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The <i>Helicobacter pylori</i>Eradication Rate in a High Prevalence Area (West Africa): Three Triple Therapy Comparative Study

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Open Journal of gastroenterology 2015年第12期5卷 200-206页

作者： Adjéka Stanislas Doffou Koffi Alain Attia Mamert Fulgence yao Bathaix Aboubacar Demba Bangoura ya Henriette Kissy-Anzouan Hartrydt Dimitri Kouamé Kouamé Alassan Mahassadi Kouamé Justin N’Da mohamed Kouyaté Constant Assi Aya Thérèse N’dri-Yoman Department of Hepatology and gastroenterology Centre Hospitalier Universitaire de Yopougon (CHU-Y) Abidjan Cote d’Ivoire Anatomopathology Laboratory of the Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire Department of Hepatology and gastroenterology Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire

In Western countries, the current trend is to use sequential quadruple therapy or bismuth-based instead of triple therapy for the eradication of Helicobacter pylori (H. pylori). In sub-Saharan Africa, high prevalence area of the H. pylori infection, the effectiveness of these triple therapies widely used in routine has been little evaluated. The purpose of this study was to evaluate and compare the effectiveness of three patterns of first-line triple therapy based on combining a proton pump inhibitors (PPI), and 3 types of antibiotics: omeprazole (O), amoxicillin (A), clarythromycin (C) and metronidazole (M). Patients and Methods: This is a randomized clinical trial opened on 3 parallel arms: OAM (group 1 or G1), OAC (group 2 or G2) or OCM (group 3 or G3). The primary endpoint was H. pylori eradication rate after seven days triple therapy. H. pylori diagnosis infection was based on bacterium detection on the histological examination of the gastric biopsies. Histological control was performed 4 weeks after the end of treatment to assess H. pylori eradication rate. Results: The average age of our 153 patients included in the study (86 men) was 44.33 ± 11.72 years. The main reason of the endoscopy was the dyspeptic syndrome (75.16%). The gastroscopy was normal in 28.76%. A gastric or duodenal peptic ulcer was found in 17% of cases and gastropathy in 45.75%. Histologically, the GC was active in 90.9% of cases, follicular in 35.3% of cases, atrophic in 22.5% of cases and was associated with intestinal metaplasia (IM) in 5.2% of cases. Patients of these three groups (n = 64 for G1, n = 56 for G2 and n = 33 for G3) were comparable for age, gender, endoscopy indications, alcohol consumption history or smoking, and anti-inflammatory drugs taking. Approximately 23% of patients experienced adverse reactions. The overall H. pylori eradication rate was 22.3%. There was no significant difference H. pylori eradication rate depending on the treatment used (28.1%, 21.4% and 15.1% fo

关键词： Helicobacter pylori Triple Therapy Eradication West Africa

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Generative Learning in VLSI Design for Manufacturability: Current Status and Future Directions

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Journal of Microelectronic Manufacturing 2019年第4期2卷 1-12页

作者： mohamed Baker Alawieh Yibo Lin Wei ye David Z.Pan Electrical and Computer Engineering University of Texas at AustinAustinUSA78712 School of Electronics Engineering and Computer Science Peking UniversityBeijingChina100871

With the continuous scaling of integrated circuit technologies,design for manufacturability(DFM)is becoming more critical,yet more ***,recent advances in machine learning have provided a new computing paradigm with promising applications in VLSI *** particular,generative learning-regarded among the most interesting ideas in present-day machine learning-has demonstrated impressive capabilities in a wide range of *** paper surveys recent results of using generative learning in VLSI manufacturing modeling and ***,we examine the unique features of generative learning that have been leveraged to improve DFM efficiency in an unprecedented way;hence,paving the way to a new data-driven DFM *** state-of-the-art methods are presented,and challenges/opportunities are discussed.

关键词： Design for Manufacturability Generative Learning Machine Learning Lithography

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Intersection Curves of Implicit and Parametric Surfaces in R<sup>3</sup>

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Applied Mathematics 2011年第8期2卷 1019-1026页

作者： mohamed Abdel-Latif Soliman Nassar Hassan Abdel-All Soad Ali Hassan Sayed Abdel-Naeim Badr 不详

We present algorithms for computing the differential geometry properties of Frenet apparatus {t,n,b,κ,τ} and higher-order derivatives of intersection curves of implicit and parametric surfaces in R3 for transversal and tangential intersection. This work is considered as a continuation to ye and Maekawa [1]. We obtain a classification of the singularities on the intersection curve. Some examples are given and plotted.

关键词： Geometric Properties Frenet Frame Frenet Apparatus Frenet-Serret Formulas Surface-Surface Intersection Transversal Intersection Tangential Intersection Dupin Indicatrices

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“阿拉伯之春”后突尼斯的选举政治

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国际研究参考 2020年第1期 9-18页

作者：雅言中国现代国际关系研究院

2010年底,突尼斯果蔬小贩穆罕默德·布瓦吉吉(mohamed Bouazizi)以自焚方式抗议政府骚扰,随即引发大规模民众抗议浪潮,最终发展为席卷中东地区的"阿拉伯之春"运动。如果从2011年1月14日突尼斯总统本·阿里(Ben Ali)仓皇出逃算起,"阿拉... 详细信息

2010年底,突尼斯果蔬小贩穆罕默德·布瓦吉吉(mohamed Bouazizi)以自焚方式抗议政府骚扰,随即引发大规模民众抗议浪潮,最终发展为席卷中东地区的"阿拉伯之春"运动。如果从2011年1月14日突尼斯总统本·阿里(Ben Ali)仓皇出逃算起,"阿拉伯之春"运动爆发至今将近9年。在这9年中,埃及、利比亚、也门、叙利亚等"阿拉伯之春"国家并没有收获和平与发展的春天,反而相继陷入军事政变、无政府内斗、内战等混乱动荡的泥沼,唯有突尼斯政治转型民主过渡相对平和。

关键词：军事政变阿拉伯之春政治转型中东地区和平与发展自焚突尼斯民主过渡

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非洲马里女性宫颈癌前病变联合筛查的调查分析

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中国卫生检验杂志 2018年第21期28卷 2639-2642页

作者：唐咏梅王乐见 Boubacar Sidiki I.Dramé Halidou M koné mohamed A Maiga 傅亚军义乌市中心医院台州市中心医院西非马里医院病理科巴马科大学浙江省嘉兴妇保院

目的筛查西非马里女性宫颈癌前病变的流行病学特征,为制定相应的干预措施提供依据。方法筛查对象来自西非马里2015年1月-2017年11月年龄为(39. 85±14. 21)岁女性1 830例,进行妇科常规检查、醋酸肉眼观察(VIA)、碘液染色肉眼观察法(VILI... 详细信息

目的筛查西非马里女性宫颈癌前病变的流行病学特征,为制定相应的干预措施提供依据。方法筛查对象来自西非马里2015年1月-2017年11月年龄为(39. 85±14. 21)岁女性1 830例,进行妇科常规检查、醋酸肉眼观察(VIA)、碘液染色肉眼观察法(VILI)、宫颈细胞学、阴道镜检查及组织病理学筛查。结果 1 830例VIA/VILI检测的敏感度为87. 67%(128/146),特异度为71. 38%(1 202/1 684); 610例细胞学宫颈癌前病变阳性检出率为20. 98%,其中首次性交年龄为15岁～20岁患者的发生癌前病变阳性检出率为10. 49%;年龄为40岁～50岁的癌前病变阳性检出率为6. 39%; 125例女性组织学宫颈癌前病变阳性检出率为76. 19%,CINⅡ及以上级别病变阳性检出率为55. 56%。结论通过本次对子宫颈癌前病变的调查发现导致宫颈病变高发与一夫多妻、首次性交年龄、医疗卫生等因素有关。

关键词：西非马里宫颈癌前病变联合筛查 VIA/VILI 宫颈细胞学组织病理学

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机会性筛查对非洲马里宫颈癌的应用研究

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中华全科医学 2020年第1期18卷 129-133页

作者：唐咏梅刘海芳 Boubacar Sidiki I.Dramé Halidou M koné mohamed A Maiga 傅亚军义乌市中心医院病理科浙江义乌322000 非洲马里医院病理科巴马科999053 UNIVERSITE DE BAMAKO HAMDALIAYE ACI 2000 RUE:405-PORTE:359-BAMAKO REPUBLIQUE DU MALI.BP E:423 嘉兴市妇幼保健院病理科浙江嘉兴314000

目的对非洲马里女性进行基础信息调查,分析2种筛查技术对宫颈癌及宫颈癌前病变(cervical intraepithelial neoplasia,CIN)在非洲马里应用的筛查效果,为提高宫颈癌及宫颈癌前病变筛查技术的质量提供数据支持和科学依据。方法选择2016年6... 详细信息

目的对非洲马里女性进行基础信息调查,分析2种筛查技术对宫颈癌及宫颈癌前病变(cervical intraepithelial neoplasia,CIN)在非洲马里应用的筛查效果,为提高宫颈癌及宫颈癌前病变筛查技术的质量提供数据支持和科学依据。方法选择2016年6月—2018年6月3658例女性作为筛查对象,符合条件女性为3638例。用双肓法分别做醋酸染色目视观察法(visual inspection with acetic acid,VIA)/Lugol碘染色目视观察法(visual inspection with Lugol’s iodine,VILI)和细胞学2种筛查技术,筛查阳性或临床可疑女性实行阴道镜下病理活检。结果在3638例参加筛查女性中,首次性交年龄为(18.19±3.26)岁,生育胎次为(4.5±3.1)胎,一夫多妻构成比为50.27%,小学及以下文化程度为48.87%,认知率为13.20%;VIA/VILI组CINⅡ+病变检出率为4.90%(χ^2=14.241,P=0.014),细胞学组CINⅡ+病变检出率为5.16%(χ^2=17.189,P=0.004);病理活检检出率为74.53%。结论加强宫颈癌预防知识的宣传,提高对宫颈癌的认知率和筛查率,规范筛查方案,对于降低非洲马里宫颈癌的发病率和死亡率具有重要的社会意义。

关键词：宫颈癌醋酸染色法/碘染色法细胞学阴道镜病理活检

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裂隙岩体精细化数值模型构建与爆破模拟

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爆破 2023年第4期40卷 44-51页

作者：叶海旺韦文蓬周汉红余梦豪李兴旺雷涛温颖王其洲石斌宏于燕张生钟传山高玉文 HASSAN Abdou mohamed Abdelkader 武汉理工大学资源与环境工程学院武汉430070 武汉市公安局治安管理局武汉430077 华新水泥股份有限公司武汉430200 五矿勘查开发有限公司北京100044

裂隙岩体爆破数值模拟过程中,裂隙分布模型的真实性,是影响数值模拟结果的关键因素之一,现有节理裂隙构建方法难以实现三维分布上的复杂表征或是实现操作过于繁杂。为探索在LS-DYNA软件中构建三维分布上真实、复杂表征的节理裂隙模型简... 详细信息

裂隙岩体爆破数值模拟过程中,裂隙分布模型的真实性,是影响数值模拟结果的关键因素之一,现有节理裂隙构建方法难以实现三维分布上的复杂表征或是实现操作过于繁杂。为探索在LS-DYNA软件中构建三维分布上真实、复杂表征的节理裂隙模型简单可行的操作方法,通过MATLAB软件对爆破数值模型K文件进行解析重组,按照节理裂隙三维分布规律进行勾勒并赋予节理裂隙材料本构,构建出符合节理裂隙分布规律的节理岩体三维精细化数值模型。以某露天石灰石矿山为实例,开展节理裂隙三维分布规律统计分析并在台阶爆破数值模型中进行还原,基于裂隙岩体精细化数值模型,开展露天台阶爆破数值模拟试验和现场爆破试验对比研究。结果表明:采用解析重组方法构建的数值节理模型与实际节理裂隙的误差小于13%;节理裂隙面使岩体内的损伤分布规律发生了变化,与完整岩体相比,损伤范围增加了12.04%,粒径处于0~100 mm的占比降低了8.11%;爆破模拟得到的损伤结果与现场破碎效果接近,统计粒径在0~100 mm之间的碎块的占比,误差为4.16%。解析重组法构建三维节理裂隙,可行、操作简便,数值模拟结果接近实际。

关键词：裂隙岩体裂隙分布规律地质模型 LS-DYNA 爆破数值模拟爆破试验

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复合材料π接头渐进失效分析

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计算机辅助工程 2011年第3期20卷 19-24页

作者：陈珅艳林志伟 mohamed yasser Mahmoud 黄海梁宪珠北京航空航天大学宇航学院北京100191 中国航空工业第一集团公司北京航空制造工程研究所北京100024

针对复合材料π接头复杂的失效形式,采用材料刚度退化的方法模拟结构的渐进失效过程.用Abaqus建立某复合材料π接头的三维有限元模型;采用三维Hashin失效准则和ye分层准则判别复合材料层合板的5种失效形式,将理想弹塑性材料模型应用于... 详细信息

针对复合材料π接头复杂的失效形式,采用材料刚度退化的方法模拟结构的渐进失效过程.用Abaqus建立某复合材料π接头的三维有限元模型;采用三维Hashin失效准则和ye分层准则判别复合材料层合板的5种失效形式,将理想弹塑性材料模型应用于胶层材料来模拟胶层材料的失效,在Abaqus中建立考虑复合材料层合板和胶层失效的分析子程序;在子程序中,定义6个场变量代表纤维拉伸破坏、纤维屈曲、基体拉伸开裂、基体压缩开裂、分层失效和胶层失效等6种失效形式.在递增的拉伸载荷作用下对所建模型进行失效分析,结果表明该方法能有效地对复合材料π接头进行初始失效位置及载荷的判别和最终失效预测.

关键词：复合材料 π接头渐进失效分析 Hashin准则 ye分层准则胶层失效 Abaqus

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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian yang Salah Hussein mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen yang Xiangfeng Cong yao Tan Wenwen Lei Xue Jun gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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