-scale empirical *** findings call for more innovative research approaches and a holistic integration of physical,socio-political,and economic dimensions to enrich climate-health discourse and inform equitable policy-making.

关键词： Climate change Health impact Human well-being Inequality Vulnerability

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A Survey on Terahertz Communications

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China Communications 2019年第2期16卷 1-35页

作者： Zhi Chen Xinying Ma Bo zhang yaxin zhang Zhongqian Niu Ningyuan Kuang Wenjie Chen Lingxiang Li Shaoqian Li National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China

With the exponential growth of the data traffic in wireless communication systems, terahertz(THz) frequency band is envisioned as a promising candidate to support ultra-broadband for future beyond fifth generation(5G), bridging the gap between millimeter wave(mmWave) and optical frequency ranges. The purpose of this paper is to provide a comprehensive literature review on the development towards THz communications and presents some key technologies faced in THz wireless communication systems. Firstly, despite the substantial hardware problems that have to be developed in terms of the THz solid state superheterodyne receiver, high speed THz modulators and THz antennas, the practical THz channel model and the efficient THz beamforming are also described to compensate for the severe path attenuation. Moreover, two different kinds of lab-level THz communication systems are introduced minutely, named a solid state THz communication system and a spatial direct modulation THz communication system, respectively. The solid state THz system converts intermediate frequency(IF) modulated signal to THz frequency while the direct modulation THz system allows the high power THz sources to input for approving the relatively long distance communications. Finally, we discuss several potential application scenarios as well as some vital technical challenges that will be encountered in the future THz communications.

关键词： Terahertz(THz)communications beyond fifth generation(5G) superheterodyne receiver modulators antennas channel model beamforming technical challenges

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Terahertz Direct Modulation Techniques for High-speed Communication Systems

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China Communications 2021年第5期18卷 221-244页

作者： Tianchi Zhou yaxin zhang Bo zhang Hongxin Zeng Zhiyong Tan Xilin zhang Lan Wang Zhi Chen Juncheng Cao Kaijun Song Ziqiang Yang University of Electronic Science and Technology of China ChengduChina Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Key Laboratory of Terahertz Solid State Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences865 Changning RoadShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Terahertz communication technology can provide abundant frequency resources,strong confidentiality,antijamming capability,communication tracking capability and the ability to achieve highspeed data transmissions and can serve as an important technical method for high-speed communications in the *** these terahertz communication technologies,terahertz direct modulation technology is a key means to achieve low system complexity and power *** this paper,a review and outlook of terahertz direct modulation technology are proposed from the aspects of high-electron-mobilitytransistor-based terahertz direct modulation,parallelswitch terahertz direct modulation,diode-based terahertz direct modulation,quantum cascade laser-based terahertz direct modulation and new-material-based terahertz direct *** hope through this paper that more readers can gain knowledge about the development and challenges of terahertz direct modulation technology for high-speed communication systems,thus promoting the development of high-speed terahertz communication technology based on direct modulation.

关键词： THz communication THz direct modulation HEMT switches diode QCL new-material

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Promoted catalytic performance of Ag-Mn bimetal catalysts synthesized through reduction route

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Journal of Environmental Sciences 2024年第3期137卷 358-369页

作者： Wenkai Hu Tao Guo Kaiyao Ma Xu Li Wangting Luo Mingzhi Wu Hao Guo yaxin zhang Wenfeng Shangguan School of Chemical Engineering and Technology Xinjiang UniversityUrumchi 830017China Research Center for Combustion and Environmental Technology Shanghai Jiao Tong UniversityShanghai 200240China

VOCs can exert great harm to both human and environment,and catalytic oxidation is believed to be an effective technique to eliminate these *** this paper,Ag-Mn bimetal catalysts with 10 wt.%of silver were synthesized using doping,impregnation,and reduction methods respectively,and then they were applied to the catalytic oxidation of *** series of characterizations it showed that the loading of silver using reduction method significantly resulted in improved physico-chemical properties of manganese oxides,such as larger surface area and pore volume,higher proportion of surface Mn~(3+)and Mn~(4+),stronger reducibility and more active of surface oxygen species,which were all beneficial to its catalytic *** a result,the Ag-Mn catalysts synthesized by reduction method showed a lower T_(90)value(equals to the temperature at which 90%of initial benzene was removed)of 203℃.Besides,both the used and fresh Ag-Mn catalysts synthesized by reduction method showed preferable stability in this research.

关键词： Ag-Mn Benzene oxidation Catalytic performance Reduction route

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Whole-exome sequencing identified compound heterozygous variants in MMKS in a Chinese pedigree with Bardet-Biedl syndrome

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Science China(Life Sciences) 2017年第7期60卷 739-745页

作者： Zhan Qi Ying Shen Qian Fu Wei Li Wei Yang Wenshan Xu Ping Chu yaxin zhang Hui Wang Beijing Key Laboratory for Genetics of Birth Defects Key Laboratory of Major Diseases in Children of Ministry of Education Center for Medical Genetics Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Beijing Key Laboratory for Chronic Renal Disease and Blood Purification Key Laboratory of Major Diseases in Children of Ministry of Education Nephrology Department Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Beijing Key Laboratory for Pediatric Disease of Otolaryngology Head and Neck Surgery Key Laboratory of Major Diseases in Children of Ministry of Education Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beij'ing 100045 China School of Pediatrics Capital Medical University Beijing 100069 China

Bardet-Biedl syndrome(BBS) is a genetically heterogeneous disorder characterized by retinal dystrophy, polydactyly, obesity,developmental delay, and renal defects. At least 21 candidate BBS-associated genes(BBS1-19, NPHP1, and IFT172) have previously been identified, and all of them play important roles in ciliary function. Here, we collected a BBS pedigree with four members and performed whole-exome sequencing on the proband. The variants were analyzed and evaluated to confirm their pathogenicity. We found compound heterozygous variants(c.1192C>T, p.Q398* and c.1175C>T, p.T392M) in MKKS in both the siblings, and these were likely to be pathogenic variants. We also found a missense variant(c.2029G>C, p.E677Q) in NPHP1 and a missense variant(c.2470C>T, p.R824C) in BBS9 in the proband only, which are variants of uncertain significance. The compound heterozygous variants were probably responsible for the BBS phenotype in this Chinese pedigree and the missense mutations in NPHP1 and BBS9 might contribute to the mutation load.

关键词： Bardet-Biedl syndrome MKKS BBS6 NPHP1 whole-exome sequencing

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Inhibition of YIPF2 Improves the Vulnerability of Oligodendrocytes to Human Islet Amyloid Polypeptide

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Neuroscience Bulletin 2024年第10期40卷 1403-1420页

作者： Nan zhang Xiaoying Ma Xinyu He yaxin zhang Xin Guo Zhiyuan Shen Xiaosu Guo Danshen zhang Shujuan Tian Xiaowei Ma Yuan Xing Hebei Key Laboratory of Brain Science and Psychiatric-Psychologic Disease The First Hospital of Hebei Medical UniversityShijiazhuang050000China Neuromedical Technology Innovation Center of Hebei Province Department of NeurologyThe First Hospital of Hebei Medical UniversityShijiazhuang050000China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang050000China Department of Neurology Hebei HospitalXuanwu Hospital of Capital Medical UniversityShijiazhuang050000China

Excessive secretion of human islet amyloid polypeptide(hIAPP)is an important pathological basis of diabetic encephalopathy(DE).In this study,we aimed to investigate the potential implications of hIAPP in DE *** magnetic resonance imaging and cognitive scales were applied to evaluate white matter damage and cognitive *** found that the concentration of serum hIAPP was positively correlated with white matter damage but negatively correlated with cognitive scores in patients with type 2 diabetes *** vitro assays revealed that oligodendrocytes,compared with neurons,were more prone to acidosis under exogenous hIAPP ***,western blotting and co-immunoprecipitation indicated that hIAPP interfered with the binding process of monocarboxylate transporter(MCT)1 to its accessory protein CD147 but had no effect on the binding of MCT2 to its accessory protein *** differential analysis of proteins co-immunoprecipitated with CD147 in oligodendrocytes revealed Yeast Rab GTPase-Interacting protein 2(YIPF2,which modulates the transfer of CD147 to the cell membrane)as a significant ***,YIPF2 inhibition significantly improved hIAPP-induced acidosis in oligodendrocytes and alleviated cognitive dysfunction in DE model *** findings suggest that increased CD147 translocation by inhibition of YIPF2 optimizes MCT1 and CD147 binding,potentially ameliorating hIAPP-induced acidosis and the consequent DE-related demyelination.

关键词： Diabetic encephalopathy Human islet amyloid polypeptide Oligodendrocytes:Yeast Rab GTPase-interacting protein 2-Monocarboxylate transporters CD147

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Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05

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Natural Products and Bioprospecting 2022年第1期12卷 403-408页

作者： Sitian zhang Shuyuan Mo Fengli Li yaxin zhang Jianping Wang Zhengxi Hu Yonghui zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Soil-derived fungi represent an insufficiently tapped reservoir for discovering new and bioactive natural products(NPs),and despite an ever-increasing number of unknown NPs have been discovered over the past few decades,much of the hidden biosynthetic potential is still in an urgent need to be *** this research,a chemical inves-tigation was performed on a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05,leading to the isolation of a total of fourteen drimane sesquiterpenoids(1-14),incorporating three new ones,namely ustusols F-H(1-3).Their structures,comprising absolute configurations,were completely authenticated by widespread spectroscopic data,quantum chemical 13C NMR and ECD calculations,and X-ray crystallography *** 14 exhibited moderate anti-inflammatory activity by inhibiting the LPS-induced NO release(IC_(50)=25.6μM).

关键词： Aspergillus calidoustus Drimane sesquiterpenoids Structure elucidation Anti-inflammatory activity

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Flexible pressure sensors with ultrahigh stress tolerance enabled by periodic microslits

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Microsystems & Nanoengineering 2024年第1期10卷 301-311页

作者： Song Wang Chenying Wang Yifan Zhao Yujing zhang yaxin zhang Xiangyue Xu Qijing Lin Kai Yao Yuheng Wang Feng Han Yu Sun Zhuangde Jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’anChina State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesSchool of Instrument Science and TechnologyXi’an Jiaotong UniversityXi’anChina The Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingboChina Department of Mechanical and Industrial Engineering University of TorontoTorontoCanada

Stress tolerance plays a vital role in ensuring the effectiveness of piezoresistive sensing films used in flexible pressure ***,existing methods for enhancing stress tolerance employ dome-shaped,wrinkle-shaped,and pyramidal-shaped microstructures in intricate molding and demolding processes,which introduce significant fabrication challenges and limit the sensing *** address these shortcomings,this paper presents periodic microslits in a sensing film made of multiwalled carbon nanotubes and polydimethylsiloxane to realize ultrahigh stress tolerance with a theoretical maximum of 2.477 MPa and a sensitivity of 18.092 kPa−*** periodic microslits permit extensive deformation under high pressure(e.g.,400 kPa)to widen the detection ***,the periodic microslits also enhance the sensitivity based on simultaneously exhibiting multiple synapses within the sensing interface and between the periodic sensing *** proposed solution is verified by experiments using sensors based on the microslit strategy for wind direction detection,robot movement sensing,and human health *** these experiments,vehicle load detection is achieved for ultrahigh pressure sensing under an ultrahigh pressure of over 400 kPa and a ratio of the contact area to the total area of 32.74%.The results indicate that the proposed microslit strategy can achieve ultrahigh stress tolerance while simplifying the fabrication complexity of preparing microstructure sensing films.

关键词： robot shaped stress

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High Power GaN Doubler with High Duty Cycle Pulse Based on Local Non-reflection Design

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Chinese Journal of Electronics 2024年第5期33卷 1196-1203页

作者： Yazhou DONG Tianchi ZHOU Shixiong LIANG Guodong GU Hongji ZHOU Jianghua YU Hailong GUO yaxin zhang School of Electronic Science and Engineering University of Electronic Science and Technology of China National Key Laboratory of Solid-State Microwave Devices and Circuits Hebei Semiconductor Research Institute

The study focuses on the development of gallium nitride(GaN) Schottky barrier diode(SBD) frequency doublers for terahertz technology. The low conversion efficiency of these doublers limits their practical applications. To address this challenge, the paper proposes a multi-objective local no-reflection design method based on a three-dimensional electromagnetic structure. The method aims to improve the coupling efficiency of input power and reduce the reflection of power output. Experimental results indicate that the proposed method significantly improves the performance of GaN SBD frequency doublers, achieving an efficiency of 16.9% and a peak output power of 160mW at 175 GHz. These results suggest that the method can contribute to the further development of GaN SBD frequency doublers for terahertz technology.

关键词： Couplings Schottky diodes Design methodology Schottky barriers Terahertz materials Power system harmonics Reflection

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