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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

World Journal of gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang Mu-Qi Wang Jiang Deng Ning gao Mei Li ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKgROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** Hepg2 and SMMC-7721 cells were transfected with the pEgFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the g0/g1 phase of the cell cycle and induced *** proportion of cells in the g0/g1 phase was significantly increased and the proportion of cells in the S phase was decreased in Hepg2 cells that were transfected with pEgFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

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World Journal of Clinical Cases 2024年第24期12卷 5589-5595页

作者： Zhi-Nian Wu Ru JI Ying Xiao ya-Dong Wang Cai-yan Zhao Department of Infectious Diseases The Hebei Medical University Third HospitalShijiazhuang 050051Hebei ProvinceChina

BACKgROUND The complexity of immunoglobulin g4(Igg4)-related diseases and their potential connection to hematologic malignancies remains *** article provided a review of the diagnosis and treatment of a patient with Igg4-related sclerosing cholangitis(SC)and essential thrombocythemia(ET),along with an analysis of relevant literature to enhance comprehension of this *** SUMMARY A 56-year-old male was admitted to two hospitals with deteriorating jaundice and pruritus prior to *** our expectations,the patient was first diagnosed with Igg4-SC and ET with the Janus kinase 2 V617F ***,the administration of acetate prednisone significantly resulted in improvements in both Igg4-SC and *** need to pay attention to immune disorders and inflammation as they contribute to the development of various disease *** When Igg4-SC is suspected without histopathological evidence,diagnostic therapy and long-term regular follow-up can lead to positive treatment *** should be mindful of the potential presence of concurrent hematologic diseases in patients with immune disorders.

关键词： Immunoglobulin g4-related sclerosing cholangitis Essential thrombocythemia Autoimmune pancreatitis Janus kinase 2 mutation glucocorticoids Case report

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Lateral ring compression test applied to a small caliber steel jacket:Identification of a constitutive model

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Defence Technology（防务技术） 2024年第6期36卷 133-148页

作者： yann Coget yael Demarty Christophe Czarnota Anthony Bracq Jean-Sebastien Brest Alexis Rusinek French-german Research Institute of Saint-Louis 5 Rue Du General Cassagnou68300 Saint-LouisFrance Laboratoire d'Etude des Microstructures et de Mecanique des Materiaux(LEM3) CNRSUniversite de LorraineArts&Metiers ParisTechF-57000 MetzFrance

The evolution of threats and scenarios requires continuous performance improvements of ballistic protections for armed *** a modeling point of view,it is necessary to use sufficiently precise material behavior models to accurately describe the phenomena observed during the impact of a projectile on a protective *** this context,the goal of this paper is to characterize the behavior of a small caliber steel jacket by combining experimental and numerical *** experimental method is based on the lateral compression of ring specimens directly machined from the thin and small *** speeds and temperatures are considered in a quasi-static regime in order to reveal the strain rate and temperature dependencies of the tested *** Finite Element Updating Method(FEMU)is *** results are coupled with an inverse optimization method and a finite element numerical model in order to determine the parameters of a constitutive model representative of the jacket *** of the present model are verified against experimental results and a parametric study as well as a discussion on the identified material parameters are *** results indicate that the strain hardening parameter can be neglected and the behavior of the thin steel jacket can be described by a modeling without strain hardening sensitivity.

关键词： Full metal jacket ammunition Lateral ring compression Inverse identification Numerical simulation

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规模化养殖园区土壤中抗生素污染特征和生态风险评价

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环境科学 2024年第7期45卷 4302-4311页

作者：陈进王亚娟陶红张锐宁夏大学地理科学与规划学院银川750021 宁夏(中阿)旱区资源评价与环境调控重点实验室银川750021 宁夏大学经济管理学院银川750021

采集规模化养殖园区不同土地利用类型的土壤,采用高效液相色谱仪检测土壤中抗生素的含量,分析抗生素与土壤理化性质之间的关系,并利用风险商值法对养殖场园区土壤中的抗生素进行生态风险评价.结果表明,养殖场周边土壤受到不同程度的抗... 详细信息

采集规模化养殖园区不同土地利用类型的土壤,采用高效液相色谱仪检测土壤中抗生素的含量,分析抗生素与土壤理化性质之间的关系,并利用风险商值法对养殖场园区土壤中的抗生素进行生态风险评价.结果表明,养殖场周边土壤受到不同程度的抗生素污染,其中检出率和含量平均值最高的是四环素(TC);不同土地利用类型的土壤中,ω(抗生素)平均值大小排序为:玉米地(1.48μg·kg^(-1))>养殖场围栏外0.5 m处(1.27μg·kg^(-1))>山药地(1.03μg·kg^(-1))>牧草地(0.69μg·kg^(-1))>林地(0.18μg·kg^(-1));冗余分析结果显示,全氮、全磷和纤维素酶对土壤样品中抗生素的含量影响较大.根据生态风险评价结果可知,土霉素(OTC)、金霉素(CTC)、强力霉素(DOC)、环丙沙星(CIP)和四环素(TC)属于低风险等级,磺胺嘧啶(SD)和磺胺二甲嘧啶(SM2)为中高风险,应当重视对养殖场周边土壤抗生素污染管控,加强兽用抗生素的管理.

关键词：抗生素污染特征冗余分析风险评价养殖场

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活性可反应亚微米壳包覆CL-20及其性能表征

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火炸药学报 2024年第5期47卷 422-429,I0004页

作者：成雅芝任慧常世隆北京理工大学爆炸科学与安全防护全国重点实验室北京100081

为了获得高能低感的CL-20颗粒,采用喷雾干燥工艺改善CL-20原料的形貌,采用顺丁橡胶BR、微晶蜡和胶体石墨对CL-20/微纳复合铝粉进行钝感包覆,构建具有可反应活性、能量补强的包覆外壳,同时提升CL-20使用安全性。采用扫描电子显微镜(SEM)... 详细信息

为了获得高能低感的CL-20颗粒,采用喷雾干燥工艺改善CL-20原料的形貌,采用顺丁橡胶BR、微晶蜡和胶体石墨对CL-20/微纳复合铝粉进行钝感包覆,构建具有可反应活性、能量补强的包覆外壳,同时提升CL-20使用安全性。采用扫描电子显微镜(SEM)观察了包覆颗粒的表观形貌,编写MATLAB程序代码对SEM图像颗粒的长宽比和圆度值进行识别计算,表征其球形度,采用有机元素分析(EA)和电感耦合等离子体原子发射光谱(ICP-AES)分析测试包覆颗粒中CL-20和铝粉的实际含量,采用X射线衍射(XRD)对包覆颗粒进行晶型结构分析,采用gJB方法对包覆颗粒的感度和爆热进行测试,并与CL-20原料进行了对比,采用差式扫描-热重-红外-质谱联用(DSC-Tg-FTIR-MS)对包覆颗粒及其分解产物进行热分析。结果表明,制备得到的包覆颗粒粒径在10μm左右,球形度较高,长宽比为1.03,圆度值为0.91;包覆颗粒中CL-20和铝粉的实际含量分别为88.17%和7.76%;包覆颗粒的晶型为β-CL-20,摩擦感度为36%,撞击感度爆炸概率为38%,撞击感度特性落高为13.4 cm,降感效果明显;爆热值为5946 J/g,是CL-20原料(6073 J/g)的97.91%,能量损失不超过3%。

关键词：物理化学 CL-20 可反应高活性喷雾干燥钝感包覆

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Multiomics analyses of two Leonurus species illuminate leonurine biosynthesis and its evolution

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Molecular Plant 2024年第1期17卷 158-177页

作者： Peng Li Meng-Xiao yan Pan Liu Dan-Jie ya.g Ze-Kun He Yun gao yan Jiang Yu Kong Xin Zhong Sheng Wu Jun ya.g Hong-Xia Wang yan-Bo Huang Le Wang Xiao-ya Chen Yong-Hong Hu Qing Zhao Ping Xu shanghai Key Laboratory of Plant Functional genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChineseAcademy of SciencesShanghaiChina College of Life Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of Plant Molecular genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina University of the Chinese Academy of Sciences Beijing 100049China The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese Medicine1200 Cailun RoadShanghai 201203China College of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China

The Lamiaceae family is renowned for its terpenoid-based medicinal components,but Leonurus,which has traditional medicinal uses,stands out for its alkaloid-rich ***,the principal active compound found in Leonurus,has demonstrated promising effects in reducing blood lipids and treating ***,the biosynthetic pathway of leonurine remains largely ***,we present the chromosome-level genome sequence assemblies of Leonurus japonicus,known for its high leonurine production,and Leonurus sibiricus,characterized by very limited leonurine *** integrating genomics,RNA sequencing,metabolomics,and enzyme activity assay data,we constructed the leonurine biosynthesis pathway and identified the arginine decarboxylase(ADC),uridine diphosphate glucosyltransferase(UgT),and serine carboxypeptidase-like(SCPL)acyltransferase enzymes that catalyze key reactions in this *** analyses revealed that the UgT–SCPL gene cluster evolved by gene duplication in the ancestor of Leonurus and neofunctionalization of SCPL in ***,which contributed to the accumulation of leonurine specifically in ***,our comprehensive study illuminates leonurine biosynthesis and its evolution in Leonurus.

关键词： Lamiaceae Leonurus japonicus Leonurus sibiricus genome sequence alkaloids leonurine gene cluster biosynthetic pathway evolution

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Application of buried auricular point combined with Wenjing Sanhan prescription in arteriosclerosis obliterans patients with resting pain

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World Journal of Clinical Cases 2024年第24期12卷 5558-5567页

作者： ya-Ping Li Tian Su Xiao-Li Xue Huan-Ren Shi Zhi-Hui Su Jun Li Department of Vascular Shijiazhuang Hospital of Traditional Chinese Medicine(Eastern Hospital District)Shijiazhuang 050011Hebei ProvinceChina

BACKgROUND Research on the combined use of ear acupoint embedding beans and warming meridians with cold-dispersing formulas for alleviating resting pain in patients with arteriosclerosis obliterans(ASO)remains *** To explore the therapeutic efficacy of auricular point embedding beans combined with Wenjing Sanhan prescription in alleviating resting pain in patients with lower-limb *** A total of 100 patients with ASO experiencing resting pain who were treated at our hospital from January 2022 to January 2023 were *** were randomly allocated into two groups using a double-blind *** control group was treated using a warming meridian with a cold-dispersing formula,while the study group received additional treatment with ear acupoint embedding *** clinical efficacy,ankle-brachial artery pressure ratio,hemorheological indicators,and traditional Chinese medicine symptom scores were compared between the two *** The clinical efficacy rate in the study group was significantly higher(94.00%)than that in the control group(72.00%,Pgnificantly higher in the study group after treatment(Pgical parameters,including whole blood viscosity,plasma viscosity(1.83±0.11)mPa/s,fibrinogen levels(3.30±0.21)g/L,platelet adhesion rate(49.87%±10.51%),and erythrocyte aggregation index(1.79±0)were improved in the study group compared to the control *** addition,the scores for decreased skin temperature(1.41±0.26),intermittent claudication(1.30±0.20),and resting pain(1.23±0.31)were significantly lower in the study group than those in the control group(all Pgroup also exhibited significant improvement(Pg beans and Wenjing Sanhan prescription demonstrates promising clin

关键词： Embedding beans in ear acupoints Prescription for warming channels and dispelling cold Lower limb arteriosclerosis obliterans Resting pain Blood flow rheology Curative effect

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超声灰度比值分析对新生儿高胆红素血症颅内基底神经核监测价值初探

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中华超声影像学杂志 2024年第3期33卷 247-251页

作者：冯蔚闫瑾仪晓立马亚首都儿科研究所附属儿童医院超声科北京100020 首都儿科研究所附属儿童医院新生儿内科北京100020 首都儿科研究所附属儿童医院放射科北京100020

目的探讨颅脑超声(CUS)苍白球与壳核灰度比值对新生儿高胆红素血症的颅内基底神经核监测价值。方法回顾性分析2022年6月至2023年6月在首都儿科研究所附属儿童医院新生儿内科住院的69例患儿的CUS、临床及磁共振成像(MRI,46例)资料。使用U... 详细信息

目的探讨颅脑超声(CUS)苍白球与壳核灰度比值对新生儿高胆红素血症的颅内基底神经核监测价值。方法回顾性分析2022年6月至2023年6月在首都儿科研究所附属儿童医院新生儿内科住院的69例患儿的CUS、临床及磁共振成像(MRI,46例)资料。使用UpToDate calculator计算每例患儿的光疗参考阈值,并结合342μmol/L节点值,将患儿分为对照组、轻-中度高胆红素血症组和重度高胆红素血症组;使用RadiAnt DICOM Viewer软件读取双侧苍白球与壳核超声灰度值,并计算比值CUS(g/P);使用MRI后处理工作站读取双侧苍白球和壳核T1信号值,并计算比值MRI(g/P)。分析CUS(g/P)与血清总胆红素(TSB)/光疗阈值、TSB/白蛋白值的相关性;CUS(g/P)与MRI(g/P)进行一致性分析;比较对照组、轻-中度高胆红素血症组、重度高胆红素血症组三组间CUS(g/P)差异。结果①CUS(g/P)与TSB/光疗阈值、TSB/白蛋白值呈正相关(rs=0.721、0.600,均Pg/P)值与MRI(g/P)值存在一致性(τ=0.743,Pg/P)值在对照组、轻-中度高胆红素血症组、重度高胆红素血症组依次增高,两两组间差异有统计学意义(均Pg/P)值和TSB间存在剂量反应关系,与MRI(g/P)值具有诊断一致性,在不同程度胆红素水平组间存在差异,可用于新生儿高胆红素血症的颅内基底神经核监测。

关键词：超声检查,颅脑磁共振成像高胆红素血症新生儿

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Application value research of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after stroke

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World Journal of Clinical Cases 2024年第21期12卷 4618-4625页

作者： Huan Xu Mei Chen Yu-Li Wu ya-Fen Lu Xin Wang Wei Jiang Yuan-Ying Zhang Department of Brain Disease Yixing Traditional Chinese Medicine HospitalYixing 214200Jiangsu ProvinceChina

BACKgROUND Stroke is a common disabling disease,whether it is ischemic stroke or hemorrhagic stroke,both can result in neuronal damage,leading to various manifestations of neurological *** To explore of the application value of swallowing treatment device combined with swallowing rehabilitation training in the treatment of swallowing disorders after *** This study selected 86 patients with swallowing disorders after stroke admitted to our rehabilitation department from February 2022 to December 2023 as research *** were divided into a control group(n=43)and an observation group(n=43)according to the *** control group received swallowing rehabilitation training,while the observation group received swallowing treatment device in addition to the *** groups underwent continuous intervention for two courses of *** The total effective rate in the observation group(93.02%)was higher than that in the control group(76.74%)(P=0.035).After intervention,the oral transit time,swallowing response time,pharyngeal transit time,and laryngeal closure time decreased in both groups compared to before *** the observation group,the oral transit time,swallowing response time,and pharyngeal transit time were shorter than those in the control group after ***,the laryngeal closure time after intervention in the observation group was compared with that in the control group(P=0.142).After intervention,average amplitude value and duration of the genioglossus muscle group during empty swallowing and swallowing 5 mL of water are reduced compared to before intervention in both *** intervention,the scores of the chin-tuck swallowing exercise and the Standardized Swallowing Assessment are both reduced compared to pre-intervention levels in both ***,the observation group scores lower than the control group after ***,the Functional Oral Intake Scale scores of both g

关键词： Swallowing therapy device Swallowing rehabilitation training Stroke Swallowing disorder Swallowing function

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石灰性土壤小麦籽粒锌硒生物强化理论技术与推广面临的挑战

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植物营养与肥料学报 2024年第7期30卷 1295-1306页

作者：田霄鸿李雅菲西北农林科技大学资源环境学院陕西杨凌712100 农业农村部西北旱地农业绿色低碳重点实验室陕西杨凌712100

锌与硒是人类生命活动必需的两种微量元素,摄入不足会引发多种疾病。我国小麦主产区恰好处于锌硒缺乏或潜在缺乏的石灰性土壤地带,籽粒中锌硒含量难以达到人体需求标准,导致缺锌缺硒人口数量庞大,已成为我国严重的公共营养与健康问题。... 详细信息

锌与硒是人类生命活动必需的两种微量元素,摄入不足会引发多种疾病。我国小麦主产区恰好处于锌硒缺乏或潜在缺乏的石灰性土壤地带,籽粒中锌硒含量难以达到人体需求标准,导致缺锌缺硒人口数量庞大,已成为我国严重的公共营养与健康问题。本文综述了小麦籽粒锌硒农艺生物强化措施,强化籽粒中锌硒的分布、安全形态、生物可给性及叶面喷施的应用现状。国内外研究大多认为,在极缺锌土壤上采用土施或土施与叶面喷施锌肥结合的方式是最有效的小麦锌强化策略;而最新研究表明,在我国潜在缺锌的石灰性土壤上,叶面喷施硫酸锌的强化效果远优于土施,在小麦灌浆前期喷施2~3次0.3%~0.4%的Zn SO_(4)·7H_(2)O (喷锌总量约2.5 kg/hm^(2))并添加表面活性剂,可以实现籽粒锌含量达40~60 mg/kg的富锌目标。小麦籽粒中锌含量由外到内逐渐降低,人体摄入最多的中心胚乳部分锌含量最低,故需更为关注胚乳中锌含量及生物有效性,制定胚乳富锌标准。此外,食物中无机态元素毒性较大,生物有效性低,吸收利用效果不理想,而有机态对人体更为安全有效,因此还需明晰强化小麦籽粒中是否将外源无机Zn转化为有机态储存。小麦硒生物强化通过土施或叶面喷施亚硒酸盐或硒酸盐均能实现,由于土施硒肥易受土壤pH、有机质等因素影响,硒肥利用率低,因此,通行的硒强化措施是在小麦灌浆前期,喷施2 0~3 0 g/h m 2的亚硒酸钠或硒酸钠,能够实现籽粒硒含量达0.2 5~0.30 mg/kg的富硒目标。与锌不同,硒在籽粒中分布相对均匀,胚乳中硒占全粒总硒的96.2%~97.4%。同时硒强化小麦籽粒中对人体安全的有机硒占总硒的80%以上,且不同有机硒在人体中的作用不同。虽然叶面单独喷锌或硒的理论技术体系完善且实际强化效果良好,但其经济效益没有充分体现,影响了该技术的应用推广。近年来,将叶面喷施锌硒与“一喷三防”农艺措施相结合的研究不断增多,与小麦实际生产形成有效对接,为小麦锌硒强化提供了可行途径。然而,锌硒与不同农药及多种微量元素共同喷施时多种物质之间的互作效应,叶面喷施进行锌硒生物强化及籽粒锌硒储存的生理及分子机制还未明晰,值得进一步探讨。

关键词：小麦籽粒锌硒农艺生物强化形态叶面喷施 “一喷三防”

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