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Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment

Computers, Materials & Continua 2024年第4期79卷 1157-1185页

作者： Sapiah Sakri Shakila Basheer Zuhaira Muhammad Zain Nurul Halimatul Asmak Ismail dua.Abdellatef Nassar Manal Abdullah Alohali Mais Ayman Alharaki Department of Information Systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Kingdom of Saudi Arabia Department of Computer Science and Information Technology Applied CollegePrincess Nourah Bint Abdulrahman UniversityRiyadh11671Kingdom of Saudi Arabia

Background:Sepsis,a potentially fatal inflammatory disease triggered by infection,carries significant healthimplications *** detection is crucial as sepsis can rapidly escalate if left *** in deep learning(DL)offer powerful tools to address this ***:Thus,this study proposeda hybrid CNNBDLSTM,a combination of a convolutional neural network(CNN)with a bi-directional long shorttermmemory(BDLSTM)model to predict sepsis *** the proposed model provides a robustframework that capitalizes on the complementary strengths of both architectures,resulting in more accurate andtimelier ***:The sepsis prediction method proposed here utilizes temporal feature extraction todelineate six distinct time frames before the onset of *** time frames adhere to the sepsis-3 standardrequirement,which incorporates 12-h observation windows preceding sepsis *** models were trained usingthe Medical Information Mart for Intensive Care III(MIMIC-III)dataset,which sourced 61,522 patients with 40clinical variables obtained from the IoT medical *** confusion matrix,the area under the receiveroperating characteristic curve(AUCROC)curve,the accuracy,the precision,the F1-score,and the recall weredeployed to evaluate ***:The CNNBDLSTMmodel demonstrated superior performance comparedto the benchmark and other models,achieving an AUCROC of 99.74%and an accuracy of 99.15%one hour beforesepsis *** results indicate that the CNNBDLSTM model is highly effective in predicting sepsis onset,particularly within a close proximity of one ***:The results could assist practitioners in increasingthe potential survival of the patient one hour before sepsis onset.

关键词： Temporal derivatives hybrid deep learning predicting sepsis onset MIMIC III machine learning(ML) deep learning

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Long-term outcomes of endoscopic submucosal dissection for undifferentiated type early gastric cancer over 2 cm with R0 resection

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 326-334页

作者： Jun Yong Bae Chang Beom Ryu Moon Sung Lee Kulwinder S dua Internal Medicine and Digestive Disease Center Seoul Medical CenterSeoul 02053South Korea Internal Medicine and Digestive Disease Center and Research Institute Soon Chun Hyang University of School of MedicineBucheon 14584South Korea Department of Medicine Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Endoscopic submucosal dissection(ESD)for over 2 cm in size undifferentiated type(UD type)early gastric cancer(EGC)confined to the mucosa is not only challenging,but also long-term outcomes are not well *** To evaluate the long-term outcomes of ESD done for UD type EGCs confined to the mucosa over 2 cm in size and compare the results with those where the lesions were less than 2 *** 143 patients with UD type EGC confirmed on histology after ESD at a tertiary hospital were *** with synchronous and metachronous lesions and a case with emergency surgery after ESD were excluded.A total of 137 cases were enrolled.79 cases who underwent R0 resection were divided into 2 cm or less(group A)and over 2 cm(group B)in *** Among 79 patients who underwent R0 resection,the number in group A and B were 51 and 28,*** mean follow-up period(SD)was 79.71±45.42 *** was a local recurrence in group A(1/51,2%)and group B(1/28,3.6%)*** patient in group A underwent surgery while the patient in group B underwent repeated ESD with no further recurrences in both *** was no regional lymph node metastasis,distant metastasis,and deaths in both *** R0 resection strategy for ESD on lesions over 2 cm,20.4%(28/137)of patients were able to avoid surgery compared with expanded *** If R0 resection is achieved by ESD,UD type EGCs over 2 cm also showed good and similar clinical outcomes as compared to lesions less than 2 cm when followed for over 5 *** R0 resection strategy,several patients can avoid surgery.

关键词： Undifferentiated type early gastric cancer Endoscopic submucosal dissection Long term outcomes Over 2 cm Early gastric cancer

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Emergency Care for Children and Adolescents after Sexual Violence, in Brazil’s Capital, Brasilia

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Open Journal of Epidemiology 2024年第2期14卷 397-403页

作者： Evaldo Lima Da Costa Karla Simônia de Pádua.Aníbal Faúndes Rui Nunes Bioethics at the School of Medicine University of Porto/Federal Council of Medicine Porto Portugal Center for Research in Women’ s Reproductive Health (CEMICAMP) Center for Integral Attention to Women (CAISM) State University of Campinas Campinas Brazil Center for Research in Women’ s Reproductive Health (CEMICAMP) State University of Campinas (UNICAMP) Campinas Brazil. The Centre of Bioethics Faculty of Medicine University of Porto Porto Portugal

Objective: Sexual violence affects women of all ages but, more commonly, children and adolescents. This study aimed to identify the extent to which services are being provided at the hospitals responsible for the emergency care of children and adolescents who have suffered sexual violence and to determine whether there is any difference in the provision of such services as a function of the victim’s age. Method: This cross-sectional study investigated differences in the care received by female children and adolescents who are victims of sexual violence in a capital city, comparing the treatment given to girls under 15 with that given to adolescents of 15 to 19 years of age. The data were extracted from the State Department of Health database between 01/01/2012 and 31/12/2016. Results: Children under 15 were much less likely to receive prophylaxis against HIV, sexually transmitted infections and hepatitis B, with the number of adolescent girls treated adequately corresponding to between twice and almost three times the number of children treated prophylactically. Only 10% of girls under 15 received emergency contraception. Conclusion: The lack of standard care established by the Ministry of Health highlights the need for urgent debates both locally and probably throughout the country, as the situation may be similar in other regions of the country.

关键词： Aggressors Children Sexual Violence Teenagers

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Do PON1-Q192R and PON1-L55M polymorphisms modify the effects of hypoxic training on paraoxonase and arylesterase activity?

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Journal of Sport and Health Science 2023年第2期12卷 266-274页

作者： Oya Yigittürk Faruk Turgay Servet Kizildag dua.zsoylu Görkem Aybars Balci Faculty of Sport Sciences Department of Sport Health SciencesEge UniversityIzmir 35040Turkey Faculty of Medicine College of Vocational School of Health ServicesDokuz Eylul UniversityIzmir 35330Turkey Faculty of Medicine Institute of Health ScienceDepartment of Medical Biology and GeneticsDokuz Eylul UniversityIzmir 35330Turkey

Background:Low levels of antioxidant paraoxonase 1(PON 1)enzyme activity,PON1-Q192R polymorphism(a glutamine(Q)to arginine(R)substitution at position 192),PON1-L55M polymorphism(a leucine(L)to methionine(M)substitution at position 55),and oxidized low-density lipoprotein(oxLDL)are risk factors for coronary heart *** exercise improves PON1 activity,but the effects of hypoxic exercise are yet *** aim of this study was to determine the effects of hypoxic underwater rugby training on PON1 activity and oxLDL levels and the role of the mentioned ***:Serum PON1 and arylesterase activities(ARE),PON1,PON3,and oxLDL protein levels(by using the enzyme-linked immunosorbent assays)were determined in an athletic group(42 trained male underwater rugby players;age=21.7±4.2 years,mean±SD)and a control group(43 sedentary men;age=23.9±3.2 years).The polymorphisms were determined from genomic DNA ***:PON1 activity(25.1%,p=0.052),PON3(p<0.001),and oxLDL(p<0.001)of the athletic group,including most genotype groups,were higher than those of the control *** comparison to the controls,PON1 activity levels(p=0.005)of the PON1-Q192R homozygote QQ genotype group and PON1 activity levels(30%,p=0.116)of the PON1-L55M homozygote LL genotype group were higher,whereas ARE activity values of athletic R allele carrier(Rc=QR+RR)(p=0.005)and LL group(p=0.002)were lower than the control genotype groups related to their ***:Hypoxic training can cause(1)significant oxidative stress,including oxLDL,and an antioxidant response(increase in PON1 activity and PON3),(2)differences in the activity of PON1 and ARE,which are modified by PON1-Q192R and PON1-L55M polymorphisms,respectively,and(3)improvements in PON1 activity of QQ and LL ***,hypoxic training can cause a disadvantage of LL and Rc groups for ARE.

关键词： Hypoxic training Paraoxonase Polymorphism Underwater rugby

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Complex Polynomial Vector Fields Having a Finitely Curved Orbit

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2247-2252页

作者： B.SCdua Instituto de Matemática C.P.68530Universidade Federal do Rio de Janeiro

The author proves that a non-singular polynomial vector field without invariant lines and having an entire finitely curved transcendent orbit on C^2 must be equivalent to a trivial vector field by a holomorphic change of coordinates. Other classification results are obtained for polynomial vector fields having a finitely curved orbit on C^2.

关键词： holomorphic foliation minimal immersion Huber-Osserman theorem

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THE MERGING OF ORAL AND LISTENING SKILLS:A STEP IN TEH IMPROVEMENT OF TEACHING METHODS——Report on co-teaching between associate professor Ge Hong Jiu(China)and foreign expert Ralf dua.Belgium).

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Chinese Journal of Applied Linguistics 1999年第1期22卷 31-36页

作者： Ralf dua Teachers' College of Jiamusi University

This paper presents the view that speaking and listening skills should be taught together in way that re-flects real-life *** classroom activities are *** authors present theirown experience,as Chinese lecturer and foreign expert,in co-teaching their combined classes in orderto integrate the teaching of speaking and listening skills.

关键词： oral Belgium China)and foreign expert Ralf dua Report on co-teaching between associate professor Ge Hong Jiu THE MERGING OF ORAL AND LISTENING SKILLS Ge

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Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review

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World Journal of Gastroenterology 2019年第16期25卷 1928-1935页

作者： dua.Abuquteish Juan Putra Division of Pathology Department of Paediatric Laboratory Medicine Hospital for Sick Children

Upper gastrointestinal(UGI) tract involvement of inflammatory bowel disease(IBD) is commonly seen in pediatric patients. Upper endoscopy is included in the routine workup of children with suspected IBD to enhance the diagnosis and management of these patients. Currently, childhood IBD is classified into ulcerative colitis(UC), atypical UC, Crohn's disease(CD) and IBD *** confirmation of UGI tract involvement, in particular the presence of epithelioid(non-caseating) granulomas, is helpful in confirming the diagnosis of IBD and its classification. Herein, we reviewed selected IBD-associated UGI tract manifestations in children. Lymphocytic esophagitis, seen predominantly in CD,is histologically characterized by increased intraepithelial lymphocytes(> 20 in one high-power field) in a background of mucosal injury with absence of granulocytes. Focally enhanced gastritis is a form of gastric inflammation in pediatric IBD marked by a focal lymphohistiocytic pit inflammation with or without granulocytes and plasma cells in a relatively normal background gastric mucosa. Duodenal inflammation seen in children with IBD includes cryptitis,villous flattening, increased intraepithelial lymphocytes, and lamina propria eosinophilia. Finally, epithelioid granulomas not associated with ruptured gland/crypt are a diagnostic feature of CD. The clinicopathologic correlation and differential diagnosis of each microscopic finding are discussed. Clinicians and pathologists should be cognizant of the utility and limitations of these histologic features.

关键词： Pediatric Inflammatory bowel disease Lymphocytic esophagitis Focally enhanced gastritis Epithelioid granuloma Crohn’s disease Ulcerative colitis

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新鲜冰冻黄瓜做为冰冻组织切片中的结膜和角膜组织衬托

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美国医学会眼科杂志（中文版） 1995年第1期7卷 39-40页

作者： dua.,HS 李彬

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Nonlinear Model-Based Process Operation under UncertaintyUsing Exact Parametric Programming

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Engineering 2017年第2期3卷 202-213页

作者： Vassilis M. Charitopoulos Lazaros G. Papageorgiou Vivek dua Center for Process Systems Engineering Department of Chemical Engineering University College London London WCI E 7JE UK

In the present work, two new, （multi-）parametric programming （mp-P）-inspired algorithms for the solutionof mixed-integer nonlinear programming （MINLP） problems are developed, with their main focus being onprocess synthesis problems. The algorithms are developed for the special case in which the nonlinearitiesarise because of logarithmic terms, with the first one being developed for the deterministic case, and thesecond for the parametric case （p-MINLP）. The key idea is to formulate and solve the square system of thefirst-order Karush-Kuhn-Tucker （KKT） conditions in an analytical way, by treating the binary variables and/or uncertain parameters as symbolic parameters. To this effect, symbolic manipulation and solution tech-niques are employed. In order to demonstrate the applicability and validity of the proposed algorithms, twoprocess synthesis case studies are examined. The corresponding solutions are then validated using state-of-the-art numerical MINLP solvers. For p-MINLP, the solution is given by an optimal solution as an explicitfunction of the uncertain parameters.

关键词： Parametric programming Uncertainty Process synthesis Mixed-integer nonlinear programming Symbolic manipulation

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Status of carbohydrate,protein and lipid profile in the mosquito larvae treated with certain phytoextracts

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 301-304页

作者： Preeti Sharma Lalit Mohan Kamal Kumar dua.Chand Narayan Srivastava Applied Entomology & Vector Control Laboratory Department of ZoologyFaculty of ScienceDayalbagh Educational Institute Deemed University

Objective:To investigate the impact of the most potent petroleum ether extract of Artemisia annua(***) and Azadirachta indica(***) on total carbohydrate,lipid and protein level of Anopheles stephensi and Culex quinquefasciatus ***:Mosquito larvae were exposed to the extracts selected as per standard WHO ***(glucose),total lipid and protein were estimated by the methods as Nelson,Bragdon and Lowry described, ***:The glucose levels were increased to 27.87%and 46.8%,respectively in anopheline larval tissues after treatment with petroleum ether extract of *** and methanolic extract of *** culicine larvae,glucose levels were reduced to 58.96%and 24.65%, *** treatment with *** extract,lipid contents in anopheline and culicine larvae decreased by 28.57%and 25.0%,respectively and increased by 14.29%and 50.00%in the Anopheles and Culex larvae,respectively after treatment with methanolic extract of Az. *** protein levels were reduced to 63.13%and 92.62%in anopheline and to 32.39%and 48.12%in culicine larvae after treatment with *** and *** extracts,respectively. Conclusions:Two extracts produce significant alterations in the biochemical pr of iles of anopheline and culicine ***,the impacting factors of extracts on carbohydrate,lipid and protein contents of larvae are species and specific *** indicates the disturbed metabolic activity of the larvae.

关键词： Anopheles Culex Artemisia Azadirachta Biochemical profile Phytoextract

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