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in-flight Energy Calibration of the GECAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-ya Guo Wen-Xi peng yan-Qiu Zhang Shuo Xiao Shao-Lin Xiong Chao Zheng Chao-yang Li Jia-Cong Liu Wang-Chen Xue Jian-Jian He Zheng-Hua An Da-Li Zhang Xin-Qiao Li Li-Ming Song Shi-Jie Zheng Ke Gong ya-Qing Liu Xin-Ying Song Xiao-Yun Zhao Xiang-yang Wen yan-Bing Xu Xiang Ma Xiao-Bo Li Ping Wang Yue Huang Ce Cai Qi-Bin Yi Yi Zhao Chen-Wei Wang institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).in this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

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H形钢梁弯曲滞回性能研究与数值模拟优化

塑性工程学报 2024年第5期31卷 179-187页

作者：田亚峰苏鹏勋董军伟内蒙古工业大学土木工程学院内蒙古呼和浩特010000 内蒙古工业大学土木工程结构与力学重点实验室内蒙古呼和浩特010000

为完善H形钢梁在纯弯曲荷载作用下的滞回性能的研究,对2类截面的H形钢梁增加一个多周滞回加载制度下的拟静力试验。此加载制度下的目标耗能量与此试件等幅升幅加载制度下达到峰值荷载时的总耗能量相等,因此对该试件的破坏模式、累积损... 详细信息

为完善H形钢梁在纯弯曲荷载作用下的滞回性能的研究,对2类截面的H形钢梁增加一个多周滞回加载制度下的拟静力试验。此加载制度下的目标耗能量与此试件等幅升幅加载制度下达到峰值荷载时的总耗能量相等,因此对该试件的破坏模式、累积损伤和耗能规律进行分析,验证了原设想中存在的不影响滞回耗能的阈值低于0.02 rad。同时进行了有限元对比分析,对此试验已有模型进行了精细化处理。有限元分析中利用热塑性方法模拟了试件焊接残余应力的变化过程,从而在模型加载过程中引入残余应力的影响,使试件的初始刚度、翼缘局部屈曲发生的时刻、极限荷载后刚度退化有显著改善。

关键词：局部屈曲纯弯曲 H形钢梁滞回有限元

急性白血病患者化疗后肺部感染的危险因素分析

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中国实验血液学杂志 2024年第3期32卷 933-939页

作者：张雪鹏席亚明兰州大学第一临床医学院甘肃兰州730000 兰州大学第一医院血液科甘肃兰州730000

目的:探讨急性白血病(AL)患者化疗后肺部感染的危险因素。方法:收集294例AL患者作为研究对象,根据化疗后是否肺部感染分为感染组(93例)和对照组(201例),分析社会人口学资料(性别、年龄、BMi)、临床资料(疾病类型、ECOG评分、侵入性操作... 详细信息

目的:探讨急性白血病(AL)患者化疗后肺部感染的危险因素。方法:收集294例AL患者作为研究对象,根据化疗后是否肺部感染分为感染组(93例)和对照组(201例),分析社会人口学资料(性别、年龄、BMi)、临床资料(疾病类型、ECOG评分、侵入性操作、基础疾病、激素治疗、经验性使用抗生素、预后分层、化疗强度、原始细胞计数、白细胞计数、中性粒细胞计数、粒缺持续时间、血小板计数、血红蛋白、白蛋白、空腹血糖)与AL化疗后肺部感染的相关性,采用COX回归法分析急性白血病患者化疗后肺部感染的危险因素。结果:294例AL患者肺部感染后30 d内死亡病例为11例。感染组与未感染组患者在年龄、吸烟史、ECOG评分、侵入性操作、激素治疗、经验性使用抗生素、预后分层、化疗强度、原始细胞计数、中性粒细胞计数、粒缺持续时间、血小板计数、血红蛋白、白蛋白、空腹血糖方面差异有统计学意义(P<0.05)。COX回归分析结果显示,吸烟史、侵入性操作、未预防性使用抗生素、预后不良、粒缺持续时间长、血小板水平低、白蛋白低是AL患者化疗后肺部感染的高危因素(P<0.05)。结论:吸烟、侵入性操作、未预防性使用抗生素、预后不良、粒缺持续时间长、血小板水平低、白蛋白低是AL患者化疗后肺部感染的高危因素。

关键词：急性白血病化疗肺部感染影响因素

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： ya-Ling Zhu Lei-Lei Meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu Jin peng Xue-Jin Lu Jian-Zhen Huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan Huang Hao-Shu Fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac integrative analysis Enhancer

口服固体制剂经鼻胃管给药体外评价试验的一般考量

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中国新药杂志 2024年第7期33卷 651-653页

作者：孟永刚侯鹏王亚敏国家药品监督管理局药品审评中心北京100076

鼻胃管给药是将药物通过适宜型号的鼻胃管经鼻腔插入胃内输送口服药的一种治疗方法,鼻胃管给药为无法正常吞咽的患者提供了一种重要的给药途径。鼻胃管给药的体外研究对保证药物准确的给药剂量、预期的安全性和有效性具有重要意义。本... 详细信息

鼻胃管给药是将药物通过适宜型号的鼻胃管经鼻腔插入胃内输送口服药的一种治疗方法,鼻胃管给药为无法正常吞咽的患者提供了一种重要的给药途径。鼻胃管给药的体外研究对保证药物准确的给药剂量、预期的安全性和有效性具有重要意义。本文参考国内外管饲给药体外研究相关指南及文献,结合审评工作经验,简要探讨鼻胃管给药体外评价研究需要关注的内容和技术要求。

关键词：口服固体制剂鼻胃管肠内给药体外研究

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山水工程管理体制现实困境与纾解策略

黑龙江生态工程职业学院学报 2024年第5期37卷 1-6,141页

作者：岳亚鹏湖南师范大学法学院湖南长沙410081

山水林田湖草沙一体化治理是贯彻各环境要素生命共同体理念、推进我国生态文明建设的重要举措,也是习近平生态文明思想在生态保护领域的具体体现。目前,我国共开展了51项山水工程,在矿山修复、流域治理、退耕还林、湿地保护等方面都取... 详细信息

山水林田湖草沙一体化治理是贯彻各环境要素生命共同体理念、推进我国生态文明建设的重要举措,也是习近平生态文明思想在生态保护领域的具体体现。目前,我国共开展了51项山水工程,在矿山修复、流域治理、退耕还林、湿地保护等方面都取得了非常突出的成绩。但是在山水工程实施的过程中,仍存在缺乏生态保护法规指导、部门协同机制不健全、工程资金整合能力弱以及项目监管机制不健全等问题。基于此,提出建立环境法典框架下的生态保护法律体系、完善政府职能耦合机制、强化生态保护资金管理、建立健全全过程监管机制的建议,以期对我国山水林田湖草沙一体化修复与保护工作提供新的解决思路。

关键词：山水工程生态保护法律体系职能耦合监管机制

Association of psychological stress with wives’hypertension across over 10 million Chinese married female population aged 20-49 years

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Chinese Medical Journal 2024年第13期137卷 1583-1591页

作者： Zhenyan Zhao Jiajing Jia Xinyi Lyu Lihua Zhang Yuanyuan Wang Yuan He Zuoqi peng ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai yan Xu Ma Ying yang State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China National Research institute for Family Planning Beijing 100081China National Human Genetic Resources Center Beijing 102206China Graduate School of Peking Union Medical College Beijing 100730China Department of Maternal and Child Health National Health and Family Planning Commission of the PRCBeijing 100044China

Background:Psychological stress has been reported to be a potential risk factor for hypertension among females,but it remains unclear whether spousal chronic stress levels alter the risk of hypertension among *** examined the associations between stress within the family and hypertension among married ***:Reproductive-aged women who were planning for pregnancy and their husbands were recruited from the National Free Pre-pregnancy Checkup Projects(NFPCP)across 31 provinces in China in 2016 and *** stress of wives or husbands was measured with a 5-point Likert-type scale,and assessed from three domains:work/life-related stress,economic stress,and overall ***-adjusted logistic regression models were used to assess the associations between stress status and the prevalence of ***:Of 10,027,644 couples,261,098(2.60%)women had *** results showed that higher stress levels among themselves or their husbands were associated with a higher prevalence of hypertension in women(P_(for trend)ith non-stressed participants,female participants with the highest stress themselves were at a greater risk of hypertension,with adjusted odds ratio(OR)of 1.31(95%confidence interval[Ci]:1.25-1.37);and compared with participants whose husbands had no stress,those whose husbands had the highest stress level were at a higher risk of hypertension with adjusted OR of 1.24(95%Ci:1.20-1.29).Moreover,compared with non-stressed status for both couples,only-wife-stressed,only-husband-stressed,and both-stressed couples were found to be significantly associated with increased risks of wives’hypertension,with adjusted ORs of 1.28(95%Ci:1.25-1.31),1.19(95%Ci:1.17-1.21),and 1.28(95%Ci:1.26-1.31),***:Moderate to severe stress in both spouses might be associated with female hypertension prevalence,which highlights the importance of paying attention to the psychological stresses of couples within the f

关键词： Psychological stress Hypertension Occupational stress Life stress Financial stress

糖皮质激素治疗中型新型冠状病毒感染高龄老年患者62例临床疗效回顾性研究

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中国感染控制杂志 2024年第6期23卷 680-686页

作者：孙雅彭定江张艺军广州中医药大学广东广州510080 中国人民解放军南部战区总医院干部病房二科广东广州510080

目的探讨小剂量短疗程糖皮质激素治疗中型新型冠状病毒感染(COViD-19)高龄老年患者的疗效。方法回顾性调查2022年12月9日—2023年2月9日某院收治的≥80岁中型COViD-19患者的临床资料。按入院后是否静脉使用小剂量糖皮质激素,分为未使用... 详细信息

目的探讨小剂量短疗程糖皮质激素治疗中型新型冠状病毒感染(COViD-19)高龄老年患者的疗效。方法回顾性调查2022年12月9日—2023年2月9日某院收治的≥80岁中型COViD-19患者的临床资料。按入院后是否静脉使用小剂量糖皮质激素,分为未使用激素组和使用激素组,描述两组患者的一般资料和实验室检查结果,观察30 d内患者病情变化,比较两组的疗效差异。结果共收集患者62例,其中未使用激素组21例,激素组41例。两组患者治疗前一般资料和实验室检查指标比较,差异均无统计学意义(均P>0.05),除是否使用糖皮质激素外,其他治疗手段比较差异均无统计学意义(均P>0.05)。患者治疗10 d后激素组咳嗽(34.1%VS 66.7%)、咯痰(19.5%VS 61.9%)、心悸(4.9%VS 23.8%)、气促(7.3%VS 28.6%)临床表现较未使用激素组减少,差异均有统计学意义(均PiD-19高龄老年患者小剂量、短疗程全身使用糖皮质激素,可以有效控制病情进展,改善患者预后。

关键词：新型冠状病毒感染高龄老人糖皮质激素 COViD-19 疗效

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简单立方点阵结构静态平压性能分析

计算力学学报 2024年第3期41卷 513-518,533页

作者：杨孝峰盛亚鹏苏宇锋郑州大学机械与动力工程学院郑州450001

为了提高简单立方(SC)点阵结构的平压力学性能,在ABAQUS中对SC单胞建立了周期边界约束方程,并通过ESO算法对周期边界条件下的SC单胞进行了拓扑优化设计。随后对优化SC单胞的等效弹性模量进行了求解,发现优化SC单胞的等效弹性模量明显优... 详细信息

为了提高简单立方(SC)点阵结构的平压力学性能,在ABAQUS中对SC单胞建立了周期边界约束方程,并通过ESO算法对周期边界条件下的SC单胞进行了拓扑优化设计。随后对优化SC单胞的等效弹性模量进行了求解,发现优化SC单胞的等效弹性模量明显优于传统SC单胞,从外部去除单胞材料可使优化单胞等效压缩模量提高27.14%,从内部去除单胞材料可使单胞等效剪切模量提高46.18%。最后将优化SC单胞从单胞层面扩展到宏观结构中,探究了三类SC点阵结构的静态平压性能。研究表明,周期边界条件与ESO相结合的拓扑优化方法,可使SC结构静态平压时的抵抗力得到明显提升。相比传统SC点阵结构,优化后的SC点阵结构抵抗力提高了20%以上。

关键词：点阵结构周期边界条件 ESO算法拓扑优化平压