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isorhamnetin Downregulates MMP2 and MMP9 to inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of integrative Medicine 2024年第4期30卷 299-310页

作者： LiU Xiao-rong Li Shuo-fu MEi Wen-ya LiU Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(ra).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated ra-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CiA)rat model was *** were randomly divided to sham,CiA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CiA *** levels of MMP2,MMP9,TNF-α,interleukin-6(iL-6),and iL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in ra-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** in in vitro studies,isorhamnetin inhibited ra-FLS viability,migration and invasion(Pisorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,iL-6,and iL-1βin ra-FLS(Pion of either MMP2 or MMP9 reversed isorhamnetin-inhibited ra-FLS migration and invasion,as well as the levels of TNF-α,iL-6,and iL-1β(Pisorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(Pion reversed the inhibitory effect of isorhamnetin on ra-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(Pin in vivo studies,isorhamnetin decreased arthritis index scores(Piated synovial *** reduced the levels of MMP2,MMP9,TNF-α,iL-6,and iL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

Correcting Climate Model Sea Surface Temperature Simulations with Generative Adversarial Networks:Climatology,interannual Variability,and Extremes

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Advances in Atmospheric Sciences 2024年第7期41卷 1299-1312页

作者： ya WANG Gang HUANG Baoxiang PAN Pengfei LiN Niklas BOERS Weichen TAO Yutong CHEN BO LiU Haijie Li State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Earth System Modelling School of Engineering and DesignTechnical University of MunichOttobrunn 85521Germany Potsdam institute for Climate impact Research Potsdam 14412Germany Department of Mathematics and Global Systems institute University of ExeterExeter EX44QEUK CMA Earth System Modeling and Prediction Centre(CEMC) Chinese Academy of Meteorological SciencesBeijing 100081China

Climate models are vital for understanding and projecting global climate change and its associated ***,these models suffer from biases that limit their accuracy in historical simulations and the trustworthiness of future *** these challenges requires addressing internal variability,hindering the direct alignment between model simulations and observations,and thwarting conventional supervised learning ***,we employ an unsupervised Cycle-consistent Generative Adversarial Network(CycleGAN),to correct daily Sea Surface Temperature(SST)simulations from the Community Earth System Model 2(CESM2).Our results reveal that the CycleGAN not only corrects climatological biases but also improves the simulation of major dynamic modes including the el Niño-Southern Oscillation(ENSO)and the indian Ocean Dipole mode,as well as SST ***,it substantially corrects climatological SST biases,decreasing the globally averaged Root-Mean-Square Error(RMSE)by 58%.intriguingly,the CycleGAN effectively addresses the well-known excessive westward bias in ENSO SST anomalies,a common issue in climate models that traditional methods,like quantile mapping,struggle to ***,it substantially improves the simulation of SST extremes,raising the pattern correlation coefficient(PCC)from 0.56 to 0.88 and lowering the RMSE from 0.5 to *** enhancement is attributed to better representations of interannual,intraseasonal,and synoptic scales *** study offers a novel approach to correct global SST simulations and underscores its effectiveness across different time scales and primary dynamical modes.

关键词： generative adversarial networks model bias deep learning el Niño-Southern Oscillation marine heatwaves

Natural Convection of a Power-Law Nanofluid in a Square Cavity with a Vertical Fin

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2091-2108页

作者： Amira M’hadbi Mohammed el Ganaoui Haïkel Ben Hamed Amenallah Guizani Khalid Chtaibi LERMAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTi Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the rayleigh number(ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant impact on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.Moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of rayleigh number ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

Effect of diluents on the extraction of praseodymium and samarium by Cyanex 923 from acidic nitrate medium

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Journal of rare Earths 2010年第2期28卷 215-220页

作者： ya el-Nadi Hot Laboratories Centre Atomic Energy Authority(Egypt)

The solvent extraction of Pr(Ⅲ) and Sm(Ⅲ) with trialkyl phosphine oxide(Cyanex 923) in chloroform,carbon tetrachloride,n-octane,cyclohexane,1,2-dichloroethane,benzene,toluene,xylene and nitrobenzene from acidic nitrate medium was *** the basis of slope analysis data,the composition of the extracted species was determined as(M(NO3)3?2CY923),CY923 refers to Cyanex *** values of the equilibrium constants and the separation factors were *** effect of the diluents on the metal extracti...

关键词： extraction diluents praseodymium samarium Cyanex 923 rare earths

iL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation

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Oncology Research 2024年第4期32卷 625-641页

作者： WEN GE ya Li YUTiNG RUAN NiNGXiA WU PEi MA TONGPENG XU YONGQiAN SHU YiNGWEi WANG WEN QiU CHENHUi ZHAO Department of immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(iL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that iL-17 receptor A(iL-17ra),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with iL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce iL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and *** investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to ***,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and ***,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus iL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all ***,these outcomes uncover that iL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.

关键词： NSCLC cell migration and invasion iL-17 p300 STAT3 MMP19 Acetylation and phosphorylation

impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

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Current Zoology 2024年第4期70卷 539-547页

作者： Lorena Vanesa Sovrano Evelina Jesica Leon Rodrigo Ezequiel Lorenzón Pamela Fernanda Olguin Adolfo Héctor Beltzer Alejandro raúl Giraudo Laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 382-395页

作者： Jing-yao Ren Meng Xu Xiang-Dong Niu Shi-Xun Ma ya-Jun Jiao Da Wang Miao Yu Hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina Gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The systemic inflammatory response index(SiRi)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the SiRi to patients who undergo robotic radical gastric cancer *** To validate the applicability of the SiRi in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SiRi levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBASE,Web of Science,and Scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the SiRi in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative SiRi levels and 5-year overall survival(OS)and disease-free survival(DFS)was *** The findings demonstrated an extensive connection between SiRi values and the outcome of patients with gastric *** SiRi levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,T-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** SiRi values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： Systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

Anti-inflammatory and DNA Repair Effects of Astragaloside iV on PC12 Cells Damaged by Lipopolysaccharide

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Current Medical Science 2024年第4期44卷 854-863页

作者： Hai-long Li Li-hua SHAO Xi CHEN Meng WANG Qi-jie QiN ya-li yaNG Guang-run ZHANG yang HAi Yi-hong TiAN Department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China Key Laboratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China Department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Public Health Gansu University of Chinese MedicineLanzhou730000China People’s Hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside iV on key targets using high-throughput sequence technology and bioinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside iV for 24 *** concentration of astragaloside iV that did not affect the cell survival rate was selected as the treatment group for subsequent *** activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,iL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western *** differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,Pith the following KEGG enrichment analysis,RT-qPCR and Western blotting were used to detect the mRNA and protein expression of DEGs related to the iL-17 pathway in different groups of PC12 *** The viability of PC12 cells was not altered by treatment with 0.01,0.1,or 1µmol/L astragaloside iV for 24 h(P>0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(Pin expression levels of ERCC2,XRCC4,XRCC2,TNF-α,iL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(Pells were pretreated with 0.01,0.1,or 1µmol/L astragaloside iV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(Pration sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside iV inflammation DNA damage

Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis

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World Journal of Hepatology 2024年第2期16卷 241-250页

作者： Ting Li Li-Li Wang ya-Ping Li Jian Gan Xi-Sheng Wei Xiao-Rong Mao Jun-Feng Li Department of infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina Department of radiology First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT)is a commonthsn complication after splenectomy in patients with ***,the predictors of postoperative PVT are not *** To investigate the predictors of PVT after splenectomy in patient with *** A total of 45 patients with cirrhosis who underwent splenectomy were consecutively enrolled from January 2017 to December *** incidence of PVT at 1 months,3 months,and 12 months after splenectomy in patients with cirrhosis was *** hematological indicators,biochemical and coagulation parameters,and imaging features were recorded at baseline and at each observation *** univariable,multivariable,receiver operating characteristic curve and timedependent curve analyses were *** The cumulative incidence of PVT was 40.0%,46.6%,and 48.9%at 1 months,3 months,and 12 months after *** analysis showed that portal vein diameter(PVD)≥14.5 mm and monthsdel end-stage liver disease(MelD)score>10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy(Pime-dependent curve showed that the cumulative incidence of PVT was significantly different between patients with MelD score≤10 and>10(Pin addition,the cumulative incidence of PVT in the PVD≥14.5 mm group was significantly higher than that in the PVDiON Wider PVD and MelD score>10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy in patient with cirrhosis.

关键词： Cirrhosis Splenectomy Portal vein thrombosis Predictors