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基于抗滑性能的路面养护工艺后评价研究

建材世界 2016年第4期37卷 24-27页

作者：查庆束冬林刘宇安徽省高速公路试验检测科研中心有限公司合肥230000

路面的抗滑性能一直以来是高速公路安全问题的核心。研究采用实际路段调查法,选取了安徽省高速公路最常用的三种养护方式—微表处、雾封层和铣刨重铺作试验段,以手工铺砂法、摆式摩擦系数法和横向力系数检测法为表征手段,评价不同养护... 详细信息

路面的抗滑性能一直以来是高速公路安全问题的核心。研究采用实际路段调查法,选取了安徽省高速公路最常用的三种养护方式—微表处、雾封层和铣刨重铺作试验段,以手工铺砂法、摆式摩擦系数法和横向力系数检测法为表征手段,评价不同养护工艺路表的抗滑性能,分析不同抗滑指标与服役时间的相关性,进一步总结出衰减规律,并推算其抗滑疲劳寿命。结果表明,三种养护工艺均可以用于改善原高速公路路面的抗滑能力,改善效果的大小依次为:微表处>铣刨重铺>雾封层。

关键词：抗滑养护服役时间衰减

减蛋综合征病毒环介导等温扩增检测方法的建立

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甘肃农业大学学报 2011年第2期46卷 1-5页

作者：董春娜李刚李伟张坤史利军哈小琴胡永浩中国农业科学院北京畜牧兽医研究所北京100193 甘肃农业大学动物医学院甘肃兰州730070 兰州军区总医院医学实验中心甘肃兰州730050

根据GenBank登录的减蛋综合征病毒(EDSV)六邻体基因的保守区,设计了3对环介导等温基因扩增(LAMP)引物,优化反应体系,并对其灵敏性、特异性进行验证.结果表明:LAMP优化后的反应体系为外引物浓度0.1μmol·L-1,内引物浓度0.8μmol·L-1,... 详细信息

根据GenBank登录的减蛋综合征病毒(EDSV)六邻体基因的保守区,设计了3对环介导等温基因扩增(LAMP)引物,优化反应体系,并对其灵敏性、特异性进行验证.结果表明:LAMP优化后的反应体系为外引物浓度0.1μmol·L-1,内引物浓度0.8μmol·L-1,环引物浓度0.4μmol·L-1,Mg2+浓度8.0 mmol·L-1,dNTP浓度0.8 mmol·L-1,甜菜碱浓度0.5 mmol·L-1,BstDna聚合酶浓度8 U,最佳反应温度65℃;扩增出的EDSV基因呈特征性梯状条带,显色反应呈绿色荧光;检测EDSV的灵敏度高,是普通PCR检测的10倍,可检测到60个拷贝的基因组Dna;特异性强,与鸡新城疫病毒(NDV)、传染性法氏囊病毒(IBDV)、传染性支气管炎病毒(IBV)、鸡胚致死孤儿病毒(CelO)无交叉反应;该方法重复性好,稳定性高,可准确快速地进行减蛋综合征病毒的检测.

关键词：减蛋综合征病毒环介导等温扩增检测

以英文发表的口服中药随机对照试验中不良事件及其影响因素的分析

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中国中药杂志 2020年第8期45卷 1948-1952页

作者：胡晶张会娜李博冯硕哈雁翔韦重阳王雪娇张瑞王巍巍首都医科大学附属北京中医医院北京市中医研究所循证医学中心北京100010 首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室北京100088

为评价英文发表的口服中药随机对照试验(randomiz.d controlled trials,RCTs)中不良事件(adverse event, AE)的发生情况及其相关影响因素,全面检索Medline,EMbase和Cochrane Central Register of Controlled Trials (CENTRAL)数据库。收集2009年1月至2018年7月以英文发表的口服中药RCTs,提取基本信息、研究人群、干预特征和AE发生情况等信息,采用Meta分析对各个AE发生率进行加权合并。最终纳入218个RCTs,其中28.4%没有对AE进行任何报告。103个口服中药研究组共发生1 634例次AE,总AE的发生率11.2%(95%CI[10.7%, 11.7%])。AE发生率最高的是血常规实验室异常,为8.0%(95%CI[6.6%, 9.7%]),其次是神经、精神系统,为7.9%(95%CI[6.6%, 9.5%]),胃肠道反应为7.8%(95%CI[6.8%, 8.9%]),和肝功能异常为7.6%(95%CI[6.4%, 8.9%])。口服中药剂型中,片剂和颗粒剂的AE发生率最高,汤药和口服液的AE发生率最低。口服中药和西药对照组合用的AE发生率最高。随着用药疗程增加,AE发生率也相应增加。儿童患者的AE发生率高于成人患者。基于现有数据及分析结果,口服中药AE发生率较高的部位集中在神经精神系统、胃肠道系统和肝功能异常。AE发生率与剂型、药物联用、用药疗程和患者年龄有关。应对中药现代剂型、中西药联用、用药疗程长以及儿童患者引起的AE予以重视。

关键词：口服中药随机对照试验不良事件 Meta分析

Production and Nutritional Quality of Tomatoes(Solanum lycopersicum ***)Are Improved in the Presence of Biochar and Inoculation with Arbuscular Mycorrhiz.e

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American Journal of Plant Sciences 2020年第3期11卷 426-436页

作者： Wilson Castaneda Marcia Toro Andi Solorz.no Doris z.niga-Dávila Laboratorio de Ecologia Microbiana y Biotecnologia Departamento de BiologiaFacultad de CienciasUniversidad Nacional Agraria La MolinaLimaPeru

Tomato is a fruit of great nutritional interest in the basic human diet. The increasing use of agrochemicals to maintain production requires new alternatives to reduce environmental impact. Arbuscular mycorrhiz.e (AM) are beneficial microorganisms that favor the growth of plants improving their nutrition and development, protecting the plant from biotic and abiotic stresses and favoring the production of bioactive compounds that increase their nutritional value. The use of biochar as soil conditioner is also considered an environmentally friendly resource. A greenhouse experiment was carried out to observe the effect of the use of biochar and AM inoculation on the quality of fruits, yield and polyphenols production of Cherry tomato, Solanum lycopersicum var. Cerasiforme. A mixture of rice husk biochar with sterile sand and two inoculums of Glomeromycota native fungi: from a wetland (GWI) and a fallow field (GFI) were used. Control treatments consisted of inoculation with both GWI and GFI in sterile sand. All treatments were irrigated with 50% La Molina? hydroponic solution. After 12 weeks plants were harvested to quantify weight, number and diameters of the fruits, and yield, total polyphenols in the fruit pulp were quantified. In the presence of biochar and the two inoculums, GFI and GWI, fruit production was favored throughout the experiment. The height of the plants was significantly greater in the presence of biochar. Plants grown in biochar and inoculated with GFI had a yield of 8.2 MT/ha, increasing in 50% this value respect to control with biochar (5.33 MT/ha). This treatment doubled the number of fruits (59.5) with respect to the control (32.5). Root coloniz.tion by GFI was not affected by the presence of biochar. It is concluded that the combined use of rice husk biochar and Glomeromycota fungal inoculation is recommended for increasing of Cherry tomato yield and improving fruit quality through the production of bioactive compounds.

关键词： Glomeromycota Fungi Yield Polyphenols

Final Diagnosis of Pediatric Patients with Prolonged in Activated Partial Thromboplastin Time Preoperative Study

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第3期4卷 241-247页

作者： Noemi Aguirre Francisca Cordova Francisca Jaime Ximena Fonseca Pamela z.niga Pediatrics Resident Pontifical Catholic University of ChileSantiagoChile School of Medicine Pontifical Catholic University of ChileSantiagoChile Pediatrician Resident of Pediatric Gastroenterology and NutritionPontifical Catholic University of ChileSantiagoChile Otorhinolaryngologist Assistant ProfessorPediatrics DivisionMedical SchoolPontifical Catholic University of ChileSantiagoChile Hematologist-Oncologist Assistant ProfessorPediatrics DivisionMedical SchoolPontifical Catholic University of ChileSantiagoChile

Introduction: Activated partial thromboplastin time (aPTT) is one of the most used coagulation tests in preoperative evaluation. Incidental detection of a prolonged aPTT is a problem in primary care, in which the general pediatrician should be able to attend its initial management. Objective: To describe final diagnosis of patients with prolonged aPTT in preoperative study. Materials and Methods: This is a descriptive study of patients referred from otorhinolaryngology. Results: Totally, 508 adenoidectomies and/or tonsillectomies were performed in our center, 38 of which referred patients (7.5%) with prolonged aPTT, and 30 of which met inclusion criteria. The median age was 4 years. 56.6% of patients were males. 76.6% of patients normaliz.d aPTT at the second follow-up. Among these, 73.9% showed a normal study, 4.3% ha2d lupus anticoagulant and in 21.7% Von Willebrand disease was detected. Among patients that persisted with prolonged aPTT, 42.8% had coagulant factors deficiency, 28.5% had lupus anticoagulant and in 28.5% of patients a diagnosis could not be achieved with the tests used in the present study. Multivariate analysis did not show correlation between final diagnosis and the variables measured. Conclusion: The presence of a prolonged aPTT in children under preoperative study is due to a pre-analytic factor in the majority of cases or to the presence of lupus anticoagulant, normaliz.ng values on follow-up. We suggest that a new aPTT be performed on these patients, and only those that persist altered or present a symptoms and family history of coagulation disorders be referred to hematology.

关键词： aPTT Preoperative Study Tonsillectomy Adenoidectomy Coagulopathy

论陀思妥耶夫斯基“非暴力”思想对周作人的影响

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南京师范大学文学院学报 2008年第1期 95-99页

作者：哈迎飞广州大学人文学院广东广州510006

陀思妥耶夫斯基对周作人早期思想发展影响极大,尤其是他的非暴力思想和"爱之福音"的文学观深刻地影响了周作人早期的文学观和人生观。在以往的研究中,陀思妥耶夫斯基的影响一直未被重视,本文试图从比较研究的角度探讨这一问题,以补周作... 详细信息

陀思妥耶夫斯基对周作人早期思想发展影响极大,尤其是他的非暴力思想和"爱之福音"的文学观深刻地影响了周作人早期的文学观和人生观。在以往的研究中,陀思妥耶夫斯基的影响一直未被重视,本文试图从比较研究的角度探讨这一问题,以补周作人早期思想研究之不足。

关键词：周作人陀思妥耶夫斯基爱 “非暴力”

Effects of Banxia Xiexin Decoction (半夏泻心汤) on Cisplatin-Induced Apoptosis of Human A549 Lung Cancer Cells

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Chinese Journal of Integrative Medicine 2018年第6期24卷 436-441页

作者： ha-Rim Kim Guem-San Lee Mi-Seong Kim Do-Gon Ryu Hong-Seob So Hyoung-Chul Moon Young-Rae Lee Sei-Hoon yang Kang-Beom Kwon Center for Metabolic Function Regulation Wonkwang University School of Medicine Iksan Jeonbuk 54538 South Korea Department of Herbology Wonkwang University School of Korean Medicine Iksan Jeonbuk 54538 South Korea Department of Korean Physiology Wonkwang University School of Korean Medicine Iksan Jeonbuk 54538 South Korea Institute of Customiz.d Physical Therapy Gwanju 62279 South Korea Department of Oral Biochemistry Wonkwang University School of Dentistry Iksan Jeonbuk 54538 South Korea Department of Internal Medicine Wonkwang University School of Medicine Iksan Jeonbuk 54538 South Korea

Objective： To examinie the synergistic effects of Banxia Xiexin Decoction （半夏泻心汤, Known as Banhasasim-tang in Korean） extract （BXDE） on cisplatin-induced cytotoxicity in the A549 human lung cancer ceil lines. Methods： A549 cells were treated with varying concentrations （50-200μg/mL） of cisplatin and BXDE alone or in combination for 96 h. We used 1-（4,5-dimethylthiaz.l-2-yl）-3,5-diphenylformaz.n assay and flow cytometry to analyz. cell viability and apoptosis, respectively. Results： The exposure of cells to cispiatin and BXDE alone or in combination decreased ceil viability dose- and time-dependently （P〈0.05）, which was found to be mediated by the apoptotic pathway as confirmed by the increase in the annexin V^＋/propidium iodide stained cell population and a ladder pattern of discontinuous Dna fragments. Furthermore, the apoptosis was inhibited by the pan-caspase inhibitor, benz.loxycarbonyI-Val-Ala-Asp （OMe） fluoromethylketone （z.VAD-FMK）. Conclusions： BXDE significantly potentiated apoptotic effects of cisplatin in A549 cells. Moreover, apoptosis induced by BXDE might be the pivotal mechanism mediating its chemopreventative action against cancer.

关键词： Banxia Xiexin Decoction cisplatin A549 cells apoptosis anticancer synergism Chinese medicine

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一种新的去除视觉文本图像椒盐噪声的算法

计算机工程与应用 2007年第14期43卷 81-83页

作者：田大增郝永哈明虎河北大学物理科学与技术学院河北保定071002 河北大学数学与计算机学院河北保定071002

针对视觉文本图像,在获取、处理、传输中产生的椒盐噪声,提出一种基于文字笔画特性消除椒盐噪声的新算法。该算法智能判断被处理像素及其邻域内的像素点是否为噪声,从而有效地把文字目标和椒盐噪声加以区分。实验结果显示,相比传统的去... 详细信息

针对视觉文本图像,在获取、处理、传输中产生的椒盐噪声,提出一种基于文字笔画特性消除椒盐噪声的新算法。该算法智能判断被处理像素及其邻域内的像素点是否为噪声,从而有效地把文字目标和椒盐噪声加以区分。实验结果显示,相比传统的去噪和平滑算法,该方法能准确地抑制噪声,同时避免了对文字笔画的影响,减少了对后继识别的干扰。

关键词：椒盐噪声视觉文本图像文字笔画

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COSINE软件包物理系统V&V策略研究

原子能科学技术 2013年第B6期47卷 323-326页

作者：刘占权杨超党哈雷陈义学国家核电技术有限公司北京软件技术中心北京100029 西安交通大学陕西西安710049

软件验证(verification)和确认(validation)(简称V&V)是保证软件质量的重要手段,合理高效的V&V策略可事半功倍,COSINE软件包全称为堆芯物理-热工设计及系统安全分析软件包,其中的物理程序包括组件参数计算程序LATC、堆芯物理分析程序COR... 详细信息

软件验证(verification)和确认(validation)(简称V&V)是保证软件质量的重要手段,合理高效的V&V策略可事半功倍,COSINE软件包全称为堆芯物理-热工设计及系统安全分析软件包,其中的物理程序包括组件参数计算程序LATC、堆芯物理分析程序CORE、中子动力学程序KIND。本文以LATC、CORE、KIND为对象,以科学计算软件V&V研究为基础,提出了基于模块的验证方法和基于功能的确认方法,共同组成COSINE软件包物理系统V&V策略。

关键词： COSINE软件包 V&V 策略